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- 저자 : Shu-min Fan (검색결과 3 건)
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Dan-Min Xu,Yi-Lin Kong,Li Wang,Hua-Yuan Zhu,Jia-Zhu Wu,Yi Xia,Yue Li,Shu-Chao Qin,Lei Fan,Jian-Yong Li,Jin-Hua Liang,Wei Xu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose The purpose of this study was to investigate the prognostic impact of Epstein-Barr virus (EBV)–microRNA (miRNA, miR)-BHRF1-1 with chronic lymphocytic leukemia (CLL) as well as role of EBV-miR-BHRF1-1 in p53 gene. Materials and Methods Quantitative reverse transcription–polymerase chain reaction and western blotting were used to quantify EBV-miR-BHRF1-1 and p53 expression in cultured CLL. Results p53 aberration was associated with the higher expression level of EBV-miR-BHRF1-1 (p < 0.001) which was also an independent prognostic marker for overall survival (p=0.028; hazard ratio, 5.335; 95% confidence interval, 1.193 to 23.846) in 97 newly-diagnosed CLL patients after adjusted with International Prognostic Index for patients with CLL. We identified EBV-miR-BHRF1-1 as a viral miRNA regulator of p53. EBV-miR-BHRF1-1 repressed luciferase reporter activity by specific interaction with the seed region within the p53 3- untranslated region. Discordance of p53 messenger RNA and protein expression was associated with high EBV-miR-BHRF1-1 levels in CLL patients and cell lines. EBV-miR-BHRF1- 1 inhibition upregulated p53 protein expression, induced cell cycle arrest and apoptosis and decreased cell proliferation in cell lines. EBV-miR-BHRF1-1 mimics downregulated p53 protein expression, decreased cell cycle arrest and apoptosis, and induced cell proliferation in cell lines. Conclusion This study supported the role of EBV-miR-BHRF1-1 in p53 regulation in vitro. Our results support the potential of EBV-miR-BHRF1-1 as a therapeutic target in EBV-associated CLL with p53 gene aberration.
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허려화(Li-Hua Xu),Shu-min Fan,김형택(Hyung-Taek Kim),유영돈(Young-Don Yoo) 한국에너지기후변화학회 2015 에너지기후변화학회지 Vol.10 No.1
중국에서는 중장기적으로 석탄을 주요 에너지원으로 사용하는 에너지소비 구조가 계속될 것으로 예상되어, 석탄의 청정 이용에 대한 실증화 연구가 활발히 진행되고 있다. 석탄액화를 포함한 현대 석탄화학 전환 기술을 통한 생산물질들은 석유화학 제품들을 대체할 수 있어 석유의 의존도를 낮출 수 있어, 중국에서는 대규모의 석탄이용 합성연료생산 플랜트가 운전 중 혹은 건설 중에 있다. 또한 중국에서는 이미 자체 F-T(Fischer Tropsch) 합성 기술을 개발하여 상업화 운전 성공하였다. 현재 중국에는 세계 최초로 백만 톤 규모의 석탄직접 액화 플랜트가 건설되어 운전 중에 있고, 세계 최대 석탄 간접액화플랜트가 건설 중에 있다. Since China government anticipates that coal is a major resource in energy demand sector during long term, demonstration research using Clean Coal Technology(CCT) has been developed actively. Coal to chemicals technology such as coal to liquids (CTL) process, which may produce chemical product and substitute to petrochemical refined through conventional oil, reduces the dependence of petroleum usage. Thus, many coal gasification plants have been operated and constructed in China. In China, the commercial synthesis plants using F-T technology developed by domestic research have been successfully operated. Currently, worlds first one million tonnes of CTL plant using direct conversion process is operated and the world largest CTL plant using indirect conversion process is constructed.
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Quantitative Presentation of the Systematic Relationships Between S. sudanense and S. bicolor
Qiu-Wen Zhan,Ping Lin,Jie-Qin Li,Min Zu,Jun-Cheng Fan,Ya Chen,Fei Fan,Shi-fu Shu 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
Fifty-four biological characters were used for quantitative classification of sorghum and sudangrass and their relationship. Discriminant analysis of all 240 individuals of 48 accessions suggested that 100% of originally grouped cases were correctly classified. Analysis of variance results showed that the differences among 48 accessions in characters were significant at the 0.01 level. Cluster analysis showed that the 48 accessions were obviously divided into two clusters by a Euclidean distance of 17.46 as the classification standards, i.e. the genus maize and genus sorghum. The 48 accessions were divided into four clusters by a Euclidean distance of 9.86, i.e. Sorghum-Sudangrass, Sorghum related species (S. propinquum and S. halepense), Zea mexicana and Z. mays. All accessions were divided into five clusters by a Euclidean distance of 8.91, namely group Ⅰ (Sudangrass-Chinese sorghum), group Ⅱ (Non-Chinese sorghum), group Ⅲ (Sorghum related species), group Ⅳ (Zea mexicana), and group Ⅴ (Z mays).
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