The Impact of Inflammatory and Infectious Diseases of Vulvar on Quality of Life

( Kıymet Handan Kelekci ),( Selcuk Ozyurt ),( Bulent Ozkan ),( Semsettin Karaca ),( Ali Karakuzu ),( Ilgul Bilgin ) 대한폐경학회 2016 대한폐경학회지 Vol.22 No.3

Objectives: This study aimed to evaluate the effects of vulvar dermatoses (VD) and vulvar infections (VE) on anxiety, depression scores, general, and dermatological quality of life (QOL) of women. Methods: We conducted a cross-sectional survey on patients diagnosed with VD and VE. All patients were assessed using a sociodemographic form, Skindex-29 scale, World Health Organization QOL (WHOQOL) BREF scale, Hamilton anxiety rating scale (HAM-A), Hamilton depression rating scale (HAM-D). Results: HAM-A score was significantly higher in the VD group than in the control group. Based on age groups, all subscales of Skindex-29 were found to be higher in women > 50 years. For women with severe pruritus, the symptom subscale was higher in patients with skin involvement and the function and emotion subscales were higher in patients with and emotion subscales were higher in patients with mucosal involvement. Conclusions: We found that VD was particularly significantly associated with decreased QOL. (J Menopausal Med 2016;22:131-138)

Numerical studies on axially loaded doubler plate reinforced elliptical hollow section T-joints

Busra Sari,Emre Ozyurt 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.43 No.1

This paper presents results of numerical studies completed on unreinforced and doubler plate reinforced Elliptical Hollow Section (EHS) T-joints subjected to axial compressive loading on the brace member. Non-linear finite element (FE) models were developed using the finite element code, ABAQUS. Available test data in literature was used to validate the FE models. Subsequently, a parametric study was carried out to investigate the effects of various geometrical parameters of main members and reinforcement plates on the ultimate capacity of reinforced EHS T-joints. The parametric study found that the reinforcing plate significantly increases the ultimate capacity of EHS T-joints up to twice the capacity of the corresponding unreinforced joint. The thickness and length of the reinforcing plate have a positive effect on the ultimate capacity of Type 1 joints. This study, however, found that the capacity of Type 1 orientation is not dependent on the brace-to-chord diameter ratio. As for type 2 orientations, the thickness and length of the reinforcement have a minimal effect on the ultimate capacity. A new design method is introduced to predict the capacity of the reinforced EHS T-joints Type 1 and 2 based on the multiple linear regression analyses.

A Numerical Study to Evaluate the Changes in Dynamic Properties of Various Steel Truss Types Under Fire Conditions

R. Sibil,E. Ozyurt 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.6

This study numerically examines the changes in dynamic properties of fire-damaged steel trusses made of square hollow sections subjected to uniform and non-uniform heating scenarios. After verifying the numerical models at both ambient and elevated temperatures, a vast number of the simulations were analysed using non-linear finite element software to evaluate the effects of fire scenarios, truss types, and fire-damaged levels on the fire dynamic characteristics of square hollow section Warren, Howe, and Pratt trusses. The results indicated that the natural frequency of steel trusses significantly decreased as the fire-damaged level increased. In the case of local fire, the natural frequencies of the trusses began to drop suddenly at temperatures above 550 °C. Whereas the drop in the natural frequency of the uniformly heated trusses started at even much lower temperature levels. Moreover, the decrease in the natural fundamental frequencies of the uniformly heated trusses was lower than the reduction rate of the modulus of elasticity at high temperatures due to the large non-linear deformations. Since the modification of the stiffness of the truss by simply the reduction factor of the elastic modulus of the steel may be inappropriate to calculate the fundamental frequency of the trusses in the local and global fires, a new method was introduced to calculate the fundamental frequency value of the steel trusses in the fire.

Are Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios Associated with Endometrial Precancerous and Cancerous Lesions in Patients with Abnormal Uterine Bleeding?

Acmaz, Gokhan,Aksoy, Huseyin,Unal, Dilek,Ozyurt, Sezin,Cingillioglu, Basak,Aksoy, Ulku,Muderris, Ipek Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Background: An easy, reproducible and simple marker is needed to estimate phase of endometrial pathologic lesions such as hyperplasia and endometrial cancer and distinguish from pathologically normal results. We here aimed to clarify associations among neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), endometrial hyperplasia and cancer in patients with abnormal uterine bleeding. Materials and Methods: Patients (n=161) who were admitted with abnormal uterine bleeding and the presence of endometrial cells on cervical cytology or thick endometrium were investigated. The study constituted of three groups according to pathologic diagnosis. Group 1 included endometrial precancerous lesions like hyperplasia (n=63), group 2 included endometrial cancerous lesions (n=38) and group 3 was a pathologically normal group (n=60). Blood samples were obtained just before the curettage procedure and the NLR was defined as the absolute neutrophil count divided by the absolute lymphocyte count; similarly, PLR was defined as the absolute platelet count divided by the absolute lymphocyte count. Results: The white blood cell count was significantly higher in patients with cancer than in those with hyperplasia (p=0.005). The platelet count and neutrophil to lymphocyte ratio were significantly higher in patients with cancer than in control patients, but there was significantly no difference between patients with hyperplasia and other groups (p=0.001 and p=0.025 respectively). PLR was significantly lower in control subjects than in other groups (p<0.001), but there was no significant difference between patients with hyperplasia and those with cancer. Conclusions: PLR was significantly lower in control subjects than in other groups. Thus both hyperplasia and cancer may be differentiated from pathologically normal patients by using PLR. White blood cell count was significantly higher in patients with cancer than in those with hyperplasia and pathologically normal patients. Therefore white blood cell count may be used for discriminate hyperplasia to cancer. By using multiple inflammation parameters, discrimination may be possible among endometrial cancer, endometrial precancerous lesions and pathologically normal patients.

Roles of White Blood Cells and Subtypes as Inflammatory Markers in Skin Cancer

Baykan, Halit,Cihan, Yasemin Benderli,Ozyurt, Kemal Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Objective: Skin tumors are the most commonly seen cancer type worldwide. Regarding pathogenesis, it is thought that disruption of kinetics through T lymphocyte-mediated development of chronic inflammation may be involved. The present study was intended to identify role of inflammatory cells such as neutrophils, monocytes and lymphocytes in the determination of risk for skin cancer. Materials and Methods: We retrospectively reviewed charts of 569 cases diagnosed as having primary skin tumors. Data regarding age, gender and histopathological subtype were recorded. Blood parameters studied on the day before surgery including WBCs, neutrophils, and lymphocyte counts, neutrophil:lymphocyte and neutrophil:monocyte ratios were also recorded. Two-hundred and two healthy individuals presented for check-up in an outpatient clinic were selected as the control group. Parameters studied in cases with skin cancer were compared to those healthy individuals. Findings: Of the cases with skin cancer, 401 were basal cell carcinoma (BCC) while 144 were squamous cell carcinoma (SCC) and 13 were malignant melanoma (MM). WBC, neutrophil and monocyte counts and the neutrophil:lymphocyte ratio were found to be lower in the patient group than in the healthy control group (p<0.001) while no significant difference was found in other parameters reviewed (p>0.05). No significant difference was found in WBC, neutrophil, neutrophil: monocyte ratio according to gender (p>0.05). Monocyte count was found to be $0.68{\pm}0.61$ in men and $0.55{\pm}0.25$ in women, indicating strong statistical significance (p<0.001). WBC, neutrophil and monocyte values were highest in control group while lowest in BCC. When BCC and SCC groups were compared to controls, significant differences found (p<0.001). There were no significant differences in lymphocyte counts among groups (p=0.976). Neutrophil:lymphocyte ratios were 3.24 in BCC, 3.59 in SCC, 3.44 in MM and 5.06 in control group (p<0.001). Conclusions: In our study, it was found that there were significant differences in complete blood count, neutrophil, monocyte and neutrophil:lymphocyte levels among groups. Neutrophil: lymphocyte ratio was found to be lowest in BCC among skin cancers.

Evaluation of Endometrial Precancerous Lesions in Postmenopausal Obese Women - A High Risk Group?

Acmaz, Gokhan,Aksoy, Huseyin,Albayrak, Evrim,Baser, Muruvet,Ozyurt, Sezin,Aksoy, Ulku,Unal, Dilek Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Aim: To evaluate precancerous lesions such as hyperplasia and endometrial polyps in obese postmenopausal women. Materials and Methods: Women who were referred with abnormal uterine bleeding in postmenopausal period or the presence of endometrial cells on cervical cytology in our department were investigated. Anthropometric measurements such as height, weight, body mass index, waist/hip ratio and endometrial thickness were compared between a precancerous lesion (hyperplasia and endometrial polyp) group and a pathologically normal group. Results: We detected statistically significant thickening of endometrium in patients with precancerous lesions. Moreover patients with precancerous lesions had higher body mass index than the pathologically normal group. Conclusions: We found elevated precancerous lesion rates in overweight and obese women in the postmenopausal period, of interest given that the prevalence of obesity is increasing in most parts of the world. Although screening for endometrial cancer is not recommended for the general population, in high-risk populations like obese postmenopausal women, it may be very important.

Relationships between Skin Cancers and Blood Groups - Link between Non-melanomas and ABO/Rh Factors

Cihan, Yasemin Benderli,Baykan, Halit,Kavuncuoglu, Erhan,Mutlu, Hasan,Kucukoglu, Mehmet Burhan,Ozyurt, Kemal,Oguz, Arzu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Background: This investigation focused on possible relationships between skin cancers and ABO/Rh blood groups. Materials and Methods: Between January 2005 and December 2012, medical data of 255 patients with skin cancers who were admitted to Kayseri Training and Research Hospital, Radiation Oncology and Plastic Surgery Outpatient Clinics were retrospectively analyzed. Blood groups of these patients were recorded. The control group consisted of 25701 healthy volunteers who were admitted to Kayseri Training and Research Hospital, Blood Donation Center between January 2010 and December 2011. The distribution of the blood groups of the patients with skin cancers was compared to the distribution of ABO/Rh blood groups of healthy controls. The association of the histopathological subtypes of skin cancer with the blood groups was also investigated. Results: Of the patients, 50.2% had A type, 26.3% had O type, 16.1% had B type, and 7.5% had AB blood group with a positive Rh (+) in 77.3%. Of the controls, 44.3% had A type, 31.5% had 0 type, 16.1% had B type, and 8.1% had AB blood group with a positive Rh (+) in 87.8%. There was a statistically significant difference in the distribution of blood groups and Rh factors (A Rh (-) and 0 Rh positive) between the patients and controls. A total of 36.8% and 20.4% of the patients with basal cell carcinoma (BCC) had A Rh (+) and B Rh (+), respectively, while 39.2% and 27.6% of the controls had A Rh (+) and B Rh (+), respectively. A significant relationship was observed between the patients with BCC and controls in terms of A Rh (-) (p=0.001). Conclusion: Our study results demonstrated that there is a significant relationship between non-melanoma skin cancer and ABO/Rh factors.