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Promotion of Blood Fluidity by Inhibition of Platelet Adhesion Using Electroacupuncture Stimulation
Shintaro Ishikawa,Makoto Murai,Takao Sato,Masataka Sunagawa,Erika Tokita,Steven K.H. Aung,Kazuhito Asano,Tadashi Hisamitsu 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.1
Stress applied to rats is known to result in a quick decrease in blood fluidity. Although electrical acupuncture stimulation (ACU) attenuates stress responses,the influence of ACU on blood fluidity has not been well examined. In the present study, the effect of ACU on blood fluidity and platelet adhesion was examined using a Micro Channel Array Flow Analyzer and a laser scattering platelet aggregometer (PA-20), respectively. Male Wistar rats (7−8 weeks old) were used. ACU (1 Hz, 3−5 V),which causes slight muscle twitching, was applied to acupoints for 60 minutes/day once or on 2 consecutive days. Stimulated acupoints were as follows: ZuSanli (ST-36), Sanyinjiao (SP-6), Hegu (L-I4), Neiguan (P-6), and Shenshu (BL-23). ACU applied to ST-36, SP-6, and L-14 revealed significant increases in blood fluidity while platelet adhesion activity decreased. No significant changes were observed when ACU was applied to P-6 and BL-23. Results indicate that ACU affects blood fluidity depending on the acupoints. Blood fluidity changed with ACU within 1 day. In other words, the effect of acupuncture has an immediate effect. In addition, platelet aggregation decreased with ACU, suggesting that an increase in blood fluidity is associated with platelet aggregation ability.
Shintaro Ishikawa,Hiroki Suga,Masaya Fukushima,Atsuhiro Yoshida,Yuri Yoshida,Masataka Sunagawa,Tadashi Hisamitsu 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.1
We have reported that electrical acupuncture stimulation (ACU) increases blood fluidity by decreasing platelet aggregation. In this study, we investigated the mechanism causing the increase of blood fluidity. The effects of ACU on blood fluidity and platelet adhesion were examined using a Micro Channel Array Flow Analyzer (MC-FAN) and a laser scattering platelet aggregometer (PA-20). Male Wistar rats (7e8 weeks old) were used in the study. ACU (1 or 100 Hz, 3e5 V),which causes slight muscle twitching, was applied to the ZuSanli (ST-36) acupoint for 15 or 60 minutes once/day. Blood samples were collected from the inferior vena cava. ACU applied to ST-36 revealed significant increases in blood fluidity, while platelet adhesion activity decreased, regardless of the difference of stimulus time. The acupuncture had an immediate effect. Even if naloxone was administered during acupuncture stimulus, the blood flow time shortened in a similar way, as in the only acupuncture stimulus group. In addition, the effect of acupuncture on blood fluidity was inhibited by a b-antagonist. The results indicate that ACU affects blood fluidity depending on the acupoints, and that the effect of ACU might involve an endogenous adrenergic mechanism.
Changes in Blood Fluidity Caused by Electroacupuncture Stimulation
Tadashi Hisamitsu,Shintaro Ishikawa 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.4
In Oriental medicine, the state of blood stagnation is called “Oketsu,” meaning preceding state or symptomatic of sickness. Acupuncture stimulation is often used clinically for the treatment of “Oketsu.” The degree of “Oketsu” is indicated by tongue color and form, swelling, paroxysmal blushing, and dark circles under the eyes. The blood’s fluidity is generally thought to be a blood stagnation factor. “Oketsu” is now considered as physio- logical blood flow and is studied from the perspective of the blood’s fluidity and vascular resistance. In our preliminary research, acupuncture stimuli were very effective in treat- ing conditions associated with a decrease in the fluidity of the blood, such as “Oketsu.” In this review, we discuss recent progress in acupuncture therapy and report mechanisms of its action; we then focus on our original findings on these topics. Furthermore, we pro- pose new factors related to acupuncture stimuli, including the blood’s fluidity, and report our investigations, using the restraint stress method, on the mechanisms underlying acupuncture stimuli.
Takahisa Shiraishi,Hiro Einishi,Shintaro Yasui,Hiroshi Funakubo,Tomohito Hasegawa,Minoru Kurosawa,Mutsuo Ishikawa,Hiroshi Uchida,Yukio Sakashita,김상수,송태권,도달현,김명호 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.7
(K0.88Na0.12)NbO3 (KNN) thick films with various thicknesses were prepared on Ni-based metal substrates by hydrothermal method. Although the deposition of KNN films was hardly observed directly on metal substrates until 12 h, the amount of KNN films deposited on both SrRuO3/LaNiO3- and SrRuO3-covered Ni based metal substrates increased to about 5 μm with increasing deposition time above 3 h. X-ray diffraction studies confirmed the formation of {100}c- and randomly-oriented KNN films on SrRuO3/LaNiO3- and SrRuO3-covered metal substrates, respectively. Ferroelecctric property studies revealed an improved remanent polarization and an improved piezoelectric response of {100}c-oriented KNN films over the randomly-oriented KNN films. In addition, the values for {100}c-oriented KNN films were similar to those of {100}c-oriented epitaxial KNN films prepared on (100)cSrRuO3//SrTiO3 substrates.
Morihiro Kogure,Naomi Mimura,Hideshi Ikemoto,Shintaro Ishikawa,Takako Nakanishi-Ueda,Masataka Sunagawa,Tadashi Hisamitsu 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.1
The purpose of this study was to compare the effectiveness of moxibustion (MOX) treatment at the GV4 and CV12 acupoints, and to determine the correlations between MOX treatment and interleukin (IL)-6 and corticosterone levels in a collagen-induced arthritis (CIA) mouse model. CIA mice were immunized twice intradermally over a 3-week interval with bovine type II collagen. After the second immunization (day 21), MOX was applied to the mouse equivalent of the GV4 and CV12 acupoints with a 1 mg moxa cone five times/day. Clinical symptoms of CIA were observed three times/week until day 35. The concentrations of IL-6 and corticosterone in the blood samples were measured by immunoassay kits. At day 35, the incidence of CIA was significantly decreased in mice treated with MOX at the GV4 acupoint (78%, nZ23, p < 0.05), compared to untreated CIA mice (100%) and mice treated with MOX at the CV12 acupoint (100%). IL-6 and corticosterone levels were significantly increased by immunization. IL-6 levels significantly decreased in mice treated with MOX at the GV4 acupoint. These results suggest that MOX treatment suppressed CIA at the GV4 acupoint, not at the CV12 acupoint, possibly through inhibition of IL-6 production.
Nozue Goro,Fujiwara Hidenori,Hamamoto Satoru,Kiss Takayuki,Tsutsumi Miwa,Oura Masaki,Ishikawa Tetsuya,Motouri Azusa,Suzuki Shintaro,Tamura Ryuji,Sekiyama Akira 한국물리학회 2023 새물리 Vol.73 No.12
We have performed Ce M4,5-edge X-ray absorption (XAS) and Ce 3d-4f resonance photoemission (RPES) spectroscopies on quasicrystal approximant Au59.2Ga25.7Ce15.1. The 3d94f1 final state originating from the itinerant 4f electronic states is negligible in the Ce M4,5-edge XAS. The Ce 3d-4f RPES spectrum shows the relatively large the spectral weight of the 4f0 final state to that of the 4f1 final state, reflecting the weak hybridization between the localized 4f orbitals and the conduction bands. The localized 4f electronic states in Au59.2Ga25.7Ce15.1 are revealed by both spectroscopies.