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Sin Do Kim,Ra-Young Park,Young-Rang Kim,In-Je Kim,Taek Won Kang,Kwang Il Nam,Kyu Youn Ahn,Choon Sang Bae,Baik Youn Kim,Sung Sik Park,Chaeyong Jung 대한해부학회 2010 Anatomy & Cell Biology Vol.43 No.4
During the prostate cancer (PCa) development and its progression into hormone independency, androgen receptor (AR) signals play a central role by triggering the regulation of target genes, including prostate-specific antigen. However, the regulation of these AR-mediated target genes is not fully understood. We have previously demonstrated a unique role of HOXB13 homeodomain protein as an AR repressor. Expression of HOXB13 was highly restricted to the prostate and its suppression dramatically increased hormone-activated AR transactivation, suggesting that prostate-specific HOXB13 was a highly potent transcriptional regulator. In this report, we demonstrated the action mechanism of HOXB13 as an AR repressor. HOXB13 suppressed androgen-stimulated AR activity by interacting with AR. HOXB13 did neither bind to AR responsive elements nor disturb nuclear translocation of AR in response to androgen. In PCa specimen, we also observed mutual expression pattern of HOXB13 and AR. These results suggest that HOXB13 not only serve as a DNA-bound transcription factor but play an important role as an AR-interacting repressor to modulate hormone-activated androgen receptor signals. Further extensive studies will uncover a novel mechanism for regulating AR-signaling pathway to lead to expose new role of HOXB13 as a non-DNA-binding transcriptional repressor.
Personalized Battery Lifetime Prediction for Mobile Devices based on Usage Patterns
Kang, Joon-Myung,Seo, Sin-Seok,Hong, James Won-Ki Korean Institute of Information Scientists and Eng 2011 Journal of Computing Science and Engineering Vol.5 No.4
Nowadays mobile devices are used for various applications such as making voice/video calls, browsing the Internet, listening to music etc. The average battery consumption of each of these activities and the length of time a user spends on each one determines the battery lifetime of a mobile device. Previous methods have provided predictions of battery lifetime using a static battery consumption rate that does not consider user characteristics. This paper proposes an approach to predict a mobile device's available battery lifetime based on usage patterns. Because every user has a different pattern of voice calls, data communication, and video call usage, we can use such usage patterns for personalized prediction of battery lifetime. Firstly, we define one or more states that affect battery consumption. Then, we record time-series log data related to battery consumption and the use time of each state. We calculate the average battery consumption rate for each state and determine the usage pattern based on the time-series data. Finally, we predict the available battery time based on the average battery consumption rate for each state and the usage pattern. We also present the experimental trials used to validate our approach in the real world.
The Role of Granzyme B Containing Cells in the Progression of Chronic Obstructive Pulmonary Disease
( Won-dong Kim ),( Hyun-sook Chi ),( Kang-hyeon Choe ),( Woo-sung Kim ),( James C. Hogg ),( Don D. Sin ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.-
Background: Lung inflammation plays a vital role in the pathogenesis of chronic obstructive pulmonary disease (COPD), but the characteristics of the inflammatory process remain unclear. There is growing interest in the role of granzyme B (GzmB) because CD8<sup>+</sup> T cells can induce apoptosis of target cells by releasing GzmB, which in turn may cause tissue injury and remodeling. However, Gzm<sup>B</sup> is also expressed by regulatory cells, which are able to suppress CD8<sup>+</sup> T cell. The role of GzmB+ cells needs to be defined in COPD. Methods: GzmB<sup>+</sup> and CD8<sup>+</sup> cells on alveolar wall of surgically resected lungs of microscopically classified 12 nonsmoking control, 12 panlobular emphysema (PLE) and 30 centrilobular emphysema (CLE) subjects were localized by immunohistochemical method. Positively stained cells on alveolar wall were counted and length of corresponding alveolar wall was measured. The results were expressed as mean number of positively stained cells per mm of alveolar wall in each subject. Results: The number of GzmB<sup>+</sup> and CD8<sup>+</sup> cells on alveolar wall of CLE was greater than that of control or PLE subjects (p<0.05 and p<0.001, respectively). There was a positive relationship between the number of alveolar GzmB<sup>+</sup> cells and forced expiratory volume in 1 second (FEV<sub>1</sub>) (r=0.610, p=0.003) in CLE subjects. The number of alveolar GzmB<sup>+</sup> cells progressively decreased with decline of FEV<sub>1</sub>. Conclusion: Our finding that number of alveolar GzmB<sup>+</sup> cells was associated with FEV<sub>1</sub> suggests that GzmB<sup>+</sup> cells might have protective role in the progression of lung destruction and airflow limitation in CLE, which is the predominant emphysema subtype of COPD.
Is Laparoscopy-assisted Radical Gastrectomy Safe in Patients with Child-Pugh Class A Cirrhosis?
Kang, Sin Jae,Jung, Mi Ran,Cheong, Oh,Park, Young Kyu,Kim, Ho Goon,Kim, Dong Yi,Kim, Hoi Won,Ryu, Seong Yeob The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.4
Purpose: We investigated early postoperative morbidity and mortality in patients with liver cirrhosis who had undergone radical gastrectomy for gastric cancer. Materials and Methods: We retrospectively reviewed the medical records of 41 patients who underwent radical gastrectomy at the Chonnam National University Hwasun Hospital (Hwasun-gun, Korea) between August 2004 and June 2009. There were few patients with Child-Pugh class B or C; therefore, we restricted patient selection to those with Child-Pugh class A. Results: Postoperative complications were observed in 22 (53.7%) patients. The most common complications were ascites (46.3%), postoperative hemorrhage (22.0%) and wound infection (12.2%). Intra-abdominal abscess developed in one (2.4%) patient who had undergone open gastrectomy. Massive ascites occurred in 4 (9.8%) patients. Of the patients who underwent open gastrectomy, nine (21.9%) patients required blood transfusions as a result of postoperative hemorrhage. However, most of these patients had advanced gastric cancer. In contrast, most patients who underwent laparoscopic gastrectomy had early stage gastric cancer, and when the confounding effect from the different stages between the two groups was corrected statistically, no statistically significant difference was found. There was also no significant difference between open and laparoscopic gastrectomy in the occurrence rate of other postoperative complications such as ascites, wound infection, and intra-abdominal abscess. No postoperative mortality occurred. Conclusions: Laparoscopic gastrectomy is a feasible surgical procedure for patients with moderate hepatic dysfunction.
+61A>G polymorphism in the <i>EGF</i> gene does not increase the risk of lung cancer
KANG, Hyo-Gyoung,CHOI, Jin Eun,LEE, Won Kee,KAM, Sin,CHA, Sung Ick,KIM, Chang Ho,JUNG, Tae Hoon,PARK, Jae Yong Blackwell Publishing Asia 2007 Respirology Vol.12 No.6
<P>Background and objectives: </P><P>Epidermal growth factor (EGF) plays an important role in tumourigenesis by binding with its receptor, EGFR. Variations in the DNA sequence in the <I>EGF</I> gene can lead to an alteration in EGF production and/or activity, which can affect an individual's susceptibility to lung cancer. To test this hypothesis, this study examined the association between the +61 A>G polymorphism in the 5′-untranslated region of the <I>EGF</I> gene and the risk of lung cancer in a Korean population.</P><P>Methods: </P><P>The <I>EGF</I>+61 A>G genotype was determined in 432 lung cancer patients and 432 healthy age- and gender-matched control subjects.</P><P>Results: </P><P>The +61 AA and +61 AG genotypes were not significantly associated with the risk of lung cancer compared with the +61 GG genotype (adjusted OR = 1.02, 95% CI: 0.77–1.37; and adjusted OR = 0.81, 95% CI: 0.51–1.29, respectively). In addition to the reference model, the <I>EGF</I>+61 A>G polymorphism had no significant association with the risk of lung cancer under both dominant and recessive models for the +61A allele (adjusted OR = 0.98, 95% CI: 0.74–1.29; and adjusted OR = 0.80, 95% CI: 0.51–1.24, respectively).</P><P>Conclusion: </P><P>These results suggest that the <I>EGF</I>+61 A>G polymorphism may not significantly affect the susceptibility to lung cancer in the Korean population.</P>
Kang, Seok-Gu,Jeun, Sin Soo,Lim, Jung Yeon,Kim, Seong Muk,Yang, Yoon Sun,Oh, Won IL,Huh, Pil-Woo,Park, Chun Kun Springer-Verlag 2008 Child's nervous system Vol.24 No.3
<P>Mesenchymal stem cells (MSCs) represent a potential useful source for cell-based glioma therapies because these cells evidence both orthodox and unorthodox plasticity and also show tropism for cancer. In this study, the authors attempted to access the cytotoxicity of human umbilical cord blood (hUCB)-derived MSCs, with or without cytokine activations against malignant glioma cells.</P>
Extended Kalman Filter Approach to Dynamic Electrical Impedance Tomography with Internal Electrodes
Kang, Suk-In,Kim, Kyung-Youn,Kim, Ho-Chan,Cho, Won-Churl,KIm, Min-Chan,Kim, Sin,Lee, Heon-Ju,Lee, Yoon-Joon 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2
Electrical impedance tomography (EIT) is a relatively new imaging modality in which the internal impedivity distribution is reconstructed based on the known sets of injected currents through the electrodes and induced voltages on the surface of the object. We describe a dynamic EIT imaging technique for the case where the resistivity distribution inside the object changes rapidly within the time taken to acquire a full set of independent measurement data. In doing so, the inverse problem is treated as the nonlinear state estimation problem and the unknown state(resistivity) is estimated with the aid of extended Kalman filter in a minimum mean square error sense. In particular, additional electrodes are attached to the known internal structure of the object to enhance the reconstruction performance and generalized Tikhonov regularization technique is employed to mitigate the ill-posedness of the inverse problem. Computer simulations are provided to illustrate the reconstruction performance of the proposed algorithm.
Feature Extraction and Matching Algorithms to Improve Localization Accuracy for Mobile Robots
Sin-Won Kang,Sang-Hyeon Bae,Tae-Yong Kuc 제어로봇시스템학회 2020 제어로봇시스템학회 국제학술대회 논문집 Vol.2020 No.10
Localization of indoor mobile robots is an important field in Simultaneous Localization and Mapping (SLAM). SLAM is a technology that generates map and estimates the current locations as robot explore random space. So, that is commonly used in indoor environments where GPS is not working. We propose the method of feature extraction and feature matching for localization. Features are represented wall and corner in line and point. We extract lines and corner points with observed data by 2D lidar sensor and match extracted features with a stored feature in the map. Finally, we show to increase the accuracy of localization by calculating differences between coordinates of matched features.