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Wettability Control and Flow Regulation Using a Nanostructure-Embedded Surface
Tafti, Ehsan Yakhshi,Londe, Ghanashyam,Chunder, Anindarupa,Zhai, Lei,Kumar, Ranganathan,Cho, Hyoung J. American Scientific Publishers 2011 Journal of Nanoscience and Nanotechnology Vol.11 No.2
<P>This work addresses the synthesis, integration and characterization of a nanostructure-embedded thermoresponsive surface for flow regulation. In order to create a hierarchic structure which consists of microscale texture and nanoscale sub-texture, hybrid multilayers consisting of poly(allylamine hydrochloride) (PAH), poly(acrylic acid) (PAA) and colloidal silica nanoparticles (average diameter = 22 nm and 7 nm) were used. Based on the electrostatic interactions between the polyelectrolytes and nanoparticles, a layer-by-layer deposition technique in combination with photolithography was employed to obtain a localized, conformally-coated patch in a microchannel. Grafted with the thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), wettability of the surface could be tuned upon heating or cooling. The measurement of differential pressure at various stages of device verified the working conditions of the nanostructure-embedded surface for regulating a capillary flow in the microchannel.</P>
Overexpression of HER-2/neu in Patients with Prostatic Adenocarcinoma
Zahir, Shokouh Taghipour,Tafti, Hamid Fallah,Rahmani, Koorosh Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Background: Prostatic adenocarcinoma is one of the main causes of cancer death, and its timely diagnosis and preventing its progression dramatically helps improve life indexes. Given the high disease recurrence rate, today, research is more inclined toward exploring causes of recurrence and development, and innovation of modern treatment methods. Several studies have explored over-expression of human epidermal growth factor receptor 2 (HER-2/neu) in prostatic cancer so far, with different results. Thus, it was decided to investigate HER-2/neu overexpression in patients with prostatic adenocarcinoma in Iran. Materials and Methods: A sample size of 40 patients with prostate cancer entered the study, using a cross-sectional, non-randomized sampling method. Parameters studied included patient age at surgery, Gleason score, serum prostatic specific antigen (PSA) before surgery, and positive sample rate after immunohistochemical staining to investigate HER-2/neu overexpression. Results: In terms of HER-2/neu receptor staining rate, of 40 slides, 16 (40%) scored 0, 13 (32.5%) 1+, 7 (17.5%) 2+, and 4 (10%) 3+. In total 27.5% of slides showed HER-2/neu overexpression. In terms of age, an inverse correlation was found (-0.181), but without significance (p=0.263). In terms of serum PSA, the correlation coefficient was 0.449 (p=0.004). With respect to Gleason score, the coefficient was 0.190 (p=0.240). Conclusions: In this study, HER-2/neu overexpression occurred in 27.5% of prostate cancer cases, which is a relatively high figure, compared to similar studies elsewhere. While, we failed to reveal any relationship between HER-2/neu expression status with progression and prognosis of disease, it was demonstrated that the serum PSA level was significantly higher in cases with increased receptor expression.
Salehiamin Mehdi,Toolee Heidar,Azami Mahmoud,Tafti Seyed Hossein Ahmadi,Mojaverrostami Sina,Halimi Shahnaz,Barakzai Shogoofa,Sobhani Aligholi,Abbasi Yasaman 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.4
BACKGROUND: In the aftermath of bone injuries, such as cranium and sternum, bone wax (BW) is used to control bleeding from the bone surfaces during surgery. Made up of artificial substances, however, it is associated with many complications such as inflammation, increased risk for infection, and bone repair delay. We, therefore, in this study set out to design and evaluate a novel BW without the above-mentioned side-effects reported for other therapies. METHODS: The pastes (new BW(s)) were prepared in the laboratory and examined by MTT, MIC, MBC, and degradability tests. Then, 60 adult male Wistar rats, divided into six equal groups including chitosan (CT), CT-octacalcium phosphate (OCP), CT-periostin (Post), CT-OCP-Post, Control (Ctrl), and BW, underwent sternotomy surgery. Once the surgeries were completed, the bone repair was assessed radiologically and thereafter clinically in vivo and in vitro using CT-scan, H&E, ELISA, and qRT-PCR. RESULTS: All pastes displayed antibacterial properties and the CT-Post group had the highest cell viability compared to the control group. In contrast to the BW, CT-Post group demonstrated weight changes in the degradability test. In the CT-Post group, more number of osteocyte cells, high trabeculae percentage, and the least fibrous connective tissue were observed compared to other groups. Additionally, in comparison to the CT and Ctrl groups, higher alkaline phosphatase activity, as well as decreased level of serumtumor necrosis factor-a, interleukin-6, andOCNin the CT-Post group was evident. Finally, Runx2, OPG, and RANKL genes’ expression was significantly higher in the CT-Post group than in other groups. CONCLUSION: Our results provide insights into the desirability of pastes in terms of cellular viability, degradability, antibacterial properties, and surgical site restoration compared to the BW group. Besides, Periostin could enhance the osteogenic properties of bone tissue defect site.
박종환,Jim J. Wang,Negar Tafti,Ronald D. Delaune 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.71 No.-
A new heterogeneous Fenton catalyst, Fe-impregnated biochar catalyst (Fe-BC) was synthesized andevaluated in detail for its catalytic activity with sulfate radical under various conditions. The optimumconditions for the removal of Eriochrome Black T (EBT) by Fe-BC were determined as 0.27 g/L K2S2O8 (PS)and 0.5 g/L Fe-BC for 0.1 g/L EBT, and which resulted 85–88% removal efficiency within 2 h. The effectiveoxidation of EBT was observed over a pH range of 2–4 and temperature of 25–45 C and maintained EBTremoval efficiency of 77.6–92.7%. Under optimum conditions, the catalytic activity was faster in the orderof PS > PS + HP > H2O2 (HP) >>Fe-BC (without oxidants). The catalytic activity of Fe-BC for EBT can beidentified in two stages, which occur rapidly within 30 min (1st stage) and followed by slow oxidationuntil 120 min (2nd stage). Catalytic activity by sulfate radical was also dominantly influenced by otherpollutant such as iodide, phosphate and humic acid. Overall, the sulfate radical generated from Fe-BC/PSwas found more economical with strong oxidation efficiency for use in Fenton-like reaction for treatingorganic pollutants compared with conventional Fenton reaction with H2O2.
Forming limit diagram of aluminum AA6063 tubes at high temperatures by bulge tests
Seyed Jalal Hashemi,Hassan Moslemi Naeini,Gholamhossein Liaghat,Rooholla Azizi Tafti,Farzad Rahmani 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.11
A free bulge test and ductile fracture criteria were used to obtain the forming limit diagrams (FLD) of aluminum alloy AA6063 tubesat high temperatures. Ductile fracture criteria were calibrated using the results of uniaxial tension tests at various elevated temperaturesand different strain rates through adjusting the Zener-Holloman parameter. High temperature free bulge test of tubes was simulated infinite element software Abaqus, and tube bursting was predicted using ductile fracture criteria under different loading paths. FLDs whichwere obtained from finite element simulation were compared to experimental results to select the most accurate criterion for prediction offorming limit diagram. According to the results, all studied ductile fracture criteria predict similarly when forming condition is close tothe uniaxial tension, while Ayada criterion predicts the FLD at 473 K and 573 K very well.
Keshvari, Amir,Badripour, Abolfazl,Keramati, Mohammad Reza,Kazemeini, Alireza,Behboudi, Behnam,Fazeli, Mohammad Sadegh,Rahimpour, Ehsan,Ghaffari, Parisa,Tafti, Seyed Mohsen Ahmadi 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.3
Purpose: Anastomotic leakage, a known major postoperative complication, potentially leads to readmission, reoperation, and increased mortality rates in patients, such as rectal cancer patients following a low anterior resection (LAR). Currently, vacuum-assisted closure, as featured by B-Braun (B-Braun Medical B.V.), is already being used for the treatment of gastrointestinal leakages and fistulas. The main aim of this study was to introduce a novel method for creating a vacuum-assisted drain for the treatment of anastomotic leakage after LAR. Methods: All 10 patients, who underwent LAR surgery from 2018 to 2019, were diagnosed with anastomotic leakage and had received neoadjuvant chemotherapy prior to surgery. Therefore, patients were treated with a handmade vacuum-assisted drain and were revisited every 5 to 7 days for further evaluations and drain replacement until leakage resolution. Physical features of cavity, time of diagnose, and duration of treatment were analyzed correspondingly. The handmade vacuum-assisted sponge drain was prepared for each patient in each session of follow-up. Results: Eight out of 10 patients experienced complete closure of the defect. The mean delay time from the day of operation to the diagnosis of anastomotic leakage was 61.0±80.4 days while the mean time for leakage closure was 117.6±68.3 days. Eventually, 7 cases underwent ileostomy reversal with no complications during a 3-month follow-up. Conclusion: In this study, we evaluated the healing process of anastomotic leakage after the usage of a handmade vacuum-assisted sponge drain in a case series method. In our trial, we provided an innovative cost-benefit method easily applicable in the operating room.