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Involvement of Orai1 in tunicamycin-induced endothelial dysfunction
Yang, Hui,Xue, Yumei,Kuang, Sujuan,Zhang, Mengzhen,Chen, Jinghui,Liu, Lin,Shan, Zhixin,Lin, Qiuxiong,Li, Xiaohong,Yang, Min,Zhou, Hui,Rao, Fang,Deng, Chunyu The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2
Endoplasmic reticulum (ER) stress is mediated by disturbance of $Ca^{2+}$ homeostasis. The store-operated calcium (SOC) channel is the primary $Ca^{2+}$ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on $Ca^{2+}$ influx in human umbilical vein endothelial cells (HUVECs) were observed with the fluorescent probe Fluo-4 AM. The effect of tunicamycin on the expression of the unfolded protein response (UPR)-related proteins BiP and CHOP was assayed by western blotting with or without inhibition of Orai1. Tunicamycin induced endothelial dysfunction by activating ER stress. Orai1 expression and the influx of extracellular $Ca^{2+}$ in HUVECs were both upregulated during ER stress. The SOC channel inhibitor SKF96365 reversed tunicamycin-induced endothelial cell dysfunction by inhibiting ER stress. Regulation of tunicamycin-induced ER stress by Orai1 indicates that modification of Orai1 activity may have therapeutic value for conditions with ER stress-induced endothelial dysfunction.
Power–Delay Tradeoff in Wireless Powered Communication Networks
Yang, Jian,Yang, Qinghai,Kwak, Kyung Sup,Rao, Ramesh R. IEEE 2017 IEEE Transactions on Vehicular Technology VT Vol.66 No.4
<P>In this paper, we investigate the power-delay tradeoff for the newly emerging wireless powered communication networks, in which wireless powered devices (WPDs) harvest energy from a power station via wireless energy transfer in the downlink and then communicate with an information receiving station in the uplink. Each WPD is equipped with an energy buffer and a data buffer to store the random harvested energy and the bursty data arrivals, respectively. To minimize the time-averaged power consumption, a stochastic optimization problem is formulated subject to both constraints of data queue stability and harvested energy availability. By employing Lyapunov optimization theory, we transform the stochastic optimization problem into a series of deterministic problems, where each is further proved to become the standard convex optimization problem and, hence, can be effectively and optimally solved by standard convex optimization techniques. Correspondingly, we propose an Online Power and TIMe Allocation (Optima) algorithm, which requires no a priori distribution knowledge of channel states and data arrivals. Most importantly, the proposed algorithm achieves the power-delay tradeoff as [O(1/V), O(V)], with V being a system control parameter, and provides a significant method to control the power-delay performance on demand in system design. Simulation results verify the theoretical analysis and validate the effectiveness of the proposed algorithm.</P>
Involvement of Orai1 in tunicamycin-induced endothelial dysfunction
Hui Yang,Yumei Xue,Sujuan Kuang,Mengzhen Zhang,Jinghui Chen,Lin Liu,Zhixin Shan,Qiuxiong Lin,Xiaohong Li,Min Yang,Hui Zhou,Fang Rao,Chunyu Deng 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2
Endoplasmic reticulum (ER) stress is mediated by disturbance of Ca2+ homeostasis. The store-operated calcium (SOC) channel is the primary Ca2+ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on Ca2+ influx in human umbilical vein endothelial cells (HUVECs) were observed with the fluorescent probe Fluo-4 AM. The effect of tunicamycin on the expression of the unfolded protein response (UPR)-related proteins BiP and CHOP was assayed by western blotting with or without inhibition of Orai1. Tunicamycin induced endothelial dysfunction by activating ER stress. Orai1 expression and the influx of extracellular Ca2+ in HUVECs were both upregulated during ER stress. The SOC channel inhibitor SKF96365 reversed tunicamycin-induced endothelial cell dysfunction by inhibiting ER stress. Regulation of tunicamycin-induced ER stress by Orai1 indicates that modification of Orai1 activity may have therapeutic value for conditions with ER stress-induced endothelial dysfunction.
V. Navakoteswara Rao(라오),Karthik Kannan(카난),Bee Lyong Yang(양비룡),Jun-Mo Yang(양준모) 한국에너지기후변화학회 2021 한국에너지기후변화학회 학술대회 Vol.2021 No.11
Hydrogen gas is cleaner fuel and generates electrical energy in proton exchange membrane fuel cell with high efficiency. Many methods they reports hydrogen production like wind power, electrolysis, paralysis of oils and gasification goober gas among them renewable energy process, photocatalysis is a promising method for hydrogen production at near ambient conditions in aqueous medium. Here in we report Bi₂S₃@NiO-In₂S₃- TiO₂ core-shell nanostructures for enhanced hydrogen generation. The present work explores systematic study on the single step modified hydrothermal method Bi₂S₃ core coated by the shell NiO-In₂S₃-TiO₂ for enhanced photocatalytic hydrogen production (see in Figure1). The core-shell material composed of flower like nanostructures conformed by SEM characterizations and elemental analysis of the composite is presented Bi, Ni, In, S, Ti and O respectively. Bi₂S₃@NiO-In₂S₃-TiO₂ flower like structures and shell thickness 5-10 nm conformed by TEM analysis. XPS spectroscopy publicized chemical state of the core-shell nanostructure exists as Bi<SUP>+2</SUP>, Ni<SUP>+2</SUP>, In<SUP>+2</SUP>, Ti<SUP>4+</SUP>, S<SUP>2-</SUP> and O<SUP>2-</SUP>respectively. Among them Bi₂S₃/TiO₂ was shows high rate of H₂ evolution 44.1 mmol.h<SUP>-1</SUP>.g<SUP>-1</SUP>cat under UV- Visible light irradiation.
V. Navakoteswara Rao(라오),Karthik Kannan(카난),Bee Lyong Yang(양비룡),Bee Lyong Yang(양준모) 한국에너지기후변화학회 2021 한국에너지기후변화학회 학술대회 Vol.2021 No.11
Growth of hierarchal nano-structured photocatalyst with ultra-thin shell materials TiO₂@NiO@ZnS is of great importance towards the stable and continuous hydrogen (H2) production, where the shell materials avoids the photo-corrosion of the core for longer stability with continuous H2 generation. Accordingly, herein, we report a comparative studies on the CdS core coated with three various shell materials like (TiO₂@NiO@ ZnO) for enhanced H2 production under visible light irradiation. The structural and morphological characterizations using XRD and TEM techniques revealed the formation of phase pure CdS@TiO₂@NiO@ZnO nanocomposites, with sphere type structures having core diameter and shell thickness of 395 and 15 nm and rod like structure with diameter 82.4 and shell thickness 6.3 nm respectively. XPS studies revealed that the constituted elements in the nanocomposite exist in their valence states of the nanocomposites, which indicated the stable structural integrity of the individual phase in the core@shell structure. The synergistic optical properties of hierarchal nanostructure showed the absorption edge around 500 nm and the decreased PL intensity indicated the improved charge recombination resistance in the core@shell nanocomposite. The photocatalytic activity comparison between these three different materials reveals in the order of TiO₂ > NiO > ZnO under visible light irradiation. Based on the obtained results, were observed among these materials the CdS@TiO₂ core@shell photocatalyst showed higher efficiency due to the increased charge separation, spatial distributions of the carriers and effect of the structural properties.
Medical Image Fusion via an Effective Wavelet-Based Approach
Yang, Yong,Park, Dong Sun,Huang, Shuying,Rao, Nini Hindawi Publishing Corporation 2010 EURASIP journal on advances in signal processing Vol.2010 No.1
<P>A novel wavelet-based approach for medical image fusion is presented, which is developed by taking into not only account the characteristics of human visual system (HVS) but also the physical meaning of the wavelet coefficients. After the medical images to be fused are decomposed by the wavelet transform, different-fusion schemes for combining the coefficients are proposed: coefficients in low-frequency band are selected with a visibility-based scheme, and coefficients in high-frequency bands are selected with a variance based method. To overcome the presence of noise and guarantee the homogeneity of the fused image, all the coefficients are subsequently performed by a window-based consistency verification process. The fused image is finally constructed by the inverse wavelet transform with all composite coefficients. To quantitatively evaluate and prove the performance of the proposed method, series of experiments and comparisons with some existing fusion methods are carried out in the paper. Experimental results on simulated and real medical images indicate that the proposed method is effective and can get satisfactory fusion results.</P>
Rao, Satunuri Venkateswar,Yang, Dong Hyo,Sohn, Jeong Soo,Kim, Soo-Kyung The Scientific World Journal 2012 The Scientific World Journal Vol.2012 No.-
<P>Solvent extraction (SX) separation of Al from Ni sulphate leach liquor (LL) of spent Raneynickel catalyst containing 0.12 M Al and 1.448 M Ni using organophosphorus extractants has been investigated. Optimization of process conditions includes aqueous pH, extractant concentration, phase ratio, and stripping. Comparison of Al extraction efficiency with 0.45 M extractant concentration for TOPS 99, PC 88 A, and Cyanex 272 at an equilibrium pH of 2.23 was 81.8%, 98.6%, and 75%, respectively. The corresponding coextraction of Ni was 0.65, 0.6, and 0.9. Among the three extractants screened, PC 88A showed better extraction efficiency for Al at lower pH values than the others. Using 0.45 M PC 88 A, extraction isotherm was obtained at an aqueous-to-organic (A : O) phase ratio of 1 : 1–3 and O : A ratio of 1 : 1–5, which predicted possible separation of Al in 2 stages at A/O ratio of 2. Quantitative stripping was achieved by H<SUB>2</SUB>SO<SUB>4</SUB>.</P>