Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea

Jin-Kyoung Oh,Hwa Young Choi,Minji Han1,Yuh-Seog Jung,Sang Joon Lee,Moran Ki 한국역학회 2021 Epidemiology and Health Vol.43 No.-

OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea. METHODS: We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1). RESULTS: During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis. CONCLUSIONS: The estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.

AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.

Han, Jung Min,Park, Bum-Joon,Park, Sang Gyu,Oh, Young Sun,Choi, So Jung,Lee, Sang Won,Hwang, Soon-Kyung,Chang, Seung-Hee,Cho, Myung-Haing,Kim, Sunghoon National Academy of Sciences 2008 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.105 No.32

<P>AIMP2/p38 is a scaffolding protein required for the assembly of the macromolecular tRNA synthetase complex. Here, we describe a previously unknown function for AIMP2 as a positive regulator of p53 in response to genotoxic stresses. Depletion of AIMP2 increased resistance to DNA damage-induced apoptosis, and introduction of AIMP2 into AIMP2-deficient cells restored the susceptibility to apoptosis. Upon DNA damage, AIMP2 was phosphorylated, dissociated from the multi-tRNA synthetase complex, and translocated into the nuclei of cells. AIMP2 directly interacts with p53, thereby preventing MDM2-mediated ubiquitination and degradation of p53. Mutations in AIMP2, affecting its interaction with p53, hampered its ability to activate p53. Nutlin-3 recovered the level of p53 and the susceptibility to UV-induced cell death in AIMP2-deficient cells. This work demonstrates that AIMP2, a component of the translational machinery, functions as proapoptotic factor via p53 in response to DNA damage.</P>

Evaluation of Treatment Response after Endoscopic Variceal Obturation with Abdominal Computed Tomography

Han Ah Lee,Hyun Gil Goh,Tae Hyung Kim,Young-Sun Lee,Sang Jun Suh,Young Kul Jung,Hyuk Soon Choi,Eun Sun Kim,Ji Hoon Kim,Hyunggin An,Yeon Seok Seo,Hyung Joon Yim,Sung Bum Cho,Yoon Tae Jeen,Jong Eun Yeon 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.1

Backgrounds/Aims: Rebleeding of gastric varices (GVs) after endoscopic variceal obturation (EVO) can be fatal. This study was performed to evaluate the usefulness of computed tomography (CT) for the prediction of rebleeding after EVO GV bleeding. Methods: Patients who were treated with EVO for GV bleeding and underwent CT before and after EVO were included. CT images of the portal phase showing pretreatment GVs and feeding vessels, and nonenhanced images showing posttreatment cyanoacrylate impaction were reviewed. Results: Fifty-three patients were included. Their mean age was 60.6±11.6 years, and 40 patients (75.5%) were men. Alcoholic liver disease was the most frequent underlying liver disease (45.3%). Complete impaction of cyanoacrylate in GVs and feeding vessels were achieved in 40 (75.5%) and 24 (45.3%) of patients, respectively. During the follow-up, GV rebleeding occurred in nine patients, and the cumulative incidences of GV rebleeding at 3, 6, and 12 months were 11.8%, 18.9%, and 18.9%, respectively. The GV rebleeding rate did not differ significantly according to the complete cyanoacrylate impaction in the GV, while it differed significantly according to complete cyanoacrylate impaction in the feeding vessels. The cumulative incidences of GV rebleeding at 3, 6, and 12 months were 22.3%, 35.2%, and 35.2%, respectively, in patients with incomplete impaction in feeding vessels, and there was no rebleeding during the follow-up period in patients with complete impaction in the feeding vessels (p=0.002). Conclusions: Abdominal CT is useful in the evaluation of the treatment response after EVO for GV bleeding. Incomplete cyanoacrylate impaction in feeding vessels is a risk factor for GV rebleeding.

The Stability Evaluation on HTS Power Cable

Joon-Han Bae,Suk-Jin Choi,Sang-Jin Lee,Ki-Deok Sim,Jeon-Wook Cho,Ho-Min Kim IEEE 2008 IEEE transactions on applied superconductivity Vol.18 No.2

<P>In order to evaluate the stable operation of high temperature superconducting (HTS) power cable, the calculation of AC loss on HTS power cable is important factor. Because AC loss has a big effect on many superconducting equipments, which are fabricated using the HTS tape. In general, AC loss of the HTS tape can be calculated by using voltage variations of the tape with respect to the external magnetic field when AC current applied to the tape. In case of HTS power cable carrying AC current, however, because the magnetic field distribution in the cable is very complicated, it is hard to compute AC loss of the HTS cable directly using above method. In this paper, the stability evaluation of the HTS power cable was performed by the following procedures. Firstly, the voltage variations of the HTS tape carrying AC current in the external magnetic field with different field angle were measured and the magnetic field distribution of HTS power cable with AC current was analyzed. Then, AC loss of the HTS power cable was calculated by using the results of both the measurement and the analysis. The stable operation of the HTS power cable was evaluated on the basis of AC loss of the cable.</P>

Comparison of Risk Prediction Model for Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis Receiving Antiviral Therapy

( Sang Jun Suh ),( Hyung Joon Yim ),( Young-sun Lee ),( Han Ah Lee ),( Tae Hyung Kim ),( Sun Young Yim ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Soon 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Various models for the prediction of hepatocellular carcinoma (HCC) in the patients with chronic hepatitis B (CHB) were suggested. The aim of study is to identify if the HCC risk scores are improved as antiviral therapy is prolonged in the patients with CHB-related liver cirrhosis. Methods: The patients with CHB who received entecavir (ETV) or tenofovir (TDF) were investigated retrospectively. Patients with liver cirrhosis patients diagnosed by sonography, CT or biopsy were enrolled. We calculated the HCC risk scores at pre-antiviral therapy, and each year from year 1 to 5 of post-antiviral therapy. The models were GAG-HCC, CU-HCC, REACH-B, modified REACH-B (mREACH-B), LSM-HCC, and PAGE-B. The primary endpoint was decrease of the risk scores after antiviral therapy. The secondary endpoint was finding the best model by AUROC after antiviral therapy. Results: A total of 362 patients were enrolled, and 198 and 164 patients were treated by ETV and TDF respectively. Child- Pugh scores were 5.7±1.3 and MELD were 9.9±3.8. Fifty six patient (15.5 %) occurred HCC at median 1.6 years (0.1-9.7 years). Most HCC scores (GAG, CU-HCC, REACH-B) decreased at year 1 and plateaued from year 1 to 5. mREACH-B and LSM-HCC scores decreased until year 2 and plateaued after year 2. PAGE-B showed no decrease from pre to post-antiviral therapy. The AUROC of PAGE-B was largest at baseline (GAG-HCC 0.472, CU-HCC 0.753, REACH-B 0.633, mREACH-B 0.688, LSM-HCC 0.649, and PAGE-B 0.760). After antiviral therapy, the AUROC changed. AUROCs of models employing HBV DNA levels increased (GAG-HCC, REACH-B, and LSM-HCC), that of liver stiffness based models (mREACH-B and PAGE-B) were persistent, and that of models employing hepatic function (CU-HCC) decreased (GAG-HCC 0.582, CU-HCC 0.686, REACH-B 0.689, mREACH-B 0.689, LSM-HCC 0.716, and PAGE-B 0.755 at 1year). The decrease of scores from baseline to each years were not different between ETV and TDF (all P>0.05). AUROC were largest in PAGE-B, however the scores were not changed after antiviral therapy. Second largest AUROC is that of LSM-HCC at year 1 and its AUROC became larger after antiviral therapy Conclusions: In conclusion, HCC prediction models such as PAGE-B and LSM-based models worked well in patients with HBV-related cirrhosis and decrease of the scores was associated with effects of the antiviral therapy.

C-jun N-terminal kinase regulates the interaction between 14-3-3 and Bad in ethanol-induced cell death

Han, Jae Yoon,Jeong, Eun Young,Kim, Yoon Sook,Roh, Gu Seob,Kim, Hyun Joon,Kang, Sang Soo,Cho, Gyeong Jae,Choi, Wan Sung Wiley Subscription Services, Inc., A Wiley Company 2008 JOURNAL OF NEUROSCIENCE RESEARCH - Vol.86 No.14

<P>Activation of the c-jun N-terminal kinase (JNK) is known to be an important step during ethanol-induced cell death, but it has yet to be identified how JNK regulates apoptosis. Therefore, we investigated the mechanism by which JNK induces cell death following ethanol treatment. Ethanol (6 g/kg, 20% in saline) was administered subcutaneously to postnatal 7 day rat pups. Twelve hours after the first ethanol administration, rat pups were decapitated, and extracts of total protein from cerebral cortices were prepared. Ethanol exposure induced phosphorylation of JNK but did not affect the expression levels of pro- and antiapoptotic proteins. Furthermore, interactions of phospho-JNK (p-JNK) with 14-3-3 as well as with Bad were enhanced in the cerebral cortices of ethanol-treated rats. Pretreatment with JNK inhibitor (SP600125) of SH-SY5Y cells inhibited JNK phosphorylation and interaction between p-JNK and 14-3-3 resulting from ethanol. Furthermore, 14-3-3 interaction with Bad was diminished in the cerebral cortices of ethanol-treated rats. These findings suggest that JNK induces Bad release from 14-3-3 by inhibiting their interaction. After this event, Bad binds to Bcl-xL, releasing Bax from Bcl-xL and leading to cell death. We hypothesize that JNK may play an important role during ethanol-induced cell death via the inhibition of antiapoptotic function of 14-3-3 as well as activation of proapoptotic function of Bad. © 2008 Wiley-Liss, Inc.</P>

Aminoacyl-tRNA Synthetase-Interacting Multifunctional Protein 1/p43 Controls Endoplasmic Reticulum Retention of Heat Shock Protein gp96 : Its Pathological Implications in Lupus-Like Autoimmune Diseases

Han, Jung Min,Park, Sang Gyu,Liu, Bei,Park, Bum-Joon,Kim, Jin Young,Jin, Cheng He,Song, Yeong Wook,Li, Zihai,Kim, Sunghoon Elsevier 2007 The American journal of pathology Vol.170 No.6

<P>Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1; previously known as p43) is a multifunctional protein that was initially found in multitRNA synthetase complex. In the present study, screening of the AIMP1-binding proteins revealed that AIMP1 can form a molecular complex with heat shock protein gp96. AIMP1 enhances gp96 dimerization and the interaction between gp96 and KDEL receptor-1 (KDELR-1), which mediates the retrieval of KDEL-containing proteins from Golgi to the endoplasmic reticulum (ER). The interaction between gp96 and KDELR-1 was reduced in AIMP1-deficient cells, and this disturbed ER retention of gp96 and increased its cell surface localization. Moreover, this localization of gp96 at the cell surface was suppressed by its interaction with AIMP1 and enhanced by the depletion of endogenous AIMP1. In addition, AIMP1-deficient mice showed dendritic cell activation attributable to increased gp96 surface presentation and lupus-like autoimmune phenotypes. These results suggest that AIMP1 acts as a regulator of the ER retention of gp96 and provide a new perspective of the regulatory mechanism underlying immune stimulation by gp96.</P>

Effects of onion peel water extracts on swimming endurance in rat

Joon-Ho Choi, Sang-Jun Han, Sunhwa Hong, Sang-Ho Park, Yung-Ho Chung, Okjin Kim 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.2

Onion (Allium cepa L.) contains high levels of dietary fibers and antioxidants, including vitamin C, D, and folates. Onion is also known as a quercetin-rich vegetable with high flavonoid content. Onion peel contains over 20 times more quercetin than onion flesh. The aim of this study was to examine the question of whether onion peel extract supplementation has an effect on maximal exercise performance in rat. Onion peel extracts were extracted with hot water. Thirty male Sprague Dawley rats were maintained on a pellet diet for one week, and then randomly divided into five groups: Normal control, Positive control (quercetin 20 mg/kg), Onion peel 4 mg/kg, Onion peel 20 mg/kg, and Onion peel 100 mg/kg. Oral administration was performed daily. The experimental period was four weeks. Thereafter, animals were then forced to swim in water and the maximal exercise performance period from the swimming start time to the exhausted time, in which they failed to rise to the surface of the water to breathe within a 7 second period, was measured. After necropsy, weights of gastrocnemius muscles were measured. Lactate dehydrogenase concentration in serum was measured using an enzymatic method, using a commercial kit. The maximal exercise performance period was significantly longer in the onion peel extracts fed groups, compared with the control group. The lactate dehydrogenase concentration of the onion peel extracts fed groups was significantly lower, compared with the control group. Based on these results, we suggest that onion peel water extract supplementation can enhance exercise capacity caused by the mechanism of decreasing lactate dehydrogenase concentration.

Design and Characteristic Analysis on the Short-Stator Linear Synchronous Motor for High-Speed Maglev Propulsion

Han-Wook Cho,Ho-Kyoung Sung,So-Young Sung,Dae-Joon You,Seok-Myeong Jang IEEE 2008 IEEE transactions on magnetics Vol.44 No.11

<P>The design and characteristic analysis on the linear synchronous motor (LSM) for high-speed maglev propulsion is discussed. We describe the techniques for the design, analysis, construction, and experiment of a prototype propulsion system with short-stator LSM. On the basis of a 2-D analytical field analysis, this paper predicts the magnetic field due to dc excitation and three-phase winding current, the back-EMF, and the electromagnetic torque characteristics. The results are validated extensively by comparison with finite-element analysis and experiment. The propulsion performance was tested by using a high-speed rotary type test wheel with linear peripheral speed up to 283 km/h.</P>

Surgical Resection versus Radiofrequency Ablation in Single Small Hepatocellular Carcinoma: Data from Korea Central Cancer Registry for Hepatocellular Carcinoma Database

( Han Ah Lee ),( Yoo Ra Lee ),( Tae Hyung Kim ),( Sun Young Yim ),( Young-sun Lee ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Dong-sik Kim ),( Hyung Joon Yim ),( Jong Eun 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: This study compared the survival benefits between surgical resection and radiofrequency ablation (RFA) in single small hepatocellular carcinoma (HCC). Methods: Patients registered in the database of Korea central cancer registry for HCC between 2008 and 2014 who received surgical resection or RFA for a single HCC of maximum size 3cm were reviewed. The cumulative overall survival (OS) and retreatment-free survival (RFS) were compared according to the type of treatment. Results: A total of 1426 patients were included, 662 (46.4%) in the resection group and 764 (53.6%) in the RFA group. The 5-year OS rates were 91.8% for resection, and 84.9% for RFA, respectively (P<0.001). The 5-year RFS rates were 77.8% for the resection and 70.5% for RFA, respectively (P=0.002). In patients with maximum tumor size <2cm, there was no significant difference in 5-year OS rates between the two groups (91.8% for resection, and 87.5% for RFA, respectively; P=0.094), while resection was superior to RFA in the 5-year RFS rates (81.0% for resection, and 72.3% for RFA, respectively; P=0.017). Resection was superior in both 5-year OS and RFS rates in those with maximum tumor size ≥2cm and <3cm (91.9% for resection, and 80.2% for RFA, respectively; P<0.001; 76.2% for resection, and 67.2% for RFA, respectively; P=0.007). In the entire cohort, type of treatment (HR 1.457, P=0.032), age (HR 1.031, P<0.001), serum albumin (HR 0.466, P<0.001), and serum creatinine level (HR 1.282, P<0.001) were independently associated with survival. Type of treatment (HR 1.544, P<0.001) and maximum size of tumor (HR 1.353, P=0.002) were independent predictors of RFS. Conclusions: In patients with maximum tumor size <2cm, OS is comparable between resection and RFA groups, while RFS is better in resection group. Surgical resection is superior in both OS and RFS in patients with maximum tumor size ≥2cm and <3cm.