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A form of the metabolic syndrome associated with mutations in DYRK1B.
Keramati, Ali R,Fathzadeh, Mohsen,Go, Gwang-Woong,Singh, Rajvir,Choi, Murim,Faramarzi, Saeed,Mane, Shrikant,Kasaei, Mohammad,Sarajzadeh-Fard, Kazem,Hwa, John,Kidd, Kenneth K,Babaee Bigi, Mohammad A,Ma Massachusetts Medical Society 2014 The New England journal of medicine Vol.370 No.20
<P>Genetic analysis has been successful in identifying causative mutations for individual cardiovascular risk factors. Success has been more limited in mapping susceptibility genes for clusters of cardiovascular risk traits, such as those in the metabolic syndrome.</P>
Shahram Manoochehry(Shahram Manoochehry ),Hamid Reza Rasouli(Hamid Reza Rasouli ),Fathollah Ahmadpour(Fathollah Ahmadpour ),Alireza Keramati(Alireza Keramati ) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: This study aimed to evaluate the role of inflammatory blood markers in predicting the pathological response rate after neoadjuvant chemoradiation (neo-CRT) in patients with locally advanced rectal cancer (LARC). Materials and Methods: In this prospective cohort study, we analyzed the data of patients with LARC who underwent neo-CRT and surgical removal of the rectal mass between 2020 and 2022 in a tertiary medical center. Patients were examined weekly during chemoradiation and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune inflammation index (SII) were calculated from weekly laboratory data. Wilcoxon signed-ranks and logistic regression analysis were utilized to determine whether any laboratory parameters during different time point assessments or their relative changes could predict the tumor response based on a permanent pathology review. Results: Thirty-four patients were recruited for the study. Eighteen patients (53%) achieved good pathologic response. Statistical analysis by Wilcoxon signed-ranks method indicated significant rises in NLR, PLR, MLR, and SII on weekly assessments during chemoradiation. Having an NLR over 3.21 during chemoradiation was correlated with the response on a Pearson chi-squared test (p = 0.04). Also, a significant correlation was found between the PLR ratio over 1.8 and the response (p = 0.02). NLR ratio over 1.82 marginally missed a significant correlation with the response (p = 0.13). On multivariate analysis, a PLR ratio over 1.8 showed a trend for response (odds ratio = 10.4; 95% confidence interval, 0.9–123; p = 0.06). Conclusion: In this study, PLR ratio as an inflammatory marker showed a trend in the prediction of response in permanent pathology to neo-CRT.
Salehi, Mona,Keramati, Abbas,Didehkhani, H. Korean Institute of Information Scientists and Eng 2010 Journal of Computing Science and Engineering Vol.4 No.1
This study proposes a framework to investigate the factors of mobile web success in the context of e-commerce, and the relative importance of these success factors in selecting the most preferred mobile web. First, the Updated Delone and Mclean IS success model (2003) is chosen to extract significant mobile web success factors in the context of e-commerce. Second, it is extended through applying an Analytic Network Process (ANP) approach for investigating the relative importance of each factor and ranking alternative mobile webs in the context of e-commerce. The choice of success measure is a function of the context, which is the objective of this study. Thus, the present study is aimed at evaluating the success of an e-commerce mobile web by customizing measures of the Updated Delone and McLean IS Success model according to the context.
A Framework for Investigating Mobile Web Success in the Context of E-commerce
Mona Salehi,Abbas Keramati,H. Didehkhani 한국정보과학회 2010 Journal of Computing Science and Engineering Vol.4 No.1
This study proposes a framework to investigate the factors of mobile web success in the context of e-commerce, and the relative importance of these success factors in selecting the most preferred mobile web. First, the Updated Delone and Mclean IS success model (2003) is chosen to extract significant mobile web success factors in the context of e-commerce. Second, it is extended through applying an Analytic Network Process (ANP) approach for investigating the relative importance of each factor and ranking alternative mobile webs in the context of ecommerce. The choice of success measure is a function of the context, which is the objective of this study. Thus, the present study is aimed at evaluating the success of an e-commerce mobile web by customizing measures of the Updated Delone and McLean IS Success model according to the context.
Keshvari, Amir,Badripour, Abolfazl,Keramati, Mohammad Reza,Kazemeini, Alireza,Behboudi, Behnam,Fazeli, Mohammad Sadegh,Rahimpour, Ehsan,Ghaffari, Parisa,Tafti, Seyed Mohsen Ahmadi 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.3
Purpose: Anastomotic leakage, a known major postoperative complication, potentially leads to readmission, reoperation, and increased mortality rates in patients, such as rectal cancer patients following a low anterior resection (LAR). Currently, vacuum-assisted closure, as featured by B-Braun (B-Braun Medical B.V.), is already being used for the treatment of gastrointestinal leakages and fistulas. The main aim of this study was to introduce a novel method for creating a vacuum-assisted drain for the treatment of anastomotic leakage after LAR. Methods: All 10 patients, who underwent LAR surgery from 2018 to 2019, were diagnosed with anastomotic leakage and had received neoadjuvant chemotherapy prior to surgery. Therefore, patients were treated with a handmade vacuum-assisted drain and were revisited every 5 to 7 days for further evaluations and drain replacement until leakage resolution. Physical features of cavity, time of diagnose, and duration of treatment were analyzed correspondingly. The handmade vacuum-assisted sponge drain was prepared for each patient in each session of follow-up. Results: Eight out of 10 patients experienced complete closure of the defect. The mean delay time from the day of operation to the diagnosis of anastomotic leakage was 61.0±80.4 days while the mean time for leakage closure was 117.6±68.3 days. Eventually, 7 cases underwent ileostomy reversal with no complications during a 3-month follow-up. Conclusion: In this study, we evaluated the healing process of anastomotic leakage after the usage of a handmade vacuum-assisted sponge drain in a case series method. In our trial, we provided an innovative cost-benefit method easily applicable in the operating room.
Lack of KRAS Gene Mutations in Chronic Myeloid Leukemia in Iran
Kooshyar, Mohammad Mahdi,Ayatollahi, Hossein,Keramati, Mohammad Reza,Sadeghian, Mohammad Hadi,Miri, Mohsen,Sheikhi, Maryam Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: The single most common proto-oncogene change in human neoplasms is a point mutation in RAS genes. A wide range of variation in frequency of KRAS mutations has been seen in hematologic malignancies. Despite this, RAS roles in leukemogenesis remain unclear. The frequency of KRAS mutations in CML has been reported to be between zero an 10%. Many attempts have been done to develop an anti-RAS drug as a therapeutic target. Materials and Methods: This cross sectional study was performed in Mashhad University of Medical Sciences, Mashhad, Iran from 2010-2012. In 78 CML patients (diagnosed according to WHO 2008 criteria) in chronic or accelerated phases, KRAS mutations in codons 12 and 13 were analyzed using a modified PCR-restriction fragment length polymorphism (RFLP) method. Results: We did not detect any KRAS mutations in this study. Conclusions: KRAS mutations are overall rare in early phase CML and might be secondary events happening late in leukemogenesis cooperating with initial genetic lesions.
Platelet volume indices in patients with varicocele
Mahdavi-Zafarghandi, Reza,Shakiba, Behnam,Keramati, Mohammad Reza,Tavakkoli, Mahmoud The Korean Society for Reproductive Medicine 2014 Clinical and Experimental Reproductive Medicine Vol.41 No.2
Objective: This study sought to evaluate platelet volume indices (mean platelet volume [MPV], platelet distribution width [PDW], and platelet large cell ratio [P-LCR]) in varicocele patients, and compare it with platelet volume parameters in healthy controls. Methods: This cross-sectional study involved 2 groups: group 1 included 51 varicocele subjects and group 2 consisted of 50 healthy control subjects of similar ages. Peripheral venous blood samples were collected with ethylenediaminetetraacetic acid-K2 anticoagulant between 8:30 AM and 10 AM following an overnight fast. Platelet volume parameters (MPV, PDW, and P-LCR) were measured in both groups within 2 hours of sampling. Results: The mean PDW, MPV, and P-LCR were $13.9{\pm}2.5%$, $10.1{\pm}1.3fL$, and $27.3{\pm}7.8%$ in varicocele patients, respectively, and were $12.6{\pm}2.4%$, $9.3{\pm}1.1fL$, and $21.9{\pm}6.4%$ in the control group, respectively. The mean PDW, MPV, and P-LCR were significantly higher in the varicocele group than the control group. Conclusion: The results of the present study suggest that vascular components may play an important role in the pathophysiology of varicocele; therefore, there is a great need for prospective studies to confirm this relationship.
Delorme’s Procedure: An Effective Treatment for a Full-Thickness Rectal Prolapse in Young Patients
Mohammad Sadegh Fazeli,Ali Reza Kazemeini,Amir Keshvari,Mohammad Reza Keramati 대한대장항문학회 2013 Annals of Coloproctolgy Vol.29 No.2
Purpose: Delorme’s procedure is infrequently applied in young adults because of its assumed higher recurrence rate. The aim of this prospective study was to assess the efficacy of the Delorme’s technique in younger adults. Methods: Fifty-two consecutive patients were entered in our study. We followed patients for at least 30 months. Their complaints and clinical exam results were noted. Results: Our study included 52 patients (mean age, 38.44 years; standard deviation, 13.7 years). Of the included patients, 41(78.8%) were younger than 50 years of age, and 11 (21.1%) were older than 50 years of age. No postoperative mortalities or major complications were noted. Minor complications were seen in 5 patients (9.6%) after surgery. The mean hospital stay was 2.5 days. In the younger group (age ≤50 years), fecal incontinence was improved in 92.3% (12 out of 13 with previous incontinence) of the patients, and recurrence was seen in 9.75% (4 patients). In the older group (age >50 years), fecal incontinence was improved in 20% (1 out of 5 with previous incontinence) of the patients, and recurrence was seen in 18.2% (2patients). In 50% of the patients with a previous recurrence (3 out of 6 patients) following Delorme’s procedure as a secondary procedure, recurrence was observed. Conclusion: Delorme’s procedure, especially in younger patients, is a relatively safe and effective treatment and should not be restricted to older frail patients. This procedure may not be suitable for recurrent cases.
Azam Eskandari,Shahrokh Nasseri,Hamid Gholamhosseinian,Sare Hosseini,Mohammad Javad Keikhai Farzaneh,Alireza Keramati,Maryam Naji,Atefeh Rostami,Mehdi Momennezhad 대한방사선종양학회 2020 Radiation Oncology Journal Vol.38 No.1
Purpose: The present study was conducted to compare dosimetric parameters for the heart and left lung between free breathing (FB) and deep inspiration breath hold (DIBH) and determine the most important potential factors associated with increasing the lung dose for left-sided breast radiotherapy using image analysis with 3D Slicer software. Materials and Methods: Computed tomography-simulation scans in FB and DIBH were obtained from 17 patients with left-sided breast cancer. After contouring, three-dimensional conformal plans were generated for them. The prescribed dose was 50 Gy to the clinical target volume. In addition to the dosimetric parameters, the irradiated volumes and both displacement magnitudes and vectors for the heart and left lung were assessed using 3D Slicer software. Results: The average of the heart mean dose (Dmean) decreased from 5.97 to 3.83 Gy and V25 from 7.60% to 3.29% using DIBH (p < 0.001). Furthermore, the average of Dmean for the left lung was changed from 8.67 to 8.95 Gy (p = 0.389) and V20 from 14.84% to 15.44% (p = 0.387). Both of the absolute and relative irradiated heart volumes decreased from 42.12 to 15.82 mL and 8.16% to 3.17%, respectively (p < 0.001); however, these parameters for the left lung increased from 124.32 to 223.27 mL (p < 0.001) and 13.33% to 13.99% (p = 0.350). In addition, the average of heart and left lung displacement magnitudes were calculated at 7.32 and 20.91 mm, respectively. Conclusion: The DIBH is an effective technique in the reduction of the heart dose for tangentially treated left sided-breast cancer patients, without a detrimental effect on the left lung.
( Sanam Javid Anbardan ),( Nasser Ebrahimi Daryani ),( Seyed Mohammad Fereshtehnejad ),( Sahar Taba Taba Vakili ),( Mohammad ),( Reza Keramati ),( Hossein Ajdarkosh ) 대한소화기기능성질환·운동학회 (구 대한소화관운동학회) 2012 Journal of Neurogastroenterology and Motility (JNM Vol.18 No.1
Background/Aims Irritable bowel syndrome (IBS) is a widespread chronic health condition which is significantly more prevalent in women. We conducted a gender difference analysis by comparing findings of men and women to determine whether any significant differences exist or not. Methods This single-center study was conducted in Tehran, Iran during 2009-2010. IBS was diagnosed on the basis of Rome III criteria. A simple "10 point" objective questionnaire was used. Results A total number of 144 IBS patients including 44 (30.6%) males and 100 (69.4%) females with the mean age of 37.50 ± 11.50 years, were assessed. The only differently observed symptom was nausea which was significantly more prevalent in females (49% vs 18.2%, P < 0.001). The commonest subtype of IBS in male patients was diarrhea predominant IBS (38.6%); while, constipation predominant IBS was the most frequent type among females (38%). Moreover, the frequency of loose, mushy or watery stools within the last 3 months was significantly higher among males (2.11 ± 1.67 vs 1.37 ± 1.50, P = 0.009). Conclusions We report that gender is important in IBS. Although qualitative comparison of different subtypes of IBS between male and female failed to meet the statistically significant level, the answers to the corresponding questions of ROME III IBS module suggest the higher prevalence of bowel movements and looser stool in males. Moreover, nausea was reported more often by females. (J Neurogastroenterol Motil 2012;18:70-77)