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RISS 인기검색어
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- 저자 : Inbeom Song (검색결과 5 건)
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Kang, Ee-Seul,Song, Inbeom,Kim, Da-Seul,Lee, Ukjae,Kim, Jang-Kyo,Son, Hyungbin,Min, Junhong,Kim, Tae-Hyung Elsevier 2018 Colloids and surfaces Biointerfaces Vol.169 No.-
<P><B>Abstract</B></P> <P>Graphene derivatives are known to be suitable for biomedical applications, especially for stem cell-based therapies. Herein, we report the size effects of graphene oxide (GO) on differentiation of human adipose-derived mesenchymal stem cells (hADMSCs), using micro-sized (MGO) and nano-sized graphene oxide (NGO) sheets. The MGO and NGO sheets having lateral sizes of 1–10 μm and 100–300 nm, respectively, are coated on glass substrates by drop casting. The hADMSCs grown on the MGO-coated substrates show enhanced cell spreading and proliferation rate when compared with those of NGO counterpart, regardless of their densities. The GO size-dependency of hADMSCs becomes more prominent when it comes to their differentiation capabilities. After 4 weeks of differentiation under the same culture conditions, the osteogenesis of hADMSCs grown on the MGO-coated substrate is particularly higher than that on the NGO-coated substrate. The difference in osteogenic differentiation of hADMSCs is found to be most dominant after 21–28 days of differentiation according to the calcification level of osteoblasts. These finding signify the importance of graphene size in controlling the osteogenesis of hADMSCs, which may shed new insight into the use of graphene-based materials for stem cell research and therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of physical sizes of GO on stem cell differentiation are highly important. </LI> <LI> Nano- and Micro-sized GO were uniformly coated on substrates for cell cultivation. </LI> <LI> Micro-sized GO was better for adhesion, spreading and growth of hADMSCs. </LI> <LI> Micro-sized GO was better for enhancing osteogenesis of hADMSCs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Guiding osteogenesis of mesenchymal stem cells using carbon-based nanomaterials
강이슬,Kim Da-Seul,인탄 로살리나,Choo Sung-Sik,Kim Seung-Jae,Song Inbeom,Kim Tae-Hyung 나노기술연구협의회 2017 Nano Convergence Vol.4 No.2
In the field of regenerative medicine, stem cells are highly promising due to their innate ability to generate multiple types of cells that could replace/repair damaged parts of human organs and tissues. It has been reported that both in vitro and in vivo function/survival of stem cells could significantly be improved by utilizing functional materials such as biodegradable polymers, metal composites, nanopatterns and nanohybrid particles. Of various biocompatible materials available for use in stem cell-based therapy and research, carbon-based materials—including fullerenes graphene/graphene oxide and carbon nanotubes—have been found to possess unique physicochemical characteristics that contribute to the effective guidance of stem cell differentiation into specific lineages. In this review, we discuss a number of previous reports that investigated the use of carbon-based materials to control stem cell behavior, with a particular focus on their immense potential to guide the osteogenesis of mesenchymal stem cells (MSCs). We hope that this review will provide information on the full potential of using various carbon-based materials in stem cell-mediated regenerative therapy, particularly for bone regeneration and repair.
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Two-dimensional material-based bionano platforms to control mesenchymal stem cell differentiation
Ee-Seul Kang,Da-Seul Kim,Intan Rosalina Suhito,Wanhee Lee,Inbeom Song,Tae-HyungKim 한국생체재료학회 2018 생체재료학회지 Vol.22 No.2
Background: In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repair damaged parts of organs and tissues, the use of stem cells still entails several limitations, such as low differentiation efficiency and difficulties in guiding differentiation. To address these limitations, nanotechnology approaches have been recently implemented in stem cell research. It has been discovered that stem cells, in combination with carbon-based functional materials, show enhanced regenerative performances in varying biophysical conditions. In particular, several studies have reported solutions to the conventional quandaries in biomedical engineering, using synergetic effects of nanohybrid materials, as well as further development of technologies to recover from diverse health conditions such as bone fracture and strokes. Main text: In this review, we discuss several prior studies regarding the application of various nanomaterials in controlling the behavior of stem cells. We focus on the potential of different types of nanomaterials, such as two-dimensional materials, gold nanoparticles, and three-dimensional nanohybrid composites, to control the differentiation of human mesenchymal stem cells (hMSCs). These materials have been found to affect stem cell functions via the adsorption of growth/differentiation factors on the surfaces of nanomaterials and the activation of signaling pathways that are mostly related to cell adhesion and differentiation (e.g., FAK, Smad, Erk, and Wnt). Conclusion: Controlling stem cell differentiation using biophysical factors, especially the use of nanohybrid materials to functionalize underlying substrates wherein the cells attach and grow, is a promising strategy to achieve cells of interest in a highly efficient manner. We hope that this review will facilitate the use of other types of newly discovered and/or synthesized nanomaterials (e.g., metal transition dichalcogenides, non-toxic quantum dots, and metal oxide frameworks) for stem cell-based regenerative therapies.
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이영재(Youngjae Lee),조종표(Chongpyo Cho),김계현(Gyehyun Kim),정중용(James Y. Jung),송인범(Inbeom Song),정현택(Hyountaeg Jung) 한국자동차공학회 2008 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
RSD (Remote Sensing Device), which is a roadside measuring device, can measure the exhaust emissions of the vehicle to pass the device without any interference. RSD is capable of measuring the CO, HC, NO, CO₂ emissions of gasoline vehicles, and additionally smoke of' diesel vehicles within I second. Therefore, it can provide thousands or on-road emissions data in a day. In the present study, RSD and conventional emission test equipments were used to analyze the relationship between these equipments. From the test results, it was concluded that RSD can replace the current exhaust gas analyzer as on-road inspection or in-use vehicles, and also can be used to identify the gross emitters and clean vehicles.
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조종표(Chongpyo Cho),이영재(Youngjae Lee),김계현(Gyehyun Kim),정중용(James Y. Jung),송인범(Inbeom Song),정현택(Hyountaeg Jung) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
RSD (Remote Sensing Device), which is a roadside measuring device, can measure the exhaust emissions from the vehicle to pass the RSD device without any interference. RSD is capable of measuring the CO, HC, NO, CO₂ emissions from on-road vehicle within 1 second. Therefore, it can provide thousands of on-road emissions data in a day. In the present study, RSD was used to measure the exhaust emissions from the gasoline and LPG vehicles on the 27 test sites in Seoul metropolitan areas. Totally 177,849 of effective data were obtained during 104 days, and these data were used to analyze the average CO, HC and NO emissions by vehicle model year, and also to analyze the cumulative distribution by the concentration of exhaust emission for the reference to identify the low and gross emitters.
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