RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Efficacy and Safety of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir in Non-Cirrhotic Asian Patients with Genotype 1b HCV Infection: ONYX-I SVR24 Results

( Lai Wei ),( Jinlin Hou ),( Yan Luo ),( Jeong Heo ),( Chi-jen Chu ),( Zhongping Duan ),( Mong Cho ),( Jun Cheng ),( Jun Li ),( Jidong Jia ),( Wenjing Lu ),( Linda M Fredrick ),( Tami Pilot-matias ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
- 원문보기
Aims: HCV genotype 1b is the most common genotype in Asian patients. ONYX-I is a phase 3, randomised, double-blind, placebo-controlled study of the 3-DAA regimen of OBV/PTV/r and DSV in treatment- naive and treatment-experienced non-cirrhotic patients with HCV GT1b infection in China, South Korea and Taiwan. Methods: In this study, the safety/efficacy of OBV/PTV/r + DSV administered for 12 weeks were evaluated in non-cirrhotic Asian patients. Patients in Arm A received active study drug during a 12-week double-blind (DB) period, while patients in Arm B received placebo during the same period followed by an open-label (OL) period in which they received 12 weeks of active study drug. Efficacy was assessed by SVR12 and SVR24. Efficacy and safety were assessed in all patients who received at least one dose of active study drugs. Results: 650 HCV GT1b patients (54% female, 100% Asian, 44% treatment-experienced) were enrolled from China (n=410) South Korea (n=120) and Taiwan (n=120), and randomised 1:1 to Arms A and B. In Arm A, SVR12 and SVR24 rates were 99.5% (183/184) in treatment-naive patients and 100% (141/141) in treatment- experienced patients. Most treatment-emergent adverse events (TEAEs) in patients receiving the active drug were mild in severity. The most common (≥5%) TEAEs in Arm A were upper respiratory tract infection (10.5%), headache (6.2%) and dizziness (5.2%). Seven patients had serious AEs during active treatment (Arm A) and one patient in Arm A discontinued treatment. Conclusions: In non-cirrhotic Asian adults with HCV GT1b-infection, treated with OBV/PTV/r + DSV for 12 weeks, SVR24 rates equalled previously reported SVR12 rates from this study (99.5% of treatment- naive and 100% of treatment-experienced patients), and are consistent with other clinical trials with this drug combination. The treatment was generally well tolerated with mostly mild TEAEs reported.
2
Border Control—A Membrane-Linked Interactome of <i>Arabidopsis</i>

Jones, Alexander M.,Xuan, Yuanhu,Xu, Meng,Wang, Rui-Sheng,Ho, Cheng-Hsun,Lalonde, Sylvie,You, Chang Hun,Sardi, Maria I.,Parsa, Saman A.,Smith-Valle, Erika,Su, Tianying,Frazer, Keith A.,Pilot, Guillaum American Association for the Advancement of Scienc 2014 Science Vol.344 No.6185
- 원문보기
<P>Cellular membranes act as signaling platforms and control solute transport. Membrane receptors, transporters, and enzymes communicate with intracellular processes through protein-protein interactions. Using a split-ubiquitin yeast two-hybrid screen that covers a test-space of 6.4 x 10(6) pairs, we identified 12,102 membrane/signaling protein interactions from Arabidopsis. Besides confirmation of expected interactions such as heterotrimeric G protein subunit interactions and aquaporin oligomerization, >99% of the interactions were previously unknown. Interactions were confirmed at a rate of 32% in orthogonal in planta split-green flourescent protein interaction assays, which was statistically indistinguishable from the confirmation rate for known interactions collected from literature (38%). Regulatory associations in membrane protein trafficking, turnover, and phosphorylation include regulation of potassium channel activity through abscisic acid signaling, transporter activity by a WNK kinase, and a brassinolide receptor kinase by trafficking-related proteins. These examples underscore the utility of the membrane/signaling protein interaction network for gene discovery and hypothesis generation in plants and other organisms.</P>
3
Benefits and challenges of agroforestry adoption: a case of Musebeya sector, Nyamagabe District in southern province of Rwanda

Pilote Kiyani,Jewel Andoh,이요한,이돈구 한국산림과학회 2017 Forest Science And Technology Vol.13 No.4
Rwanda’s natural forest is under pressure due to increasing rural population growth and subsistence farming. The Rwanda Ministry of Agriculture has therefore introduced agroforestry technology in forest-dependent communities to minimize the pressures on the forests and improve local people’s livelihoods. This new technology has, however, not seen massive adoption in the country. This study examined the socioeconomic and environmental beneﬁts of the agroforestry technology introduced particularly in Nyamagabe District and the challenges facing its adoption. Results showed that the agroforestry practices are contributing to an increase in income of agroforestry adopters compared to non-agroforestry adopters, and are improving soil fertility, reducing deforestation, and conserving soil and water in the district. However, results showed that, due to lack of skills and technical know-how, capital and quality seeds, some farmers are declining to adopt the new agroforestry practices. The respondents perceived that by providing subsidies to farmers, regular training, and informal education, establishing tree nurseries to improve the production of quality seeds, and also involving farmers in decision-making will increase agroforestry adoption. The government and other stakeholders should consider the views expressed by the farmers and take the necessary steps to address these challenges facing agroforestry technology adoption.