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Kim, Hye-Jin,Kwon, Sojung,Nam, Seo Hee,Jung, Jae Woo,Kang, Minkyung,Ryu, Jihye,Kim, Ji Eon,Cheong, Jin-Gyu,Cho, Chang Yun,Kim, Somi,Song, Dae-Geun,Kim, Yong-Nyun,Kim, Tai Young,Jung, Min-Kyo,Lee, Kyun The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.4
<P>Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are often localized to specific regions, as with lipid rafts or tetraspanin-enriched microdomains; however, the dynamic interactions of tetraspanins with diverse receptors within tetraspanin-enriched microdomains on cellular surfaces remain largely unexplored. Here, we investigated effects of tetraspan(in) TM4SF5 (transmembrane 4 L6 family member 5)-enriched microdomains (T5ERMs) on the directionality of cell migration. Physical association of TM4SF5 with epidermal growth factor receptor (EGFR) and integrin alpha 5 was visualized by live fluorescence cross-correlation spectroscopy and higher-resolution microscopy at the leading edge of migratory cells, presumably forming TM4SF5-enriched microdomains. Whereas TM4SF5 and EGFR colocalized at themigrating leading region more than at the rear, TM4SF5 and integrin a5 colocalized evenly throughout cells. Cholesterol depletion and disruption in TM4SF5 post-translational modifications, including N-glycosylation and palmitoylation, altered TM4SF5 interactions and cellular localization, which led to less cellular migration speed and directionality in 2-or 3-dimensional conditions. TM4SF5 controlled directional cell migration and invasion, and importantly, these TM4SF5 functions were dependent on cholesterol, TM4SF5 post-translational modifications, and EGFR and integrin alpha 5 activity. Altogether, we showed that TM4SF5 dynamically interacted with EGFR and integrin a5 in migratory cells to control directionality and invasion.-Kim, H.-J., Kwon, S., Nam, S. H., Jung, J. W., Kang, M., Ryu, J., Kim, J. E., Cheong, J.-G., Cho, C. Y., Kim, S., Song, D.-G., Kim, Y.-N., Kim, T. Y., Jung, M.-K., Lee, K.-M., Pack, C.-G., Lee, J. W. Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2-and 3-dimensional environments. FASEB J. 31, 1461-1481 (2017). www.fasebj.org</P>
Partial Necrosis of the Mandibular Proximal Segment Following Transoral Vertical Ramus Osteotomy
Kim, Somi,Kim, Sang Yoon,Kim, Gi-Jung,Jung, Hwi-Dong,Jung, Young-Soo Korean Association of Maxillofacial Plastic and Re 2014 Maxillofacial Plastic Reconstructive Surgery Vol.36 No.3
Transoral vertical ramus osteotomy (TOVRO) procedure can result in a variety of complications. Complications commonly reported include extensive bleeding due to major blood vessel injury, unpredictable fracture, postoperative infection, neurosensory deficit related Inferior alveolar nerve, insufficient osteosynthesis, and temporomandibular joint problem. The authors describe a case of partial necrosis of the mandibular proximal segment following TOVRO, a rarely reported complication. A 37-year-old otherwise healthy woman underwent Lefort l osteotomy and TOVRO to correct mandibular prognathism. Postoperatively, she developed pain and swelling in the right submandibular region and was found to have a partial necrosis of proximal segment.
Kim, Somi,Cho, Chang Yun,Lee, Doohyung,Song, Dae-Geun,Kim, Hye-Jin,Jung, Jae Woo,Kim, Ji Eon,Park, Dasomi,Lee, Haesong,Um, Hyejin,Park, Jinsoo,Choi, Yoonjeong,Kim, Yoomin,Nam, Seo Hee,Lee, Jung Weon Elsevier 2018 Cancer letters Vol.438 No.-
<P><B>Abstract</B></P> <P>CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD133, TM4SF5, CD44, and protein tyrosine phosphatase receptor type F (PTPRF) in a three-dimensional (3D) sphere growth system. We found that CD133 upregulated TM4SF5 and CD44, whereas TM4SF5 and CD44 did not affect CD133 expression. Signaling activity following CD133 phosphorylation caused TM4SF5 expression and sphere growth. TM4SF5 bound to CD133 and promoted c-Src activity for CD133 phosphorylation as a positive feedback loop, leading to CD133-mediated sphere growth that was inhibited by TM4SF5 inhibition or suppression. TM4SF5 also bound PTPRF and promoted paxillin phosphorylation. Decreased sphere growth upon CD133 suppression was recovered by TM4SF5 expression and partially by PTPRF suppression. TM4SF5 inhibition enhanced PTPRF levels and abolished PTPRF suppression-mediated sphere growth. Altogether, CD133-induced TM4SF5 expression and function were important for liver cancer sphere growth and may be a promising target to block metastasis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The role of TM4SF5 and CD133 cross-talk in the CSC properties of HCC is unknown. </LI> <LI> CD133-induced c-Src, Akt, and β-catenin signaling mediates TM4SF5 induction. </LI> <LI> TM4SF5 drives CD133 phosphorylation via a bidirectional positive feedback loop. </LI> <LI> TM4SF5 binds PTPRF to regulate cellular signaling for anchorage-independent growth. </LI> <LI> CD133/TM4SF5/PTPRF and CD44 are potential biomarkers for HCC metastasis. </LI> </UL> </P>
Kim, So-Hyun,K. Cho, Somi,Min, Tae-Sun,Kim, Yujin,Yang, Seung-Ok,Kim, Hee-Su,Hyun, Sun-Hee,Kim, Hana,Kim, Young-Suk,Choi, Hyung-Kyoon the Society for Free Radical Research Japan 2011 Journal of clinical biochemistry and nutrition Vol.48 No.3
<P>The ameliorating effects of Mango (<I>Mangifera indica</I> L.) flesh and peel samples on plasma ethanol level were investigated using a mouse model. Mango fruit samples remarkably decreased mouse plasma ethanol levels and increased the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase. The <SUP>1</SUP>H-NMR-based metabolomic technique was employed to investigate the differences in metabolic profiles of mango fruits, and mouse plasma samples fed with mango fruit samples. The partial least squares-discriminate analysis of <SUP>1</SUP>H-NMR spectral data of mouse plasma demonstrated that there were clear separations among plasma samples from mice fed with buffer, mango flesh and peel. A loading plot demonstrated that metabolites from mango fruit, such as fructose and aspartate, might stimulate alcohol degradation enzymes. This study suggests that mango flesh and peel could be used as resources for functional foods intended to decrease plasma ethanol level after ethanol uptake.</P>
Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF)
Kim, Somi,Yu, Nam-Kyung,Shim, Kyu-Won,Kim, Ji-il,Kim, Hyopil,Han, Dae Hee,Choi, Ja Eun,Lee, Seung-Woo,Choi, Dong Il,Kim, Myung Won,Lee, Dong-Sung,Lee, Kyungmin,Galjart, Niels,Lee, Yong-Seok,Lee, Jae-H Society for Neuroscience 2018 The Journal of neuroscience Vol.38 No.22
<P>The molecular mechanism of long-term memory has been extensively studied in the context of the hippocampus-dependent recent memory examined within several days. However, months-old remote memory maintained in the cortex for long-term has not been investigated much at the molecular level yet. Various epigenetic mechanisms are known to be important for long-term memory, but how the 3D chromatin architecture and its regulator molecules contribute to neuronal plasticity and systems consolidation is still largely unknown. CCCTC-binding factor (CTCF) is an 11-zinc finger protein well known for its role as a genome architecture molecule. Male conditional knock-out mice in which CTCF is lost in excitatory neurons during adulthood showed normal recent memory in the contextual fear conditioning and spatial water maze tasks. However, they showed remarkable impairments in remote memory in both tasks. Underlying the remote memory-specific phenotypes, we observed that female CTCF conditional knock-out mice exhibit disrupted cortical LTP, but not hippocampal LTP. Similarly, we observed that CTCF deletion in inhibitory neurons caused partial impairment of remote memory. Through RNA sequencing, we observed that CTCF knockdown in cortical neuron culture caused altered expression of genes that are highly involved in cell adhesion, synaptic plasticity, and memory. These results suggest that remote memory storage in the cortex requires CTCF-mediated gene regulation in neurons, whereas recent memory formation in the hippocampus does not.</P>
Lee, Siyoung,Kim, Eunsom,Jhun, Hyunjhung,Hong, Jaewoo,Kwak, Areum,Jo, Seunghyun,Bae, Suyoung,Lee, Jongho,Kim, Busun,Lee, Jungmin,Youn, Sulah,Kim, Somi,Kim, Miyeon,Kim, Hyunwoo,Lee, Youngmin,Choi, Dong American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.28
<P>Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but mature INS was unable to induce an immune response. An affinity-purified rabbit polyclonal antibody raised against mature IL-1α recognized IL-1α and pINS but failed to detect mature INS and IL-1β. Analysis of the pINS sequence revealed the existence of an INS/IL-1α motif in the C-peptide of pINS. Surprisingly, the INS/IL-1α motif was recognized by monoclonal antibody raised against IL-1α. Deleting the INS/IL-1α motif in pINSd and IL-1α changed their activities. To investigate the pINSd receptor, the reconstitution of IL-1 receptor 1 (IL-1R1) in Wish cells restored pINSd activity that was reversed by an IL-1R antagonist. These data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1.</P>
Ambipolar thermoelectric power of chemically-exfoliated RuO<sub>2</sub> nanosheets
Kim, Jeongmin,Yoo, Somi,Moon, Hongjae,Kim, Se Yun,Ko, Dong-Su,Roh, Jong Wook,Lee, Wooyoung IOP Pub 2018 Nanotechnology Vol.29 No.1
<P>The electrical conductivity and Seebeck coefficient of RuO<SUB>2</SUB> nanosheets are enhanced by metal nanoparticle doping using Ag-acetate solutions. In this study, RuO<SUB>2</SUB> monolayer and bilayer nanosheets exfoliated from layered alkali metal ruthenates are transferred to Si substrates for device fabrication, and the temperature dependence of their conductivity and Seebeck coefficients is investigated. For pristine RuO<SUB>2</SUB> nanosheets, the sign of the Seebeck coefficient changes with temperature from 350–450 K. This indicates that the dominant type of charge carrier is dependent on the temperature, and the RuO<SUB>2</SUB> nanosheets show ambipolar carrier transport behavior. By contrast, the sign of the Seebeck coefficient for Ag nanoparticle-doped RuO<SUB>2</SUB> nanosheets does not change with temperature, indicating that the extra charge carriers from metal nanoparticles promote n-type semiconductor behavior.</P>
Somi Kim(김소미),Duyen Thi Hai Nguyen,Junyoung Park(박준영) 한국기계가공학회 2021 한국기계가공학회지 Vol.20 No.3
Despite advances in technology, crushing accidents still occur during emergency evacuations of crowded public spaces. To prevent crushing accidents, it is necessary to understand the flow of pedestrians during evacuation scenarios through experiments. Since experiments with humans can generate real accidents, we performed experiments on rodents to approximate human behavior. To trigger an emergency evacuation response, we applied electrical stimulation to the feet of the rodents. Although electrical stimulation has been applied to mice in many experiments, studies on the intensity and pattern of electric stimulation required to evoke a rapid evacuation response in mice is still lacking. In this study, we experimentally investigated how the evacuation flow of mice changes according to the amplitude, event, and duration of electric stimulation.