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홍경원,김희수,Joo-MiYi,Kyung-MiShin,Tae-HyungKim,Jae-WonHuh,Young-ChoonLee,Won-HoLee,TimothyJ.Crow 한국유전학회 2003 Genes & Genomics Vol.25 No.2
A human endogenous retroviral family (HERV-W) has been related to multiple sclerosis virus (SZRV) sequences. The HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using cDNA libraries derived from human brains, we performed PCR amplification and identified new 16 HERV-W env elements (9 from human adult brain and 7 from human fetal brain). Those sequences showed a high degre of sequence similarity (89.2-99.6%) with HERV-W env (GenBank acesion no. AF072506). Clones HB-1, HB-9 from adult brain and FB-2, FB-5 from fetal brain showed no frameshift and termination codons by deletion/insertion or point mutation. Synonymous and nonsynonymous calculation indicated that these sequences (HB-1, HB-9, FB-2, FB-5) could be asociated with an active provirus in human brain tisues. In phylogenetic analysis, clones HB-1, HB-9, FB-2, FB-5 containing putative amino acid sequences showed sister relationship with the HERV-W and W-7-1 derived from human chromosome 7. Taken together, our data suggest that the related genes of the HERV-W env sequences are expresed in human brains and may contribute to an understanding of biological function connected to neuropsychiatric diseases.
Implementation of location based creator matching platform
한현민(Hyun-Min Han),이정윤(Jeong-YunLee),유재인,안준영(Jun-YungAhn),구민정(Min-JungKu),고석주(Seok-JuKo),김태형(Tae-HyungKim) 대한전자공학회 2018 대한전자공학회 학술대회 Vol.2018 No.11
In this paper, O2O(oline to offline) based photographer matching mobile platform is proposed. It is possible to compare and book photographers in this platform. By identifying the problems of photographic industry, this mobile application can the growth of photographic industry and satisfaction of customer.
Two-dimensional material-based bionano platforms to control mesenchymal stem cell differentiation
Ee-Seul Kang,Da-Seul Kim,Intan Rosalina Suhito,Wanhee Lee,Inbeom Song,Tae-HyungKim 한국생체재료학회 2018 생체재료학회지 Vol.22 No.2
Background: In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repair damaged parts of organs and tissues, the use of stem cells still entails several limitations, such as low differentiation efficiency and difficulties in guiding differentiation. To address these limitations, nanotechnology approaches have been recently implemented in stem cell research. It has been discovered that stem cells, in combination with carbon-based functional materials, show enhanced regenerative performances in varying biophysical conditions. In particular, several studies have reported solutions to the conventional quandaries in biomedical engineering, using synergetic effects of nanohybrid materials, as well as further development of technologies to recover from diverse health conditions such as bone fracture and strokes. Main text: In this review, we discuss several prior studies regarding the application of various nanomaterials in controlling the behavior of stem cells. We focus on the potential of different types of nanomaterials, such as two-dimensional materials, gold nanoparticles, and three-dimensional nanohybrid composites, to control the differentiation of human mesenchymal stem cells (hMSCs). These materials have been found to affect stem cell functions via the adsorption of growth/differentiation factors on the surfaces of nanomaterials and the activation of signaling pathways that are mostly related to cell adhesion and differentiation (e.g., FAK, Smad, Erk, and Wnt). Conclusion: Controlling stem cell differentiation using biophysical factors, especially the use of nanohybrid materials to functionalize underlying substrates wherein the cells attach and grow, is a promising strategy to achieve cells of interest in a highly efficient manner. We hope that this review will facilitate the use of other types of newly discovered and/or synthesized nanomaterials (e.g., metal transition dichalcogenides, non-toxic quantum dots, and metal oxide frameworks) for stem cell-based regenerative therapies.