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Is Season a Prognostic Factor in Breast Cancer?
Mutlu, Hasan,Akca, Zeki,Cihan, Yasemin Benderli,Kurnaz, Fatih,Aslan, Tuncay,Erden, Abdulsamet,Ugur, Hediye,Aksahin, Arzu,Buyukcelik, Abdullah Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: Some studies have indicated an inverse relationship between cancer risk and sunlight exposure. Others have reported that the prognosis of some cancers such as prostate, colon, ovarian and non melanoma skin cancer, were affected by the season in which the cancer was diagnosed. In our study, we evaluated whether season is prognostic in Turkish patients with breast cancer. Materials and Methods: A total of 517 patients from Kayseri Training and Research Hospital were analysed retrospectively. Patients were divided into 4 groups according to season of cancer diagnosis: winter, spring, summer and autumn. The prognostic factors for disease free survival and overall survival were investigated. Results: No significant differences were found among groups regarding prognostic factors overall. Only estrogen receptor status and lymphovascular invasion were independent prognostic factors (p=0.001 and p=0.001 respectively). We found significantly differences for mean disease free survival among groups (p=0.019). Winter group had better mean DFS while summer group had worse DFS. Mean overall survival was similar in the four groups (p=0.637). Conclusions: The season is not an independent predictive factor. However, due to interaction with other factors, we think that the season of cancer diagnosis is important for cancer prognosis.
Mutlu Erhan,Duman Güler Sıla,Karaca Doğukan,Özvarol Yaşar,Şahin Ahmet 한국해양과학기술원 2023 Ocean science journal Vol.58 No.1
The biometrical dynamics of Posidonia oceanica were studied with regard to variation and its depthwise extension with four major bottom types along the entire Turkish Mediterranean coasts in winter and summer during 2019. The bottom type which mainly consisted of rock, matte (hard bottom), sand, and mud (soft bottom) was a key determinant for biometrical (density and morphometric) changes which were more prominent in summer. The upper and lower limits of vertical depthwise extension of the meadows were restricted by the zonal distribution of the hard bottom. The limits were not restricted on the soft bottom. However, some large areas of the soft bottoms were devoid of the meadows depending on the existence of mobile substrate affected by the high dynamic of water movement. The density variables were higher on hard bottoms than on the soft bottoms; the inter-nodal distance was longer on matte than on rock, sand, and mud, in contrast to leaf biomass. Mud had the lowest number of leaves per shoot and shoot density, whereas rock had the highest number. The shortest rhizome was measured on the rock, while the longest rhizome was measured on matte, which also had the longest leaves. The soft bottoms had wider leaves than the hard bottoms had. Besides the seasonal and depthwise differences in the biometrics, the biometrics were separately assembled between rock and mud. Contrary to the morphometric variables, the density biometrics decreased linearly from the hard bottom to the soft bottom.
Mutlu, A.,Lee, B.K.,Park, G.H.,Yu, B.G.,Lee, C.H. Pergamon Press ; Elsevier [distribution] 2012 Atmospheric environment Vol.47 No.-
The long-term concentrations of cadmium (Cd) in total suspended particulate (TSP) were calculated from data obtained from 30 ambient air-monitoring stations (AAMSs) located in seven metropolitan cities throughout Korea. The annual mean levels of Cd in TSP in port cities, industrial cities, and an inland city showed a decreasing trend over the 7-year study period. The overall highest average concentration was observed in Incheon with an annual mean of 3.92+/-1.62ngm<SUP>-3</SUP>, followed by Ulsan and Busan. The long-term Cd mean levels from international port and/or industrial cities (Incheon, Ulsan, Busan) were much higher than those from inland cities (Seoul, Daegu, Daejeon, and Gwangju). Temporal analysis indicated that there were no significant differences among Cd levels in different seasons. However, in Incheon, the seasonal average concentrations of Cd in spring, winter, and fall were 5.20 (+/-3.27)ngm<SUP>-3</SUP>, 4.01 (+/-0.93)ngm<SUP>-3</SUP>, and 3.5 (+/-0.77)ngm<SUP>-3</SUP>, respectively, which were significantly higher levels than those measured in the other cities for the corresponding seasons. These high concentrations in Incheon are likely due to the combined effects of local industries, traffic, ship emissions, and long-range transported PM from the northeastern industrial regions of China. The long-term summer average concentration in Ulsan, the largest industrial city, was 4.58+/-1.15ngm<SUP>-3</SUP>, which was significantly higher than the other seasonal values and also the summer averages of the other cities. This can be explained by downwind location effects of prevailing winds that pass through the industrial and port sectors of Ulsan. Excess cancer risk (ECR) estimates indicated that the carcinogenic risk due to inhaled Cd is 7, 6, and 4 persons per million of population in Incheon, Ulsan, and Busan, respectively.
Mutlu, Hasan,Buyukcelik, Abdullah,Karaca, Halit,Aksahin, Arzu,Berk, Veli,Aslan, Tuncay,Erden, Abdulsamet,Akca, Zeki,Ozkan, Metin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Introduction: Mesothelioma is a rare neoplasm arising from mesothelial surfaces with the malignant pleural mesothelioma (MPM) as the most common form. Secondline chemotherapy in MPM is still controversial and in this study we evaluated whether it is superior to best supportive care. Materials and Methods: A total of 51 patients with MPM from Acibadem Kayseri Hospital, Kayseri Training and Research Hospital and Erciyes University were analyzed retrospectively. The patients treated with secondline chemotherapies (SLCT) were compared with those treated with best supportive care (BSC) for overall survival. Results: The median overall survival (OS) for firstline chemotherapy${\rightarrow}$SLCT and firstline chemotherapy${\rightarrow}$BSC groups were 20.3 and 14.7 months respectively (p=0.079). After firstline chemotherapy the median OS for SLCT and BSC were 5.9 and 4.7 months (p=0.355). Discussion: Although there was a trend for improvement in overall survival in patients treated with secondline chemotherapy, the difference was not statistically significant. Our results do not support the proposal that secondline chemotherapy could be effective in patients with MPM.
Mutlu, Atilla,Lee, Byeong-Kyu Ecomed 2012 Environmental Science and Pollution Research Vol.19 No.6
<P>This study collected long-term airborne lead concentrations in the Korean peninsula and analyzed their temporal, spatial, and cancer risk characterization.</P>
Does Sunlight Exposure Improve Survival in Patients with Non-small Cell Lung Cancer?
Mutlu, Hasan,Buyukcelik, Abdullah,Aksahin, Arzu,Kibar, Mustafa,Cihan, Yasemin Benderli,Kaya, Eser,Seyrek, Ertugrul,Yavuz, Sinan,Erden, Abdulsamet,Calikusu, Zuleyha,Aslan, Tuncay,Akca, Zeki Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Some epidemiological studies reported that sunlight exposure and highvitamin D levels may decrease the morbidity and mortality related to cancer. We aimed to evaluate whether sunlight exposure has an impact on survival in patients with non small cell lung cancer. Materials and Methods: A total of 546 patients with NSCLC from two different regions (Kayseri and Adana) differing according to sunlight exposure were analysed retrospectively. Results: The median overall survival (OS) rates were 11. 6 (CI: 9.50-13.6) and 15.6 months (CI: 12.4-18.8) for Kayseri and Adana, respectively, in all patients (p=0.880). Conclusions: There were no differences between groups in terms of OS. While there is strong evidence regarding inverse relationship between cancer incidence and sunlight exposure, it is still controversial whether sunlight exposure is a good prognostic factor for survival in patients with lung cancer.
Lack of Sunlight Exposure Influence on Primary Glioblastoma Survival
Mutlu, Hasan,Akca, Zeki,Erden, Abdulsamet,Aslan, Tuncay,Ucar, Kadir,Kaplan, Bunyamin,Buyukcelik, Abdullah Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10
Background: The prognosis of primary glioblastoma (GBM) is poor. Approximately 2/3 of primary brain tumor diagnoses are GBM, of which 95% are primary lesions. In this study, we aimed to evaluate whether more sunlight exposure has an effect on survival of patients with primary GBM. Materials and Methods: A total of 111 patients with primary GBM were enrolled from Kayseri in inner Anatolia which has a cold climate (n: 40) and Mersin in Mediterranean region with a warm climate and more sunlight exposure (n: 71). The patients with primary GBM were divided into two groups as Kayseri and Mersin and compared for progression free survival (PFS) and overall survival (OS).Results: The PFS values were 7.0 and 4.7 months for Kayseri and Mersin groups, respectively (p=0.10) and the repsective OS values were 13.3 and 9.4 months (p=0.13). We did not found any significant difference regarding age, sex, comorbidity, smoking, surgery, resurgery, adjuvant chemoradiotherapy and palliative chemotherapy between the groups. Conclusions: We found that more sunlight exposure had no impact on prognosis of patients with primary GBM, adding inconsistency to the literature about the relationship between sunlight and GBM.