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권세진(Sejin Kwon) 한국추진공학회 2008 한국추진공학회지 Vol.12 No.1
Thanks to the breakthroughs in micro fabrication technology, numerous concepts of micro aerospace systems including micro aerial vehicle, nano satellite and micro robot have been proposed. In order to activate these mobile micro systems, high density power in a small scale power source is required. However, we still do not have micro power source that has energy density that can support these systems. In the present article, status of micro power sources are described and alternatives that have been derived from the past experience are proposed.
이중유화법을 통하여 BSA 수용액을 PLGA 마이크로캡슐 입자에 봉입하는 과정에서의 공정변수의 영향
권세진(Sejin Kwon),구자경(Ja-Kyung Koo) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.6
이중유화법을 통하여 BSA 수용액을 봉입하는 PLGA 마이크로캡슐 입자를 제조하였다. 마이크로캡슐 입자 외부의 수용액 상에서는 입자 표면의 경화를 위하여 유화제를 금속염으로 대체하였다. 제조한 마이크로캡슐 입자에 대하여서 모폴로지, 입자직경 BSA 봉입효율 및 in-vitro 방출실험을 수행하였다. 전자현미경(SEM) 촬영을 통하여 마이크로캡슐 입자는 l-7㎛ 유화액 내 내부 수용액 대비 고분자 용액의 부피 비 그리고 입자 외부 수용액에서의 금속염의 농도에 직접적인 영향을 받았다. 또한 이러한 요소는 단백질 봉입효율과 in-vitro 방출에도 일부 영향을 미쳤다. 본 실험에서 제조한 마이크로캡슐 입자는 in-vitro 방출 실험에서 초기에 높은 유속의 방출 현상을 보였다. 그렇지만 본 연구에서 제조한 마이크로캡슐 입자는 다른 연구의 결과에 비해 긴 기간 동안의 방출을 보였다. 이상의 결과를 통해 2가의 금속염이 마이크로캡슐 입자의 제조에서 유화제를 대체할 수 있는 좋은 방편이 될 수 있다는 결론을 내릴 수 있었다. PLGA microcapsule particles encapsulating BSA aqueous solutions were prepared using a water-in-oil-in-water emulsion method. The morphology, particle size, BSA encapsulating efficiency, and in-vitro release test were also studied using the microcapsule particles. In the outer aqueous phase, an emulsifier, e.g., PVA, was replaced with metal salts for surface solidification. Scanning electron microscopy (SEM) showed that the microcapsule particles had smooth surfaces and were between 1㎛ and 7㎛ in size. The micro capsule particle morphology was affected directly by the ratio between the polymer solution and inner aqueous solution, and composition of the outer aqueous solution. The factors also partially affected the BSA encapsulation efficiencies and in-vitro release rates. All the micro capsule particles showed an initial burst release through the in-vitro release test. On the other hand, the particles also showed a relatively long release period. Metal salts could be good choices to replace the emulsifier to solidify the microcapsule particle surfaces.
Yongjun Kwon,Sejin Kim,Marana Park,Juwon Yoo,Joon-Ho Lee 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.05
Effectiveness of Encarsia formosa (Hymenoptera: Aphelinidae) to control Trialeurodes vaporariorum (Hemiptera: Aleyrodidae) was investigated in the commercial tomato greenhouse from January to June, 2010. Densities of T. vaporariorum were monitored using the yellow sticky trap for adult, and a lupe (x10) for 4th instar nymph and pupa at 1 week interval. Tomato seedlings were transplanted in mid-January and the nymph and adult of T. vaporariorum were first discovered in February 4th. E. formosa was applied as a mummy card at a recommended density (3 parasitoids per 1m2) at 2 weeks interval for 8 times. Mummy cards were collected 2 weeks later and the emergence and survival ratio of E. formosa were examined. Density of adult T. vaporariorum was significantly lower in the treatment plot (F=42.48, p=0.0001). The control efficiency ranged from 57.3% to 88.5%. The nymphal density was also significantly lower in the treatment plot (F=8.85, p=0.0053). The control efficiency was 84% on 25th March, 75% on 18th May and 95% on 25th May. Maximum 50% parasitism by E. formosa occurred in the treatment plot. The emergence and survival rates of E. formosa on mummy cardboards that were released in the greenhouse during February to March were only 53% and 41%, respectively. These rates increased to >70% as the temperature rises.
Seasonal Occurrences of Peach Pyralid Moth and Persimmon Fruit Moth in Persimmon Orchards
Hunsung Kim,Taegyun Kim,Yongjun Kwon,Sejin Kim,Joon-Ho Lee 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05
This study was conducted to identify the seasonal occurrence patterns of peach pyralid moth, Dichocroscis punctiferalis (Guenee), and persimmon fruit moth, Satthmopoda masinissa Meyrick, in persimmon orchards in four different regions, Ulsan and Jinyeong in Gyeongsangbuk-do, and Naju and Yeongam in Jeollanam-do. Three pheromone traps (Delta trap, GreeAgro Tech) for each moth species were installed at each site and checked with 1 week intervals. Peach pyralid moth and persimmon fruit moth occurred in all four study sites. Two moth species exhibited two distinctive peaks, but there were some time differences in the peak among sites. Peach pyralid moth first occurred in late May to early June in Ulsan, Jinyeong and Naju but occurred in late July in Yeongam. Overall, the first peak appeared in mid- to late June but the time of the second peak varied widely among sites. Persimmon fruit moth first occurred in early to mid-June in Ulsan, Jinyeong and Naju but occurred in mid-May in Yeongam. The first peak appeared in mid- to late June in Ulsan, Jinyeong and Naju but it appeared in late May in Yeongam. The time of the second peak was around late August in the study sites except Ulsan where the second peak time was in late September.
Sejin Oh,Jaeyoon Lee,Yukang Kim,Kwon-Ho Song,Eunho Cho,Minsung Kim,Heejae Jung,김태우 대한면역학회 2020 Immune Network Vol.20 No.1
Cancer immunotherapy, in the form of vaccination, adoptive cellular transfer, or immune checkpoint inhibitors, has emerged as a promising practice within the field of oncology. However, despite the developing field's potential to revolutionize cancer treatment, the presence of immunotherapeutic-resistant tumor cells in many patients present a challenge and limitation to these immunotherapies. These cells not only indicate immunotherapeutic resistance, but also show multi-modal resistance to conventional therapies, abnormal metabolism, stemness, and metastasis. How can immunotherapeutic-resistant tumor cells render multi-malignant phenotypes? We reasoned that the immune-refractory phenotype could be associated with multi-malignant phenotypes and that these phenotypes are linked together by a factor that acts as the master regulator. In this review, we discussed the role of the embryonic transcription factor NANOG as a crucial master regulator we named “common factor” in multi-malignant phenotypes and presented strategies to overcome multi-malignancy in immunotherapeutic-resistant cancer by restraining the NANOG-mediated multi-malignant signaling axis. Strategies that blunt the NANOG axis could improve the clinical management of therapy-refractory cancer.
권세진 울산대학교 1995 공학연구논문집 Vol.26 No.1
난류 예혼합 제트 화염의 전파에 관한 수치적 연구를 수행하였다. 화염은 얇은 화염편 영역으로 국한하였으며 계산을 용이하게 하기 위하여 기존의 난류 경계층 모델링을 사용하였다. 반응도 변수가 연료 당량비에 무관한 기존 모델의 단점을 극복하기 위하여 생성항에 층류 화염 전파 속도를 포함시켰다. 생성항에 사용된 변수들은 당량비 3.57, 레이놀즈수 40000의 실험 데이터와 합치하도록 선택되어졌다. 모델의 검증을 위하여 기존의 실험 데이터가 알려져 있는 난류 예혼합 제트 화염에 적용하여 그 결과를 비교하였다. 본 연구에서 제안된 모델은 반응도, 난류 화염 전파 속도, 축방향 속도, 축방향 난류 속도 성분 등에서 당량비의 영향을 잘 묘사하고 있으며, 실험치와 같은 경향을 보였으나, 일반적으로 실험치를 다소 과소 평가하였다. A numerical analysis of turbulent premixed jet flames is described, limited to the thin laminar-flamelet regime. To make the computation practical, existing turbulent boundary layer model was used with a modified source term for reaction progress variable. The Source term involves laminar burning velocity in order to account the effects of fuel equivalence ratios. The source term includes additional parameters, which were obtained by matching with the measurements at φ=3.57, Re=40000. Test results of the model were compared with existing measurements of turbulent premixed jet flames. The prosed model describes accurately the effects of fuel equivalence ratios on reaction progress variables, turbulent burning velocities, mean axial velocities on burner axis and axial velocity fluctuations. However the model slightly underestimated the measurements.