Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1

Sharma, R.,Sharma, R.,Khaket, T. P.,Dutta, C.,Chakraborty, B.,Mukherjee, T. K. Springer Science + Business Media 2017 CELLULAR ONCOLOGY Vol.40 No.3

<P>Conclusions This study focuses on recent progress on the role of VCAM-1, an important glycoprotein belonging to the immunoglobulin (Ig) superfamily of cell surface adhesion molecules in breast cancer angiogenesis, survival and metastasis. Targeting VCAM-1, expressed on the surface of breast cancer cells, and/or its specific ligand VLA-4/alpha 4 beta 1 integrin, expressed on cells at the site of metastasis, may be a useful strategy to reduce breast cancer cell invasion and metastasis. Various approaches to therapeutically target VCAM-1 and VLA-4 are also discussed.</P>

Studies on Effect of Temperature and Relative Humidity on Aspergillosis in Silkworm, Bombyx mori L.

Singh, G.P.,Sharma, S.D.,Selvakumar, T.,Natraju, B.,Datta, R.K. Korean Society of Sericultural Science 2002 International Journal of Industrial Entomology Vol.5 No.1

The growth and multiplication of Aspergillus flavus Link and A. tamarii Kita were observed in vitro under variable temperatures of $22-31^{\circ}C$. The matte weight of mycelium and number of conidia/ml were significantly higher (P < 0.01) at the higher temperature than the lower temperature in both the species of Aspergillus. In vivo the mortality in silkworm, Bombyx mori L. with the infection of Aspergillus species was significantly (P < 0.01) different at different temperature and relative humidity conditions.

Electrical spin injection into moderately doped silicon enabled by tailored interfaces

Jansen, R.,Min, B. C.,Dash, S. P.,Sharma, S.,Kioseoglou, G.,Hanbicki, A. T.,van ’t Erve, O. M. J.,Thompson, P. E.,Jonker, B. T. American Physical Society 2010 Physical review. B, Condensed matter and materials Vol.82 No.24

Higher Prevalence of Metabolic Syndrome in Child-adolescent Patients with Bipolar Disorder

Satyajit Mohite,Hanjing Wu,Shiva Sharma,Luca Lavagnino,Cristian P. Zeni,Terrence T. Currie,Jair C. Soares,Teresa A. Pigott 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.2

Objective: Previous studies have indicated a convergent and bidirectional relationship between metabolic syndrome (MetS) and bipolar disorder (BD). As most of these studies focused mainly on adults diagnosed with BD, our study aims to investigate and characterize metabolic disturbances in child-adolescents diagnosed with BD. Methods: We retrospectively examined the medical records of psychiatric hospitalizations with admitting diagnosis of BD in child-adolescents (age < 18 years). Body mass index (BMI), lipid profile, fasting blood glucose, and blood pressure were primary variables. National Cholesterol Education Program criteria were used to define MetS. Reference group data was obtained from the National Health and Nutrition Examination Survey study. Statistical analyses included t tests, chi-square tests, and Fisher’s exact tests. Results: We identified 140 child-adolescent patients with BD (mean age = 15.12 ± 1.70 years, 53% male). MetS was significantly more common in BD compared to the reference group: 14% (95% confidence interval [95% CI] 8−20) vs. 6.7% (95% CI 4.1−9.2), p = 0.001 with no significant difference by sex. MetS components were higher in the BD group, particularly BMI ≥ 95% (25% vs. 11.8%, p < 0.001) and high blood pressure (17% vs. 8%, p = 0.05). Moreover, female patients had lower odds of high blood pressure (odds ratio = 0.24 [95% CI 0.08−0.69], p = 0.005). Conclusion: Compared with the general child-adolescent population, the prevalence of MetS was significantly higher in patients with BD of same age. This reiterates the notion of an increased risk of MetS in patients diagnosed with BD; and thus, further exploration is warranted.

Effect of Naked Neck Gene on Immune Competence, Serum Biochemical and Carcass Traits in Chickens under a Tropical Climate

Rajkumar, U.,Reddy, B.L.N.,Rajaravindra, K.S.,Niranjan, M.,Bhattacharya, T.K.,Chatterjee, R.N.,Panda, A.K.,Reddy, M.R.,Sharma, R.P. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.7

A comprehensive study was undertaken to evaluate the effect of naked neck (Na) gene on immune competence, serum biochemical parameters and carcass quality traits in three genotypes (NaNa, Nana and nana) of the naked neck chicken under a tropical climate (Southern India). Sixty day-old chicks (20 from each genotype) were selected randomly and reared under similar environmental conditions up to eight weeks of age. The cell mediated immune (CMI) response to phytohaemoagglutinin-P (PHA-P) was significantly higher ($p{\lgq}0.01$) in NaNa and Nana genotypes compared to nana birds. The humoral response as measured by antibody titre to sheep red blood cells (SRBC) was also significantly higher in NaNa. The total cholesterol, LDL and VLDL cholesterol levels were significantly ($p{\leq}0.01$) lower whereas HDL cholesterol level was significantly higher in NaNa and Nana compared to nana genotype. The presence of Na allele significantly increased the live weight and dressing yield, and decreased the feather cover and abdominal fat. The naked neck genotypes (NaNa/Nana) performed better than the normal (nana) siblings for almost all the traits studied.

Development of Anodic Stripping Voltammetry for the Determination of Palladium in High Level Nuclear Waste

T. K. BHARDWAJ,H. S. SHARMA,P. C. JAIN,S. K. AGGARWAL 한국원자력학회 2012 Nuclear Engineering and Technology Vol.44 No.8

Deposition potential, deposition time, square wave frequency, rotation speed of the rotating disc electrode, and palladium concentration were studied on a Glassy Carbon Electrode (GCE) in 0.01M HCl for the determination of palladium in High Level Nuclear Waste (HLNW) by anodic stripping voltammetry. Experimental conditions were optimized for the determination of palladium at two different, 10-8 and 10-7 M, levels. Error and standard deviation of this method were under 1% for all palladium standard solutions. The developed technique was successfully applied as a subsidiary method for the determination of palladium in simulated high level nuclear waste with very good precision and high accuracy (under 1 % error and standard deviation).

Synthesis and tuning the exchange bias in Ni-NiO nanoparticulate systems

Sharma, S. K.,Vargas, J. M.,Knobel, M.,Pirota, K. R.,Meneses, C. T.,Kumar, Shalendra,Lee, C. G.,Pagliuso, P. G.,Rettori, Carlos American Institute of Physics 2010 JOURNAL OF APPLIED PHYSICS - Vol.107 No.9

Wind induced internal pressure overshoot in buildings with opening

T. K. Guha,R.N. Sharma,P.J. Richards 한국풍공학회 2013 Wind and Structures, An International Journal (WAS Vol.16 No.1

The wind-induced transient response of internal pressure following the creation of a sudden dominant opening during the occurrence of high external pressure, in low-rise residential and industrial buildings was numerically investigated. The values of the ill-defined parameters namely the flow contraction coefficient, loss coefficient and the effective slug length were calibrated by matching the analytical response with the computational fluid dynamics predictions. The effect of a sudden i.e., “instantaneously created”windward opening in the Texas Technical University (TTU) test building envelope was studied for two different envelope flexibility-leakage combinations namely: (1) a quasi-statically flexible and non-porous envelope and (2) a quasi-statically flexible and porous envelope. The responses forced by creating the openings at different time leads/lags with respect to the occurrence of the peak external pressure showed that for cases where the openings are created in close temporal proximity to the peak pressure, the transient overshoot values of internal pressure could be higher than the peak values of internal pressure in the pre-sequent or subsequent resonant response. In addition, the influence of time taken for opening creation on the level of overshoot was also investigated for the TTU building for the two different envelope characteristics. Non-dimensional overshoot factors are presented for a variety of cavity volume-opening area combinations for (1) buildings with rigid/quasi-statically flexible non-porous envelope, and (2) buildings with rigid/quasi-statically flexible and porous envelope (representing most low rise residential and industrial buildings). While the factors appear slightly on the high side due to conservative assumptions made in the analysis, a careful consideration regarding the implication of the timing and magnitude of such overshoots during strong gusts, in relation to the steady state internal pressure response in cyclonic regions, is warranted.

Isolation of a New Microsporidian sp. (NIK-5hm) forming Spores within the Haemocytes of Silkworm, B. mori L.

( T. Selvakumar ),( B. Nataraju ),( K. Chandrasekharan ),( S. D. Sharma ),( M. Balavenkatasubbaiah ),( P. Sudhakara Rao ),( V. Thiagarajan ),( S. B. Dandin ) 한국잠사학회 2005 International Journal of Industrial Entomology Vol.11 No.1

While observing silkworm larval samples received from field, microsporidian spores formed within the haemocytes of silkworm haemolymph were observed. The spores of microsporidian sp. were purified and characterized for morphological characters viz., size, shape as well as serological affinity with different Nosema spp. (M11 and M12). The infectivity of the isolated spores to silkworm was also studied. The microsporidian sp. was found to be highly pathogenic to silkworm, B. mori. The isolated microsporidian sp. was designated as NIK-5hm, which formed ovocylindrical spore in the haemocytes of silkworm and differed in spore size (length, 4.55 μm & width, 2.10 μm) and shape from Nosema bombycis (NIK-1s), NIK-2r (Nosema sp. Mysore [3.6 & 2.8 μm]), NIK-3h (Nosema sp. M11 [3.8 & 1.8 μm]), NIK-4m (Nosema sp. M12 [5.0 & 2.1 μm]) and Lb㎳ (Nosema sp. in Lamerine breed of silkworm [4.36 & 2.14]). In immonological test (Latex agglutination test), the isolated microsporidian spores did not react with antibody sensitized latex particles of N. bombycis, M11, M12 and Lb㎳ and thus are different type of microsporidian sp., parasitic to silkworm, Bombyx mori L.

Temperature dependent photoluminescence processes in ZnO thin films grown on sapphire by pulsed laser deposition

P. Misra,T.K. Sharma,L.M. Kukreja 한국물리학회 2009 Current Applied Physics Vol.9 No.1

Temperature dependence of the photoluminescence (PL) transitions in the range of 10–300 K was studied for ZnO thin films grown on sapphire by pulsed laser deposition. The low temperature PL spectra were dominated by recombination of donor bound excitons (BX) and their phonon replicas. With increasing temperature, free exciton (FX) PL and the associated LO phonon replicas increased in intensity at the expense of their bound counterparts. The BX peak with line width of ~6 meV at 10 K exhibited thermal activation energy of~17 meV, consistent with the exciton-defect binding energy. The separation between the FX and BX peak positions was found to reduce with increasing temperature, which was attributed to the transformation of BX into the shallower donor bound exciton complexes at consecutive lower energy states with increasing temperature, which are possible in ZnO. The energy separation between FX peak and its corresponding 1-LO phonon replica showed stronger dependence on temperature than that of 2-LO phonon replica. However, their bound counterparts did not exhibit this behavior. The observed temperature dependence of the energy separation between the free exciton and it is LO phonon replicas are explained by considering the kinetic energy of free exciton. The observed PL transitions and their temperature dependence are consistent with observations made with bulk ZnO crystals implying high crystalline and optical quality of the grown films. Temperature dependence of the photoluminescence (PL) transitions in the range of 10–300 K was studied for ZnO thin films grown on sapphire by pulsed laser deposition. The low temperature PL spectra were dominated by recombination of donor bound excitons (BX) and their phonon replicas. With increasing temperature, free exciton (FX) PL and the associated LO phonon replicas increased in intensity at the expense of their bound counterparts. The BX peak with line width of ~6 meV at 10 K exhibited thermal activation energy of~17 meV, consistent with the exciton-defect binding energy. The separation between the FX and BX peak positions was found to reduce with increasing temperature, which was attributed to the transformation of BX into the shallower donor bound exciton complexes at consecutive lower energy states with increasing temperature, which are possible in ZnO. The energy separation between FX peak and its corresponding 1-LO phonon replica showed stronger dependence on temperature than that of 2-LO phonon replica. However, their bound counterparts did not exhibit this behavior. The observed temperature dependence of the energy separation between the free exciton and it is LO phonon replicas are explained by considering the kinetic energy of free exciton. The observed PL transitions and their temperature dependence are consistent with observations made with bulk ZnO crystals implying high crystalline and optical quality of the grown films.