Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer

Shrimali, D.,Shanmugam, M.K.,Kumar, A.P.,Zhang, J.,Tan, B.K.H.,Ahn, K.S.,Sethi, G. Elsevier Science Ireland 2013 Cancer letters Vol.341 No.2

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolated from roots and barks of numerous plants, molds, and lichens. It is found as an active ingredient in different Chinese herbs including Rheum palmatum and Polygonam multiflorum, and has diuretic, vasorelaxant, anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. The anti-inflammatory effects of emodin have been exhibited in various in vitro as well as in vivo models of inflammation including pancreatitis, arthritis, asthma, atherosclerosis and glomerulonephritis. As an anti-cancer agent, emodin has been shown to suppress the growth of various tumor cell lines including hepatocellular carcinoma, pancreatic, breast, colorectal, leukemia, and lung cancers. Emodin is a pleiotropic molecule capable of interacting with several major molecular targets including NF-κB, casein kinase II, HER2/neu, HIF-1α, AKT/mTOR, STAT3, CXCR4, topoisomerase II, p53, p21, and androgen receptors which are involved in inflammation and cancer. This review summarizes reported anti-inflammatory and anti-cancer effects of emodin, and re-emphasizes its potential therapeutic role in the treatment of inflammatory diseases and cancer.

GAUSSIAN VERTEX PRIME LABELING OF SOME GRAPHS

NARENDRA PURSHOTTAMBHAI SHRIMALI,SACHIN KUMAR SINGH 충청수학회 2021 충청수학회지 Vol.34 No.3

In the present work we introduce Gaussian vertex prime labeling and investigate Gaussian vertex prime labeling for gear graph, book graph, wheel graph, kayak paddle, one point union of gear graph and one point union of wheel graph.

Seismic Response of Elevated Liquid Storage STEEL Tanks Under Bi-direction Excitation

M. K. Shrimali 한국강구조학회 2007 International Journal of Steel Structures Vol.7 No.4

Seismic response of elevated cylindrical liquid storage stel tanks isolated by resilient-friction base isolator is investigatedmass, impulsive mass and rigid mass. The coresponding equivalent stiffness associated with these lumped masses is computedfrom properties of the contained liquid and tank wall. The governing equations of motion of the isolated tank are derived andsolved iteratively. The frictional forces mobilized at the interface of the sliding system are assumed to be velocity dependentand their interaction in two horizontal directions is duly considered. A parametric study is also conducted to study the effectsconsidered are (i) aspect ratio of tank, (ii) the period of isolation, (iii) the damping of isolation bearings and (iv) the coeficientof friction of the resilient-friction-base-isolator. It has ben found that the bi-directional interaction of frictional forces havenoticeable effects and if these effects are ignored then the sliding base displacements will be underestimated which can becrucial from design point of view.

An Advanced Resource Allocation Algorithm for PON-LTE Converged Networks

Abhishek Gaur,Vibhakar Shrimali International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.7

Enhanced radio access technologies (RAT) are deployed in Next Generation Convergence Networks by the service providers so as to satisfy the basic requirements of end-users for e.g. QoS. Whenever the available resources are being shared simultaneously and dynamically by multiple users or distribution of allocated channels randomly, the deficiency of spectral resources and dynamic behavior of Network traffic in real time Networking, we may have problem. In order to evaluate the performance of our proposed algorithm, computer simulation has been performed on NS-2 simulator and a comparison with the existing algorithms has been made.

AgriOnBlock: Secured Data Harvesting for Agriculture Sector using Blockchain Technology

Hiren Patel,Bela Shrimali 한국통신학회 2023 ICT Express Vol.9 No.2

The existing agriculture system is having several components such as supply chain management, crop insurance, the shipment of goods, and it involves numerous untrusted stakeholders such as users (farmers, retailers, customers, wholesalers, etc.), agencies (bank, insurance company) and regulators (assessor, surveyors). Due to the active engrossment of the middle man (mostly human beings or agencies operated by human beings) some key issues are raised such as transparency, timeliness, traceability, security, and immutability resulting in financial loss, crop contamination, and spoilage. Secure distributed public ledger technology and decentralized computing paradigm make Blockchain an appropriate alternative to resolve these issues and to achieve profitability & trust for all its stakeholders. In this research, we intend to propose a Blockchain-based mechanism viz. AgriOnBlock which would address the issues mentioned in the agriculture sector by connecting various stakeholders through the usage of IoT devices and smart contracts in Ethereum. We further discuss implications, constraints (methodological, awareness related, regulatory, etc.), and potential for actual adoption of AgriOnBlock.

Seismic demand assessment of semi-rigid steel frames at different performance points

Vijay Sharma,Mahendra K. Shrimali,Shiv D. Bharti,Tushar K. Datta 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.5

The seismic performance of rigid steel frames is widely investigated, but that of semi-rigid (SR) steel frames are not studied extensively, especially for near-field earthquakes. In this paper, the performances of five and ten-story steel SR frames having different degrees of semi-rigidity are evaluated at four performance points in the four different deformation states, namely, the elastic, elasto-plastic, plastic, and near collapse states. The performances of the SR frames are measured by the response parameters including the maximum values of the top floor displacement, base shear, inter-story drift ratio, number of plastic hinges, and SRSS of plastic hinge rotations. These response parameters are obtained by the capacity spectrum method (CSM) using pushover analysis. The validity of the response parameters determined by the CSM is evaluated by the results of the nonlinear time history analysis (NLTHA) for both near and far-field earthquakes at different PGA levels, which are consistent with the performance points. Results of the study show that the plastic hinges of SR frame significantly increase in the range of plastic to near-collapse states for both near and far-field earthquakes. The effect of the degree of semi-rigidity is pronounced only at higher degrees of semi-rigidity. The predictions of the CSM are fairly well in comparison to the NLTHA.

Behavior of semi-rigid steel frames under near- and far-field earthquakes

Vijay Sharma,Mahendra K. Shrimali,Shiv D. Bharti,Tushar K. Datta 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.34 No.5

The realistic modeling of the beam-column semi-rigid connection in steel frames attracted the attention of many researchers in the past for the seismic analysis of semi-rigid frames. Comparatively less studies have been made to investigate the behavior of steel frames with semi-rigid connections under different types of earthquake. Herein, the seismic behavior of semi-rigid steel frames is investigated under both far and near-field earthquakes. The semi-rigid connection is modeled by the multilinear plastic link element consisting of rotational springs. The kinematic hysteresis model is used to define the dynamic behavior of the rotational spring, describing the nonlinearity of the semi-rigid connection as defined in SAP2000. The nonlinear time history analysis (NTHA) is performed to obtain response time histories of the frame under scaled earthquakes at three PGA levels denoting the low, medium and high-level earthquakes. The other important parameters varied are the stiffness and strength parameters of the connections, defining the degree of semi-rigidity. For studying the behavior of the semi-rigid frame, a large number of seismic demand parameters are considered. The benchmark for comparison is taken as those of the corresponding rigid frame. Two different frames, namely, a five-story frame and a ten-story frame are considered as the numerical examples. It is shown that semi-rigid frames prove to be effective and beneficial in resisting the seismic forces for near-field earthquakes (PGA ≈ 0.2g), especially in reducing the base shear to a considerable extent for the moderate level of earthquake. Further, the semi-rigid frame with a relatively weaker beam and less connection stiffness may withstand a moderately strong earthquake without having much damage in the beams.

Evaluation of responses of semi-rigid frames at target displacements predicted by the nonlinear static analysis

Vijay Sharma,Mahendra K. Shrimali,Shiv D. Bharti,Tushar K. Datta 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.36 No.4

Responses of semi-rigid frames having different degrees of semi-rigidity obtained by the nonlinear static analysis (NSA) are evaluated at specific target displacements by comparing them with those obtained by the nonlinear time-history analysis (NTHA) for scaled earthquakes. The peak ground accelerations (PGA) of the earthquakes are scaled such that the obtained peak top story displacements match with the target displacements. Three different types of earthquakes are considered, namely, far-field and near-field earthquakes with directivity and fling-step effects. In order to make the study a comprehensive one, three degrees of semi-rigidity (one fully rigid and the other two semi-rigid), and two frames having different heights are considered. An ensemble of five-time histories of ground motion is included in each type of earthquake. A large number of responses are considered in the study. They include the peak top-story displacement, maximum inter-story drift ratio, peak base shear, total number of plastic hinges, and square root of sum of the squares (SRSS) of the maximum plastic hinge rotations. Results of the study indicate that the nonlinear static analysis provides a fairly good estimate of the peak values of top-story displacements, inter-story drift ratio (for shorter frame), peak base shear and number of plastic hinges; however, the SRSS of maximum plastic hinge rotations in semi-rigid frames are considerably more in the nonlinear static analysis as compared to the nonlinear time history analysis.

Antagonistic Potential of Native Trichoderma viride Strain against Potent Tea Fungal Pathogens in North East India

Naglot, A.,Goswami, S.,Rahman, I.,Shrimali, D.D.,Yadav, Kamlesh K.,Gupta, Vikas K.,Rabha, Aprana Jyoti,Gogoi, H.K.,Veer, Vijay The Korean Society of Plant Pathology 2015 Plant Pathology Journal Vol.31 No.3

Indigenous strains of Trichoderma species isolated from rhizosphere soils of Tea gardens of Assam, north eastern state of India were assessed for in vitro antagonism against two important tea fungal pathogens namely Pestalotia theae and Fusarium solani. A potent antagonist against both tea pathogenic fungi, designated as SDRLIN1, was selected and identified as Trichoderma viride. The strain also showed substantial antifungal activity against five standard phytopathogenic fungi. Culture filtrate collected from stationary growth phase of the antagonist demonstrated a significantly higher degree of inhibitory activity against all the test fungi, demonstrating the presence of an optimal blend of extracellular antifungal metabolites. Moreover, quantitative enzyme assay of exponential and stationary culture filtrates revealed that the activity of cellulase, ${\beta}$-1,3-glucanase, pectinase, and amylase was highest in the exponential phase, whereas the activity of proteases and chitinase was noted highest in the stationary phase. Morphological changes such as hyphal swelling and distortion were also observed in the fungal pathogen grown on potato dextrose agar containing stationary phase culture filtrate. Moreover, the antifungal activity of the filtrate was significantly reduced but not entirely after heat or proteinase K treatment, demonstrating substantial role of certain unknown thermostable antifungal compound(s) in the inhibitory activity.

Retrofitting of a weaker building by coupling it to an adjacent stronger building using MR dampers

Mahdi Abdeddaim,Abdelhafid Ounis,Mahendra K. Shrimali,Tushar K. Datta 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.2

Among various retrofitting strategies, use of semi-active control for retrofitting a building structure has gained momentum in recent years. One of the techniques for such retrofitting is to connect a weaker building to an adjacent stronger building by semi-active devices, so that performances of a weaker building are significantly improved for seismic forces. In this paper, a ten storey weaker building is connected to an adjacent stronger building using magneto-rheological (MR) dampers, for primarily improving the performance of the weaker building in terms of displacement, drift and base shear. For this, a fuzzy logic controller is specifically developed by fuzzyfying the responses of the coupled system. The performance of the control strategy is compared with the passive-on and passive-off controls. Pounding Mitigation between the two buildings is also investigated using all three control strategies. The results show that there exists a fundamental frequency ratio between the two buildings for which maximum control of the weaker building response takes place with no penalty on the stronger building. There exists also a fundamental frequency ratio where control of the weaker building response is achieved at the expense of the amplification of the stronger building. However, coupling strategy always improves the possibility of pounding mitigation.