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Parkin induces apoptotic cell death in TNF-α-treated cervical cancer cells
( Kyung Hong Lee ),( Min Ho Lee ),( Yeo Wool Kang ),( Ki Jong Rhee ),( Tae Ue Kim ),( Yoon Suk Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.9
Many malignant tumors become resistant to tumor necrosis factor-alpha (TNF-α)-induced cell death during carcinogenesis. In the present study, we examined whether parkin acts as a tumor suppressor in HeLa cells, a human cervical cancer cell line resistant to TNF-α-induced cell death. TNF-α-treatment alone did not affect HeLa cell viability. However, expression of parkin restored TNF-α-induced apoptosis in HeLa cells. Increased cell death was due to the activation of the apoptotic pathway. Expression of parkin in TNF-α-treated HeLa cells stimulated cleavage of the pro-apoptotic proteins caspase-8, -9, -3, -7 and poly ADP ribose polymerase (PARP). In addition, parkin expression resulted in decreased expression of the caspase inhibitory protein, survivin. These results suggest that parkin acts as a tumor suppressor in human cervical cancer cells by modulating survivin expression and caspase activity. We propose that this pathway is a novel molecular mechanism by which parkin functions as a tumor suppressor. [BMB Reports 2012; 45(9): 526-531]
Influence of Tyrosol on Cell Growth Inhibition of KB Human Oral Cancer Cells
Ue-Kyung Lee,Su-Gwan Kim,Dae-San Go,Sun-Kyoung Yu,Chun Sung Kim,Jeongsun Kim,Do Kyung Kim 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.4
Tyrosol, a phenylethanoid and a derivative of phenethyl alcohol, possesses various biological properties, such as anti-oxidative and cardioprotective activity. Olive oil is the principal source of tyrosol in the human diet. However, so far the anti-cancer activity of tyrosol has not yet been well defined. This study therefore undertakes to examine the cytotoxic activity and the mechanism of cell death exhibited by tyrosol in KB human oral cancer cells. Treatment of KB cells with tyrosol induced the cell growth inhibition in a concentration- and a time-dependent manner. Furthermore, the treatment of tyrosol induced nuclear condensation and fragmentation of KB cells. Tyrosol also promoted proteolytic cleavage of procaspase-3, -7, -8 and –9, increasing the amounts of cleaved caspase-3, -7, -8 and –9. In addition, tyrosol increased the levels of cleaved PARP in KB cells. These results suggest that tyrosol induces the suppression of cell growth and cell apoptosis in KB human oral cancer cells, and is therefore a potential candidate for anti-cancer drug discovery.
이의진(Ue Jin Lee),김명기(Myung-ki Kim),이재관(Jae Kwan Lee),이상호(Sang Ho Lee),강경태(Kyung-Tae Kang) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.11
An inkjet printing among these printing techniques has been extensively demonstrated with attractive advantages regarding high registration accuracy of direct writing in targeted active area without unnecessary waste of functional materials. The 3% of highefficiency in inkjet printed organic bulk heterojunction solar cell using P3HT:PCBM composite ink in mixed solution of 68% of ortho-dichlorobenzene (oDCB) and 32% of mesitylene has been recently reported.³ However, although a high boiling ink formulation with oDCB or its mixed solvent was irresistibly applied to prevent vaporization of the solvent at the nozzle orifice, its use seems to be hard to control the morphology of BHJ film on PEDOT:PSS underlayer compared to that spin-cast. This paper presents that direct writing of P3HT:PCBM composite in BHJ solar cell can be efficiently addressed by inkjet printing technology using conventional chlorobenzene ink solution.
Lee, Na-Kyung,Kim, Hyun-Jeong,Yang, Seung-Ju,Kim, Yoon-Suk,Choi, Hyun-Il,Shim, Moon-Jeong,Awh, Ok-Doo,Kim, Tae-Ue Korean Society for Biochemistry and Molecular Biol 2001 Journal of biochemistry and molecular biology Vol.34 No.3
Taxol, a natural product extracted from the Taxus brevifolia, is known to have significant anti-tumor activities against many common cancers, including ovarian and breast cancers. Despite the pronounced anti-tumor activity of this compound, its poor solubility in aqueous solutions hampers its clinical applications. We studied the anticancer mechanisms of the water-soluble taxol diethylenetriamine pentaacetate (DTPA) used for radiolabeling, and compared it to that of taxol. In vitro cytotoxicities of taxol and taxol-DTPA conjugate were tested in HT29 human colorectal cancer cells by the MTT method. As the result, the $IC_{50}$ value of the taxol-DTPA conjugate was about three fold higher than that of taxol. When analyzed by an agarose gel electrophoresis, the DNA ladders became evident after the incubation of cells with the taxol-DTPA conjugate for 24 h. We also found morphological changes of the cells undergoing apoptosis with electron microscopy Next, we examined the signal pathway of taxol-DTPA conjugate-induced apoptosis in HT29 cells. The activation of extracellular signal-regulated protein kinase (ERK1/2) occurred at 10, 30, 60 and 120 min after 200 nM taxol-DTPA conjugate treatment. The pretreatment of the MEK inhibitor (PD98059) completely blocked the taxol-DTPA conjugate-induced ERK1/2 activation. The activated ERK1/2 translocated into the nucleus at the same time and phosphorylated its transcriptional factor, c-Jun. These results suggest that the taxol-DTPA conjugate has an apoptotic activity in HT29 cells, and that its proapoptic activity might be related with the signal transduction via ERK1/2 and c-Jun similar to that of taxol.
정의석(Ue Suk Joung),고은미(Eun Mi Koh),김성주(Sung Ju Kim),이경희(Kyung Hee Lee),박만철(Man Chul Park),이용우(Yong Woo Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.12
Heterotopic pregnancy occurs when there are coexisiting intrauterine and ectopic pregnances. It occure, more often, due to assisted reproductive technology such as IVF-ET, GIFT and increased pelvic inflammatory diseases. We present a case of heterotopic pregnancy confirmed by surgical removal of ruptured left ovarian pregnancy and sonographic finding of the intrauterine pregnancy following natural conception.
이헌권(Heon-Kwon Lee),김창남(Chang-Nam Kim),손경빈(Kyung-Bin Son),김의간(Ue-Kan Kim) 한국마린엔지니어링학회 2005 한국마린엔지니어링학회 학술대회 논문집 Vol.2005 No.-
기계의 동적거동에 관한 특성을 좀 더 명확하게 파악하기 위하여 모드해석법이 기계설계의 여러 분야에 적용 되고 있다. 본 연구에서는 실험모드해석을 통하여 자동차 배기계의 모드특성치를 구하고, 상용 프로그램을 활용한 고유진동수의 제어 방법에 대해 검토하고자 한다.