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이정훈,신희성,김용재,백세환,ShouguangJin쇼강진,하운환 한국미생물학회 2014 The journal of microbiology Vol.52 No.12
The proinflammatory cytokine interleukin-1β plays an importantrole in protecting the host against airway infection;however, it can also trigger a massive influx of neutrophilsinto the airways, causing tissue damage. Anti-inflammatorytreatments are particularly in demand for patients sufferingfrom chronic inflammatory diseases. Sophora flavescens is atraditional herbal medicine used to reduce inflammation,but no study has examined its ability to block IL-1β production. Here, we show that S. flavescens reduced the Pseudomonasaeruginosa-induced expression of IL-1β by lung epithelialcells and macrophages. S. flavescens was also effectiveat reducing IL-1β production induced by either Staphylococcusaureus or phorbol 12-myristate 13-acetate, indicatingthat the effect is generalizable to diverse inflammatorystimuli. In addition, S. flavescens blocked the phosphorylationof IKKα/β, key upstream kinases involved in the degradationof IκBα, and the cleavage of caspase-1, a key componentof the inflammasome. Thus, this study demonstratesthat S. flavescens exerts its anti-inflammatory effects by blockingP. aeruginosa-mediated NF-κB/inflammasome activationand the subsequent production of IL-1β.