Hypoglycemic effect of a polyherbal aqueous extract in experimentally induced diabetic rats

Vasu, Vihas T.,Thaikoottathil, Jyoti V.,Gupta, Sarita Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.2

The present study was carried out to investigate the hypoglycemic effect of a polyherbal aqueous extract (Curcuma longa Linn., Emblica officinalis Gaertn., Trigonella foenum-graecum Linn., Enicostemma littorale Blume) in alloxan-induced diabetic rats. Short term experiments showed a decrease in blood glucose levels at $2^{nd}\;hr$ of administration of the aqueous extract in alloxan-induced diabetic rats with increase in serum insulin levels. The extract did not show any effect on blood glucose or serum insulin levels in normoglycaemic rats. Treatment with the extract (1.5 g dry plant equivalent extarct/100 g body weight/day) for 20 days in diabetic rats showed a significant decrease in blood glucose and glycosylated haemoglobin levels and an increase in serum insulin levels. The aqueous extract also showed an enhanced glucose-induced insulin release at 11.1 mM glucose from isolated rat pancreatic islets. The extract did not show any toxicity at the particular dose used.

A hybrid feature selection algorithm integrating an extreme learning machine for landslide susceptibility modeling of Mt. Woomyeon, South Korea

Vasu, N.N.,Lee, S.R. Elsevier 2016 Geomorphology Vol.263 No.-

<P>An ever-increasing trend of extreme rainfall events in South Korea owing to climate change is causing shallow landslides and debris flows in mountains that cover 70% of the total land area of the nation. These catastrophic, gravity-driven processes cost the government several billion KRW (South Korean Won) in losses in addition to fatalities every year. The most common type of landslide observed is the shallow landslide, which occurs at 1-3 m depth, and may mobilize into more catastrophic flow-type landslides. Hence, to predict potential landslide areas, susceptibility maps are developed in a geographical information system (GIS) environment utilizing available morphological, hydrological, geotechnical, and geological data. Landslide susceptibility models were developed using 163 landslide points and an equal number of nonlandslide points in Mt. Woomyeon, Seoul, and 23 landslide conditioning factors. However, because not all of the factors contribute to the determination of the spatial probability for landslide initiation, and a simple filter or wrapper-based approach is not efficient in identifying all of the relevant features, a feedback-loop-based hybrid algorithm was implemented in conjunction with a learning scheme called an extreme learning machine, which is based on a single-layer, feed-forward network Validation of the constructed susceptibility model was conducted using a testing set of landslide inventory data through a prediction rate curve. The model selected 13 relevant conditioning factors out of the initial 23; and the resulting susceptibility map shows a success rate of 85% and a prediction rate of 89.45%, indicating a good performance, in contrast to the low success and prediction rate of 69.19% and 56.19%, respectively, as obtained using a wrapper technique. (C) 2016 Elsevier B.V. All rights reserved.</P>

“Direct” Mechanical Thrombectomy in Acute Ischemic Stroke during Percutaneous Coronary Intervention

Vasu Saini,Marie-Christine Brunet,Samir Sur,Amer M. Malik,Priyank Khandelwal,Shashvat Desai,Robert M. Starke,Eric C. Peterson,Ashutosh P. Jadhav,Mauricio G. Cohen,Dileep R. Yavagal 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.2

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HYDROGEN USE IN INTERNAL COMBUSTION ENGINE : A REVIEW

Vasu Kumar,Dhruv Gupta,Naveen Kumar 국제문화기술진흥원 2015 International Journal of Advanced Culture Technolo Vol.3 No.2

Fast depletion of fossil fuels is urgently demanding a carry out work for research to find out the viable alternative fuels for meeting sustainable energy demand with minimum environmental impact. In the future, our energy systems will need to be renewable and sustainable, efficient and cost-effective, convenient and safe. Hydrogen is expected to be one of the most important fuels in the near future to meet the stringent emission norms. The use of the hydrogen as fuel in the internal combustion engine represents an alternative use to replace the hydrocarbons fuels, which produce polluting gases such as carbon monoxide (CO), hydro carbon (HC) during combustion. In this paper contemporary research on the hydrogen-fuelled internal combustion engine can be given. First hydrogen-engine fundamentals were described by examining the engine-specific properties of hydrogen and then existing literature were surveyed.

A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee

Vasu Karlapudi,Anjaneya Venkata Vara Prasad Mungara,Krishanu Sengupta,Barbara A. Davis,Siba Prasad Raychaudhuri 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.5

LI73014F2 is a novel composition prepared from extracts of Terminalia chebula fruit, Curcuma longa rhizome, and Boswellia serrata gum resin with synergistic benefit in 5-Lipoxygenase (5-LOX) inhibition. This herbal composition with strong anti-5-LOX activity exhibited significant pain relief as indicated through improvements in weight-bearing capacity in a monosodium iodoacetate-induced osteoarthritis (OA) model of Sprague–Dawley rats. A 90-day randomized, placebo-controlled double-blind study evaluates the clinical efficacy and tolerability of LI73014F2 in the management of symptoms of OA of the knee (Clinical Trial Registration No. CTRI/2014/01/004338). Subjects, (n = 105), were randomized into three groups: placebo (n = 35), 200 mg/day of LI73014F2 (n = 35), and 400 mg/day of LI73014F2 (n = 35). All study participants were evaluated for pain and physical function by using standard tools, that is, Visual Analog Scale, Lequesne's Functional Index, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at the baseline (day 0) and on day 14 ± 3, 30 ± 3, 60 ± 3, and at the end of the study (day 90 ± 3). In addition, routine examinations on biochemical parameters in serum, urine, and hematological parameters were conducted on each visit to assess the safety of the study material. At the end of the trial period, LI73014F2 conferred significant pain relief, improved physical function, and quality of life in OA patients. In conclusion, preclinical and clinical data together strongly suggest that the herbal formulation LI73014F2 is a safe and effective intervention for management of joint discomfort, demonstrating efficacy as early as 14 days.

Antidiabetic effect of Enicostemma littorale Blume aqueous extract in newly diagnosed non-insulin-dependent diabetes mellitus patients (NIDDM): A preliminary investigation

Vasu, Vihas T.,Ashwinikumar, C.,Maroo, Jyoti,Gupta, Sharad,Gupta, Sarita Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.2

The antidiabetic efficacy of Enicostemma littorale Blume (chhota chirayata) aqueous extract was examined in newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients taking only the extract and was administered as two divided doses, half an hour before meal as 5g of aqueous extract per single dose. Out of the 20 patients volunteered, 11 successfully completed the 2 month trial and a significant decrease in fasting & postprandial blood glucose and glycosylated haemoglobin levels were observed along with a significant improvement in the antioxidant parameters of the patients. There was also a significant increase in serum insulin levels in 7 patients after extract treatment as compared to levels before treatment. Serum total cholesterol and serum triglyceride levels were decreased significantly with a significant increase in serum HDLCholesterol levels. Other vital parameters remained stable and no side effects were observed. This is the first report showing the hypoglycemic, antioxidant and hypolipidemic properties of the aqueous extract of E. littorale Blume in non-insulin dependent diabetes mellitus patients.

The performance simulation of an indoor unit of a heat pump according to refrigerant circuitry

Amal Vasu(아말와수),Yeon Sung Yoo(유연성),Young Soo Chang(장영수) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.4

HYDROGEN USE IN INTERNAL COMBUSTION ENGINE: A REVIEW

Kumar, Vasu,Gupta, Dhruv,Kumar, Naveen The International Promotion Agency of Culture Tech 2015 International Journal of Advanced Culture Technolo Vol.3 No.2

Fast depletion of fossil fuels is urgently demanding a carry out work for research to find out the viable alternative fuels for meeting sustainable energy demand with minimum environmental impact. In the future, our energy systems will need to be renewable and sustainable, efficient and cost-effective, convenient and safe. Hydrogen is expected to be one of the most important fuels in the near future to meet the stringent emission norms. The use of the hydrogen as fuel in the internal combustion engine represents an alternative use to replace the hydrocarbons fuels, which produce polluting gases such as carbon monoxide (CO), hydro carbon (HC) during combustion. In this paper contemporary research on the hydrogen-fuelled internal combustion engine can be given. First hydrogen-engine fundamentals were described by examining the engine-specific properties of hydrogen and then existing literature were surveyed.

Biomaterials-based Approaches for Cardiac Regeneration

Samhita Vasu,Justin Zhou,Jeffrey Chen,Peter V. Johnston,Deok-Ho Kim 대한심장학회 2021 Korean Circulation Journal Vol.51 No.12

The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as that involve bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in clinical trials and animal studies in improving cardiac function, promoting angiogenesis, and reducing adverse immune response. This review will focus on current clinical studies of three contemporary biomaterials-based approaches for cardiac regeneration (extracellular vesicles, injectable hydrogels, and cardiac patches), remaining challenges and shortcomings to be overcome, and future directions for the use of biomaterials to promote cardiac regeneration.

A new approach to temporal modelling for landslide hazard assessment using an extreme rainfall induced-landslide index

Nedumpallile Vasu, N.,Lee, S.R.,Pradhan, A.M.S.,Kim, Y.T.,Kang, S.H.,Lee, D.H. Elsevier Pub. Co 2016 Engineering geology Vol.215 No.-

An ever-increasing trend of extreme rainfall events in South Korea due to climate change is causing shallow landslides and shallow landslide induced debris flows in the mountains that cover 70% of the total land area of the nation. These catastrophic, gravity-driven processes cost the government several billion won in losses, and attendant fatalities, every year. The most common type of landslide observed is the shallow landslide occurring at 1-3m depth, which may mobilize into a catastrophic debris flow. A landslide early warning system encompassing different scale-based stages is used to predict potential areas for both the landslide types. Current study focusing on the first stage landslide hazard assessment at regional or medium scale requires the development of spatially evolving landslide hazard maps for both types of landslides based on the real-time rainfall. However, lack of complete landslide inventory data motivates the development of temporal and spatial models as independent components of the landslide hazard. Most of the existing temporal assessment schemes traditionally rooted in recurrence-based concepts does not consider soil factors and are not suitable to be incorporated in to the landslide early warning system since real-time rainfall cannot be considered. This motivated the development of a new probabilistic temporal model termed the extreme rainfall-induced landslide index. The probabilistic index was developed in Gangwon Province through a logistic regression using four factors; namely, continuous rainfall, 20-days antecedent rainfall, saturated hydraulic conductivity, and storage capacity. The developed model exhibited high area under the curve (AUC) values of 82% and 91% obtained for the training and validation curves, exhibiting good performance of the statistical index. Also, a high performance susceptibility model (training and validation AUC values of 96% and 94%, respectively) was developed using a logistic regression analysis, for Deokjeok-ri Creek, located in Gangwon province. Assuming the independence of the hazard components, a dynamic hazard index (DHI) was established through a joint probability of both the well validated models. The DHI was used to study the evolution of landslide hazard for the July 2006 extreme rainfall-induced landslide events in Deokjeok-ri Creek.