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- 저자 : Bo Shuchun (검색결과 1 건)
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Yang Weina,Kang Qian,Li Chunlei,Bo Shuchun,Wang Yue 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background During preeclampsia (PE), reactive oxygen species (ROS) production and infl ammation are increased. Matrine exerts diverse pharmacological eff ects, including anti-infl ammatory and anti-apoptotic eff ects. Objective The present study aimed to study the therapeutic eff ects of matrine on PE. Human trophoblasts (HTR-8/SVneo cells) were treated with H 2 O 2 to simulate oxidative stress, followed by treatment with various concentrations of matrine. Next, fl ow cytometry was used to examine apoptosis. Cell invasion and migration were examined by Transwell and scratch wound assays, respectively. The concentrations of IL-6, IL-8, and TNF-α were quantifi ed by enzyme-linked immunosorbent assays. The expression levels of miR-19a-3p and ZEB2 were quantifi ed by qRT-PCR. The interaction between miR-19a-3p and ZEB2 was examined by a dual-luciferase reporter assay. Result Matrine attenuated H 2 O 2 -induced increases in ROS levels, apoptosis, and cytokine release in HTR/SVneo cells. Matrine also increased cell migration and invasion during oxidative stress by reducing miR-19a-3p expression. Moreover, miR-19a-3p can target ZEB2 directly. Conclusion During oxidative stress, matrine can reduce ROS levels, apoptosis, and infl ammation in human trophoblasts and promote migration and invasion via miR-19a-3p, off ering a potential new approach for the treatment of PE.
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