http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effect of Developmental Lead Exposure on the Expression of Hippocampal NMDA Receptor Subunit mRNA
Kim, Tae-Wan,Chung, In-Sung,Bae, Jae-Hoon,Shin, Dong-Hoon,Lee, Mi-Young,Kim, Joon-Sik 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4
목적: in vivo 및 vitro에서 해마 신경세포의 발생단계별 NMDA 수용체 아단위 mRNA 발현에 대한 연 폭로 영향을 알아보고자 하였다. 방법: 흰쥐 해마 신경세포의 발생단계별 NMDA 수용체 NR2A, NR2B 아단위 mRNA 발현에 대한 연의 영향은 정상군과 연 폭로군의 출생 후 7일, 14일, 22일 흰쥐의 해마에서 in situ hybridization으로 mRNA 발현 정도를 densitometer로 측정하여 비교하였고, 연과 NMDA 의 세포독성은 해마 신경세포 일차배양 후 도립현미경을 이용한 형태학적인 관찰과 LDH 활성도를 이용하여 측정하였다. 결과: 연 과 NMDA 에 의한 세포독성에 대한 in vitro 실험에서 형태학적 소견과 LDH 활성도에서 해마 미성숙 신경세포와 성숙 신경세포사이의 차이가 있었으므로, 연과 NMDA 독성효과는 해마 신경세포의 발달 단계에 따라 차이가 있다. 정상군의 해마에서의 NR2A mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나, NR2B mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나 NR2B mRNA 발현은 연령의 증가에 따른 변화가 없었다. 연 폭로에 희한 NR2A mRNA 발현은 유의하게 감소하였으나(p<0.05), NR2B mRNA 발현은 변화가 나타나지 않았다. 만성적 연 폭로는 NR2A를 포함하는 NMDA 수용체를 감소시킬 수 있음을 알 수 있다. 결론: 연은 해마신경세포의 발생단계에서 NMDA 수용체 아단위 특히 NR2A mRNA 발현의 변화를 야기하여 시냅스 신호 전달에 영향을 나타냄을 알 수 있었다. Hippocampus
디스패칭 룰 기반의 시뮬레이션 모델을 활용한 S-PMS 설계
이재용(Jae-yong Lee),김상태(Sang-tae Kim),박선영(Seon-young Park),신문수(Moonsoo Shin1),조용주(Yongju Cho) 한국산업경영시스템학회 2015 한국산업경영시스템학회 학술대회 Vol.2015 No.추계
The up-to-date small and medium-sized enterprises (SMEs) in Korea have tried to respond flexibly and rapidly to dynamic business environment and to establish efficient production management system based on information technologies. However, most of SMEs have faced with low applicability of the production management system resulting from high costs of introduction and maintenance. In this paper, a production planning and control system, that is S-PMS (production management system for SMEs), is proposed to solve the problem of low applicability and limited human resources. S-PMS enables production managers to efficiently collect and manage master data with the actual target production systems and explores the bottleneck process by means of simulation techniques to improve productivity. Furthermore, it implements rescheduling mechanism in terms of a variety of process routes. In essence, intuitive dispatching rules and integrated data management of S-PMS improve field applicability of production management system. Consequently, S-PMS is expected to be used as an efficient production management system of SMEs in Korea.
Ancillary signs of subscapularis tendon tear in magnetic resonance arthrography
Sang-Wook Shin,Jeong Ah Ryu,Seung Hyun Kim,Tae-Soo Park 대한정형외과 스포츠의학회 2015 Arthroscopy and Orthopedic Sports Medicine Vol.2 No.2
Background: This study assessed the correlation of ancillary magnetic resonance (MR) arthrographic signs and the presence of subscapularis tendon tears. Methods: Thirty-two consecutive patients who presented with chronic shoulder pain between December 2010 and September 2011 were evaluated using MR arthroscopy and arthroscopy. Arthroscopically, we confirmed that 8 patients sustained a subscapularis tendon tear and 32 did not. Through MR arthroscopy on all the shoulders, we assessed for (1) subluxation, dislocation, or tear of the long head of biceps tendon, (2) tear of the supraspinatus or the infraspinatus tendon, and (3) fatty degeneration of the supraspinatus or the infraspinatus muscle. The MR arthrograms were reviewed by two radiologists who had no prior knowledge of the patient’s medical history for the presence or absence of these MR arthrographic signs. These ancillary signs were correlated to arthroscopically diagnosed subscapularis tears. Results: We found that fatty degeneration of the subscapularis muscle was correlated with statistical significance to having a subscapularis tendon tear (P = 0.018). Subluxation or dislocation of the tendon of the long head of biceps brachii was also correlated but the correlation was not statistically significant. The two radiologists reached a substantial interobserver agreement (K > 0.6) in their assessment of all MR arthrographic signs except the subluxation/dislocation of long head of the biceps tendon (K = 0.59). Conclusion: Fatty degeneration of the subscapularis muscle may be a useful ancillary sign when diagnosing subscapularis tendon tears.
Sang Bin Lee,Doosoo Hyun,Tae-june Kang,Chanseung Yang,Sungsik Shin,Heonyoung Kim,Sungbong Park,Tae-Sik Kong,Hee-Dong Kim IEEE 2016 IEEE transactions on industry applications Vol.52 No.1
<P>Motor current signature analysis (MCSA) has become an essential part of the preventive maintenance program for monitoring the condition of the rotor cage in medium-voltage induction motors in the pulp and paper industry. However, many cases of false indications due to interference from the motor or the load have been reported. False indications can result in unnecessary inspection and outage costs (false positives) or major repair/replacement costs and loss of production (false negatives). The objective of this paper is to present the potential root causes of false indications and provide guidelines on how commercially available offline and online tests can be applied for identifying false indications from a field engineers' perspective. Case studies of false MCSA indications and results of alternative commercial tests for improving the reliability of the diagnosis are provided through measurements on 6.6-kV and laboratory motor samples. Finally, new test methods under research and development for reliable rotor fault detection are summarized, and unresolved problems are listed. This paper is expected to help field maintenance engineers prevent unnecessary motor inspection and forced outages and guide researchers target future research toward industrial needs.</P>
No Association between PIK3CA Polymorphism and Lung Cancer Risk in the Korean Population
Sung, Jae-Sook,Park, Kyong-Hwa,Kim, Seung-Tae,Seo, Jae-Hong,Shin, Sang-Won,Kim, Jun-Suk,Kim, Yeul-Hong Korea Genome Organization 2010 Genomics & informatics Vol.8 No.4
The PIK3CA gene, oncogenic gene located on human chromosome 3q26.3, is an important regulator of cell proliferation, death, motility and invasion. To evaluate the role of PIK3CA gene in the risk of Korean lung cancer, genotypes of the PIK3CA polymorphisms (rs11709323, rs2699895, rs3729679, rs17849074 and rs1356413) were determined in 423 lung cancer patients and 443 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the PIK3CA gene were not significantly associated with the risk of lung cancer in the Korean population, suggesting that these PIK3CA polymorphisms do not contribute to the genetic susceptibility to lung cancer in the Korean population.
Analysis of QTLs for vegetative stage drought tolerance using DH population in rice
Tae-Heon Kim,Soo-Kwon Park,Woon-Ha Hwang,Jong-Hee Lee,Sang-Ik Han,Jun-Hyun Cho,You-Chun Song,Min-Hee Nam,Dong-Soo Park,Dong-Jin Shin 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Drought is a one of the most serious abiotic stresses limiting rice production. However, little progress has been made in the genetic analysis of drought tolerance, because it is a complex trait controlled by a number of genes and affected by various environmental factors. The most efficient method for drought tolerance breeding is using drought tolerance genetic resources. We used a doubled-haploid (DH) population consist of 101 lines derived from a cross the drought tolerant cultivar ‘Samgang’ and the drought sensitive cultivar ‘Nagdong’ for QTL analysis. Drought stress was treated by withholding water for 6 weeks, and then rewatered for 7 days. After rewatering visual phenotype was observed according to the standard evaluation system for rice, IRRI. Drought sensitive parent ‘Nagdong’ was almost died, while tolerant parent ‘Samgang’ showed slightly leaf tip dring phenotype. The qdr11 detected on chromosome 11 with flanking markers RM26755-RM287 and accounted for 19% phenotype variation with a LOD score of 3.7.
( Shin Hwang ),( Young-joo Lee ),( Ki-hun Kim ),( Chul-soo Ahn ),( Deok-bog Moon ),( Tae-yong Ha ),( Seung-mo Hong ),( Eun Sil Yu ),( Sung-gyu Lee ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Purpose: Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is rare. We investigated the clinicopathological features of cHCC-CC and analyzed the prognostic influence of tumor type according to the 2010 WHO classification. Methods: A cohort of 100 patients with cHCC-CC who underwent resection from July 2012 to June 2015 was selected as the study group. The control group comprised 200 propensity score-matched patients with intrahepatic cholangiocarcinoma (ICC). Results: The mean tumor diameter of the cHCC-CC group was 4.4±2.8cm and 95 patients had single tumor disease. The cancers were classified as classical in 46 patients and subtypes with stem cell features in 54. The latter was further subdivided into typical (n=12), intermediate-cell (n=18), cholangiocellular (n=11), and un- classified (n=13) subtypes. Their 1- and 3-year tumor recurrence vs patient survival rates were 31.7% vs 92.5% and 59.8% vs 77.3%, respectively (Fig. 1). There was definite prognostic stratification of tumor recurrence and patient survival rates according to the tumor type (P ≤ 0.008). There was no difference in tumor recurrence compared with the ICC control group (P=0.523) but the cHCC-CC group showed better survival (P=0.008). The cHCC-CC group of subtypes with stem cell features showed better survival (P=0.001), but no significant survival difference was observed between the cHCC-CC classical group and the ICC control group (P=0.058). Conclusion: cHCC-CC is a neoplasm with wide histologic diversity, indicating a strong association with hepatic progenitor cells. A close relationship exists between prognosis and tumor type according to the 2010 WHO classification. The complex mixture of histologic subtypes remains a challenge for the definitive classification of cHCC-CC.
Laparoscopic Transabdominal Transfer of Blastocysts in Korean Black Goats
Sang-Cheol Cho,Jong-Ki Cho,Sang Tae Shin 한국수정란이식학회 2017 한국동물생명공학회지 Vol.32 No.2
As a part of the effort to improve post-transfer survival rate of embryos in Korean black goats, a technique for laparoscopic uterine transfer of blastocysts was carried out. A total of 26 transferrable embryos (morula to expanded blastocysts) were transferred to 13 recipient goats via transabdominal laparoscopic method. In consequence of our hormone protocol, 65% of the recipients (13/20) were found to have synchronized estrus. After confirmation of corpus luteum in each recipient goat, a Babcock laparoscopic forceps was inserted into the lower abdominal cavity to hold a uterine horn and fasten it near the peritoneum without causing injury. Then 7.5cm long 16G IV catheter was inserted directly into the uterine lumen through the abdominal wall. After removal of the stylet of the IV catheter, the embryo transfer tube (identical in size to the stylet and loaded with blastocysts) was inserted into the uterine lumen through the catheter to unload the embryos. Of the 13 estrus synchronized recipients, 9 were transferred blastocysts and 4 were transferred molurae (2 embryos in each recipient) in uterine ipsilateral to the ovary with corpus luteum. Four of the 9 recipients which blastocysts were transferred using this method has been confirmed pregnant (44.4% pregnancy rate).