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        Epidemiologic features of ınflammatory bowel disease in Western Blacksea region of Turkey for the last 10 years: retrospective cohort study

        Güray Can,Emrah Poşul,Bülent Yılmaz,Hatice Can,Uğur Korkmaz,Fatih Ermiş,Mevlüt Kurt,Ülkü Dağlı 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.3

        Background/Aims: There are only a few epidemiological study about inflammatory bowel disease in the last 10 years in Turkey, especially in Western Blacksea region. In our study, we aimed to identify the changes in the incidence and the prevalence of inflammatory bowel disease in Western Blacksea region at the last 10 years. Methods: Totally 223 patients with inf lammatory bowel disease (160 ulcerative colitis, 63 Crohn’s disease) were enrolled in the study followed up between 2004 to 2013 years. The epidemiological characteristics of patients were recorded. Results: The prevalences were 12.53/105 and 31.83/105 for Crohn’s disease and ulcerative colitis respectively. Mean annual incidences increased from 0.99/105 and 0.45/105 for ulcerative colitis and Crohn’s disease (2004 to 2005 years) to 4.87/105 and 2.09/105 for ulcerative colitis and Crohn’s disease respectively (2011 to 2013 years). While the prevalence was higher in urban areas in Crohn’s disease (12.60/105), it was higher in rural areas in ulcerative colitis (36.17/105). In ulcerative colitis, mean annual incidences were 2.91/105 and 2.86/105 for urban and rural areas respectively. In Crohn’s disease, they were 1.37/105 and 1.08/105 for urban and rural areas respectively. Conclusions: The incidence of inflammatory bowel disease seems to increase in Western Blacksea region at the last 10 years. This increment is more prevalent in rural areas.

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        The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random- Pattern Skin Flaps in Rats

        Utku Can Dölen,Nezih Sungur,Gökhan Koca,Onur Ertunç,Ayşe Tülay Bağcı Bosi,Uğur Koçer,Meliha Korkmaz 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.6

        Background It is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of randompattern skin flaps were studied. Methods Forty female Sprague-Dawley rats were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing menthol and methyl salicylate was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap necrosis was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. Results According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). Conclusions Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

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