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Fuzzy Logic and Causal Analysis in Biomedical Sensing System
Hiroshi Nakajima,Naoki Tsuchiya,Kenta Yamamoto,Yutaka Hata 한국지능시스템학회 2010 한국지능시스템학회 학술발표 논문집 Vol.20 No.2
This article proposes the combination of fuzzy logic and causal analysis regarding biomedical sensing. As one of the applications, a heart rate monitoring system is introduced. It monitors heart rate of human body during sleep or lying on the bed. The system consists of an air pressure sensor and data analysis computation part. Fuzzy logic is employed as a role of filtering heart beat signals from an air pressure sensor data which superimposes vibration signals of heart beat, body movement, and respiration. Causal analysis plays a role of making transparent of calculation flow in heart rate from the extracted heat beat signals. The experiments were conducted to prove the performance of the proposed method. Experimental results were very high correlation coefficient of around 0.85.
Hara Susumu,Tsuchiya Mitsuo,Kimura Tetsuya,Akai Naoki 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.3
Recently, many studies have presented on realizing novel mobility technologies with consideration for aging society. The aim of these studies is to establish autonomous driving technology (ADT). The objects of ADT are mainly four-wheel motor vehicles. On the other hand, ADT for motorcycles has not been fully addressed yet. Motorcycles have straight-line stability in the state of high-speed driving. However, their stability tends to diminish when being driven at extremely low speed. This study addresses how a motorcycle should be stabilized under low-speed driving. From the viewpoint of actual use, including high-speed driving, major structural changes should be avoided. In order to obtain a linearized motorcycle model without skidding, a model based on SPACAR, a finite element method computation program, is introduced. Furthermore, velocity-dependent gain-scheduling control is applied to utilize the feedback control gains obtained by the linearized model with respect to velocity. Following the deceleration simulation success in the authors’ previous paper, we mainly verify the experimental investigation of the above model and control system design. The gain-scheduling method is improved from that in the previous simulation study. The experimental responses show stable driving at 1.5 km/h.
Solvate Ionic Liquid Electrolyte for Li–S Batteries
Dokko, Kaoru,Tachikawa, Naoki,Yamauchi, Kento,Tsuchiya, Mizuho,Yamazaki, Azusa,Takashima, Eriko,Park, Jun-Woo,Ueno, Kazuhide,Seki, Shiro,Serizawa, Nobuyuki,Watanabe, Masayoshi The Electrochemical Society 2013 Journal of the Electrochemical Society Vol.160 No.8
<P>Innovation in the design of electrolyte materials is crucial for realizing next-generation electrochemical energy storage devices such as Li–S batteries. The theoretical capacity of the S cathode is 10 times higher than that of conventional cathode materials used in current Li–ion batteries. However, Li–S batteries suffer from the dissolution of lithium polysulfides, which are formed by the redox reaction at the S cathode. Herein, we present simple solvate ionic liquids, glyme–Li salt molten complexes, as excellent electrolyte candidates because they greatly suppress the dissolution of lithium polysulfides. The molten complexes do not readily dissolve other ionic solutes, which leads to the stable operation of the Li–S battery over more than 400 cycles with discharge capacities higher than 700 mAh g-sulfur<SUP>−1</SUP> and with coulombic efficiencies higher than 98% throughout the cycles. Such high performance has not been realized to the best of our knowledge. Furthermore, the addition of a nonflammable fluorinated solvent, which does not break the solvate structure of the glyme–Li salt molten complexes, greatly enhances the power density of the Li–S battery. The strategic design of electrolyte properties provides opportunities for the development of new electrochemical devices with many different electrode materials.</P>
Piras, Vincent,Selvarajoo, Kumar,Fujikawa, Naoki,Choi, Sang-Dun,Tomita, Masaru,Giuliani, Alessandro,Tsuchiya, Masa Korea Genome Organization 2007 Genomics & informatics Vol.5 No.3
MicroRNAs (miRNAs) are known to negatively control protein-coding genes by binding to messenger RNA (mRNA) in the cytoplasm. In innate immunity, the role of miRNA gene silencing is largely unknown. In this study, we performed microarray-based experiments using lipopolysaccharide (LPS)-stimulated macrophages derived from wild-type, MyD88 knockout (KO), TRIF KO, and MyD88/TRIF double KO mice. We employed a statistical approach to determine the importance of the commonality and specificity of miRNA binding sites among groups of temporally co-regulated genes. We demonstrate that both commonality and specificity are irrelevant to define a priori groups of co-down regulated genes. In addition, analyzing the various experimental conditions, we suggest that miRNA regulation may not only be a late-phase process (after transcription) but can also occur even early (1h) after stimulation in knockout conditions. This further indicates the existence of dynamic interactions between miRNA and signaling molecules/transcription factor regulation; this is another proof for the need of shifting from a 'hard-wired' paradigm of gene regulation to a dynamical one in which the gene co-regulation is established on a case-by-case basis.
Satoshi Kato,Satoru Demura,Yuki Kurokawa,Naoki Takahashi,Kazuya Shinmura,Noriaki Yokogawa,Noritaka Yonezawa,Takaki Shimizu,Ryo Kitagawa,Hiroyuki Tsuchiya 대한재활의학회 2020 Annals of Rehabilitation Medicine Vol.44 No.3
Objective To examine the efficacy and safety of an innovative, device-driven abdominal trunk muscle strengthening program, with the ability to measure muscle strength, to treat chronic low back pain (LBP) in elderly participants. Methods Seven women with non-specific chronic LBP, lasting at least 3 months, were enrolled and treated with the prescribed exercise regimen. Patients participated in a 12-week device-driven exercise program which included abdominal trunk muscle strengthening and 4 types of stretches for the trunk and lower extremities. Primary outcomes were adverse events associated with the exercise program, improvement in abdominal trunk muscle strength, as measured by the device, and improvement in the numerical rating scale (NRS) scores of LBP with the exercise. Secondary outcomes were improvement in the Roland-Morris Disability Questionnaire (RDQ) score and the results of the locomotive syndrome risk test, including the stand-up and two-step tests. Results There were no reports of increased back pain or new-onset abdominal pain or discomfort during or after the device-driven exercise program. The mean abdominal trunk muscle strength, NRS, RDQ scores, and the stand-up and two-step test scores were significantly improved at the end of the trial compared to baseline. Conclusion No participants experienced adverse events during the 12-week strengthening program, which involved the use of our device and stretching, indicating the program was safe. Further, the program significantly improved various measures of LBP and physical function in elderly participants.
Yanagita, Kengo,Nagashio, Ryo,Ryuge, Shinichiro,Katono, Ken,Jiang, Shi-Xu,Tsuchiya, Benio,Nakashima, Hiroyasu,Fukuda, Eriko,Goshima, Naoki,Saegusa, Makoto,Satoh, Yukitoshi,Masuda, Noriyuki,Sato, Yuich Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: Identification of predictive markers for the efficacy of platinum-based chemotherapy is necessary to improve the quality of the life of cancer patients. Materials and Methods: We detected proteins recognized by autoantibodies in pretreated sera from patients with lung adenocarcinoma (AC) evaluated as showing progressive disease (PD) or a partial response (PR) after cisplatin-based chemotherapy by proteomic analysis. Then, the levels of the candidate autoantibodies in the pretreated serum were validated by dot-blot analysis for 22 AC patients who received platinum-based chemotherapy, and the expression of identified proteins was immunohistochemically analyzed in 40 AC biopsy specimens. Results: An autoantibody against galectin-3 (Gal-3) was detected in pretreated sera from an AC patient with PD. Serum IgG levels of anti-Gal-3 autoantibody were significantly higher in patients evaluated with PD than in those with PR and stable disease (SD) (p = 0.0084). Furthermore, pretreated biopsy specimens taken from patients evaluated as showing PD following platinumbased chemotherapy showed a tendency to have a higher positive rate of Gal-3 than those with PR and SD (p = 0.0601). Conclusions: These results suggest that serum IgG levels of anti-Gal-3 autoantibody may be useful to predict the efficacy of platinum-based chemotherapy for patients with lung AC.