Hemiarthroplasty in the Hip Fracture Patient with Renal Impairment: To Cement or Not to Cement

Tong Leng Tan,Sean Wei Loong Ho,Arjunan Edward Kumanan Graetz,Ernest Beng Kee Kwek 대한고관절학회 2019 Hip and Pelvis Vol.31 No.4

Purpose: Patients with chronic kidney disease (CKD) have a higher risk of complications when undergoing hip hemiarthroplasty. The primary aim is to test the null hypothesis that there is no difference between cemented and uncemented stem loosening rates in patients with CKD who receive a hip hemiarthroplasty for femoral neck fractures. The secondary aim is to determine the effect of increasing severity of renal disease on the rate of stem loosening in this CKD patient subset. Materials and Methods: A retrospective study of all patients with CKD who underwent a hip hemiarthroplasty for a traumatic femoral-neck fracture between 2003 and 2013 was performed. Patients with a minimum of twoyear follow-up were included; those with pathological fractures or loosening due to infection were excluded. The outcome measure was radiographic aseptic loosening of the stem, defined as progressive radiolucency of more than 2 mm, progressive subsidence or migration of the implant. Results: One-hundred and nineteen cases were included in this study. Loosening occurred in 11 cases (9.24%). A comparison between cemented and uncemented groups revealed no difference in the rate of loosening (P=0.079). In all cases, worsening renal function did not increase the rate of loosening (P=0.311). The rate of loosening did not increase with worsening renal function in either the cemented (P=0.678) or uncemented groups (P=0.307). Conclusion: There is no difference in the rate of loosening between cemented and uncemented hemiarthroplasty for femoral neck fractures in the elderly with CKD. The rate of loosening did not increase with worsening renal function. All patients with renal impairment, not just those with end-stage renal failure, warrant close follow-up as early loosening can occur throughout the entire spectrum of renal disease.

Hypotensive Effects Induced by Herbal Fomentation at Yongquan Point

YanQing Tong,QiPing Yu,Yan Leng 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.6

Objective: This study aimed at assessing the adequacy of blood pressure (BP) control with the Chinese herbal fomentation at Yongquan point (K1). Method: A total of 51 participants as a group were enrolled. In 10 participants as the subgroup, BP data were compared with those simultaneously recorded from the radial artery of the same side. After the baseline examination, each enrolled patient participated in one session lasting 24 hours, during which Yongquan point (K1) of both sides were fomented with a mixture of Chinese herbs. The technique of 24-hour Ambulatory BP monitoring (ABPM) was repeated at baseline and on the day after the therapy. Results: The systolic and diastolic BP measured intra-arterially during the test were, on average, similar to those measured noninvasively. Patients obtained a 6.0 mmHg reduction for systolic BP and a 4.8 mmHg reduction for diastolic BP during daytime. The rate of adverse events was 2.0% in the group. Conclusion: Our data demonstrated that BP recording by the ABPM method in our study provided a relatively accurate estimate of the average radial BP of the population. So the conclusion, “Chinese herbal fomentation at Yongquan point (K1) of both sides has some hypotensive potentials” was more reliable. Objective: This study aimed at assessing the adequacy of blood pressure (BP) control with the Chinese herbal fomentation at Yongquan point (K1). Method: A total of 51 participants as a group were enrolled. In 10 participants as the subgroup, BP data were compared with those simultaneously recorded from the radial artery of the same side. After the baseline examination, each enrolled patient participated in one session lasting 24 hours, during which Yongquan point (K1) of both sides were fomented with a mixture of Chinese herbs. The technique of 24-hour Ambulatory BP monitoring (ABPM) was repeated at baseline and on the day after the therapy. Results: The systolic and diastolic BP measured intra-arterially during the test were, on average, similar to those measured noninvasively. Patients obtained a 6.0 mmHg reduction for systolic BP and a 4.8 mmHg reduction for diastolic BP during daytime. The rate of adverse events was 2.0% in the group. Conclusion: Our data demonstrated that BP recording by the ABPM method in our study provided a relatively accurate estimate of the average radial BP of the population. So the conclusion, “Chinese herbal fomentation at Yongquan point (K1) of both sides has some hypotensive potentials” was more reliable.

ALLOCATION CONTROL ALGORITHMS DESIGN AND COMPARISON BASED ON DISTRIBUTED DRIVE ELECTRIC VEHICLES

Bo Leng,Lu Xiong,Zhuoping Yu,Tong Zou 한국자동차공학회 2018 International journal of automotive technology Vol.19 No.1

For a distributed drive electric vehicle (DDEV) which is equipped with redundant actuators, allocation control is a key technique. Three different allocation control algorithms are designated with fixed efficiency matrix, dynamic efficiency matrix, and direct yaw moment distribution, respectively. All these algorithms are applied in a vehicle stability control system with hierarchical control structure and evaluated from three aspects, namely, control precision, real-time characteristics, and control energy. Comparison results demonstrate that the algorithm with dynamic efficiency matrix has the best comprehensive performance, which is also validated in field tests based on a DDEV equipped with four motors.

Silence of LncRNA GAS5 Protects Cardiomyocytes H9c2 against Hypoxic Injury via Sponging miR-142-5p

Du, Jian,Yang, Si-Tong,Liu, Jia,Zhang, Ke-Xin,Leng, Ji-Yan Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.5

The regulatory role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in both cancerous and noncancerous cells have been widely reported. This study aimed to evaluate the role of lncRNA GAS5 in heart failure caused by myocardial infarction. We reported that silence of lncRNA GAS5 attenuated hypoxia-triggered cell death, as cell viability was increased and apoptosis rate was decreased. This phenomenon was coupled with the down-regulated expression of p53, Bax and cleaved caspase-3, as well as the up-regulated expression of CyclinD1, CDK4 and Bcl-2. At the meantime, the expression of four heart failure-related miR-NAs was altered when lncRNA GAS5 was silenced (miR-21 and miR-142-5p were up-regulated; miR-30b and miR-93 were down-regulated). RNA immunoprecipitation assay results showed that lncRNA GAS5 worked as a molecular sponge for miR-142-5p. More interestingly, the protective actions of lncRNA GAS5 silence on hypoxia-stimulated cells were attenuated by miR-142-5p suppression. Besides, TP53INP1 was a target gene for miR-142-5p. Silence of lncRNA GAS5 promoted the activation of PI3K/AKT and MEK/ERK signaling pathways in a miR-142-5p-dependent manner. Collectively, this study demonstrated that silence of lncRNA GAS5 protected H9c2 cells against hypoxia-induced injury possibly via sponging miR-142-5p, functionally releasing TP53INP1 mRNA transcripts that are normally targeted by miR-142-5p.

Silence of LncRNA GAS5Protects Cardiomyocytes H9c2 against Hypoxic Injury via Sponging miR-142-5p

Jian Du,Si-Tong Yang,Jia Liu,Ke-Xin Zhang,Ji-Yan Leng 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.5

The regulatory role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in both cancerous and noncancerous cells have been widely reported. This study aimed to evaluate the role of lncRNA GAS5 in heart failure caused by myocardial infarction. We reported that silence of lncRNA GAS5 attenuated hypoxia-triggered cell death, as cell viability was increased and apoptosis rate was decreased. This phenomenon was coupled with the down-regulated expression of p53, Bax and cleaved caspase-3, as well as the up-regulated expression of CyclinD1, CDK4 and Bcl-2. At the meantime, the expression of four heart failure-related miRNAs was altered when lncRNA GAS5 was silenced (miR-21 and miR-142-5p were up-regulated; miR-30b and miR-93 were down-regulated). RNA immunoprecipitation assay results showed that lncRNA GAS5 worked as a molecular sponge for miR-142-5p. More interestingly, the protective actions of lncRNA GAS5 silence on hypoxia-stimulated cells were attenuated by miR-142-5p suppression. Besides, TP53INP1 was a target gene for miR-142-5p. Silence of lncRNA GAS5 promoted the activation of PI3K/AKT and MEK/ERK signaling pathways in a miR-142-5p-dependent manner. Collectively, this study demonstrated that silence of lncRNA GAS5 protected H9c2 cells against hypoxia-induced injury possibly via sponging miR-142-5p, functionally releasing TP53INP1 mRNA transcripts that are normally targeted by miR-142-5p.

Flexure-Hinges Guided Nano-Stage for Precision Manipulations: Design, Modeling and Control

Peng-Bo Liu,Peng Yan,Zhen Zhang,Tong-Tong Leng 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

In this paper, a novel piezoelectric actuator driven nano-stage with bridge type mechanism is studied from the perspectives of design optimization, dynamical modeling, as well as controller synthesis for high precision manipulation purposes. FEM (Finite Element Method) analysis and dynamical modeling are provided to derive the system model including the hysteresis nonlinearity. Considering the complexities of dynamical uncertainties and hysteresis nonlinearity, an active disturbance rejection controller is developed consisting of extended state observer (ESO), state feedback controller and profile generator. With the proposed algorithm, the nonlinear dynamics, system uncertainties and external disturbances can be treated as part of the “total disturbances”, such that the extended state observer can be used to estimate and suppress the effects of these complex dynamics. The proposed control algorithm is deployed in real time implementations on the designed nano-stage, where experimental results demonstrate good control performance in terms of high precision positioning, hysteresis compensation and disturbance rejection.