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수요자 맞춤형 스마트설계 플랫폼 구축을 위한 비즈니스 모델 관점의 사용자 수요인식 조사 및 분석
이민규(Mingyu Lee),이성곤(Seongkon Lee),이욱현(Wookhyun Lee),구기관(Kikwan Koo),한경진(Kyungjin Han),유재경(Jaekyung Yoo),박성준(Sungjoon Park),이유경(Youkyoung Lee) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Discovering users demands is essential for successfully developing a service or product. Users perception and demand play a critical role in developing the Smart Design Platform that is a platform service helping thermal energy-intensive industrial facilities to more efficiently and easily design their products. This study investigates a process and analysis of perception and demands from the two viewpoints: technology providers and consumers who are targeted users of the Smart Design Platform. A preliminary online survey gained a total of 630 potential users’ feedbacks. It will demonstrate sufficient demands for the Smart Design Platform. For an advanced analysis of users’ demands, additional interviews will be conducted with technology providers and consumers.
Hypertensive Encephalopathy with Reversible Brainstem Edema
Lee, Sungjoon,Cho, Byung-Kyu,Kim, Hoon The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.2
Presented here is a 36-year-old male with arterial hypertension who developed brainstem edema and intracranial hemorrhage. Magnetic resonance scan revealed diffuse brainstem hyperintensity in T2-weighted and fluid-attenuated inversion-recovery images, with an increase in apparent diffusion coefficient values. After a reduction in blood pressure, rapid resolution of the brainstem edema was observed on follow-up. The patient's condition was thus interpreted as hypertensive brainstem encephalopathy. While many consider this a vasogenic phenomenon, induced by sudden, severe hypertension, the precise mechanism remains unclear. Prompt recognition and aggressive antihypertensive treatment in such patients are essential to prevent permanent or life-threatening neurologic injury.
Liquid‐metal‐fluidically polarization reconfigurable microstrip patch antenna
Lee, Minjae,Son, Hyunwoo,Lim, Daecheon,Lee, Sukwon,Lim, Sungjoon John Wiley Sons, Inc. 2019 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.61 No.10
<P><B>Abstract</B></P><P>In this article, we propose a liquid‐metal‐fluidically polarization reconfigurable microstrip patch antenna. The edge‐truncated patch is designed to generate circular polarization (CP), and two microfluidic channels are designed for the polarization reconfigurability. Therefore, the polarization of the proposed antenna is switched to linear polarization (LP) from the CP when the liquid metal is injected on the microfluidic channels. The microfluidic channels are fabricated on the polydimethylsiloxane (PDMS) material, and eutectic gallium‐indium (EGaIn) is used as the liquid metal. The performance of the proposed antenna is numerically and experimentally demonstrated. The measured 10‐dB impedance bandwidth is 1.579‐1.619 GHz and 1.563‐1.587 GHz for the CP and LP modes, respectively. At the CP mode, the measured axial ratio (AR) and RHCP gain at 1.595 GHz are 2.267 dB and 6.59 dBic, respectively. At the LP mode, the measured AR and peak gain at 1.585 GHz are 12.335 dB and 5.18 dBi, respectively.</P>
Deep learning of mutation-gene-drug relations from the literature
Lee, Kyubum,Kim, Byounggun,Choi, Yonghwa,Kim, Sunkyu,Shin, Wonho,Lee, Sunwon,Park, Sungjoon,Kim, Seongsoon,Tan, Aik Choon,Kang, Jaewoo BioMed Central 2018 BMC bioinformatics Vol.19 No.-
<P><B>Background</B></P><P>Molecular biomarkers that can predict drug efficacy in cancer patients are crucial components for the advancement of precision medicine. However, identifying these molecular biomarkers remains a laborious and challenging task. Next-generation sequencing of patients and preclinical models have increasingly led to the identification of novel gene-mutation-drug relations, and these results have been reported and published in the scientific literature.</P><P><B>Results</B></P><P>Here, we present two new computational methods that utilize all the PubMed articles as domain specific background knowledge to assist in the extraction and curation of gene-mutation-drug relations from the literature. The first method uses the Biomedical Entity Search Tool (BEST) scoring results as some of the features to train the machine learning classifiers. The second method uses not only the BEST scoring results, but also word vectors in a deep convolutional neural network model that are constructed from and trained on numerous documents such as PubMed abstracts and Google News articles. Using the features obtained from both the BEST search engine scores and word vectors, we extract mutation-gene and mutation-drug relations from the literature using machine learning classifiers such as random forest and deep convolutional neural networks.</P><P>Our methods achieved better results compared with the state-of-the-art methods. We used our proposed features in a simple machine learning model, and obtained F1-scores of 0.96 and 0.82 for mutation-gene and mutation-drug relation classification, respectively. We also developed a deep learning classification model using convolutional neural networks, BEST scores, and the word embeddings that are pre-trained on PubMed or Google News data. Using deep learning, the classification accuracy improved, and F1-scores of 0.96 and 0.86 were obtained for the mutation-gene and mutation-drug relations, respectively.</P><P><B>Conclusion</B></P><P>We believe that our computational methods described in this research could be used as an important tool in identifying molecular biomarkers that predict drug responses in cancer patients. We also built a database of these mutation-gene-drug relations that were extracted from all the PubMed abstracts. We believe that our database can prove to be a valuable resource for precision medicine researchers.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s12859-018-2029-1) contains supplementary material, which is available to authorized users.</P>
A 20-Year-Old Retained Surgical Gauze Mimicking a Spinal Tumor: A Case Report
Sungjoon Lee,Bomi Kim,Jung Soo Kim,Byeong Sam Choi 대한척추신경외과학회 2016 Neurospine Vol.13 No.3
A 79-year-old man visited our clinic complaining of lower back and left leg radiating pain that began 1 month prior to his presentation. He underwent surgery for lumbar disc herniation 20 years ago at another hospital. Magnetic resonance imaging revealed left-sided foraminal stenosis at L4-5. In addition, a paraspinal mass occupying the L4 spinous process and left lamina was observed. We subsequently performed an L4-5 decompression and fusion. During the operation, retained surgical gauze with granulation tissue was found. The term gossypiboma is used to define a mass lesion consisting of retained surgical gauzes and an adjacent foreign body reaction. Gossypibomas are uncommon in the paraspinal area and are mostly asymptomatic in chronic cases. Because there are no specific clinical or radiological signs, they can be confused with other tumorous conditions. Gossypibomas should be included in the differential diagnosis of paraspinal soft-tissue masses detected in patients with a history of prior spinal surgery.
Sungjoon Yoon,Seon Deuk Kim,Juhee Lee,Mu Seong Kim,Yong Woo Shin,Eung-Joon Lee 대한신경초음파학회 2021 대한신경초음파학회지 (JNN) Vol.13 No.2
Nilotinib is a Bcr-Abl tyrosine kinase inhibitor used to treat chronic myelogenous leukemia. There have been case reports of nilotinib-related vasculopathy. However, most cases present peripheral artery disease, whilst reports of nilotinib-related cerebrovascular disease are quite uncommon. Herein, we report a case of nilotinib- induced intracranial stenosis in a patient with recurrent transient ischemic attacks and discuss the results of serial vessel wall magnetic resonance imaging.
Supratentorial Intracerebral Schwannoma : Its Fate and Proper Management
Lee, Sungjoon,Park, Sung-Hye,Chung, Chun Kee The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.4
Intracerebral schwannomas are rare and there have been none reported in Korea. We present the case of a 25-year-old man with newly developed right-side weakness and recent seizure aggravation. His seizures started approximately 9 years prior to admission. At that time, a 1 cm diameter intra-axial enhancing mass at the left precentral gyrus was found on magnetic resonance image (MRI). After 9 years of observation and treatment with antiepileptic medication, an MRI taken due to symptom aggravation revealed peri-tumoral cyst formation with tumor enlargement. The tumor was surgically removed. Subsequently, right-side weakness diminished and there was good seizure control. Pathologic diagnosis was schwannoma. Schwannoma is a very rare tumor and there are no pathognomonic findings on radiologic images; thus, it is challenging to make a correct diagnosis. However, considering the natural course and excellent prognosis after surgical treatment of this kind of intra-axial mass with benign features, early surgery for diagnosis and proper treatment is highly recommended.
Desmoplastic Fibroma of the Cranium in a Young Man
Lee, Sungjoon,Jung, Sung-Mook,Cho, Byung-Kyu,Kim, Hoon The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.52 No.6
Desmoplastic fibroma, which develops predominantly in long bones and the mandible, is a rare and benign but locally aggressive tumor. Desmoplastic fibroma of the cranium is extremely rare. We report a case of desmoplastic fibroma of the frontal bone in a young man. Because of its locally aggressive behavior, complete surgical excision with a safety margin is essential.