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Immunosensors for Point-of-Care Testing
백세환,조정환,조일훈,오병근,김영기 한국바이오칩학회 2007 BioChip Journal Vol.1 No.1
Although immuno-chromatographic assays on membrane strips have been employed at points of care for more than 20 years, their applications have become limited to qualitative analyses of the analytes present at relatively high concentrations in samples. An evolution of technology in this field will be required in order to achieve the capability of detection sufficient for early diagnosis as well as a degree of quantification sufficient to allow for the monitoring of the sease progress, a digital display of analytical results, and automatic recording and correlation in a database. In order to attain proper sensitivity, the colloidal gold normally used as a tracer for colorimetry may be replaced with different signal generators, including fluorophores, magnetic beads, electrochemiluminescent substances, and enzymes. The means by which ntigen-antibody binding in the assay can be quantified as a measurable signal also varies, depending on the tracer employed and the transduction technology available. Indeed, we have devoted ourselves for more than ten years to the investigation of combinatorial substitutes onsisting of novel immunosensors that fulfill the demands inherent to medical diagnostics. In this review, selected immunosensor technologies developed in our laboratories are introduced, along with their detection principles and analytical characteristics.
사질토 지반에서의 말뚝관입으로 인한 흙의 변형에 관한 연구
백세환,이장덕 한국지반공학회 1990 대한토질공학회지 Vol.6 No.3
말뚝관입으로 인한 사질토 지반의 변형을 모형말뚝 관입시험을 수행하여 분석하였다. 실제 현장 조건, 특히 현장의 음력수준을 재현하기 위해서 수직, 수평응력을 별도로 가압할 수 있는 모형토조를 사용 하여 실험하였다. 흙의 변형은 5개의 토압계를 사용하여 측정하였으며 실험결과를 공동확장 이론에 의한 값들과 비교하였다. The soil deformation due to a pile penetration in sandy soils has been analysed in model pile penetration tests. To simulate the actual ground conditions, especially the in-situ stress levee the tests were performed in a calibration chamber where both the vertical and the horizontal stresses could be applied separately. The deformation was monitored via 5 earth pressure cells. The results, were compared with the theortical values based on the theory of cavity expansion.
백세환,이명환,이원제,Baek, Se-Hwan,Lee, Myeong-Hwan,Lee, Won-Je 한국지반공학회 1990 대한토질공학회지 Vol.6 No.4
정적관입저항 또는 선단지지말뚝의 선단지지력을 해석함에 있어서는 유효수직응력이 기준음력으로 사용되어 왔다. 그러나 정적관입저항은 유효수직응력보다 원위치 유효수평응력에 관계된다는 것이 많은 실험연구결과로부터 보고 되었다. 이와같은 문제점을 규명하기 위하여 기 보고된 실험결과를 다시 분석하였으며 실험실에서의 관입시험이 실시되었다. 연구결과 정적관입저항은 유효수직 응력과 유효수평응력 모두에 영향을 받는 것으로 나타나고 있으며 해석시에는 평균주응력이 기준응력으로 사용되어야 함을 결론 지을 수 있었다. In the analysis of the static cone penetration resistance or the point resistance of end bearing piles, the vertical effective stress has been chosen as the reference stress. However many reported experimental results indicate that the cone tip resistance is dependent rather on the in -situ horzontal stress than the vertical effective stress. To clarify this point, published experimental results have been re-evaluated and the laboratory penetration tests have been performed. From the results it is concluded that the cone tip resistance is influenced by both the vertical effective stress and the horizontal effective stress. It is further concluded that the mean normal stress should be used as the reference stress in the analysis.
Real-time Monitoring of Biomarkers: Current Status and Future Perspectives
백세환 한국바이오칩학회 2020 BioChip Journal Vol.14 No.1
Real-time monitoring is a technique that can be accomplished in the future by continuous or high-frequency analyses of biomarkers indicating disorders (e.g., acute myocardial infarction) in an unattended manner, which eventually will occur in wearable or implantable biosensor formats (refer to Figure 1)1. This technique can enable early diagnosis and prognosis for target diseases, and even provide information related to the disease in progress and therapeutic effect in personalized medicine. The biochemical signs related to a disease will be combined with real-time physical signals such as cardiac impulse and pulsation, significantly increasing diagnostic accuracy2. A great number of disease-related biomarkers have been clinically validated, and various types of analytes from simple molecules, such as ions and metabolites, to large, complex markers, such as proteins and cells, are available. To achieve unattended care through real-time monitoring, unmet technical demands remained are as follows: 1) (semi-)continuous drawings of venous blood without pains and infection, 2) (semi-)continuous separation of blood cells, 3) recyclable immunosorbent, 4) miniaturized, possibly, label-free sensor system, 5) in situ baseline correction algorithm, and 6) secure data transmission.