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RISS 인기검색어
- 검색키워드
- 저자 : Farruk M. Lutful Kabir (검색결과 2 건)
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Farruk M. Lutful Kabir,Patricia DeInnocentes,Payal Agarwal,Christopher P. Mill,David J. Riese 2nd,R. Curtis Bird 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.2
Well characterized, stable, p16-defective canine mammary cancer (CMT) cell lines and normal canine mammary epithelial cells were used to investigate expression of the major breast cancer-specific hormone receptors estrogen receptor alpha (ER1) and progesterone receptor (PR) as well as luminal epithelial-specific proto-oncogenes encoding c-erbB-1 (epidermal growth factor receptor/EGFr), c-erbB-2/HER2, c-erbB-3, and c-erbB-4 receptors. The investigation developed and validated quantitative reverse transcriptase polymerase chain reaction assays for each transcript to provide rapid assessment of breast cancer phenotypes for canine cancers, based on ER1, PR, and c-erbB-2/HER2 expressions, similar to those in human disease. Roles for relatively underexplored c-erbB-3 and c-erbB-4 receptor expressions in each of these breast cancer phenotypes were also evaluated. Each quantitative assay was validated by assessment of amplicon size and DNA sequencing following amplification. Differential expression of ER1, PR, and c-erbB-2 in CMT cell lines clearly defined distinct human-like breast cancer phenotypes for a selection of CMT-derived cell lines. Expression profiles for EGFr family genes c-erbB-3 and c-erbB-4 in CMT models also provided an enriched classification of canine breast cancer identifying new extended phenotypes beyond the conventional luminal-basal characterization used in human breast cancer.
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Autologous hybrid cell fusion vaccine in a spontaneous intermediate model of breast carcinoma
R. Curtis Bird,Patricia DeInnocentes,Allison E. Church Bird,Farruk M. Lutful Kabir,E. Gisela Martinez-Romero,Annette N. Smith,Bruce F. Smith 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.5
Breast cancer is among the most common malignancies affecting women and reproductivelyintact female dogs, resulting in death from metastatic disease if not treated effectively. Tobetter manage the disease progression, canine mammary tumor (CMT) cells derived frommalignant canine mammary cancers were fused to autologous dendritic cells (DCs) toproduce living hybrid-cell fusion vaccines for canine patients diagnosed with spontaneousmammary carcinoma. The high-speed sorting of rare autologous canine patient DCs fromthe peripheral blood provides the autologous component of fusion vaccines, and fusion tomajor histocompatibility complex-unmatched CMT cells were produced at high rates. Thevaccinations were delivered to each patient following a surgical resection 3 times at 3-weekintervals in combination with immuno-stimulatory oligonucleotides and Gemcitabineadjunct therapy. The immunized patient animals survived 3.3-times longer (median survival611 days) than the control patients (median survival 184 days) and also appeared to exhibit anenhanced quality of life. A comparison of vaccinated patients diagnosed with inflammatorymammary carcinoma resulted in a very short median survival (42 days), suggesting no effectof vaccination. The data showed that the development of autologous living DC-based vaccinestrategies in patient animals designed to improve the management of canine mammarycarcinoma can be successful and may allow an identification of the antigens that can betranslatable to promote effective immunity in canine and human patients.
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