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이금산 ( Guem San Lee ),김정훈 ( Jung Hoon Kim ),최고야 ( Go Ya Choi ),강대훈 ( Dae Hoon Kang ),황성연 ( Sung Yeoun Hwang ),정승일 ( Seung Il Jeong ),김홍준 ( Hong Jun Kim ),주영승 ( Young Sung Ju ) 대한본초학회 2008 大韓本草學會誌 Vol.23 No.4
Objectives: To determine the standards for discrimination of Magnoliae Cortex, the experiment of specific external-internal characters and the physicochemical pattern analysis were performed. Methods: External characteristics was observed using a stereoscope. Paraffin-mediated sectioned materials were stained by Ju`s method. Physicochemical patterns of materials were analyzed using HPLC. Results: 1. Botanical characteristics: Magnolia officinalis had one seed and a white flower, while M. obovata had two seeds and a white flower. Machilus thunbergii had berry and spherical fruits and yellowish green panicles. 2. External characteristics: M. officinalis and M. obovata were dark and thick. M. officinalis was gray brown and greasy while M. obovata was light-gray, less oily and smoothly sectioned. Machilus thunbergii was thin and relatively light or yellow-brown, coarsely sectioned and faintly specific scents. 3. Internal characteristics: The bast parts of M. officinalis and M. obovata were commonly wider than Machilus thunbergii. The cork cortex of M. officinalis was 10~mg/L cell layers with many oil cells, while that of M. obovata was 4~7 cell layers with less oil cells. Machilus thunbergiis xylem which consisted of ring-shaped cambium at 1st and 2nd part was occupied in large portion. 4. Physicochemical pattern: Both M. officinalis and M. obovata involved honokiol and magnolol. All kinds of M. officinalis involved Magnatriol B but one kind of M. ovobata and all of Machilus thunbergii didn`t. Machilus thunbergii showed different pattern of chromatogram from that of 2 species above. Conclusions: These results could be used as standards for discrimination of Magnoliae Cortex and as the method of objectification in medicinal herbs giving the basic resource for bioactivity research.
Advanced Sensing Techniques of Energy Detection in Cognitive Radios
Wang, Han-O,Noh, Go-San,Kim, Dong-Kyu,Kim, Sung-Tae,Hong, Dae-Sik The Korea Institute of Information and Commucation 2010 Journal of communications and networks Vol.12 No.1
Recently, spectrum sensing has been intensively studied as a key technology in realizing the cognitive radio. There have been advances in the performance of spectrum sensing through both multi-antenna and cooperative sensing schemes. In this paper, the performances and complicated scenarios of the latest spectrum sensing schemes are analytically compared and arranged into a technical tree while considering practical concerns. This paper will give a macroscopic view of spectrum sensing and will also provide insight into future spectrum sensing works.
MicroRNA-203 Induces Apoptosis by Targeting<i>Bmi-1</i>in YD-38 Oral Cancer Cells
KIM, JAE-SUNG,CHOI, DAE WOO,KIM, CHUN SUNG,YU, SUN-KYOUNG,KIM, HEUNG-JOONG,GO, DAE-SAN,LEE, SEUL AH,MOON, SUNG MIN,KIM, SU GWAN,CHUN, HONG SUNG,KIM, JEONGSUN,KIM, JONG-KEUN,KIM, DO KYUNG Potamitis Press 2018 Anticancer research Vol.38 No.6
Apoptotic Activity of Curcumin and EF-24 in HTB-41 Human Salivary Gland Epidermoid Carcinoma Cells
Ji-Won Kim,Seul Ah Lee,Dae-San Go,Byung-Sun Park,Su-Gwan Kim,Sun-Kyoung Yu,Ji-Su Oh,Chun Sung Kim,Jeongsun Kim,Jong-Tae Park,Do Kyung Kim 대한구강생물학회 2015 International Journal of Oral Biology Vol.40 No.2
Curcumin (diferuloylmethane), a constituent of turmeric powder derived from the rhizome of Curcuma longa, has been shown to inhibit the growth of various types of cancer cells by regulating cell proliferation and apoptosis. However, a need exists to design more effective analogs because of curcumin's poor intestinal absorption. EF-24 (diphenyl difluoroketone), the monoketone analog of curcumin, has shown good efficacy in anticancer screens. However, the effects of curcumin and EF-24 on salivary gland epidermoid carcinoma cells are not clearly established. The main goal of this study was to investigate the effects of curcumin and EF-24 on cell growth and induction of apoptosis in human salivary gland epidermoid carcinoma cells. Our studies showed that curcumin and EF-24 inhibited the growth of HTB-41 cells in a dose- and time-dependent manner, and the potency of EF-24 was > 34-fold that of curcumin. Treatment with curcumin or EF-24 resulted in nuclear condensation and fragmentation in HTB-41 cells, whereas the control HTB-41 cell nuclei retained their normal regular and oval shape. Curcumin and EF-24 promoted proteolytic cleavages of procaspase-3/-7/-9, resulting in an increase in the amount of cleaved caspase-3/-7/-9 in the HTB-41 cells. Caspase-3 and -7 activities were detected in viable HTB-41 cells treated with curcumin or EF-24. These results suggest that the curcumin and EF-24 inhibit cell proliferation and induce apoptosis in HTB-41 human salivary gland epidermoid carcinoma cells, and that they may have potential properties as an anti-cancer drug therapy.
Influence of Tyrosol on Cell Growth Inhibition of KB Human Oral Cancer Cells
Ue-Kyung Lee,Su-Gwan Kim,Dae-San Go,Sun-Kyoung Yu,Chun Sung Kim,Jeongsun Kim,Do Kyung Kim 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.4
Tyrosol, a phenylethanoid and a derivative of phenethyl alcohol, possesses various biological properties, such as anti-oxidative and cardioprotective activity. Olive oil is the principal source of tyrosol in the human diet. However, so far the anti-cancer activity of tyrosol has not yet been well defined. This study therefore undertakes to examine the cytotoxic activity and the mechanism of cell death exhibited by tyrosol in KB human oral cancer cells. Treatment of KB cells with tyrosol induced the cell growth inhibition in a concentration- and a time-dependent manner. Furthermore, the treatment of tyrosol induced nuclear condensation and fragmentation of KB cells. Tyrosol also promoted proteolytic cleavage of procaspase-3, -7, -8 and –9, increasing the amounts of cleaved caspase-3, -7, -8 and –9. In addition, tyrosol increased the levels of cleaved PARP in KB cells. These results suggest that tyrosol induces the suppression of cell growth and cell apoptosis in KB human oral cancer cells, and is therefore a potential candidate for anti-cancer drug discovery.
Kyung In Jeong,Su-Gwan Kim,Dae-San Go,Do Kyung Kim* 대한구강생물학회 2020 International Journal of Oral Biology Vol.45 No.1
Bilobalide isolated from the leaves of Ginkgo biloba has several pharmacological activities such as neuroprotective, anti-inflammatory, and anticonvulsant. However, the effect of bilobalide on cancer has not been clearly established. The main purpose of this study was to investigate the effect of bilobalide on cell growth and apoptosis induction in FaDu human pharyngeal squamous cell carcinoma. This was examined by 3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide assay, nuclear 4′,6-diamidino-2-phenylindole dihydrochloride staining, DNA fragmentation analysis, and immunoblotting. Bilobalide inhibited the growth of FaDu cells in dose- and time-dependent manners. Treatment with bilobalide resulted in nuclear condensation and DNA fragmentation in FaDu cells. Furthermore, it promoted the proteolytic cleavage of procaspase-3/-7/-8/-9 with increase in the amount of cleaved caspase-3/-7/-8/-9. Bilobalide-induced apoptosis in FaDu cells was mediated by the expression of Fas and the activation of caspase-8, caspase-3, and poly (ADP-ribose) polymerase. Immunoblotting revealed that the antiapoptotic mitochondrial protein Bcl-2 was downregulated, but the proapoptotic protein Bax was upregulated by bilobalide in FaDu cells. Bilobalide significantly increased Bax/Bcl-2 ratio. These results suggest that bilobalide inhibits cell proliferation and induces apoptosis in FaDu human pharyngeal squamous cell carcinoma via both the death receptor-mediated extrinsic apoptotic pathway and the mitochondrial-mediated intrinsic apoptotic pathway.
Growth inhibition by metformin in YD-38 oral cancer cells derived from Korean
( Dong Kuk Seo ),( Su-gwan Kim ),( Dae-san Go ),( Chun Sung Kim ),( Sun-kyoung Yu ),( Do Kyung Kim ) 조선대학교 구강생물학연구소 2017 Oral Biology Research (Oral Biol Res) Vol.41 No.2
Metformin (1,1-dimethylbiguanide hydrochloride), derived from French lilac (Galega officinalis), is a first-line drug prescribed for patients with type 2 diabetes. It has been reported to have anti-cancer effects in a variety of cancer cells. However, effects of metformin on oral cancer cells have not been clearly established. The main goal of this study was to investigate the effect of metformin on cell growth and apoptosis induction in oral cancer cells derived from Korean patients. The effect of metformin on cell growth and apoptosis induction in oral cancer cells was examined by inhibition of cell growth, DNA fragmentation analysis and immunoblotting in YD-38 human oral cancer cells derived from Korean patients. Treatment with metformin induced inhibition of cell growth depending on the metformin treatment time and concentration in YD-38 human oral cancer cells. Treatment with metformin induced nuclear fragmentation in YD-38 human oral cancer cells. Metformin promoted proteolytic cleavage of procaspase-3 with an increase in the amount of cleaved caspase-3. Cleaved PARP was increased by metformin in YD-38 human oral cancer cells. Treatment of YD-38 human oral cancer cells with metformin increased the level of Bax, but it decreased the level of Bcl-2. These results suggest that metformin can induce suppression of cell growth and cell apoptosis in YD-38 human oral cancer cells derived from Korean patients.
MicroRNA-27 Promotes Odontoblast Differentiation via Wnt1 Signaling
Ji-Ho Cho,Su-Gwan Kim,Byung-Sun Park,Dae-San Go,Joo-Cheol Park,Do Kyung Kim 대한구강생물학회 2015 International Journal of Oral Biology Vol.40 No.4
MicroRNA (miRNA, miR) is essential in regulating cell differentiation either by inhibiting mRNA translation or by inducing its degradation. However, the role of miRNA in odontoblastic cell differentiation is still unclear. In this study, we examined the molecular mechanism of miR-27-mediated regulation of odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. The results of the present study demonstrated that the miR-27 expression increases significantly during MDPC-23 odontoblastic cell differentiation. Furthermore, miR-27 up-regulation promotes the differentiation of MDPC-23 cells and accelerates mineralization without cell proliferation. The over-expression of miR-27 significantly increased the expression levels of Wnt1 mRNA and protein. In addition, the results of target gene prediction revealed that Wnt1 mRNA has an miR-27 binding site in its 3’UTR, and is increased by miR-27. These results suggested that miR-27 promotes MDPC-23 odontoblastic cell differentiation by targeting Wnt1 signaling. Therefore, miR-27 is a critical odontoblastic differentiation molecular target for the development of miRNA based therapeutic agents in dental medicine.
Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells
Sung-Su Yang,Su-Gwan Kim,Byung-Sun Park,Dae-San Go,Sun-Kyoung Yu,Chun Sung Kim,Jeongsun Kim,Do Kyung Kim 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.3
β-carotene is present in carrots, pumpkins, and sweet potatoes. It suppresses many types of cancers by regulating cellular proliferation and apoptosis through a variety of mechanisms. However, the effects of β -carotene on oral cancer cells have not been clearly established. The main goal of this study was to investigate the effects of β-carotene on cell growth and apoptosis in oral cancer cells. Our results demonstrate that treatment with β-carotene induced inhibition of cell growth, and that the effect was dependent on β-carotene treatment time and concentration in KB cells. Furthermore, treatment with β-carotene induced nuclear condensation and fragmentation in KB cells. β-carotene promoted proteolytic cleavage of procaspase-3, -7, -8 and –9 with associated increases in the concentration of cleaved caspase-3, -7, -8 and –9. In addition, the level of cleaved PARP was increased by β-carotene treatment in KB cells. These results suggest that β-carotene can suppress cell growth and induce apoptosis in KB human oral cancer cells, and that it may have potential usefulness in anti-cancer drug discovery efforts.
( Kyong Sup Yim ),( Su Gwan Kim ),( Byung Sun Park ),( Dae San Go ),( Chun Sung Kim ),( Do Kyung Kim ) 조선대학교 구강생물학연구소 2016 Oral Biology Research (Oral Biol Res) Vol.40 No.1
Trans-3,4`,5,-trihydroxystilbene (resveratrol), a phytoalexin that is present in grape skin and red wine, suppresses many types of cancers by regulating cell proliferation and apoptosis through a variety of mechanisms. However, resveratrol`s effects on salivary gland tumors including squamous carcinomas are not clearly established. The main goal of this study was to investigate the effect of resveratrol on cell growth and induction of apoptosis in salivary gland epidermoid carcinoma cells. Treatment with resveratrol induced inhibition of cell growth and was dependent on resveratrol treatment time and concentration in HTB-41 cells. Treatment with resveratrol induced nuclear condensation and fragmentation in HTB-41 cells. Activation of caspases-3 and -7 was detected in living HTB-41 cells by fluorescence microscopy. Resveratrol promoted proteolytic cleavage of procaspases-3, -7, -8 and -9 with increases in the amount of cleaved caspases- 3, -7, -8 and -9. Cleaved PARP increased consider in the presence of resveratrol in HTB-41 cells. These results suggest that resveratrol can induce the suppression of cell growth and cell apoptosis in HTB-41 human submaxillary salivary gland epidermoid carcinoma cells, and that it may have potential properties for anti-cancer drug development.