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Nguyen Ngoc Minh,Duong Men Thi Hoai,Nguyen Phuong Linh,Bui Bich Phuong,Ahn Hee-Chul,Cho Jungsook 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.5
Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential inhibitor of c-Jun N-terminal kinase 3 (JNK3). Although its antihypertensive effect is widely known, the role of efonidipine in the central nervous system has remained elusive. The present study investigated the effects of efonidipine on the inflammation and cell migration induced by lipopolysaccharide (LPS) using murine BV2 and human HMC3 microglial cell lines and elucidated signaling molecules mediating its effects. We found that the phosphorylations of JNK and its downstream molecule c-Jun in LPS-treated BV2 cells were declined by efonidipine, confirming the finding from virtual screening. In addition, efonidipine inhibited the LPS-induced production of pro-inflammatory factors, including interleukin-1β (IL-1β) and nitric oxide. Similarly, the IL-1β production in LPS-treated HMC3 cells was also inhibited by efonidipine. Efonidipine markedly impeded cell migration stimulated by LPS in both cells. Furthermore, it inhibited the phosphorylation of inhibitor kappa B, thereby suppressing nuclear translocation of nuclear factor-κB (NF-κB) in LPS-treated BV2 cells. Taken together, efonidipine exerts anti-inflammatory and anti-migratory effects in LPS-treated microglial cells through inhibition of the JNK/NF-κB pathway. These findings imply that efonidipine may be a potential candidate for drug repositioning, with beneficial impacts on brain disorders associated with neuroinflammation.
NGUYEN, Phuong-Linh,PHAN, Dinh-Quyet,NGUYEN, Thi-Uyen Korea Distribution Science Association 2023 유통과학연구 Vol.21 No.1
Purpose: This study aims to investigate the linkages among cross-channel integration capability (CCI), showrooming, webrooming, and customer value of retail enterprises. From the literature review, this research proposes the research model on the direct impact of showrooming and webrooming on customer value as well as the indirect impact of cross-channel integration capability on customer value which is mediated by both showrooming and webrooming of retail enterprises. Research design, data, and methodology: By conducting a survey of 304 consumers in the five biggest retailers in Hanoi-Vietnam from mid-September 2021 to the end of November 2021, the PLS-SEM was used to test the hypotheses. Results: The research results reveal the favorable impact of (CCI) on improving showrooming and webrooming, and the important role of developing both showrooming and webrooming in bringing more value to the customer of retail enterprises. The findings also express that showrooming and webrooming acts mediating role in the favorable relationship between (CCI) and customer value of retailers. Conclusions: This research clarifies the positive impact of (CCI), showrooming, and webrooming on customer value. In addition, this study suggests practical implications for retail managers to provide more value for customers by enhancing (CCI) and developing both showrooming and webrooming.
Development of Monoclonal Antibodies for Diagnosis of Plasmodium vivax
Nguyen Thi Phuong Linh,박현,이진영,Dong-Xu Liu,서가은,손혜진,한진희,한은택,신호준,여선주 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6
Plasmodium lactate dehydrogenase (pLDH) is a strong target antigen for the determination of infection with Plasmodium species specifically. However, a more effective antibody is needed because of the low sensitivity of the current antibody in many immunological diagnostic assays. In this study, recombinant Plasmodium vivax LDH (PvLDH) was experimentally constructed and expressed as a native antigen to develop an effective P. vivax-specific monoclonal antibody (mAb). Two mAbs (2CF5 and 1G10) were tested using ELISA and immunofluorescence assays (IFA), as both demonstrated reactivity against pLDH antigen. Of the 2 antibodies, 2CF5 was not able to detect P. falciparum, suggesting that it might possess P. vivax-specificity. The detection limit for a pair of 2 mAbs-linked sandwich ELISA was 31.3 ng/ml of the recombinant antigen. The P. vivax-specific performance of mAbs-linked ELISA was confirmed by in vitro-cultured P. falciparum and P. vivax-infected patient blood samples. In conclusion, the 2 new antibodies possessed the potential to detect P. vivax and will be useful in immunoassay.
Factors Affecting Online Payment Method Decision Behavior of Consumers in Vietnam
NGUYEN, Thi Phuong Linh,NGUYEN, Van Hau Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.10
E-commerce development led to the explosion of online payment. Consumers have many choices when deciding on the online payment method for each transaction. Using a combination of both qualitative and quantitative methods with the help of SPSS AMOS version 22.0, the article explores the factors that influence consumers' online payment method decision behavior in Vietnam. Research results show that awareness of usefulness, awareness of risk, awareness of trust, awareness ease of use, product uncertainly perception and perceived behavioral control have effects on the behavior of deciding on online payment methods. Awareness of risk has the strongest negative impact on online payment method decision behavior and awareness of usefulness has the strongest positive impact on online payment method decision behavior. Based on these important results, the article proposes a number of implications: (i) continuing to invest and upgrade modern technology to ensure customer information absolutely confidential; (ii) converting all ATM cards on the market to EMV chip standard card technology; (iii) improving service activities, quickly handle things to create confidence for customers; (iv) credit institutions operating in the field of online payment linked to e-commerce sites, supermarkets, convenience stores, restaurants must ask partners to increase transparency for the products.
The Perceived Value of Customers: Antecedents and Its Effect on Word-of-mouth
Phuong-Linh Nguyen,Dinh-Quyet Phan,Thi-Uyen Nguyen People & Global Business Association 2024 Global Business and Finance Review Vol.29 No.1
Purpose: This study aims to investigate the antecedents of the customer's perceived value, including multi-channel integration and brand equity, and the impact of the perceived value on word-of-mouth. Design/methodology/approach: A quantitative approach by PLS-SEM was used in the research. This paper conducted a survey of 414 respondents who are customers of retail firms in Vietnam. Findings: The research results illustrate the significant impact of multi-channel integration and brand equity on the perceived value of customers. The study also found that word-of-mouth is directly and positively influenced by the customer's perceived value. Research limitations/implications: Besides multi-channel integration and brand equity, other factors that may act as antecedents of the perceived value have not been recognized in the study. The study only focuses on the retail industry with a relatively small sample size which is a limitation of the sample representative. Originality/value: This study provides reliable evidence about the important role of building an integrated multi- channel system and nurturing brand equity to increase the perceived value in customer's minds. Additionally, the research reinforces the convincing evidence of the significant and positive relationship between the customer's perceived value and their positive word-of-mouth communication.