Soccer Transfer Gossip Analysis using Keyword Ranking

Sinn, Seung-Woo,Kang, Dae-Ki The International Promotion Agency of Culture Tech 2017 International Journal of Advanced Culture Technolo Vol.5 No.4

In every Summer and Winter, there open soccer transfer markets. And these markets draw huge attention from soccer fans and other ordinary people all around world. This phenomenon might indicate great interest of people from the amount of news, blog articles, public messages and replies from online community and forums about popular players and clubs of many leagues. Especially, transfer markets in the year 2017 have generated many gossips than before. In this research, we performed keyword analysis and ranking of news and messages collected and analyzed from online news sites and online forum sites, in order to investigate who and what clubs are mainly discussed.

Effectiveness of each Bethesda marker in defining microsatellite instability when screening for Lynch syndrome.

Sinn, Dong Hyun,Chang, Dong Kyung,Kim, Young-Ho,Rhee, Poong-Lyul,Kim, Jae J,Kim, Dae Shick,Park, Cheol Keun,Kim, Jong Won,Yun, Seong Hyeon,Lee, Woo-Yong,Chun, Ho-Kyung,Rhee, Jong Chul G. Thieme 2009 Hepato-gastroenterology Vol.56 No.91

<P>BACKGROUND/AIMS: A panel of five markers (two mononuclotide markers and three dinucleotide markers; the so-called Bethesda markers) has been proposed to define MSI status. However reducing these 5 markers into one or two markers have been suggested to be sufficient for detection of the MLH1- or MSH2-mutated Lynch syndrome. We attempted to examine the effectiveness of each Bethesda marker for the determination of MSI status clinically relevant to Lynch syndrome. METHODOLOGY: We compared the MSI status obtained using each or a combination of two Bethesda markers to those obtained using all five Bethesda markers in 1,531 non-selected colorectal cancer patients. RESULTS: At least one mononucleotide marker was unstable in 94% of the MSI-H tumors defined by the Bethesda markers (126 of 134). After sequencing MLH1 and MSH2 genes from 31 of 86 patients eligible for the genetic test, 18 germline mutations were detected. Seventeen of these mutations were from high MSI tumors, and 1 was from a MSS tumor defined by 5 Bethesda markers. A combination of two mononucleotide markers was able to identify all 17 mutation-positive individuals with MSI-H tumors defined by the five Bethesda markers. CONCLUSIONS: Instability in two mononucleotide markers, BAT26 and BAT25, was most effective markers at defining MSI status. Sensitivity is only slightly impaired by using two mononucleotide markers instead of five markers.</P>

Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation

Sinn, Dong-In,Kim, Se-Jeong,Chu, Kon,Jung, Keun-Hwa,Lee, Soon-Tae,Song, Eun-Cheol,Kim, Jeong-Min,Park, Dong-Kyu,Kun Lee, Sang,Kim, Manho,Roh, Jae-Kyu Elsevier 2007 Neurobiology of disease Vol.26 No.2

<P><B>Abstract</B></P><P>The modification of histone N-terminal tails by acetylation or deacetylation can alter the interaction between histones and DNA, and thus regulate gene expression. Recent experiments have demonstrated that valproic acid (VPA), a well-known anti-epileptic drug, can directly inhibit histone deacetylase (HDAC) activity and cause the hyperacetylation of histones. Moreover, VPA has been shown to mediate neuronal protection by activating signal transduction pathways and by inhibiting proapoptotic factors. In this study, we attempted to determine whether VPA alleviates cerebral inflammation and perihematomal cell death after intracerebral hemorrhage (ICH). Adult male rats received intraperitoneal injections of 300?mg/kg VPA or PBS twice a day after ICH induction. VPA treatment inhibited hematoma expansion, perihematomal cell death, caspase activities, and inflammatory cell infiltration. In addition, VPA treatment had the following expressional effects; it activated the translations of acetylated histone H3, pERK, pAKT, pCREB, and HSP70; up-regulated bcl-2 and bcl-xl but down-regulated bax; and down-regulated the mRNAs of Fas-L, IL-6, MMP-9, MIP-1, MCP-1, and tPA. VPA-treated rats also showed better functional recovery from 1?day to 4?weeks after ICH. Here we show that VPA induces neuroprotection in a murine ICH model and that its neuroprotective effects are mediated by transcriptional activation following HDAC inhibition.</P>

Change in cross‐sectional area of esophageal muscle does not correlate with the outcome of achalasia after pneumatic balloon dilatation

Sinn, Dong Hyun,Choi, Yong Sung,Kim, Jeong Hwan,Kim, Eun Ran,Son, Hee Jung,Kim, Jae J,Rhee, Jong Chul,Rhee, Poong‐,Lyul Blackwell Publishing Asia 2010 Journal of gastroenterology and hepatology Vol.25 No.3

<P><B>Abstract</B></P><P><B>Background and Aim: </B> Patients with achalasia have a thicker muscularis propria compared to normal patients. Because pneumatic balloon dilatation (PD) is an effective treatment for achalasia, the changes in the esophageal muscles after PD may predict treatment outcomes, if muscular change is of primary importance. In the present study, we aimed to observe the changes in esophageal muscle thickness following PD and assessed whether symptom relapse can be predicted on the basis of the esophageal muscle cross‐sectional area (CSA), as measured by high‐frequency intraluminal ultrasound (HFIUS).</P><P><B>Methods: </B> Fifteen patients treated by PD were studied and followed up for a median of 3.6 years. An HFIUS was done before PD and 6 months after PD. The esophageal muscle CSA measured at the lower esophageal sphincter (LES), and 3 and 6 cm above the LES, was used to see whether any association was present between symptom recurrence and the esophageal muscle CSA.</P><P><B>Results: </B> A single PD resulted in a 2‐year remission rate of 66%. A significance variance in change (−65%–248%) was noticed in the muscle CSA after PD. The predilation muscle CSA, post‐dilation muscle CSA, and change in the muscle CSA after PD was not associated with symptom recurrence.</P><P><B>Conclusion: </B> Our findings suggest that measuring the muscle CSA does not help to predict treatment outcome. Muscular changes in achalasia might be just reactive changes.</P>

Methylation and API2/MALT1 fusion in colorectal extranodal marginal zone lymphoma

Sinn, Dong H,Kim, Young-Ho,Lee, Eui J,Ko, Young-Hyeh,Kim, Kyoung-Mee Springer Science and Business Media LLC 2009 Modern pathology Vol.22 No.2

<P>Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is rarely found in the large intestine. Because of its rarity, the underlying epigenetic and genetic changes in the pathogenesis and prognostic factors have yet to be well established. For this purpose, methylation profiles and API2/MALT1 fusion in marginal zone B-cell lymphoma of MALT in the colorectum were studied and compared with treatment outcomes. For methylation analyses, 7 independent CpG islands (p15, p16, DAP kinase, hMLH1, MINT1, MINT2, and MINT31) were examined and RT-PCR for detection of API2/MALT1 fusion transcripts were performed in 15 colorectal marginal zone B-cell lymphoma of MALT in a single institution. Marginal zone B-cell lymphomas of MALT from both gastric and colorectal locations were also examined. In methylation analyses (n=13), 8 of 13 (62%) cases were classified as CIMP (CpG island methylator phenotype)-positive. Methylation was more frequently observed in cases with advanced disease stages than with earlier stages; an average of two methylated loci for earlier stages (IE or IIE) versus four loci in advanced ones (IVE; P=0.02). The estimated 5-year progression-free survival was 42% for CIMP-positive and 100% for CIMP-negative cases (P=0.03). API2/MALT1 fusion transcripts were found in two of nine cases (22%). In two cases with concurrent gastric and colorectal involvement of marginal zone B-cell lymphoma of MALT, methylation patterns and API2/MALT1 fusion results were different by location. Our results suggest that methylation profiles define a clinically more aggressive subgroup and multiclonal origin for marginal zone B-cell lymphoma of MALT with multiorgan involvement.</P>

Formal Documentation of Withdrawal Time Improves the Quality of Colonoscopic Observation

Sinn, D.H.,Chang, D.K.,Choi, W.-S.,Kim, J.Y.,Lee, J.H.,Kim, Y.-H.,Son, H.J.,Rhee, P.-L.,Kim, J.J.,Rhee, J.C. HGE UPDATE MEDICAL PUBLISHING SA 2011 Hepato-gastroenterology Vol.58 No.107

군 장병에서 흡연과 위장관 질환의 연관성에 대한 연구

신동현 ( Sinn Dong Hyun ),임성우 ( Lim Seong Woo ),김경묵 ( Kim Kyung Mook ),유호열 ( You Ho Yeol ),최종권 ( Choi Jong Kown ) 국군의무사령부 2010 대한군진의학학술지 Vol.41 No.1

Objectives: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) is commonly diagnosed disease among military soldiers. We investigated the role of smoking in young military soldiers in GERD and FD. Methods: A survey was conducted to the random sample of military soldiers who visited Armed Forces Daejeon Hospital during March 2009 to April 2009. A total of 374 responded and completed the survey. Results: GERD and FD were diagnosed in 7.5% and 5.6% of participants, respectively. GERD was diagnosed more frequently among smokers (13.7%) compared to non-smoker (4.8%, p = 0.008). FD was diagnosed more frequently among smokers (12.6%) compared to past smoker (4.4%, p = 0.045) or non-smoker (2.7%, p = 0.001). Compared to smokers, non smoking was a protective factor for GERD (odds ratio: 0.34, 95% Confidence interval (CI): 0.13 - 0.83, p = 0.018) and FD (odd ratio: 0.20, 95% CI: 0.07 - 0.59, p = 0.004). Conclusions: Smoking is a factor associated with GERD and FD in the young military soldiers. Smoking cessation should be recommended for patients with GERD and FD, and anti-smoking campaign can be effective strategy to reduce GERD and FD in the military.

문이과 통합형 개정 교육과정에 따른 이공계열 신입생의 고교 : 수학 및 과학 교과목 학습경험 분석: S 대학교를 중심으로

신동주(Sinn, Dongjoo),김진호(Kim, Jinho) 한국공학교육학회 2022 공학교육연구 Vol.25 No.1

The purpose of this study is to empirically analyze the learning experiences of high school mathematics and science subjects of new students in science and engineering, and to provide basic data and respond to strengthen basic knowledge of science and engineering students in the future. The subjects of the survey were 481 freshmen in science and engineering at S University. First, as a result of analyzing the learning experiences of freshmen, the geometric subjects were significantly lower, which is the result of students sensitive responses to transitional changes in the curriculum and SAT system after revision. In science, general elective subjects were higher than career elective subjects, and there was a deviation between science subjects, which is a result of reflecting the diversity and hierarchy of science subjects. Next, as a result of analyzing the difference in learning experience after revision compared to before the revision of the curriculum, the learning experience of Mathematics II increased significantly and the geometry decreased significantly. Both Chemistry I and II increased significantly compared to before the revision, and Earth Science I decreased significantly. This can be seen as a result of strategic choices based on obtaining grades in the CSAT and disadvantages in college entrance exams. As a result of the study, students sensitive reactions to changes in the high school education environment were confirmed, basic mathematics and science-related courses were opened to alleviate variations in the academic ability due to elective courses, and countermeasures tailored to each university s situation.

Preference and intake frequency of high sodium foods and dishes and their correlations with anthropometric measurements among Malaysian subjects

Stella Sinn-Yee Choong,Sumitha Nair Balan,Leong-Siong Chua,Yee-How Say 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.3

This study investigated the preference and intake frequency of a list of 15 commonly available high sodium Malaysian foods/dishes, discretionary salt use, and their possible association with demographics, blood pressures and anthropometric measurements among 300 Malaysian university students (114 males, 186 females; 259 ethnic Chinese, 41 Indians; 220 lean, 80 overweight). French fries and instant soup noodle were found to be the most preferred and most frequently consumed salty food, respectively, while salted fish was least preferred and least frequently consumed. Males had a significantly higher intake frequency of at least 6 of the salty foods, but the preference of most salty foods was not significantly different between genders. Ethnic Chinese significantly preferred more and took more frequently traditional and conventional Malaysian foods like asam laksa (a Malaysian salty-sour-spicy noodle in fish stock), salted biscuits and salted vegetable, while Indians have more affinity and frequency towards eating salty Western foods. Body Mass Index was significantly negatively correlated with the intake frequency of canned/packet soup and salted fish while waist circumference was significantly positively correlated with the preference of instant noodle. Also, an increased preference of potato chips and intake frequency of salted biscuits seemed to lead to a decreased WHR. Other than these, all the other overweight/obesity indicators did not seem to fully correlate with the salty food preference and intake frequency. Nevertheless, the preference and intake frequency of asam laksa seemed to be significant negative predictors for blood pressures. Finally, increased preference and intake frequency of high sodium shrimp paste (belacan)-based foods like asam laksa and belacan fried rice seemed to discourage discretionary salt use. In conclusion, the preference and intake frequency of the high sodium belacan-based dish asam laksa seems to be a good predictor for ethnic difference, discretionary salt use and blood pressures.

Dental arch wires with tooth-like color

Chen, Sinn-Wen,Wu, Hsin-Jay,Liu, Chih-Hao,Chien, Yuan-Chun,Hu, Chih-Chang Techno-Press 2012 Advances in materials research Vol.1 No.1

Unique tooth-like (milky white) color ${\beta}$-Ti dental arch wires are prepared by anodization in a 1M $H_2SO_4$ electrolyte at $30^{\circ}C$ and 30 V for 88 min and 40 s. Aggregates are formed on these surfaces of the anodized wires with tooth-like colors, and the results are different from those of the anodized wires with monochromatic colors which have smooth oxide surfaces. Similar to the monochromatic wires, the composition of the oxide layer is $TiO_{2-x}$ and the x approaches zero at the outer layer. But different from the amorphous structure observed in monochromatic wires, the oxide layers are partially crystallized with an anatase structure. The milky white colors result from the rough and crystalized oxide layers, not by the interference effect as observed in monochromatic wires.