Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

벡터드라이버를 이용한 편측형 선형유도전동기 구동특성에 관한 연구

장용해,임홍우,신사현,조금배,백형래 조선대학교 에너지.자원신기술연구소 2001 에너지·자원신기술연구소 논문지 Vol.23 No.2

The input voltage of Single-sided linear induction motors (SLIMs) is involved with the time harmonics because most LIM is driven by inverter. Therefore the equivalent circuit for an inverter-fed SLIM has t o be modifided to represent every harmonic present in supply voltage. This paper describes that the dynamic characteristic can be used effectively for analyzing the characteristics of a single-sided linear induction motor using vector driver for PI controller.

광연대 측정의 원리와 응용

노희삼,홍사용,류지욱,이춘우 공주대학교 기초과학연구소 2000 自然科學硏究 Vol.9 No.-

광연대 측정의 기본 원리와 몇 가지 응용을 기술하였다. 광 연대측정은 결정체의 결함이 외부 에너지원으로부터 자극을 받아 여기된 전자를 구속할 있으며 구속된 전자는 열이나 빛과 같은 외부 자극에 의해 바닥 상태로 전이되며 이 때 빛을 발생하는 원리를 이용한다. 광연대 측정은 몇 십년 단위부터 몇 십만년 단위의 연대 측정이 가능하며 고고학적 지질학적 연구에 적합하다. The basic theory of the luminescence dating and its applications is described. The optical dating utilizes that crystal defects can trap electrons excited by natural radioactivity and give luminescence when external stimulat'ion such as light and heat, is applied. The range of the optical dating is from a few decades to hundreds of thousand years, which is useful for both archeological and geological dating. There are some commercially available systems, which automate the measurements.

와편의 연대결정에서 SAAD방법과 SAR방법으로 측정한 연대측정 결과 비교

김현식,홍사용,서만철 공주대학교 문화재보존과학연구소 2003 문화재과학기술 Vol.2 No.1

경기도 하남시 천왕사지에서 채취한 와편으로부터 석영을 분리하여 SAAD방법과 SAR방법을 적용 연대를 측정하였다. SAAD 방법에 의한 자연축적선량 값은 5.37±0.32Gy, SAR 방법에 의한 값은 5.40±0.22Gy이었다. 이것은 오차범위 내에서 일치하는 값이다. 연간선량은 4.31±0.17Gy/ka로, 측정연대는 SAAD방법의 경우 AD 756±53년, SAR방법의 경우 AD 750±45년이다. The roof tiles excavated from Cheonwangsaji at Hanam-shi in Gyeonggi province were dated by using SAAD and SAR protocols. The paleodoses by SAAD and SRR protocols were 5.37±0.32 Gy and 5.40±0.22 Gy, which were agreed with in the range of the measurement error. The evaluated dose rate from the soil around the excavated roof tiles and the tile themselves was 4.31±0.17Gy/ka and the ages of the roof tiles were determined to be (756±53)AD by SAAD and (750±45)AD by SAR.

다공질 실리콘의 미세구조에 관한 연구

金英猷,洪思容,崔哲鍾 公州大學校 基礎科學硏究所 1994 自然科學硏究 Vol.3 No.-

단결정 실리론(p형)을 불화수소 속에서 양극 산화반응으로 다공질 실리콘을 제작하고 SEM과 AFM을 이용하여 그 미세구조를 조사하였다. 그리고 액체접촉에 의한 전기루미네선스(EL) 결과와 비교하여 논의 하였다. 이 결과 다공질 실리콘의 표면에는 0.1㎛정도의 미세입자가 형성되었으며, 이때 입자의 외형은 제작시간의 증가에 따라 다공도가 증가하여 입자로서의 형태가 뚜렷해졌으며 그 크기는 약간 작아졌다. 이 입자를 AFM으로 관찰한 결과 10nm정도의 미세한 실리콘 기둥과 이들 사이의 구멍으로 형성된 미세한 세선(細線)으로 형성되어 있었다. 한편 발광에 기여하는 구조는 미세입자라기 보다는 미세입자에 형성된 미세세선인 것으로 보여진다. 그리고 다공질 실리콘에서의 전기루미네선스의 최대 스펙트럼은 다공도에 영향을 받아 미세구조와 상당한 관계가 있는 것으로 나타났다. The porous silicon layers(PLS) were formed by electrochemical anodization of p-type Si wafers in 10%HF-ethanol solution. The micrometer to nanometer scale finestructures of porous silicon are investigated by using high resolution scanning electron microscope and atomic force microscope. The electroluminescence(EL) from PLS was investigated silicon/electrolyte interface in Na2SO4 aqueous solution. SEM and AFM observations revealed that the micrometer-scale structures of porous silicon are greatly depended on anodization time at costant current density. In contrast to these structures, nanometer-scale structures of porous silicon consisted of single crystalline silicon column and holes which have sizes of about tens nm. The EL spectrum changed by the porosity of finestructures.

지진하중 조건에서 SA106 Gr.C 배관재의 파괴인성에 미치는 동적변형시효 영향

김진원(Jin Weon Kim),이사용(Sa Yong Lee),김홍덕(Hong Deok Kim) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.5

회전거울을 이용한 광속도 측정에 대한 연구

柳志旭,洪思容,金英猷,李春雨 公州大學校 基礎科學硏究所 1993 自然科學硏究 Vol.2 No.-

회전거울을 이용한 광속측정법은 거울의 회전에 기인한 광원점의 상 변위를 측정함으로써 단순한 장치로 비교적 정확한 측정값을 기대할 수 있다. 그러나 정밀하고 적절한 기구정렬이 없이는 상을 찾기 어렵다. 이 논문에서는 이와 같은 문제점을 고찰하고 그 해결책을 모색하였다. 정밀한 기구정렬을 거쳐 공기중에서 측정한 광속은 c=2.99±.16×108m/s이었다. An advanced undergrauate laboratory experiment is described which uses a laser, a rotating mirror assembly, a fixed mirror and a measuring microscope to determine the speed of light using time of flight. We investigated the alignment methods to obtain a good image. The measurement value was c=2.99±.16×108m/s in air.

Experimental Study on Impact Loads Acting on Free-falling Modified Wigley

Hong, Sa-Young,Kim, Young-Shik,Kyoung, Jo-Hyun,Hong, Seok-Won,Kim, Yong-Hwan Korean Society of Ocean Engineers 2012 International journal of ocean system engineering Vol.2 No.3

The characteristics of an impact load and pressure were experimentally investigated. Drop tests were carried out using a modified Wigley with CB = 0.56. The vertical force, pressures, and vertical accelerations were measured. A 6-component load cell was used to measure the forces, piezo-electric sensors were used to capture the impact pressure, and strain-gauge type accelerometers were used to measure the vertical accelerations. A 50-kHz sampling rate was applied to capture the peak values. The repeatability of the measured data was confirmed and the basic characteristics of the impact load and pressure such as the linearity to the falling height were observed for all of the measurements. A simple formula was derived to extract the physical impact load from the measured force based on a simple mass-sensor-mass diagram, which was validated by comparing impact forces with existing data using the mathematical model of Faltinsen and Chezhian (2005). The effects of the elasticity of the model and change in acceleration during the water entry were investigated. It is interesting to observe that the impact loads occurred and reached peak values at the same time duration after water entry for all drop heights.

Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice

Hong, Sa-Ik,Kwon, Seung-Hwan,Hwang, Ji-Young,Ma, Shi-Xun,Seo, Jee-Yeon,Ko, Yong-Hyun,Kim, Hyoung-Chun,Lee, Seok-Yong,Jang, Choon-Gon The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2

Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this study, we investigated the relationship between melatonin (MT) and dopamine D2-like receptor signaling in pentobarbital-induced sleep and the intracellular mechanisms of sleep maintenance in the cerebral cortex. In mice, pentobarbital-induced sleep was augmented by intraperitoneal administration of 30 mg/kg MT. To investigate the relationship between MT and D2-like receptors, we administered quinpirole, a D2-like receptor agonist, to MT- and pentobarbital-treated mice. Quinpirole (1 mg/kg, i.p.) increased the duration of MT-augmented sleep in mice. In addition, locomotor activity analysis showed that neither MT nor quinpirole produced sedative effects when administered alone. In order to understand the mechanisms underlying quinpirole-augmented sleep, we measured protein levels of mitogen-activated protein kinases (MAPKs) and cortical protein kinases related to MT signaling. Treatment with quinpirole or MT activated extracellular-signal-regulated kinase 1 and 2 (ERK1/2), p38 MAPK, and protein kinase C (PKC) in the cerebral cortex, while protein kinase A (PKA) activation was not altered significantly. Taken together, our results show that quinpirole increases the duration of MT-augmented sleep through ERK1/2, p38 MAPK, and PKC signaling. These findings suggest that modulation of D2-like receptors might enhance the effect of MT on sleep.

Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice

( Sa Ik Hong ),( Seung Hwan Kwon ),( Ji Young Hwang ),( Shi Xun Ma ),( Jee Yeon Seo ),( Yong Hyun Ko ),( Hyoung Chun Kim ),( Seok Yong Lee ),( Choon Gon Jang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2

Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this study, we investigated the relationship between melatonin (MT) and dopamine D2-like receptor signaling in pentobarbital-induced sleep and the intracellular mechanisms of sleep maintenance in the cerebral cortex. In mice, pentobarbital-induced sleep was augmented by intraperitoneal administration of 30 mg/kg MT. To investigate the relationship between MT and D2-like receptors, we administered quinpirole, a D2-like receptor agonist, to MT- and pentobarbital-treated mice. Quinpirole (1 mg/kg, i.p.) increased the duration of MT-augmented sleep in mice. In addition, locomotor activity analysis showed that neither MT nor quinpirole produced sedative effects when administered alone. In order to understand the mechanisms underlying quinpirole-augmented sleep, we measured protein levels of mitogen-activated protein kinases (MAPKs) and cortical protein kinases related to MT signaling. Treatment with quinpirole or MT activated extracellular-signal-regulated kinase 1 and 2 (ERK1/2), p38 MAPK, and protein kinase C (PKC) in the cerebral cortex, while protein kinase A (PKA) activation was not altered significantly. Taken together, our results show that quinpirole increases the duration of MT-augmented sleep through ERK1/2, p38 MAPK, and PKC signaling. These findings suggest that modulation of D2-like receptors might enhance the effect of MT on sleep.