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      • KCI등재

        Valveless Piezoelectric Micropump of Parallel Double Chambers

        Li Guo,Weiping Yan,Yinghua Xu,Yiru Chen 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.

        The driving performance of the piezoelectric actuator was simulated by ANSYS software, and the relationship between structure parameters and center displacement/frequency of piezoelectric actuator were obtained. The nozzle/diffuser pipes’structure parameters were optimized according to the results of ANSYS numerical simulation, and flow characteristic parameters such as flow rate and pressure distribution in the pipe were researched. The chamber was manufactured on glass, and nozzle/diffuser pipes were fabricated on <100> silicon by selective-wet etch using MEMS technology. These two components were glued with piezoelectric actuator together to form micropumps with single chamber and micropumps with parallel double chambers. The flow rates of micropumps in different conditions were measured by test system. Finally, a comparison between the test results of micropump with double chambers and that of the single chamber micropump is given.

      • KCI등재

        Prediction of the sound pressure level of blanking noise during sheet-metal blanking using servo press with counterforce

        Qinxiang Xia,Teng Xu,Guohua Hong,Weiping Ruan 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.5

        In this research, a prediction model of the sound pressure level during blanking using servo press with counterforce was establishedbased on the acoustic theory as well as the vibration equation of punch in the course of breakthrough process. The theoretical values ofthe sound pressure level of blanking noise were calculated based on the developed prediction model. The variation of the sound pressurelevel of blanking noise with different parameters was also investigated and compared with the experimental results. It reveals that theblanking noise increases with the shear strength and the thickness of sheet metal, and further the blanking speed. The relative error betweenthe experimental results and the theoretical ones determined based on the prediction model is less than 1.7%, and the applicationexample of the prediction model in batch production is given. The prediction model is thus proved to be promising and efficient for noiseprediction during blanking using servo press with counterforce.

      • KCI등재

        Risk Factors and Characteristics of the Recurrence of Juvenile Nasopharyngeal Angiofibroma: A 22-Year Experience With 123 Cases at a Tertiary Center

        Ruihua Fang,Jian Li,Weiping Wen,Wei Sun,Rui Xu,Jianbo Shi,Liang Peng,Yinyan Lai,Fenghong Chen,Yihui Wen 대한이비인후과학회 2022 Clinical and Experimental Otorhinolaryngology Vol.15 No.4

        Objectives. Despite the efficacy of surgical treatments, the high rate of recurrence in juvenile nasopharyngeal angiofibroma (JNA) after surgery remains an unresolved problem. The present study comprehensively analyzed the risk factors and characteristics of JNA recurrence, providing clinical guidance for reducing recurrence. Methods. A total of 123 patients who underwent surgery for JNA between 1997 and 2019 at a single hospital were analyzed retrospectively. Univariate and multivariate analyses were used to assess the clinical risk factors for the recurrence of JNA. The relapse-free survival and annual cumulative recurrence rates were analyzed for subgroups defined according to clinical parameters. Results. After screening, 78 of the 123 patients were included in the present study. The main risk factors associated with JNA recurrence included the year of diagnosis, tumor size, sphenoid bone invasion, Radkowski stage, surgical approach, and intraoperative bleeding. Importantly, the surgical approach and sphenoid bone invasion were independent prognostic factors affecting recurrence. Patients who underwent endoscopic surgery without sphenoid bone invasion exhibited longer relapse-free survival. In the present study, the overall cumulative recurrence rate of JNA was 38.7%, and recurrence occurred mainly in the first year after the initial surgery. Conclusion. Endoscopic surgery achieved better relapse-free survival in JNA patients, and patients with sphenoid bone invasion should be carefully explored to avoid residual JNA. The recurrence rate of JNA differed among subgroups defined based on clinical parameters and was highest in the first year after surgery. Computed tomography or magnetic resonance imaging, along with close follow-up, should be performed strictly within 1 year after the primary operation.

      • KCI등재

        Impeller inlet geometry effect on performance improvement for centrifugal pumps

        Xianwu Luo,Yao Zhang,Junqi Peng,Hongyuan Xu,Weiping Yu 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.10

        This research treats the effect of impeller inlet geometry on performance improvement for a boiler feed pump, who is a centrifugal pump having specific speed of 183 m⋅m3min-1⋅min-1 and close type impeller with exit diameter of 450 mm. The hydraulic performance and cavitation performance of the pump have been tested experimentally. In order to improve the pump, five impellers have been considered by extending the blade leading edge or applying much larger blade angle at impeller inlet compared with the original impeller. The 3-D turbulent flow inside those pumps has been analyzed basing on RNG k-ε turbulence model and VOF cavitation model. It is noted that the numerical results are fairly good compared with the experiments. Based on the experimental test and numerical simulation, the following conclusions can be drawn: (1) Impeller inlet geometry has important influence on performance improvement in the case of centrifugal pump. Favorite effects on performance improvement have been achieved by both extending the blade leading edge and applying much larger blade angle at impeller inlet; (2) It is suspected that the extended leading edge have favorite effect for improving hydraulic performance, and the much larger blade angle at impeller inlet have favorite effect for improving cavitation performance for the test pump; (3) Uniform flow upstream of impeller inlet is helpful for improving cavitation performance of the pump.

      • SCISCIESCOPUS

        Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling.

        Yang, Wulin,Thein, Shermaine,Lim, Chun-Yan,Ericksen, Russell E,Sugii, Shigeki,Xu, Feng,Robinson, Robert C,Kim, Jae Bum,Han, Weiping Portland Press Ltd. 2014 Biochemical journal Vol.464 No.2

        <P>Extensive actin cytoskeleton remodelling occurs during adipocyte development. We have previously shown that disruption of stress fibres by the actin-severing protein cofilin is a requisite step in adipogenesis. However, it remains unclear whether actin nucleation and assembly into the cortical structure are essential for adipocyte development. In the present study we investigated the role of cortical actin assembly and of actin nucleation by the actin-related protein 2/3 (Arp2/3) complex in adipogenesis. Cortical actin structure formation started with accumulation of filamentous actin (F-actin) patches near the plasma membrane during adipogenesis. Depletion of Arp2/3 by knockdown of its subunits Arp3 or ARPC3 strongly impaired adipocyte differentiation, although adipogenesis-initiating factors were unaffected. Moreover, the assembly of F-actin-rich structures at the plasma membrane was suppressed and the cortical actin structure poorly developed after adipogenic induction in Arp2/3-deficient cells. Finally, we provide evidence that the cortical actin cytoskeleton is essential for efficient glucose transporter 4 (GLUT4) vesicle exocytosis and insulin signal transduction. These results show that the Arp2/3 complex is an essential regulator of adipocyte development through control of the formation of cortical actin structures, which may facilitate nutrient uptake and signalling events.</P>

      • KCI등재

        Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

        Lei Cheng,Jianjun Chen,Qingling Fu,Shaoheng He,Huabin Li,Zheng Liu,Guolin Tan,Zezhang Tao,Dehui Wang,Weiping Wen,Rui Xu,Yu Xu,Qintai Yang,Chonghua Zhang,Gehua Zhang,Ruxin Zhang,Yuan Zhang,Bing Zhou,Do 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4

        Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2-3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.

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