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Takeshi Nishioka,Masaharu Fujino,Akihiro Homma,Tetsuro Yamashita,Akira Sato,Keiichi Ohmori,Kenichi Obinata,Hiroki Shirato,Kenichi Notani,Masamichi Nishio 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.4
Purpose: Deciding on treatment carcinoma of the tongue when the tumor has a thickness of 1.5 cm or more is difficult. Surgery often requires wide resection and re-construction, leading to considerable functional impairment. A cesium implant is an attractive option, but according to the Manchester System, a two plane implant is needed. Materials and Methods: According to the textbook, a tumor is sandwiched between the needles, which are implanted at the edge of the tumor. This may cause an unnecessarily high dose to the outer surface of the tongue,which sometimes leads to a persistent ulcer. To avoid this complication, we invented a modified implantation method, and applied the method to five consecutive patients. Results: With a minimum follow-up of 2 years, all primary tumors in 5consecutive patients have been controlled. No complications occurred in soft tissue of the tongue or in the mandible. Conclusion: Our modified Manchester System was feasible and effective for tumors that has a thickness of 1.5 cm or more.
( Rieko Kamiyama ),( Takeshi Ogura ),( Atsushi Okuda ),( Akira Miyano ),( Nobu Nishioka ),( Miyuki Imanishi ),( Wataru Takagi ),( Kazuhide Higuchi ) 대한간학회 2018 Gut and Liver Vol.12 No.4
Background/Aims: Electrohydraulic lithotripsy (EHL) under endoscopic retrograde cholangiopancreatography (ERCP) guidance can be an option to treat difficult stones. Recently, a digital, single-operator cholangioscope (SPY-DS) has become available. Peroral transluminal cholangioscopy (PTLC) using SPY-DS has also been reported. In this retrospective study, the technical feasibility and clinical effectiveness of EHL for difficult bile duct stones under ERCP guidance and under PTLC guidance was examined. Methods: In this pilot study, patients with difficult bile duct stones between July 2016 and July 2017 were retrospectively enrolled. Results: Forty-two consecutive patients underwent EHL using a SPY-DS; 34 patients underwent EHL under ERCP guidance, and the other 8 patients underwent EHL under PTLC guidance. Median procedure time was 31 minutes (range, 19 to 66 minutes). The median number of EHL sessions was 1 (range, 1 to 2), and that of ERCP sessions was also 1 (range, 1 to 3). The rate of complete stone clearance was 98% (41/42). Adverse events such as cholangitis and acute pancreatitis were seen in 14% (6/42), which could be treated conservatively. Conclusions: EHL using SPY-DS was technically feasible, not only under ERCP guidance, but also PTLC guidance. A prospective clinical study of EHL using SPY-DS is needed. (Gut Liver 2018;12:457-462)
( Atsushi Okuda ),( Takeshi Ogura ),( Miyuki Imanishi ),( Akira Miyano ),( Nobu Nishioka ),( Kazuhide Higuchi ) 대한간학회 2018 Gut and Liver Vol.12 No.4
Background/Aims: Recently, recombinant human soluble thrombomodulin (rTM) has been developed as a new drug for disseminated intravascular coagulation (DIC). This study aims to evaluate the clinical benefit of rTM in patients with sepsis-induced DIC caused by acute cholangitis who underwent biliary drainage. Methods: Patients were divided into two groups: the rTM therapy group and the non-rTM therapy group. The primary outcome was the DIC resolution rate at 7 days, and the secondary outcome was 28-day mortality rate. Results: Thirty-five patients were treated by rTM, and 36 patients were treated without rTM for DIC. The rate of resolution of DIC at day 7 was significantly higher in the rTM group than in the non-rTM group (82.9% vs 55.6%, p=0.0012). Compared with the non-rTM group, the 28-day survival rate of the r-TM group was significantly higher (rTM vs non-rTM, 91.4% vs 69.4%, p=0.014). According to multivariate analysis, non-rTM (hazard ratio [HR], 2.681) and CRP (HR, 2.370) were factors related to decreased survival. Conclusions: rTM treatment may have a positive impact on improving DIC and survival rates in patients with severe acute cholangitis. (Gut Liver 2018;12:471-477)
A Symmetrical Floating Impedance Scaling Circuit with Improved Low-frequency Characteristics
Fujihiko MATSUMOTO,Syuzo NISHIOKA,Shota MATSUO,Takeshi OHBUCHI 대한전자공학회 2017 IEIE Transactions on Smart Processing & Computing Vol.6 No.6
Impedance scaling techniques are known as methods to realize large capacitance with a small capacitor. Recently, a symmetrical floating impedance scaling (SFIS) circuit was proposed. However, the circuit has restrictions on operations at a lower frequency. In this paper, improvement techniques for low-frequency characteristics of the SFIS circuit are proposed. In order to enhance the terminal resistance, a negative impedance converter (NIC) block is employed in the SFIS circuit. In addition, cascode transistors are introduced to enhance the internal resistance associated with a capacitor in the SFIS circuit. The proposed techniques make the pole frequency lower. The proposed SFIS circuit is applied to a third-order Chebyshev filter via simulation. Cutoff frequency fc of the filter is set to 100 Hz, and the passband ripple of the filter is set to 0.5 dB. Simulation results show that the filter employing the proposed SFIS circuit is superior to a conventional one.
Saori Miyazaki,Koutatsu Maruyama,Kiyohide Tomooka,Shinji Nishioka,Noriko Miyoshi,Ryoichi Kawamura,Yasunori Takata,Haruhiko Osawa,Takeshi Tanigawa,Isao Saito 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.3
Objectives: Few studies examined the association between deterioration of masticatory ability assessed by objective marker and physical function. Therefore, we examined the association between salivary flow rate which is one of the objective and surrogate marker of masticatory ability and lower Timed Up & Go (TUG) performance which is one of major measurement of physical function among aging Japanese. Methods: This cross-sectional study enrolled 464 Japanese aged 60e84 years old. Participants chewed tasteless and odorless gum for 5 min, calculated stimulated salivary flow rate (g/min) during all chews. The 3 m TUG was conducted, and 75th percentile value (6.8 s for men and 7.0 s for women) or higher was defined as lower TUG performance. Logistic regression analysis was used to examine the association between stimulated salivary flow rate and lower TUG performance. Results: We found that the stimulated salivary flow rate tended to be negatively associated with the TUG time. We also observed significant negative association between stimulated salivary flow rate and lower TUG performance; the multivariable-adjusted OR (95% confidence interval, CIs) of lower TUG performance for the highest quartile of stimulated salivary flow rate compared with the lowest quartile was 0.34 (0.16-0.69, P for trend = 0.02). Further adjusting for BMI, the association was attenuated but remaind significant; the OR (95% CIs) in highest quartile was 0.37 (0.18-0.76, P for trend = 0.04). Conclusions: Higher stimulated salivary flow, which means well masticatory ability, was inversely associated with lower TUG performance in the aging Japanese population.