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Shuhan Sun,Shiling Li,Yibing Hao,Xiao Yang,Xiaomin Dou 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12
g/C3N4-ZnO composite catalysts were synthesized through surface hybridization of the delocalized conjugated- structure of g/C3N4 with the closely contacted surface of ZnO via a successive and simultaneous calcinationprocedure, and two kinds of photocatalysts, g/C3N4-ZnO1 and g/C3N4-ZnO2, were obtained. Heterojunctions wereformed between the two components, which promote the separation of photogenerated carriers efficiently, and thenenhanced the degradation of 100mg/L of AMX. The degradation rate of g/C3N4-ZnO1 was 1.54, 11.33, and 2.52-foldthat of g/C3N4-ZnO2, g/C3N4, and ZnO, respectively, at a 3.5-h reaction period, with the dosage of 0.3 g/L, and solutionpH at 7.0±0.2. The recycle and reuse ability was excellent and 90.5% of AMX mitigation was achieved in the fifthcycle. For g/C3N4-ZnO1, electrons migrated from the conduction band of g/C3N4 to that of ZnO via the heterojunction. ·OH and h+ were the main active species for AMX degradation, compared to ·O2 dominated for g/C3N4. Twelveintermediate products were identified, and two degradation pathways were inferred for g/C3N4-ZnO1 and g/C3N4-ZnO2, respectively. Finally, transformation products without lactam rings were achieved, which lost most of the antibacterialpotencies, and the ecotoxicity was also dramatically decreased as indicated by the ECOSAR program.
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Sun, Qiaochu,Kim, Hye-Eun,Cho, Hyejoung,Shi, Shuhan,Kim, Byungkuk,Kim, Okjoon Elsevier 2018 Journal of photochemistry and photobiology Biology Vol.186 No.-
<P><B>Abstract</B></P> <P>Oxidative stress, in which the amount of oxidants exceeds the capacity of antioxidant defense system, is a well-accepted pathogenesis of several human diseases. Light-emitting diode irradiation (LEDI) is an efficient strategy to counteract this condition. The biological effect of phototherapy, using visible light, has attracted recent attention especially in dermatological practice. However, little is known about the molecular mechanism of the anti-oxidant and anti-inflammatory effects of red light irradiation. We evaluated these effects of LEDI in HaCaT human keratinocyte cells under phorbol-12-myristate-13-acetate (PMA) induced reactive oxygen species (ROS). Microarray analysis revealed changes in 309 genes after LEDI. LEDI at 625 nm produced ROS scavenging and anti-inflammatory effects. One of the most important genes identified by microarray analysis was sphingosine kinase-1 (SPHK1), which is a key molecule in sphingolipid metabolism. SPHK1 knock-down drastically reduced ROS scavenging efficiency as well as expression levels of inflammation-related proteins in PMA-treated HaCaT cells. These results not only indicate the potential for the clinical application of 625-nm LEDI in treating skin disorders via ROS and/or inflammation, but also suggest SPHK1 as a potential therapeutic target in phototherapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> LEDI at 625 nm produced ROS scavenging and anti-inflammation. </LI> <LI> Sphingosine kinase-1 (SPHK1) was identified by microarray analysis in the experimental conditions. </LI> <LI> LEDI 625 nm has the potential for treating skin disorder via ROS and/or inflammation through SPHK1/NF-κB pathway. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Botrytis cinerea hypovirulent strain BcSpd1 induced Panax ginseng defense
Shuhan Zhang,Junyou Han,Ning Liu,Jingyuan Sun,Huchen Chen,Jinglin Xia,Huiyan Ju,Shouan Liu 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6
Background: Gray mold, caused by Botrytis cinerea, is one of the major fungal diseases in agriculture. Biological methods are preferred over chemical fungicides to control gray mold since they are less toxicto the environment and could induce the resistance to pathogens in plants. In this work, we try tounderstand if ginseng defense to B. cinerea could be induced by fungal hypovirulent strain △BcSpd1. BcSpd1 encodes Zn(II)2Cys6 transcription factor which regulates fungal pathogenicity and we recentlyreported △BcSpd1 mutants reduced fungal virulence. Methods: We performed transcriptomic analysis of the host to investigate the induced defense responseof ginseng treated by B. cinerea △BcSpd1. The metabolites in ginseng flavonoids pathway were determinedby UPLC-ESI-MS/MS and the antifungal activates were then performed. Results: We found that △BcSpd1 enhanced the ginseng defense response when applied to healthyginseng leaves and further changed the metabolism of flavonoids. Compared with untreated plants, theapplication of △BcSpd1 on ginseng leaves significantly increased the accumulation of p-coumaric acidand myricetin, which could inhibit the fungal growth. Conclusion: B. cinerea△BcSpd1 could effectively induce the medicinal plant defense and is referred to asthe biological control agent in ginseng disease management.
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Cho, Hyejoung,Zheng, Hui,Sun, Qiaochu,Shi, Shuhan,He, YuZhu,Ahn, Kyuhyeon,Kim, Byunggook,Kim, Hye-Eun,Kim, Okjoon Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Photodynamic therapy (PDT) is generally safer and less invasive than conventional strategies for head and neck cancer treatment. However, currently available photosensitizers have low selectivity for tumor cells, and the burden and side effects are so great that research is needed to develop safe photosensitizers. In this study, it was confirmed that the<I> Buddleja officinalis</I> (BO) extract, used in the treatment of inflammation and vascular diseases, shows fluorescence when activated by LED light, and, based on this, we aimed to develop a new photosensitive agent suitable for PDT. MTT, Diff-Quick® staining, and DCF-DA were performed to measure the effects of treating head and neck cancer cells with BO extract and 625 nm LED light (BO-PDT). Cell cycle, TUNEL, and western blot assays, as well as acridine orange staining, were performed to explore the mechanism of BO-PDT-induced cell death. We found that when the BO extract was irradiated with 625 nm LED light, it showed sufficient fluorescence and stronger intracellular toxicity and ROS effect than the currently commercially available hematoporphyrin. BO-PDT resulted in a decrease of mTOR activity that was correlated with an increase in the levels of ATG5, beclin-1, and LC3-II, which interfere with the formation of autophagosomes. In addition, BO-PDT induced the activation of PARP and led to an increase in the expression of proapoptotic protein Bax and a decrease in the expression of the antiapoptotic protein Bcl-2. Moreover, BO-PDT has been shown to induce the autophagy pathway 4 h after treatment, while apoptosis was induced 16 h after treatment. Finally, we confirmed that BO-PDT caused cell death of head and neck cancer cells via the intrinsic pathway. Therefore, we suggest that BO extract can be used as a new photosensitizer in PDT of head and neck cancer.</P>
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이은수,HE YUZHU,조혜중,SUN QIAOCHU,SHI SHUHAN,김영,김옥준 대한구강악안면병리학회 2018 대한구강악안면병리학회지 Vol.42 No.6
Extranodal intraoral Hodgkin lymphoma is not common. We report the case of a 78-year-old male patient with ulcer of the mandibular oral mucosa that was not cured for about 3 weeks. In biopsy and histopathologic examination, it was found to be extranodal intraoral Hodgkin lymphoma. Early diagnosis of oral lesions led to early detection of lesions of the opposite neck lymph node in an additional PET-CT scan We report this case and review relevant literature
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