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( Sang Gyun Kim ),( Ho June Song ),( Il Ju Choi ),( Joo Young Cho ),( Hwoon Yong Jung ),( Bora Keum ),( Jae Hee Cheon ),( Yong Chan Lee ),( Jae Gyu Kim ),( Sue K. Park ),( Byung Joo Park ),( Hyun Chae 대한소화기기능성질환·운동학회 2010 Gut and Liver Vol.4 No.4
Background/Aims: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. This study involved designing a randomized, double-blinded, placebo-controlled, multicenter trial, performed by the Korean College of Helicobacter and Upper Gastrointestinal Research and the Medical Research Collaboration Center, Seoul National University Hospital. Methods: We intend to enroll up to 232 patients H.-pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection. The enrolled patients are being randomly allocated to the H.-pylori-eradication-plus-proton-pump-inhibitor group or the placebo-plus-proton-pump-inhibitor group based on their histology results and the size of the resected specimen. After random allocation, the iatrogenic ulcer size and stage are evaluated at 4- and 8-week follow-ups (with a window of ±7 days). The primary end point is the healing rate of the ulcer by stage, and the secondary end point is the rate of ulcer size reduction, relief rate from ulcer-related symptoms, and adverse-event rates. Results: More than 90% of the target subjects have already been enrolled into the study and are receiving ongoing periodic monitoring by the Medical Research Collaboration Center. Conclusions: Completion of the study should reveal whether H. pylori eradication can facilitate the healing of ulcer after endoscopic resection in Korea. (Gut Liver 2010;4:514-517)
( June Hong Kim ),( Jae Hoon Choi ),( Hyun Kook Lee ),( Woo Hyung Bae ),( Kook Jin Chun ),( Yun Seong Kim ),( Sang Kwon Lee ),( Hyung Hoi Kim ),( Taek Jong Hong ),( Yong Woo Shin ) 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.3
Background/Aims: We examined the ischemia-modified albumin (IMA) level during exercise in patients with coronary artery disease (CAD). Methods: Forty patients with a history of chest pain underwent both symptom-limited treadmill exercise stress testing and coronary angiography within one week. During the treadmill tests, blood samples were obtained at baseline and 5 min after exercise to measure the serum IMA level. Results: Of the 40 patients, fourteen (35%, CAD group) had significant coronary artery stenosis, while the other 26 (65%, non-CAD group) did not. The baseline and post-exercise IMA levels in the two groups did not differ significantly (105.2±7.2 vs. 107.7±6.7 U/mL at baseline and 93.1±10.1 vs. 94.8±5.7 U/mL at post-exercise in the CAD and non-CAD groups, p=0.29 and 0.57, respectively). The changes in IMA after exercise did not differ either (-10.4±7.5 vs. -14.0±7.6 U/mL in the CAD and non-CAD groups, respectively, p=0.10). Similarly, the change in IMA between the exercise ECG test positive (TMT positive, n=9) and negative (TMT negative, n=20) groups did not differ (-14.63±5.19, vs -8.50±9.01 U/mL, p=0.15, in the TMT positive and negative groups, respectively). Conclusions: Our results suggest that IMA has limitation in detecting myocardial ischemia during symptom-limited exercise stress tests.
Choi, Hongyoon,Bang, Ji-In,Cheon, Gi Jeong,Kim, Yong Hwy,Park, Chul-Kee,Park, Sung-Hye,Kang, Keon Wook,Chung, June-Key,Kim, Euishin E.,Lee, Dong Soo Wolters Kluwer Health | Lippincott Williams Wilkin 2015 Nuclear medicine communications Vol.36 No.3
INTRODUCTION: Methylation status of the methyl-guanine methyltransferase (MGMT) promoter is associated with a favorable response to a DNA alkylating agent in high-grade gliomas. We analyzed PET scans of patients with high-grade gliomas to determine whether the MGMT methylation status affects the tumor metabolic characteristics. PATIENTS AND METHODS: Twenty-three patients with high-grade glioma, who were initially examined with C-methionine (MET) and F-fluorodeoxyglucose (FDG) PET, were retrospectively enrolled. MET and FDG PET images were coregistered to each other and quantitative uptake of MET or FDG was assessed using tumor-to-normal uptake ratio of the cortex (TNR). TNRs for MET and FDG PET were compared between the two groups classified by MGMT promoter methylation status. RESULTS: Maximum TNRFDG of the MGMT methylated group was significantly higher than that of the MGMT unmethylated group (1.80±0.90 vs. 1.29±0.19; P=0.02). The MGMT methylated group also showed a trend for increased mean TNRFDG compared with the unmethylated group (0.85±0.21 vs. 0.72±0.11; P=0.10). There was no significant difference in TNRMET between the groups. In subgroup analyses with WHO grade 3 and 4, a trend for higher maximum TNRFDG was found in the MGMT methylated group compared with the unmethylated group. CONCLUSION: The MGMT methylated group showed higher glucose metabolism compared with the unmethylated group, whereas MET uptake did not show a significant difference. This suggests that MGMT methylation in high-grade gliomas could affect the tumor glucose metabolism. Thus, MGMT methylation status can cause a discrepancy in the prognostic prediction of high-grade gliomas by FDG PET, especially in patients scheduled for DNA alkylating chemotherapeutics.
Open Channel Block of Kv3.1 Currents by Fluoxetine
Sung, Min Ji,Ahn, Hye Sook,Hahn, Sang June,Choi, Bok Hee The Japanese Pharmacological Society 2008 Journal of pharmacological sciences Vol.106 No.1
<P>The action of fluoxetine, a serotonin reuptake inhibitor, on the cloned neuronal rat Kv3.1 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Fluoxetine reduced Kv3.1 whole-cell currents in a reversible, concentration-dependent manner, with an IC<SUB>50</SUB> value and a Hill coefficient of 13.4 μM and 1.4, respectively. Fluoxetine accelerated the decay rate of inactivation of Kv3.1 currents without modifying the kinetics of current activation. The inhibition increased steeply between 0 and +30 mV, which corresponded with the voltage range for channel opening. In the voltage range positive to +30 mV, inhibition displayed a weak voltage dependence, consistent with an electrical distance δ of 0.38. The binding (k<SUB>+1</SUB>) and dissociation (k<SUB>−</SUB><SUB>1</SUB>) rate constants for fluoxetine-induced block of Kv3.1 were 5.7 μM<SUP>−</SUP><SUP>1</SUP>s<SUP>−</SUP><SUP>1</SUP> and 53.5 s<SUP>−</SUP><SUP>1</SUP>, respectively. The theoretical K<SUB>D</SUB> value derived by k<SUB>−</SUB><SUB>1</SUB>/k<SUB>+1</SUB> yielded 9.3 μM. Fluoxetine did not affect the ion selectivity of Kv3.1. Fluoxetine slowed the deactivation time course, resulting in a tail crossover phenomenon when the tail currents, recorded in the presence and absence of fluoxetine, were superimposed. Inhibition of Kv3.1 by fluoxetine was use-dependent. The present results suggest that fluoxetine acts on Kv3.1 currents as an open-channel blocker.</P>
QUADRATIC TRANSFORMATIONS INVOLVING HYPERGEOMETRIC FUNCTIONS OF TWO AND HIGHER ORDER
Choi, June-Sang,Rathie, Arjun K. The Youngnam Mathematical Society Korea 2006 East Asian mathematical journal Vol.22 No.1
By applying various known summation theorems to a general transformation formula based upon Bailey's transformation theorem due to Slater, Exton has obtained numerous and new quadratic transformations involving hypergeometric functions of order greater than two(some of which have typographical errors). We aim at first deriving a general quadratic transformation formula due to Exton and next providing a list of quadratic formulas(including the corrected forms of Exton's results) and some more results.
Management of Otogenic Brain Abscess Using the Transmastoid Approach
Choi, June,Choi, Jong Il,Kim, Sang-Dae The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.55 No.3
Despite significant advances in the treatment of all forms of chronic otitis media (COM), complications still can and do occur, with intracranial complications representing the most life-threatening cases, often requiring immediate therapeutic intervention. Herein, we present a rare case of rapidly progressing facial paralysis with concomitant severe headache and ipsilateral hearing loss secondary to an otogenic brain abscess, treated with the transmastoid approach, drainage, and facial nerve decompression.
Choi, Hongyoon,Phi, Ji Hoon,Paeng, Jin Chul,Kim, Seung-Ki,Lee, Yun-Sang,Jeong, Jae Min,Chung, June-Key,Lee, Dong Soo,Wang, Kyu-Chang MIT Press 2013 Molecular imaging Vol.12 No.4
<P>Enhanced expression of integrin αvβ3 is commonly used as a biomarker for angiogenesis, which is one of the key pathophysiologic processes in cerebral infarct. Integrin αvβ3 can be imaged with arginine-glycine-aspartic acid (RGD) peptide agents. In this study, characteristics of positron emission tomography (PET) using a 68Ga-labeled RGD were investigated in pediatric cerebral infarct. Pediatric patients with moyamoya disease underwent 68Ga-RGD PET in a research protocol for neovascularization evaluation. In these patients, 17 cerebral infarct lesions of 10 patients were included in the analysis. On 68Ga-RGD PET, the infarct lesion to contralateral brain ratio (LCR) of the infarct lesion was measured and analyzed with regard to postinfarct time interval (PTI) and perfusion single-photon emission computed tomography (SPECT) findings. An increase in 68Ga-RGD uptake was observed in cerebral infarct, particularly in recent lesions. The LCR was significantly higher in the recent than in the chronic lesions, and a significant correlation existed between the LCR and PTI. Additionally, the LCR was significantly higher in the lesions with hyperperfusion on SPECT. This study, as the first human study using an RGD agent for in vivo cerebral infarct imaging, demonstrated that 68Ga-RGD PET has a potential for molecular imaging of integrin αvβ3 expression in cerebral infarct as a biomarker of angiogenesis.</P>
Olfactory Interaction based on ISO/IEC 23005 Standard
Choi, Jang-Sik,Chang, Sung-June,Lee, Hae-Ryong,Byun, Hyung-Gi The Korean Sensors Society 2017 센서학회지 Vol.26 No.5
Realistic media comprised of metadata of the five senses to provide enhanced experiences by stimulating our memory and sensations have had an increasingly pervading effect in our daily lives. Many researchers and companies are in the process of developing their own authoring systems running on different platforms to serve realistic media, resulting in compatibility issues among the systems. To tackle these issues, the International Organization for Standardization have standardized the interface, data format, protocol, API, etc. required to provide the realistic media. In particular, the ISO/IEC 23005 standard, which is called MPEG-V in SC29/WG 11, has defined XML schemas for olfaction interaction based on electronic nose (E-Nose), and scent display. In this paper, the MPEG-V standard for olfaction interaction is reviewed, and a data flow diagram that can be used for olfactory interaction based on the MPEG-V standard was designed. In addition, the necessary schemas related to the E-Nose sensor for olfactory interaction was provided.
Choi, Yeon Sik,Sung, Jinwoo,Kang, Seok Ju,Cho, Sung Hwan,Hwang, Ihn,Hwang, Sun Kak,Huh, June,Kim, Ho‐,Cheol,Bauer, Siegfried,Park, Cheolmin WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.9
<P><B>Abstract</B></P><P>Films made of 2D networks of single‐walled carbon nanotubes (SWNTs) are one of the most promising active‐channel materials for field‐effect transistors (FETs) and have a variety of flexible electronic applications, ranging from biological and chemical sensors to high‐speed switching devices. Challenges, however, still remain due to the current hysteresis of SWNT‐containing FETs, which has hindered further development. A new and robust method to control the current hysteresis of a SWNT‐network FET is presented, which involves the non‐volatile polarization of a ferroelectric poly(vinylidene fluoride‐trifluoroethylene) (P(VDF‐TrFE)) gate insulator. A top‐gate FET with a solution‐processed SWNT‐network exhibits significant suppression of the hysteresis when the gate‐voltage sweep is greater than the coercive field of the ferroelectric polymer layer (≈50 MV m<SUP>−1</SUP>). These near‐hysteresis‐free characteristics are believed to be due to the characteristic hysteresis of the P(VDF‐TrFE), resulting from its non‐volatile polarization, which makes effective compensation for the current hysteresis of the SWNT‐network FETs. The onset voltage for hysteresis‐minimized operation is able to be tuned simply by controlling the thickness of the ferroelectric film, which opens the possibility of operating hysteresis‐free devices with gate voltages down to a few volts.</P>