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Big Data Analysis of Weather Condition and Air Quality on Cosmetics Marketing
Wang, Zebin,Wu, Tong,Zhao, Xinshuang,Cheng, Shuchun,Dai, Genghui,Dai, Weihui Korea Data Strategy Society 2017 Journal of information technology applications & m Vol.24 No.3
Demands of cosmetics are affected not only by the well-known elements such as brand, price, and customer's consumption capacity, but also by some latent factors, for example, weather and air environment. Due to complexity and dynamic changes of the above factors, their influences can hardly be estimated in an accurate way by the traditional approaches such as survey and questionnaires. Through modeling and statistical analysis of big data, this article studied the impacts of weather condition and air quality on customer flow and sales of the cosmetics distributors in China, and found several hidden influencing factors. It provided a big-data based method for the analysis of unconventional factors on cosmetics marketing in the changing weather condition and air environment.
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Big Data Analysis of Weather Condition and Air Quality on Cosmetics Marketing
Zebin Wang,Tong Wu,Xinshuang Zhao,Shuchun Cheng,Genghui Dai,Weihui Dai 한국데이타베이스학회 2017 Journal of information technology applications & m Vol.24 No.3
Demands of cosmetics are affected not only by the well-known elements such as brand, price, and customer"s consumption capacity, but also by some latent factors, for example, weather and air environment. Due to complexity and dynamic changes of the above factors, their influences can hardly be estimated in an accurate way by the traditional approaches such as survey and questionnaires. Through modeling and statistical analysis of big data, this article studied the impacts of weather condition and air quality on customer flow and sales of the cosmetics distributors in China, and found several hidden influencing factors. It provided a big-data based method for the analysis of unconventional factors on cosmetics marketing in the changing weather condition and air environment.
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Yang Weina,Kang Qian,Li Chunlei,Bo Shuchun,Wang Yue 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background During preeclampsia (PE), reactive oxygen species (ROS) production and infl ammation are increased. Matrine exerts diverse pharmacological eff ects, including anti-infl ammatory and anti-apoptotic eff ects. Objective The present study aimed to study the therapeutic eff ects of matrine on PE. Human trophoblasts (HTR-8/SVneo cells) were treated with H 2 O 2 to simulate oxidative stress, followed by treatment with various concentrations of matrine. Next, fl ow cytometry was used to examine apoptosis. Cell invasion and migration were examined by Transwell and scratch wound assays, respectively. The concentrations of IL-6, IL-8, and TNF-α were quantifi ed by enzyme-linked immunosorbent assays. The expression levels of miR-19a-3p and ZEB2 were quantifi ed by qRT-PCR. The interaction between miR-19a-3p and ZEB2 was examined by a dual-luciferase reporter assay. Result Matrine attenuated H 2 O 2 -induced increases in ROS levels, apoptosis, and cytokine release in HTR/SVneo cells. Matrine also increased cell migration and invasion during oxidative stress by reducing miR-19a-3p expression. Moreover, miR-19a-3p can target ZEB2 directly. Conclusion During oxidative stress, matrine can reduce ROS levels, apoptosis, and infl ammation in human trophoblasts and promote migration and invasion via miR-19a-3p, off ering a potential new approach for the treatment of PE.
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Nan Kang,Yinli Zhang,Shichao Guo,Ran Chen,Fangzhou Kong,Shuchun Wang,Mingming Yuan,Rongrong Chen,Danhua Shen,Jianliu Wang 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose The unique chromosomal rearrangements of endometrial stromal sarcoma (ESS) make it possible to distinguish high-grade ESS (HGESS) and low-grade ESS (LGESS) from the molecular perspective. Analysis of ESS at the genomic and transcriptomic levels can help us achieve accurate diagnosis of ESS and provide potential therapy options for ESS patients.Materials and Methods A total of 36 ESS patients who conducted DNA- and/or RNA-based next-generation sequencing were retrospectively enrolled in this study. The molecular characteristics of ESS at genomic and transcriptomic levels, including mutational spectrum, fusion profiles, gene expression and pathway enrichment analysis and features about immune microenvironment were comprehensively explored.Results <i>TP53</i> and <i>DNMT3A</i> mutations were the most frequent mutations. The classical fusions frequently found in <i>HGESS</i> (<i>ZC3H7B-BCOR</i> and <i>NUTM2B-YWHAE</i>) and LGESS (<i>JAZF1-SUZ12</i>) were detected in our cohort. <i>CCND1</i> was significantly up-regulated in HGESS, while the expression of <i>GPER1</i> and <i>PGR</i> encoding estrogen receptor (ER) and progesterone receptor (PR) did not differ significantly between HGESS and LGESS. Actionable mutations enriched in homologous recombination repair, cell cycle, and phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathways were detected in 60% of HGESS patients. Genes with up-regulated expression in HGESS were significantly enriched in five immune-related pathways. Most HGESS patients (85.7%) had positive predictors of immunotherapy efficacy. Moreover, immune microenvironment analysis showed that HGESS had relatively high immune infiltration. The degree of immune infiltration in HGESS patients with <i>ZC3H7B-BCOR</i> fusion was relatively higher than that of those with <i>NUTM2B-YWHAE</i> fusion.Conclusion This study investigated the molecular characteristics of ESS patients at the genomic and transcriptomic levels and revealed the potentially high sensitivity of targeted therapy and immunotherapy in a subset of HGESS with specific molecular features, providing a basis for guiding decision-making of treatment and the design of future clinical trials on precision therapy.
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