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A retrospective analysis of second-Line chemotherapy in patients with advanced gastric cancer (초)
( Sang Hoon Ji ),( Do Hyoung Lim ),( Min Jae Park ),( Seong Yoon Yi ),( Kyoung Ha Kim ),( Hyo Song Kim ),( Hyun Jung Jun ),( Ji Eun Uhm ),( Jee Yun Lee ),( Se Hoon Park ),( Joon Oh Park ),( Young Suk 대한내과학회 2008 대한내과학회지 Vol.75 No.1S
Uhm, Sang Jun,Gupta, Mukesh Kumar,Chung, Hak-Jae,Kim, Jin Hoi,Park, Chankyu,Lee, Hoon Taek Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.4
In vitro produced porcine embryos have potential application in reproductive biotechnology. However, their development potential has been very low. This study evaluated the in vitro developmental ability and quality of cloned and parthenogenetic porcine embryos having 2-4 cells or 5-8 cells on Day 2 of in vitro culture. Analysis of results showed that 2 to 4 cell embryos had higher ability to form blastocysts than 5 to 8 cell embryos (p<0.05). Blastocysts produced from culture of 2 to 4 cell embryos also contained higher cell numbers and had lower BAX:BCLxL transcript ratio than those produced from 5 to 8 cell embryos (p<0.05), thereby suggesting 2 to 4 cell embryos have higher development potential. Further investigation revealed that 5 to 8 cell embryos had higher incidence (100${\pm}$0.0%) of blastomeric fragmentation than 2 to 4 cell embryos (15.2${\pm}$5.5% for parthenogenetic and 27.7${\pm}$7.1% for cloned embryos). This suggests that low development potential of 5 to 8 cell embryos was associated with blastomeric fragmentation. In conclusion, we have shown that morphological selection of embryos based on cell number on Day 2 of in vitro culture could offer a practical and valuable non-invasive means to select good quality porcine embryos.
Further Results on Piecewise Constant Hazard Functions in Aalen's Additive Risk Model
Uhm, Dai-Ho,Jun, Sung-Hae The Korean Statistical Society 2012 응용통계연구 Vol.25 No.3
The modifications suggested in Uhm et al. (2011) are studied using a partly parametric version of Aalen's additive risk model. A follow-up time period is partitioned into intervals, and hazard functions are estimated as a piecewise constant in each interval. A maximum likelihood estimator by iteratively reweighted least squares and variance estimates are suggested based on the model as well as evaluated by simulations using mean square error and a coverage probability, respectively. In conclusion the modifications are needed when there are a small number of uncensored deaths in an interval to estimate the piecewise constant hazard function.
Uhm, Sang Jun,Gupta, Mukesh Kumar,Das, Ziban Chandra,Kim, Nam-Hyung,Lee, Hoon Taek Mary Ann Liebert 2011 Cellular reprogramming Vol.13 No.5
<P>UV-irradiation of oocytes during enucleation and serum starvation of donor cells during cell cycle synchronization may compromise the development competence of cloned embryos through excessive generation of reactive oxygen species (ROS). Here, we show that 3-hyroxyflavone (a flavonoid having hydroxyl group at 3 carbon position) inhibits UV- and serum starvation-induced ROS production in oocytes and donor cells, respectively, and thereby improves the in vitro development of cloned porcine embryos (p<0.05). In a parthenogenetic model, UV-irradiation for 5?sec or more was found to reduce the in vitro development and quality of the embryo, which could be rescued by their culture in the presence of 3-hydroxyflavone. The rescuing effect of 3-hydroxyflavone was associated with significant reduction in ROS level (14.41.0 vs. 47.16.7), increase in ERK signaling molecules by 2.1-fold, and decrease in Caspase3 expression by 3.2-fold. Culture of donor cells (18.51.4 vs. 13.01.7%) or cloned embryos (20.61.1 vs. 12.21.1%) in the presence of 3-hydroxflavone also increased (p<0.05) the rates of blastocyst formation in cloned embryos produced by the nuclear transfer of serum-starved donor cells into recipient cytoplasts exposed to UV-irradiation during the enucleation step. Importantly, both parthenotes and cloned embryos cultured in the presence of 3-hydroxyflavone had significantly increased ability to expand, and contained a higher number of cells than those of the control group (p<0.05). These results suggest that 3-hydroxyflavone may be useful for improving the in vitro developmental potential of cloned embryos through inhibition of ROS production induced by the UV-irradiation of oocyte and/or the serum starvation of donor cells.</P>
A Classification Method Using Data Reduction
Uhm, Daiho,Jun, Sung-Hae,Lee, Seung-Joo Korean Institute of Intelligent Systems 2012 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.12 No.1
Data reduction has been used widely in data mining for convenient analysis. Principal component analysis (PCA) and factor analysis (FA) methods are popular techniques. The PCA and FA reduce the number of variables to avoid the curse of dimensionality. The curse of dimensionality is to increase the computing time exponentially in proportion to the number of variables. So, many methods have been published for dimension reduction. Also, data augmentation is another approach to analyze data efficiently. Support vector machine (SVM) algorithm is a representative technique for dimension augmentation. The SVM maps original data to a feature space with high dimension to get the optimal decision plane. Both data reduction and augmentation have been used to solve diverse problems in data analysis. In this paper, we compare the strengths and weaknesses of dimension reduction and augmentation for classification and propose a classification method using data reduction for classification. We will carry out experiments for comparative studies to verify the performance of this research.