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- 저자 : Rams, Thomas E. (검색결과 5,048 건)
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María de los Ángeles Carrasco-Ruiz,Laura G. Hernández-Aragón,Jesús Ramsés Chávez-Ríos,Jorge Rodríguez-Antolín,Pablo Pacheco,Margarita Martínez-Gómez,Estela Cuevas-Romero,Francisco Castelán 대한배뇨장애요실금학회 2018 International Neurourology Journal Vol.22 No.3
Purpose: To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. Methods: The muscles were excised from virgin rats during the metestrus and proestrus stages of the estrous cycle, and from sham and ovariectomized rats implanted with empty or estradiol benzoate–filled capsules. The expression of estrogen receptors (ERs) was inspected in the muscles at metestrus and proestrus. Relative Glut4 expression, glycogen content, and serum glucose levels were measured. Appropriate statistical tests were done to identify significant differences (P≤0.05). Results: The pubococcygeus and iliococcygeus muscles expressed ERα and ERβ. Glut4 expression and glycogen content in the pubococcygeus muscle were higher at proestrus than at metestrus. No significant changes were observed in the iliococcygeus muscle. In ovariectomized rats, the administration of estradiol benzoate increased Glut4 expression and glycogen content in the pubococcygeus muscle alone. Conclusions: High serum estradiol levels increased Glut4 expression and glycogen content in the pubococcygeus muscle, but not in the iliococcygeus muscle.
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McCawley, Thomas K.,McCawley, Mark N.,Rams, Thomas E. Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.-
Purpose: This pilot study assessed the immediate in vivo effect of high peak pulse power neodymium-doped yttrium aluminum garnet (Nd:YAG) laser monotherapy on selected red/orange complex periodontal pathogens in deep human periodontal pockets. Methods: Twelve adults with severe periodontitis were treated with the Laser-Assisted New Attachment Procedure (LANAP®) surgical protocol, wherein a free-running, digitally pulsed, Nd:YAG dental laser was used as the initial therapeutic step before mechanical root debridement. Using a flexible optical fiber in a handpiece, Nd:YAG laser energy, at a density of 196 J/cm<sup>2</sup> and a high peak pulse power of 1,333 W/pulse, was directed parallel to untreated tooth root surfaces in sequential coronal-apical passes to clinical periodontal probing depths, for a total applied energy dose of approximately 8-12 joules per millimeter of periodontal probing depth at each periodontal site. Subgingival biofilm specimens were collected from each patient before and immediately after Nd:YAG laser monotherapy from periodontal pockets exhibiting ≥6 mm probing depths and bleeding on probing. Selected red/orange complex periodontal pathogens (Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia/nigrescens, Fusobacterium nucleatum, Parvimonas micra, and Campylobacter species) were quantified in the subgingival samples using established anaerobic culture techniques. Results: All immediate post-treatment subgingival biofilm specimens continued to yield microbial growth after Nd:YAG laser monotherapy. The mean levels of total cultivable red/orange complex periodontal pathogens per patient significantly decreased from 12.0% pretreatment to 4.9% (a 59.2% decrease) immediately after Nd:YAG laser monotherapy, with 3 (25%) patients rendered culture-negative for all evaluated red/orange complex periodontal pathogens. Conclusions: High peak pulse power Nd:YAG laser monotherapy, used as the initial step in the LANAP® surgical protocol on mature subgingival biofilms, immediately induced significant reductions of nearly 60% in the mean total cultivable red/orange complex periodontal pathogen proportions per patient prior to mechanical root instrumentation and the rest of the LANAP® surgical protocol.
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Thomas K. McCawley,Mark N. McCawley,Thomas E. Rams 대한치주과학회 2022 Journal of Periodontal & Implant Science Vol.52 No.1
Purpose: This pilot study assessed the immediate in vivo effect of high peak pulse power neodymium-doped yttrium aluminum garnet (Nd:YAG) laser monotherapy on selected red/ orange complex periodontal pathogens in deep human periodontal pockets. Methods: Twelve adults with severe periodontitis were treated with the Laser-Assisted New Attachment Procedure (LANAP®) surgical protocol, wherein a free-running, digitally pulsed, Nd:YAG dental laser was used as the initial therapeutic step before mechanical root debridement. Using a flexible optical fiber in a handpiece, Nd:YAG laser energy, at a density of 196 J/cm2 and a high peak pulse power of 1,333 W/pulse, was directed parallel to untreated tooth root surfaces in sequential coronal-apical passes to clinical periodontal probing depths, for a total applied energy dose of approximately 8–12 joules per millimeter of periodontal probing depth at each periodontal site. Subgingival biofilm specimens were collected from each patient before and immediately after Nd:YAG laser monotherapy from periodontal pockets exhibiting ≥6 mm probing depths and bleeding on probing. Selected red/ orange complex periodontal pathogens (Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia/nigrescens, Fusobacterium nucleatum, Parvimonas micra, and Campylobacter species) were quantified in the subgingival samples using established anaerobic culture techniques. Results: All immediate post-treatment subgingival biofilm specimens continued to yield microbial growth after Nd:YAG laser monotherapy. The mean levels of total cultivable red/ orange complex periodontal pathogens per patient significantly decreased from 12.0% pretreatment to 4.9% (a 59.2% decrease) immediately after Nd:YAG laser monotherapy, with 3 (25%) patients rendered culture-negative for all evaluated red/orange complex periodontal pathogens. Conclusions: High peak pulse power Nd:YAG laser monotherapy, used as the initial step in the LANAP® surgical protocol on mature subgingival biofilms, immediately induced significant reductions of nearly 60% in the mean total cultivable red/orange complex periodontal pathogen proportions per patient prior to mechanical root instrumentation and the rest of the LANAP® surgical protocol.
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C. Sánchez de Rojas Candela,A. Riquelme,P. Rodrigo,J. Rams 대한금속ᆞ재료학회 2023 METALS AND MATERIALS International Vol.29 No.2
The difficulty of getting a correct distribution of the reinforcement in the metal matrix and the complexity for achievinga good-metallurgy matrix-reinforcement bonding has limited the development of additive manufacturing of metal matrixcomposites. This research proposes the use of a reactive atmosphere during the fabrication process to obtain titanium matrixcomposites reinforced with TiN. The relation between the carrying gas and the process parameters used with the presence ofporous and defects, the microstructure, and microhardness has been obtained. Nitrogen was used as the carrying gas of thetitanium powder. Under laser irradiation, the particles melt and react with nitrogen, resulting in the formation of a titaniummatrix composite highly reinforced with TiN. The composite obtained had a microhardness increase between 50 and 100%in comparison with titanium samples fabricated in the same conditions in an argon atmosphere. Three reaction mechanismshave been proposed to take place in the microstructure, depending on the amount of nitrogen in the titanium particles, andits diffusion in them during the manufacture.
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C. Sánchez de Rojas Candela,A. Riquelme,P. Rodrigo,J. Rams 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.3
The difficulty of getting a correct distribution of the reinforcement in the metal matrix and the complexity for achievinga good-metallurgy matrix-reinforcement bonding has limited the development of additive manufacturing of metal matrixcomposites. This research proposes the use of a reactive atmosphere during the fabrication process to obtain titanium matrixcomposites reinforced with TiN. The relation between the carrying gas and the process parameters used with the presence ofporous and defects, the microstructure, and microhardness has been obtained. Nitrogen was used as the carrying gas of thetitanium powder. Under laser irradiation, the particles melt and react with nitrogen, resulting in the formation of a titaniummatrix composite highly reinforced with TiN. The composite obtained had a microhardness increase between 50 and 100%in comparison with titanium samples fabricated in the same conditions in an argon atmosphere. Three reaction mechanismshave been proposed to take place in the microstructure, depending on the amount of nitrogen in the titanium particles, andits diffusion in them during the manufacture.
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Ti6Al4V/SiC Metal Matrix Composites Additively Manufactured by Direct Laser Deposition
C. Sánchez de Rojas Candela,A. Riquelme,V. Bonache,P. Rodrigo,J. Rams 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.12
Nowadays, research on additive manufacturing of Ti6Al4V alloy is growing exponentially but there are just a few studiesabout additive manufacturing of metal matrix composite components. In this work, highly reinforced Ti6Al4V matrix compositeswith SiC particles have been additively manufactured by direct laser deposition (DLD). Ti6Al4V powder and SiCparticles have been deposited layer by layer to form an additive thin wall structure. The geometry, microstructure, and microhardnessof the samples are strongly influenced by the laser scanning speed used during de fabrication process. In addition,the effect of the SiC increment in reinforcement concentrations and the influence of SiC particle sizes in the microstructurehave been evaluated, and the reaction mechanisms have been established. The percentage of reinforcement measured is lowerthan expected due to the reinforcement-matrix reactivity that results in partially dissolved SiC particles and the formationof a TiC and Si5Ti3ring around them. The size and number of particles and reaction products depend on the initial size andpercentage of reinforcement and the DLD scanning speed. The higher the size and percentage of SiC particles and reactionproducts in the matrix, the higher the hardening effect of the composite matrix.
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Systematic Design of High-Resolution High-Frequency Cascade Continuous-Time Sigma-Delta Modulators
Ramón Tortosa,Rafael Castro-López,Elisenda Roca,Ángel Rodríguez-Vázquez,F.V. Fernández 한국전자통신연구원 2008 ETRI Journal Vol.30 No.4
This paper introduces a systematic top-down and bottom-up design methodology to assist the designer in the implementation of continuous-time (CT) cascade sigmadelta (ΣΔ) modulators. The salient features of this methodology are (a) flexible behavioral modeling for optimum accuracy-efficiency trade-offs at different stages of the top-down synthesis process, (b) direct synthesis in the continuous-time domain for minimum circuit complexity and sensitivity, (c) mixed knowledge-based and optimization-based architectural exploration and specification transmission for enhanced circuit performance, and (d) use of Pareto-optimal fronts of building blocks to reduce re-design iterations. The applicability of this methodology will be illustrated via the design of a 12-bit 20 MHz CT ΣΔ modulator in a 1.2 V 130 nm CMOS technology.
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Ramón Fuentes,Tania Flores,Pablo Navarro,Carlos Salamanca,Víctor Beltrán,Eduardo Borie 대한치주과학회 2015 Journal of Periodontal & Implant Science Vol.45 No.5
Purpose: The aim of this study was to analyze the anatomical dimensions of the buccal bone walls of the aesthetic maxillary region for immediate implant placement, based upon cone-beam computed tomography (CBCT) scans in a sample of adult patients. Methods: Two calibrated examiners analyzed a sample of 50 CBCT scans, performing mor¬phometric analyses of both incisors and canines on the left and right sides. Subsequently, in the sagittal view, a line was traced through the major axis of the selected tooth. Then, a second line (E) was traced from the buccal to the palatal wall at the level of the observed bone ridges. The heights of the buccal and palatal bone ridges were determined at the ma¬jor axis of the tooth. The buccal bone thickness was measured across five lines. The first was at the level of line E. The second was at the most apical point of the tooth, and the other three lines were equidistant between the apical and the cervical lines, and parallel to them. Statistical analysis was performed with a significance level of P≤0.05 for the bone thick¬ness means and standard deviations per tooth and patient for the five lines at varying depths. Results: The means of the buccal wall thicknesses in the central incisors, lateral incisors and canines were 1.14±0.65 mm, 0.95±0.67 mm and 1.15±0.68 mm, respectively. Additionally, only on the left side were significant differences in some measurements of buccal bone thickness observed according to age and gender. However, age and gender did not show significant differences in heights between the palatal and buccal plates. In a few cases, the buccal wall had a greater height than the palatal wall. Conclusions: Less than 10% of sites showed more than a 2-mm thickness of the buccal bone wall, with the exception of the central incisor region, wherein 14.4% of cases were ≥2 mm.
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Ramí,rez-Lugo, Juan S,Yoo, Hae Yong,Yoon, Su Jin,Dunphy, William G Landes Bioscience 2011 Cell cycle Vol.10 No.3
<P>In the presence of double-stranded DNA breaks (DSBs), the activation of ATR is achieved by the ability of ATM to phosphorylate TopBP1 on serine 1131, which leads to an enhancement of the interaction between ATR and TopBP1. In Xenopus egg extracts, the Mre11-Rad50-Nbs1 (MRN) complex is additionally required to bridge ATM and TopBP1 together. In this report, we show that CtIP, which is recruited to DSB-containing chromatin, interacts with both TopBP1 and Nbs1 in a damage-dependent manner. An N-terminal region containing the first two BRCT repeats of TopBP1 is essential for the interaction with CtIP. Furthermore, two distinct regions in the N-terminus of CtIP participate in establishing the association between CtIP and TopBP1. The first region includes two adjacent putative ATM/ATR phosphorylation sites on serines 273 and 275. Secondly, binding is diminished when an MRN-binding region spanning residues 25-48 is deleted, indicative of a role for the MRN complex in mediating this interaction. This was further evidenced by a decrease in the interaction between CtIP and TopBP1 in Nbs1-depleted extracts and a reciprocal decrease in the binding of Nbs1 to TopBP1 in the absence of CtIP, suggestive of the formation of a complex containing CtIP, TopBP1, and the MRN complex. When CtIP is immunodepleted from egg extracts, the activation of the response to DSBs is compromised and the levels of ATR, TopBP1, and Nbs1 on damaged chromatin are reduced. Thus, CtIP interacts with TopBP1 in a damage-stimulated, MRN-dependent manner during the activation of ATR in response to DSBs.</P>
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