Die Geschichte hat sich ans Werk gemacht Der Wandel der sowjetischen Position zur Deutschen Frage

Riese, Von Hans-Peter 東亞大學校 獨逸學硏究所 1991 獨逸學硏究 Vol.- No.7

Die Geschichte hat sich ans Werk gemacht Der Wandel der sowjetischen Position zur Deutschen Frage

Hans-Peter Riese 동아대학교 독일학연구소 1991 獨逸學硏究 Vol.- No.7

Symposia special lectures : PROLIFERATION OF CERVICAL CARCINOMA CELL LINES IS INHIBITED BY INTRODUCTION OF A PAPILLOMAVIRUS REGULATORY GENE

Eun Seong Hwang,David J . Riese,Ⅱ,Daniel DiMaio 생화학분자생물학회(구 한국생화학분자생물학회) 1992 추계학술대회집 Vol.- No.-

A comprehensive observational filter for satellite infrared limb sounding of gravity waves

Trinh, Q. T.,Kalisch, S.,Preusse, P.,Chun, H.-Y.,Eckermann, S. D.,Ern, M.,Riese, M. Copernicus GmbH 2015 Atmospheric measurement techniques Vol.8 No.3

<P><p><strong>Abstract.</strong> This paper describes a comprehensive observational filter for satellite infrared limb sounding of gravity waves. The filter considers instrument visibility and observation geometry with a high level of accuracy. It contains four main processes: visibility filter, projection of the wavelength on the tangent-point track, aliasing effect, and calculation of the observed vertical wavelength. The observation geometries of the SABER (Sounding of the Atmosphere using Broadband Emission Radiometry) and HIRDLS (High Resolution Dynamics Limb Sounder) are mimicked. Gravity waves (GWs) simulated by coupling a convective GW source (CGWS) scheme and the gravity wave regional or global ray tracer (GROGRAT) are used as an example for applying the observational filter. Simulated spectra in terms of horizontal and vertical wave numbers (wavelengths) of gravity wave momentum flux (GWMF) are analyzed under the influence of the filter. We find that the most important processes, which have significant influence on the spectrum are the visibility filter (for both SABER and HIRDLS observation geometries) and aliasing for SABER and projection on tangent-point track for HIRDLS. The vertical wavelength distribution is mainly affected by the retrieval as part of the 'visibility filter' process. In addition, the short-horizontal-scale spectrum may be projected for some cases into a longer horizontal wavelength interval which originally was not populated. The filter largely reduces GWMF values of very short horizontal wavelength waves. The implications for interpreting observed data are discussed.</p> </P>

Tuning of a convective gravity wave source scheme based on HIRDLS observations

Trinh, Quang Thai,Kalisch, Silvio,Preusse, Peter,Ern, Manfred,Chun, Hye-Yeong,Eckermann, Stephen D.,Kang, Min-Jee,Riese, Martin Copernicus GmbH 2016 Atmospheric Chemistry and Physics Vol.16 No.11

<P>Abstract. Convection as one dominant source of atmospheric gravity waves (GWs) has been the focus of investigation over recent years. However, its spatial and temporal forcing scales are not well known. In this work we address this open issue by a systematic verification of free parameters of the Yonsei convective GW source scheme based on observations from the High Resolution Dynamics Limb Sounder (HIRDLS). The instrument can only see a limited portion of the gravity wave spectrum due to visibility effects and observation geometry. To allow for a meaningful comparison of simulated GWs to observations, a comprehensive filter, which mimics the instrument limitations, is applied to the simulated waves. By this approach, only long horizontal-scale convective GWs are addressed. Results show that spectrum, distribution of momentum flux, and zonal mean forcing of long horizontal-scale convective GWs can be successfully simulated by the superposition of three or four combinations of parameter sets reproducing the observed GW spectrum. These selected parameter sets are different for northern and southern summer. Although long horizontal-scale waves are only part of the full spectrum of convective GWs, the momentum flux of these waves is found to be significant and relevant for the driving of the QBO (quasi-biennial oscillation). The zonal momentum balance is considered in vertical cross sections of GW momentum flux (GWMF) and GW drag (GWD). Global maps of the horizontal distribution of GWMF are considered and consistency between simulated results and HIRDLS observations is found. The latitude dependence of the zonal phase speed spectrum of GWMF and its change with altitude is discussed. </P>

Estrogen receptor-α, progesterone receptor, and c-erbB/HER-family receptor mRNA detection and phenotype analysis in spontaneous canine models of breast cancer

Farruk M. Lutful Kabir,Patricia DeInnocentes,Payal Agarwal,Christopher P. Mill,David J. Riese 2nd,R. Curtis Bird 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.2

Well characterized, stable, p16-defective canine mammary cancer (CMT) cell lines and normal canine mammary epithelial cells were used to investigate expression of the major breast cancer-specific hormone receptors estrogen receptor alpha (ER1) and progesterone receptor (PR) as well as luminal epithelial-specific proto-oncogenes encoding c-erbB-1 (epidermal growth factor receptor/EGFr), c-erbB-2/HER2, c-erbB-3, and c-erbB-4 receptors. The investigation developed and validated quantitative reverse transcriptase polymerase chain reaction assays for each transcript to provide rapid assessment of breast cancer phenotypes for canine cancers, based on ER1, PR, and c-erbB-2/HER2 expressions, similar to those in human disease. Roles for relatively underexplored c-erbB-3 and c-erbB-4 receptor expressions in each of these breast cancer phenotypes were also evaluated. Each quantitative assay was validated by assessment of amplicon size and DNA sequencing following amplification. Differential expression of ER1, PR, and c-erbB-2 in CMT cell lines clearly defined distinct human-like breast cancer phenotypes for a selection of CMT-derived cell lines. Expression profiles for EGFr family genes c-erbB-3 and c-erbB-4 in CMT models also provided an enriched classification of canine breast cancer identifying new extended phenotypes beyond the conventional luminal-basal characterization used in human breast cancer.

Possible clinical implications of prostate capsule thickness and glandular epithelial cell density in benign prostate hyperplasia

Katherine G. Holder,Bernardo Galvan,Andrew S. Knight,Freedom Ha,Reagan Collins,Preston E. Weaver,Luis Brandi,Werner T. de Riese 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.4

Purpose: The negative correlation between BPH-size and incidence of prostate cancer (PCa) is well-documented in the literature, however the exact mechanism is not well-understood. The present study uses histo-anatomical imaging to study prostate volume in correlation to prostate capsule thickness, and glandular epithelial cell density within the peripheral zone (PZ). Materials and Methods: Specimens were selected from radical prostatectomies ranging from 20 to 160 mL based on ease of anatomical reconstruction by the slides. A total of 60 patients were selected and underwent quantitative measurements of prostate capsule thickness and glandular epithelial density within the PZ using computer-based imaging software. Pearson's correlation and a stepwise multiple linear regression analysis was conducted to determine the relationship between these measured parameters and the clinical characteristic of these patients. Results: Pearson's correlation analysis revealed a strongly significant, negative correlation between prostate volume and glandular epithelial cell density (r(58)=−0.554, p<0.001), and a strongly significant, positive correlation between prostate volume and average capsule thickness (r(58)=0.462, p<0.001). Results of multiple regression analysis showed that average glandular epithelial cell density added statistically to this prediction (p<0.05). Conclusions: The results suggest that growth of the transition zone in BPH causes increased fibrosis of the PZ, leading to atrophy and fibrosis of glandular cells. As 80% of PCa originates from the glandular epithelium within the PZ, this observed phenomenon may explain the inverse correlation between BPH and PCa that is well-documented in the literature.

Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis

Winthrop, K L,Park, S-H,Gul, A,Cardiel, M H,Gomez-Reino, J J,Tanaka, Y,Kwok, K,Lukic, T,Mortensen, E,Ponce de Leon, D,Riese, R,Valdez, H BMJ Publishing Group 2016 Annals of the Rheumatic Diseases Vol.75 No.6

<P><B>Objectives</B></P><P>To evaluate the risk of opportunistic infections (OIs) in patients with rheumatoid arthritis (RA) treated with tofacitinib.</P><P><B>Methods</B></P><P>Phase II, III and long-term extension clinical trial data (April 2013 data-cut) from the tofacitinib RA programme were reviewed. OIs defined a priori included mycobacterial and fungal infections, multidermatomal herpes zoster and other viral infections associated with immunosuppression. For OIs, we calculated crude incidence rates (IRs; per 100 patient-years (95% CI)); for tuberculosis (TB) specifically, we calculated rates stratified by patient enrolment region according to background TB IR (per 100 patient-years): low (≤0.01), medium (>0.01 to ≤0.05) and high (>0.05).</P><P><B>Results</B></P><P>We identified 60 OIs among 5671 subjects; all occurred among tofacitinib-treated patients. TB (crude IR 0.21, 95% CI of (0.14 to 0.30)) was the most common OI (n=26); median time between drug start and diagnosis was 64 weeks (range 15–161 weeks). Twenty-one cases (81%) occurred in countries with high background TB IR, and the rate varied with regional background TB IR: low 0.02 (0.003 to 0.15), medium 0.08 (0.03 to 0.21) and high 0.75 (0.49 to 1.15). In Phase III studies, 263 patients diagnosed with latent TB infection were treated with isoniazid and tofacitinib concurrently; none developed TB. For OIs other than TB, 34 events were reported (crude IR 0.25 (95% CI 0.18 to 0.36)).</P><P><B>Conclusions</B></P><P>Within the global tofacitinib RA development programme, TB was the most common OI reported but was rare in regions of low and medium TB incidence. Patients who screen positive for latent TB can be treated with isoniazid during tofacitinib therapy.</P>

Progressive Screening of Thermostable Yeasts for Phytase Production

Edi Franciele Ries,Gabriela Alves Macedo 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.3

Biotechnological phytase preparations are commercially available and are currently used in animal feeding. However, thermostability constraints, low yields, and the high cost of the enzyme have limited its use. This study represents a new perspective for the food enzyme market. The research screened thermostable yeast strains for their ability to produce phytase. The screening was carried out with a gradual increase in temperature (30-48℃). Sixteen strains (1 strain identified as Saccharomyces cerevisiae) maintained the ability to produce phytase at 48℃ and their phytase activity was confirmed using 2 phytase assay methodologies. The yeast strains tested in this study seem to be potential efficient producers of phytase, indicating a possible new source of thermostable phytase of commercial interest, particularly that from S. cerevisiae.

Fuse Protection of IGBT Modules against Explosions

Blaabjerg, Fred,Ion, Florin,Ries, Kareten The Korean Institute of Power Electronics 2002 JOURNAL OF POWER ELECTRONICS Vol.2 No.2

The demand for protection of power electronic application has during the last couple of vears increased regarding the high-power IGBT modules. Even with an active protection, a high power IGBT still has a risk of exhibiting a violent rupture in the case of a fault if IGBT Fuses do not protect it. By introducing fuses into the circuit this will increase the circuit inductance and slight inductance over-voltage during the turn-off of the diode and the IGBT. It is therefore vital when using fuses that the added inductance is kept at a minimum. This paper discuss three issues regarding the IGBT Fuse protection of adding inductance of existing High-speed and new Typower Fuse protection. First, the problem of adding inductance of exiting High-speed and new Typower Fuse DC-link circuit is treated, second a short discussion of protection of the IGBT module is done, and finally, the impect of the high frwquency loading on the currying capability of the fuses is presented.