Suppressive effect of Spirulina fusiformis in relation to lysosomal acid hydrolases, lipid peroxidation, antioxidant status, and inflammatory mediator TNF-alpha on experimental gouty arthritis in mice

Rasool, Mahaboob Khan,Sabina, Evan Prince,Nithya, Pichandy,Lavanya, Kumar Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.2

The anti-inflammatory effect of Spirulina fusiformis on monosodium urate crystal-induced inflammation in mice has been investigated and compared with the non-steroidal anti-inflammatory drug Indomethacin. The paw volume, lysosomal enzyme activities, lipid peroxidation, anti-oxidant status and inflammatory mediator tumour necrosis factor-$\alpha$ were studied in control and monosodium urate crystal-induced mice after oral administration of Spirulina platensis in an experimental model for gouty arthritis. In the induced mice, the levels of lysosomal enzymes, inflammatory mediator tumour necrosis factor-$\alpha$, lipid peroxidation and the paw volume increased significantly, whereas the antioxidant status decreased when compared to control mice. $\beta$-glucuronidase and lactate dehydrogenase level were also found to be increased in untreated monosodium urate crystal-incubated polymorphonuclear leucocytes. After the oral administration of Spirulina fusiformis, the physical and biochemical changes observed in monosodium urate crystal-induced animals were significantly restored to near normal levels. The results clearly indicated the anti-inflammatory role of Spirulina fusiformis, a promising drug for gouty arthritis.

Enhanced photostability in polymer solar cells achieved with modified electron transport layer

Rasool, Shafket,Van Doan, Vu,Lee, Hang Ken,Lee, Sang Kyu,Lee, Jong-Cheol,Moon, Sang-Jin,So, Won Wook,Song, Chang Eun,Shin, Won Suk Elsevier 2019 THIN SOLID FILMS - Vol.669 No.-

<P><B>Abstract</B></P> <P>Photostability of the polymer solar cells (PSCs) remains a challenge to attain, as number of factors including the electron transport layers contribute to the degradation of PSCs when they are tested under 1 sun illumination, along with heat and humidity. Especially electron transport layers (ETLs) have considerable contribution to the overall degradations in these solar cells. Most studied ETL into the fabrication of inverted PSCs is zinc oxide (ZnO) yet the photostability of these PSCs is limited. This degradation most probably occurred due to the direct contact of zinc metal with the photoactive layer. This interface between ZnO and photoactive layer results in the initiation of degradations in PSCs. Keeping in view of this issue, we have modified the ZnO ETL by mixing ZnO nano particles with ethoxylated polyethyleneimine (PEIE) and then passivating this modified ZnO (m-ZnO) with ultrathin PEIE buffer layer. The power conversion efficiency is not affected by this approach, but when PSCs were subjected to 1 sun illumination, these m-ZnO/PEIE based PSCs have shown the enhanced light soaking (LS) stability. These findings indicate that optimizing the interface between the photoactive layer and the electron transport layer can lead to enhanced LS stability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ethoxylated polyethylenimine (PEIE) passivated ZnO (m-ZnO) as electron transport layer (ETL). </LI> <LI> The direct contact of ZnO with photoactive layer is avoided. </LI> <LI> The m-ZnO/PEIE layer help in enhanced light soaking (LS) stability. </LI> <LI> The m-ZnO/PEIE layer has nitrogen enriched surface. </LI> <LI> The nitrogen enriched ETL surface contributes to enhanced LS stability. </LI> </UL> </P>

Characteristics, kinetics and thermodynamics of Congo Red biosorption by activated sulfidogenic sludge from an aqueous solution

Rasool, K.,Lee, D. S. Springer-Verlag 2015 International journal of environmental science and Vol.12 No.2

Arterial Compliance and Vitamin E Blood Levels with a Self Emulsifying Preparation of Tocotrienol Rich Vitamin E

Rasool, Aida Hanum Ghulam,Rahman, Abd Rashid Abd.,Yuen, Kah Hay,Wong, Abdul Rahim 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9

The tocotrienol vitamin E has potent antioxidant property, however absorption is low due to high lipid solubility. A self emulsifying preparation of tocotrienol rich vitamin E (SF-TRE) had been reported to increase their bioavailability. This randomized, placebo controlled, blinded end point clinical study aimed to determine the effects of 50, 100 and 200 mg daily of SF-TRE and placebo for two months on arterial compliance and vitamin E blood levels. Assessment of arterial compliance by carotid femoral pulse wave velocity (PWV) and augmentation index (AI), plasma vitamin E, serum total cholesterol and low density lipoprotein cholesterol were taken before and after 2 months' treatment in 36 healthy males. Un-supplemented tocotrienol levels were low, after treatment, all SF-TRE treated groups had significantly higher plasma $\alpha$, $\delta$ and $\delta$ tocotrienol concentrations compared to placebo. Augmentation index change from baseline to end of treatment for groups placebo, 50, 100, and 200 mg were $2.22{\pm}1.54$, $-6.59{\pm}2.84$, $-8.72{\pm}3.77$, and $-6.27{\pm}2.67%$ respectively (p=0.049, 0.049, and 0.047 respectively). Groups 100 and 200 mg showed significant improvement after treatment with pulse wave velocity reductions of 0.77 m/s and 0.65 m/s respectively (p=0.007 and p=0.002). There was no effect of SF-TRE on serum lipids. We conclude that there was a trend towards improvement in arterial compliance with 2 months' of SF-TRE.

Effect of Ensiling Sudax Fodder with Broiler Litter and Candida Yeast on the Changes in pH, Lactic Acid and Nitrogen Fractions

Rasool, S.,Gilani, A.H. Asian Australasian Association of Animal Productio 1997 Animal Bioscience Vol.10 No.1

Sudax fodder (Sorghum sudanense ${\times}$ Sorhum vulgare) was ensiled in laboratory silos with or without 20, 30, or 40 percent broiler litter and 6 percent molasses with or without Candida yeast. The samples were analyzed for pH, lactic acid and nitrogen fractions at the start of the experiment and at 5 days interval, thereafter till 40 days. A sharp decline in pH and increase in lactic acid content was observed on fifth day of ensiling. Thereafter, the rate of pH decline decreased till 20 days and that of lactic acid increase till 25 days and the remained constant. Increasing levels of broiler litter had adverse effect on pH drop and lactic acid increase of silages. Total-N content of the silages had little variation throughout the ensiling period. A sharp decline in protein-N and increase in ammonia-N content was observed on day 5 of ensiling. Thereafter, the content of protein-N increased till 20 days and that of ammonia-N decreased till 15 days, but these changes were very small compared to that occurred during the first 5 days of ensiling. The level of broiler litter had inverse relationship with protein degradation and direct relationship with ammonia production. The yeast inoculum failed to produce any significant effect.

IMPACT OF FOURWING SALTBUSH ON FEED AND WATER INTAKE AND ON BLOOD SERUM PROFILE IN SHEEP

Rasool, E.,Rafique, S.,Haq, I.U.,Khan, A.G.,Thomson, E.F. Asian Australasian Association of Animal Productio 1996 Animal Bioscience Vol.9 No.2

Sixteen Harnai males were used to evaluate the influence of varying levels of fourwing saltbush hay on feed and water intakes as well as the blood serum mineral status in a completely randomized design. The animals were grouped randomly into four, with four animals in each. The four groups were randomly allotted low, medium, high and very high levels of saltbush hay supplementation in addition to wheat straw. The animals were given fresh water at free of choice. Weekly body weight was recorded for each individual animal. Blood serum was collected for mineral contents. The experiment lasted for eight weeks. The inclusion of saltbush leaves in the diet showed a non-significant effect on the total dry matter intake. There has been a significant increase in the water intake when very high levels of saltbush were included in the ration. Lower levels showed no effect on the water intake. The animals maintained their body weight from week 1 to week 8. No treatment by weeks interactions on the potassium and sodium levels were detected. However higher levels of saltbush increased significantly the potassium and sodium contents in the serum. Calcium contents were significantly(p<0.01) lowered with the inclusion of saltbush leaves in the diet. Whereas Phosphorous contents showed an increasing(p<0.05) trend with the higher levels of saltbush. No clinical or sub-clinical toxicological symptoms were observed in the sheep with the higher mineral contents.

Utilization of Sunflower Crop Residues as Feed in Small Ruminants

Rasool, Ejaz,Khan, M.F.,Nawaz, M.,Rafiq, M. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.3

Sheep and goats in Pakistan have not been able to produce to the best of their potential. This may primarily be attributed to under feeding and malnutrition. Ranges have been depleted due to overgrazing and mismanagement and are not in position to feed the existing small ruminant population. To overcome the shortage of good quality fodder and balanced feed supply, the alternate means like cereal straws and other crop residues are being commonly used. Sunflower crop residues like stalks and heads provide a good quality forage for livestock. These crop byproducts are rich in crude protein and lower in crude fibre. Their inclusion in the diet of small ruminants at 20, 30 and 40 percent levels in ration has shown significantly (p < 0.05) increased feed intake and weight gain. Daily feed intake was 1,130, 1,180 and 1,750 g for sunflower crop residue, soybean crop residue and wheat straw, respectively, when added at the rate of 20 percent in the ration. The drymatter digestibility of sunflower, soybean crop residues and wheat straw was also comparable. The maximum performance of the animals was observed at the 20 percent level of inclusion of sunflower crop residue in the diet.

Preparation and Nutritional Evaluation of Hatchery Waste Meal for Broilers

Rasool, S.,Rehan, M.,Haq, A.,Alam, M.Z. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.4

Hatchery waste including infertile eggs, dead embryos in shell, dead or low grade chicks was cooked at $100^{\circ}C$ for 15 minutes and then oven dried and ground. Hatchery waste meal (HWM) thus prepared contained 44.25% protein, 4,573 kcal/kg gross energy, 3,600 kcal/kg metabolizable energy, 30% ether extract, 1.9% fibre, 14% ash, 9.8% nitrogen free extract, 7.26% Ca, 0.84%P, 1.86% lysine and 0.66% methionine with no Salmonella and E. coli. In biological evaluation trial, significantly higher weight gain was observed in ration containing 12% HWM compared with that containing similar amount of fish meal. Protein efficiency ratio on the two rations was 3.96 vs 2.85; protein digestibility, 86.02 vs 71.9; net protein utilization, 64.9 vs 42.37 and biological value, 75.37 vs 58.84, respectively, indicating better balance of amino acids in HWM compared with fish meal. Growth performance trial on broiler chicks also revealed better weight gain and feed efficiency on ration containing 12% HWM than that containing similar level of fish meal.

Effects of Sulfidation on ZnO Nanoparticle Dissolution and Aggregation in Sulfate-Containing Suspensions

Rasool, Kashif,Lee, Dae Sung American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.9

Transient heat transfer analysis of functionally graded CNT reinforced cylinders with various boundary conditions

Rasool Moradi-Dastjerdi,Gholamhassan Payganeh 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.24 No.3

In this work, transient heat transfer analysis of functionally graded (FG) carbon nanotube reinforced nanocomposite (CNTRC) cylinders with various essential and natural boundary conditions is investigated by a mesh-free method. The cylinders are subjected to thermal flux, convection environments and constant temperature faces. The material properties of the nanocomposite are estimated by an extended micro mechanical model in volume fraction form. The distribution of carbon nanotube (CNT) has a linear variation along the radial direction of axisymmetric cylinder. In the mesh-free analysis, moving least squares shape functions are used for approximation of temperature field in the weak form of heat transform equation and the transformation method is used for the imposition of essential boundary conditions. Newmark method is applied for solution time depended problem. The effects of CNT distribution pattern and volume fraction, cylinder thickness and boundary conditions are investigated on the transient temperature field of the nanocomposite cylinders.