In Silico Studies of Indole Derivatives as Antibacterial Agents

Shah Mridul,Kumar Adarsh,Singh Ankit Kumar,Singh Harshwardhan,Narasimhan Balasubramanian,Kumar Pradeep 대한약침학회 2023 Journal of pharmacopuncture Vol.26 No.2

Objectives: Molecular docking and QSAR studies of indole derivatives as antibacterial agents. Methods: In this study, we used a multiple linear regressions (MLR) approach to construct a 2D quantitative structure activity relationship of 14 reported indole derivatives. It was performed on the reported antibacterial activity data of 14 compounds based on theoretical chemical descriptors to construct statistical models that link structural properties of indole derivatives to antibacterial activity. We have also performed molecular docking studies of same compounds by using Maestro module of Schrodinger. A set the molecular descriptors like hydrophobic, geometric, electronic and topological characters were calculated to represent the structural features of compounds. The conventional antibiotics sultamicillin and ampicillin were not used in the model development since their structures are different from those of the created compounds. Biological activity data was first translated into pMIC values (i.e. –log MIC) and used as a dependent variable in QSAR investigation. Results: Compounds with high electronic energy and dipole moment were effective antibacterial agents against S. aureus, indole derivatives with lower κ 2 values were excellent antibacterial agents against MRSA standard strain, and compounds with lower R value and a high 2 χ v value were effective antibacterial agents against MRSA isolate. Conclusion: Compounds 12 and 2 showed better binding score against penicillin binding protein 2 and penicillin binding protein 2a respectively.

Complete Bony Segment Flap Failure without Skin Paddle Compromise in Fibular Free Flap: A Case Report of a Rare Early Complication

Singh Hardeep,Jain Ankit,Jain Rahul,Mahendru Sanjay,Khazanchi Rakesh Kumar 대한창상학회 2023 Journal of Wound Management and Research Vol.19 No.1

The free fibula flap is sometimes associated with partial flap loss. A 62-year-old man with squamous carcinoma of the lower alveolus underwent anterior arch resection and reconstruction with a fibula osteocutaneous flap containing three bony segments. There were two perforators in the skin flap; the first perforator was proximal to the bony segments and the other perforator was at the level of the middle segment. Atherosclerosis was observed in the anastomotic vessels. During surgery, thrombosis occurred in the arterial anastomosis, but was revised before the operation was over. The patient’s early postoperative course was uneventful. In the second week, purulent discharge was observed from the drains. Flap exploration showed devascularization of bony segments and periosteum, but the skin paddle was viable. The peroneal vessel had thrombosed distal to the takeoff of the proximal perforator and the viable skin paddle perfused by proximal perforators falsely indicated the well-being of underlying bones. The de-vascularized bones and sloughed periosteum were removed at the time of exploration, after which the skin paddle was reoriented for coverage of the defect. The patient completed chemoradiation without any bony reconstruction afterwards. This is the only reported case of early total bony flap portion loss with a viable skin paddle in free fibula flap transfer.

Morphotectonic analysis of Sheer Khadd River basin using geospatial tools

Ankit Sharma,Prafull Singh,Praveen Kumar Rai 대한공간정보학회 2018 Spatial Information Research Vol.26 No.4

In the present study, a quantitative morphotectonic analysis of Sheer Khadd River basin has been carried out based on geomorphic and morphometric indices such as hypsometric integral, drainage basin asymmetry, mountain front sinuosity, basin elongation ratio, valley floor width to valley height ratio, river sinuosity and stream length gradient index using ASTER digital elevation model (DEM) and Google Earth images to understand the morphotectonics of the basin. The results indicate that Sheer Khadd River basin is tilting towards east and is elongated in shape due to active faulting and folding activity in the terrain. A moderate hypsometric integral value indicates that the basin is still under mature stage of erosion and reflecting a complexity in topography. Fluctuations in stream length gradient index over fault zones indicate irregularities in the drainage course due to the presence of fluvial knick points. The results of morphotectonic and morphometric analysis using DEM data is useful tool for morphotectonic evaluation of any complex terrain.

A Novel approach for Evil Twin or Rogue AP mitigation in wireless environment

Ankit Panch,Santosh Kumar Singh 보안공학연구지원센터 2010 International Journal of Security and Its Applicat Vol.4 No.4

Challenges in Microsurgical Free Tissue Transfer for a 1-Year-Old Child

Hardeep Singh,Rakesh Kumar Khazanchi,Sanjay Mahendru,Ankit Jain 대한창상학회 2020 Journal of Wound Management and Research Vol.16 No.2

Challenges faced during complex reconstructions in the pediatric age group are rarely discussed in literature. This study is to share our experience in a 1-year-old patient. The patient had an exposed knee joint following trivial trauma, which was resurfaced with a free latissimus dorsi flap. On the patient’s 5th day in the ward, the flap was discolored and inadequate perfusion was noted. The patient also had loose stools overnight. Before she was re-examined, the dressings were loosened and the patient was kept warm and was started on intravenous fluids. When examined in the operating room, the vascularity of the flap had improved without any intervention. The monitoring skin paddle necrosed while the muscle survived. The patient then underwent skin grafting and had uneventful recovery. The postoperative monitoring in children is critical as they have poor reserves and are prone to complications. We believe pediatric microsurgery should be done in specialized microsurgical centers that also have good intensive care units.

Hatchet Thigh Flap with Hemi-gluteus Flap for Recurrent Ischial Sore Reconstruction

Hardeep Singh,Ankit Jain,Sanjay Mahendru,Rakesh Kumar Khazanchi 대한창상학회 2020 Journal of Wound Management and Research Vol.16 No.3

Background: Ischial pressure sores are the most challenging sores to treat because of associated bursa and high rate of recurrence. Reconstruction flaps originating in the thigh have a disadvantage as movement may increase shear forces, and tension during closure may lead to wound dehiscence. To circumvent these problems, we hereby present a hatchet thigh flap with good mobility, which can be used for recurrent cases as well.Methods: All patients treated at our hospital in the last 5 years for ischial pressure sores were included in the study. The flap is elevated in the subfascial plane from lateral to medial until the medial circumflex artery perforators are revealed. In recurrent cases the lower half of the gluteus maximus muscle is used to fill in the cavity while the flap from the previous surgery is re-advanced.Results: Sixteen patients (11 males and five females) were in the study. The median age of the patient was 54 years (range, 25–82 years). All the flaps survived fully. Two patients had recurrence at three sites, which were successfully reconstructed by advancing the same flap and hemi-gluteus muscle. An average of 6 months follow-up after surgery for recurrence showed stable reconstruction.Conclusion: The hatchet thigh flap is easy to dissect and reliable for ischial pressure sores. It can be used effectively in recurrent cases when combined with hemi-gluteus flaps.

Single Crystal Growth and Properties of 2D Antiferromagnet Ni<SUB>1-x</SUB>Zn<SUB>x</SUB>PS₃

Nashra Pistawala,Ankit Kumar,Dibyata Rout,Luminita Harnagea,Surjeet Singh 한국물리학회 2023 새물리 Vol.73 No.12

NiPS₃ is a rare Ni-based negative charge transfer insulator with an antiferromagnetically ordered ground state with Ni spins ordered in a zigzag configuration. Recent reports indicate the presence of strong spin-phonon and spin-charge coupling in NiPS₃. In this study, we report on the growth of high-quality single crystals of Ni<SUB>1-x</SUB>Zn<SUB>x</SUB>PS₃ (x = 0, 0.05, 0.08, 0.13, and 0.14) using the physical vapor transport method. The Raman spectra of all the compositions were measured at 300 K. We show that the phonon mode E<SUP>(2)</SUP><SUB>g</SUB> at 176 cm<SUP>-1</SUP> attributed to the vibration of Ni ions can only be well-fitted using the Breit-Wigner Fano line shape. The parameter |1/q|, which quantifies the strength of the coupling of the phonon E<SUP>(2)</SUP><SUB>g</SUB> to a broad continuum, is found to have a considerably high value of 0.13. The |1/q| parameter increases with increasing Zn doping. Our findings indicate the presence of charge-phonon coupling in NiPS3 at room temperature.

Assessment of Knowledge, Attitudes, and Practices of Parents/Caregivers Towards Migraine in Children: A Cross-Sectional Observational Study

Rahul Sinha,Ankit Kumar Meena,Maneesh Uniyal,Sonali Singh,Ashish Upadhyay 대한소아신경학회 2024 대한소아신경학회지 Vol.32 No.1

Purpose: This study aimed to evaluate the knowledge, attitudes, and practices (KAP) of parents or caregivers of children suffering from migraines at a tertiary care center in North India. Methods: We conducted a cross-sectional study involving 100 parents or caregivers, using convenience sampling. A 20-item questionnaire was administered in English and also translated into the local language (Hindi). The study included children with migraines who visited the pediatric outpatient department within a 6-month period (December 2022 to May 2023). Results: Over 60% of caregivers were aware of the chronic nature of the illness, its triggering factors, the role of family history, and the importance of lifestyle modifications. However, only 46% understood the pathophysiology of the illness, and 53% were aware of the medication used for childhood migraines. More than 85% of caregivers believed that recurrent headaches necessitate a doctor’s consultation, may require regular visits for optimal treatment, and were willing to alter their child’s lifestyle to prevent headaches. However, a significant percentage of caregivers (47%) practised self-medication for their children’s headaches. Most caregivers believed that lifestyle modifications and avoiding triggers were the best treatments for migraines. There were significant associations (P<0.05) between the level of education and responses to questions related to migraine definition, prophylaxis, treatment, investigations, lifestyle modifications, and screen time. Conclusion: Most participants were well-educated on migraine, and their KAP regarding migraine prevention and treatment were generally adequate. However, the practice of self-medication without professional guidance is a significant concern.

Kinematic Viscosity Prediction of Nanolubricants Employed in Heavy Earth Moving Machinery Using Machine Learning Techniques

Gaurav Sharma,Ankit Kotia,Subrata Kumar Ghosh,Prashant Singh Rana,Seema Bawa,Mohamed Kamal Ahmed Ali 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.10

Recent researchers widely used nanoparticle additives for improving thermal and rheological properties of machine lubricant. In present study the effect of Al2O3 and CeO2 nanoparticles on transmission oil (SAE30), hydraulic oil (HYDREX100) and gear oil (EP90) of heavy earth moving machinery is investigated. Nano-lubricant samples are prepared in 0.01–4% nanoparticle volume fraction range. Four machine learning techniques namely decision tree (DT), random forest (RF), generalized linear models and neural network (NN) have been used to predict the kinematic viscosity for Al2O3 and CeO2 nanolubricants. Further, multi-criteria decision-making technique named technique for order of preference by similarity to ideal solution have been used to find the best predictive method in each category of the nanolubricants. DT, RF and NN methods are found to be most accurate in kinematic viscosity prediction of transmission oil (R 2 = 0.861), hydraulic oil (R 2 = 0.971) and gear oil (R 2 = 0.973), respectively.

Ultrasonic Bone Scalpel versus Conventional Methods for Osteotomy in Posterior Surgery for Cervical Spondylotic Myelopathy: A Review and Meta-Analysis

Bansal Parth,Kumar Vishal,Vatkar Arvind Janardhan,Gaurav Ankit,Dhatt Sarvdeep Singh 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.5

Posterior methods for cervical myelopathy include laminoplasty and laminectomy with/without fusion. A more recent innovation in these treatments is the use of an ultrasonic bone shaver for osteotomy. In this study, we examined the perioperative results after laminectomy/laminoplasty between conventional methods (rongeur/high-speed drill) vs. piezosurgery-based instruments. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed and the search was performed on four databases (PubMed, Scopus, EMBASE, and Google Scholar). Seven comparative studies were chosen after thorough screening by the authors and a meta-analysis was performed between piezosurgery and conventional technique to ascertain intraoperative and postoperative results after laminectomy/laminoplasty. The analysis includes four retrospective cohort studies and three randomized controlled trials published between 2015 and 2022. The mean age ranged from 55.5 to 64.2 years. Blood loss was significantly reduced in the piezosurgery group, other findings were not significant. On subgroup analysis, laminoplasty dramatically reduced blood loss and the rate of iatrogenic dural rips in the piezosurgery group. The use of ultrasonic bone shaver for osteotomy in cervical spondylotic myelopathy is related to significantly decreased blood loss and no significant increase in postoperative drainage, operative time, complication rate, and functional outcomes as compared to traditional techniques. We noticed significantly reduced blood and rate of dural tears in the laminoplasty subgroup with the use of ultrasonic bone shaver, which was not mirrored in the laminectomy subgroup. Careful intraoperative handling of the instrument can help prevent iatrogenic dural tears and nerve damage.