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The Effect of ZD 1839 (Iressa) in the Treatment of RefractoryNon Small Cell Lung Cancer
Yong Tai Kim,Chul Kim,Joo Hyuk Sohn,So Young Park,Soo Young Park,Nae Choon Yu,Young Sam Kim,Se Kyu Kim,Joon Chang,Kil Dong Kim,Kyung Young Chung,Joo Hang Kim 대한암학회 2003 Cancer Research and Treatment Vol.35 No.6
Purpose: The aim of this study was to evaluate theefficacy and the safety of ZD 1839 (Iressa) as a 3rd or4th line chemotherapy regimen in NSCLC patients whoare refractory to a previous chemotherapy regimen.Materials and Methods: Twenty-five patients who wererefractory to previous chemotherapy were selected forthis study. The eligible patients had an ECOG performancestatus of 0 to 2, and an appropriate end organfunction. ZD 1839 (Iressa) 250 mg/d was orally administereduntil the patients experienced disease progressionor unacceptable toxicity.Results: Twenty-five patients were analyzed. The medianage of the patients was 57 years. The response ratewas 12.0% with partial responses in 3 patients. Fourteenpatients (56%) remained in the stable disease state and8 patients progressed. The median overall survival was9.0 months (95% CI 6.7~11.2). The median progressionfree survival was 3 months (95% CI 2.2~3.8). Hematologicaltoxicities of grade 3 or 4 neutropenia, anemia andthrombocytopenia were absent. Non-hematological toxicitieswere grade 2 or 3 skin rashes in 10 (40.0%) patientsand 1 (4.0%) patient and grade 3 nausea in 3 (12.0%) patients.No patient failed to continue chemotherapy due toany drug-related adverse events.Conclusion: The results suggest that ZD 1839 (Iressa)monotherapy is effective and tolerable as a 3rd or 4th linesalvage treatment for NSCLC patients refractory to previouschemotherapy regimens. (Cancer ResTreat. 2003;35:502-506)
Yu, Shi Nae,Jung, Jiwon,Kim, Yong-Kyun,Lee, Ju Young,Kim, Sun-Mi,Park, Su Jin,Lee, Sang-Oh,Choi, Sang-Ho,Kim, Yang Soo,Woo, Jun Hee,Kim, Sung-Han Williams & Wilkins Co 2015 Medicine Vol.94 No.28
<P><B>Abstract</B></P><P>IFN-gamma releasing assays (IGRAs) such as T-SPOT.<I>TB</I> assay and QuantiFERON-TB In-Tube (QFT-GIT) have yielded promising results for the diagnosis of tuberculosis (TB). However, little is known about the usefulness of these assays for diagnosing disseminated TB. We therefore compared their usefulness with traditional tests in patients with disseminated TB. All adult patients with suspected disseminated TB were prospectively enrolled at a tertiary hospital in an intermediate TB-burden country during a 6-year period. Disseminated TB was defined as involvement of the bone marrow or ≥2 noncontiguous organs, or presence of miliary lung lesions. A total of 101 patients with confirmed and probable disseminated TB were finally analyzed. Of these 101 patients, 52 (52%) had miliary TB and the remaining 49 (48%) had nonmiliary disseminated TB. In addition, 63 (62%) had no underlying disease. Chronic granuloma with/without necrosis, acid-fast bacillus staining, <I>Mycobacterium tuberculosis</I> PCR, and culture for <I>M tuberculosis</I> were positive in 77% (41/53), 43% (43/101), 70% (67/96), and 72% (73/101), of the patients, respectively. The T-SPOT.<I>TB</I> assay was positive in 90% (91/101) of them. The sensitivity of the T-SPOT.<I>TB</I> assay in patients with miliary TB (90%) was similar to that in patients with nonmiliary TB (90%) (<I>P</I> > 0.99). In a subgroup analysis of the 58 patients in whom both QFT-GIT and the T-SPOT.<I>TB</I> results were available, the sensitivity of QFT-GIT (67%) was lower than that of T-SPOT.<I>TB</I> (95%) (<I>P</I> < 0.001).</P><P>In conclusion, T-SPOT.TB assay may be a helpful adjunct test for disseminated TB.</P>
김내유 ( Nae Yu Kim ),조인성 ( In Sung Cho ),공수정 ( Soo Jung Gong ),이미란 ( Mee Ran Lee ),박미자 ( Mee Ja Park ),임춘화 ( Chun Hwa Ihm ),이정애 ( Jung Ae Lee ) 대한내과학회 2008 대한내과학회지 Vol.74 No.4
자궁경부에서 발생하는 악성 림프종은 그 발생이 매우 드물고 질도말검사 등으로 진단이 어려우므로 진단이 늦어져 적절한 치료시기를 놓칠 수 있다. 질출혈, 골반동통 등의 자궁병변을 의심할 수 있는 증상을 보일때 림프종의 가능성을 염두에 두고 조직검사를 통한 조직학적, 면역학적인 확진이 필요하고, 이차 병소의 침범을 확인하기 위하여 양전자 방사 단층 촬영 등을 통한 정확한 병기 결정이 필수적이라 생각한다. 저자들은 성교 후 비정상 질출혈을 주소로 내원한 32세 여자 환자에서 유방 침범을 동반한 미만성 대세포형의 원발성 자궁경부림프종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Primary lymphoma arising from the uterine cervix has been rarely encountered, and breast involvement is rare because of the relative paucity of lymphoid tissue in the breast. A 32-year-old woman with a primary malignant lymphoma of the uterine cervix and breast involvement is reported. The patient presented with post-coital vaginal bleeding, and punch biopsy of the cervix revealed the diffuse large B cell type of malignant lymphoma. PET-scan was done for staging, and abnormal FDP uptakes were detected in a uterine cervical mass and breast nodule. Ultrasonography-guided needle biopsy was done for the breast mass, and 2 biopsied nodules revealed fibroadenoma and diffuse large B cell lymphoma. The patient (Ann Arbor stage IV) was treated with 6 cycles of combination chemotherapy with CHOP plus rituximab. The patient went into complete remission. Thereafter, 4500cGy pelvic irradiation was done for adjuvant therapy.(Korean J Med 74:435-440, 2008)
( Kyung-min Kim ),( Seung-hoon Lee ),( Seung-min Kim ),( Nae-yu Kim ),( Ho-shin Gwak ),( Sang-hoon Shin ),( Ji-woong Kwon ),( Heon Yoo ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2019 Brain Tumor Research and Treatment Vol.7 No.2
Background The aim of this study was to compare epidermal growth factor receptor (EGFR) mutations between non-small cell lung cancer (NSCLC) and corresponding brain metastases (BMs) in Korea society. Methods From 2011 to 2016, a total of 74 patients underwent surgical resection of a metastatic brain tumor from NSCLC. Among them, we performed retrospective analysis for 46 patients who underwent EGFR sequencing of primary NSCLC tissues. Results Among these 46 cases, 18 (39.1%) cases showed EGFR mutation in primary lung cancer. Detected mutation sites were exon 19 (8 cases), exon 21 (6 cases), exon 18 (1 cases), and multiple mutations (3 cases). In 18 cases of BM, EGFR mutation studies were done. Among them, 8 (25.6%) cases showed mutation on exon 19 (5 cases) or exon 21 (3 cases). To compare EGFR mutation status between primary lung cancer and BM, 18 paired tissues from both NSCLC and matched BM were collected. Four (22.5%) patients were discordant for the status of EGFR between primary and metastatic sites. Conclusion EGFR mutations were significantly discordant between primary tumors and corresponding metastases in a significant portion of NSCLC. In treatment of BM of EGFR mutant metastatic NSCLC, due to possibility of discordance, pathologic confirming through brain biopsy is recommended.
김동진 ( Dong Jin Kim ),이재민 ( Jae Min Lee ),이상옥 ( Sang Ok Lee ),김내유 ( Nae Yu Kim ),이정윤 ( Jung Yun Lee ),김현진 ( Hyun Jin Kim ),박강서 ( Kang Seo Park ) 대한내과학회 2008 대한내과학회지 Vol.74 No.5
자가면역성 저혈당은 이전 인슐린 치료의 기왕력이 없던 환자에게서 발생한 인슐린 자가항체로 인해 생기는 것으로 고인슐린혈증, 인슐린 자가항체, 공복시 저혈당을 특징으로 나타나는 질환이다. 이는 그레이브병이나 류마티스 관절염과 같은 자가면역성 질환에 동반될 수 있으며, sulfhydryl를 포함한 약제 등에 의해서도 유발될 수 있다. 저자들은 이전에 보고되지 않았던 폐결핵 의증하에 항결핵제 치료 도중 발생한 자가면역성 저혈당 1예를 경험하였기에 이에 보고하는 바이다. Autoimmune hypoglycemia is characterized by insulin autoantibody, hyperinsulinemia and fasting hypoglycemia without previous insulin immunization. Negative results on the anatomic studies of the pancreas and an inability to reproduce hypoglycemia during a prolonged fast may be helpful in excluding insulinoma. Autoimmune hypoglycemia is self-limited disorder. We recently experienced a case of autoimmune hypoglycemia in a patient with insulin antibody, and the patient was without previous insulin injection therapy or any evidence of insulinoma, during treatment with anti-tuberculosis drugs. We present this case along with a review of the literature.(Korean J Med 74:574-577, 2008)
Incidence and Risk Factors of Ocular Infection Caused by <i>Staphylococcus aureus</i> Bacteremia
Jung, Jiwon,Lee, Junyeop,Yu, Shi Nae,Kim, Yong Kyun,Lee, Ju Young,Sung, Heungsup,Kim, Mi-Na,Kim, Sung-Han,Lee, Sang-Oh,Choi, Sang-Ho,Woo, Jun Hee,Lee, Joo Yong,Kim, Yang Soo,Chong, Yong Pil American Society for Microbiology 2016 Antimicrobial Agents and Chemotherapy Vol.60 No.4
<P>Staphylococcus aureus bacteremia (SAB) often leads to ocular infections, including endophthalmitis and chorioretinitis. However, the incidence, risk factors, and outcomes of ocular infections complicated by SAB are largely unknown. We retrospectively analyzed the incidence and risk factors of ocular involvement in a prospective cohort of patients with SAB at a tertiary-care hospital. Ophthalmologists reviewed the fundoscopic findings and classified the ocular infections as endophthalmitis or chorioretinitis. During the 5-year study period, 1,109 patients had SAB, and data for 612 (55%) who underwent ophthalmic examinations within 14 days after SAB onset were analyzed. Of those 612 patients, 56 (9% [95% confidence interval [CI], 7 to 12%]) had ocular involvement, including 15 (2.5%) with endophthalmitis and 41 (6.7%) with chorioretinitis. In a multivariate analysis, infective endocarditis (adjusted odds ratio [aOR], 5.74 [95% CI, 2.25 to 14.64]) and metastatic infection (aOR, 2.38 [95% CI, 1.29 to 4.39]) were independent risk factors for ocular involvement. Of the 47 patients with ocular involvement who could communicate, only 17 (36%) had visual disturbances. Two-thirds of the patients with endophthalmitis (10/15 patients) were treated with intravitreal antibiotics combined with parenteral antibiotics, whereas all of the patients with chorioretinitis were treated only with systemic antibiotics. No patients became blind. Among 42 patients for whom follow-up assessments were available, the ocular lesions improved in 29 (69%) but remained the same in the others. Ocular involvement was independently associated with death within 30 days after SAB onset. Ocular involvement is not uncommon among patients with SAB. Routine ophthalmic examinations should be considered for patients with infective endocarditis or metastatic infections caused by SAB.</P>
Moon Seong Baek,Seong-Ho Choi,Won-Young Kim,Min-Chul Kim,Eun-Jeong Joo,Mi Suk Lee,Hyun Ah Kim,Sook In Jung,Yu Shi Nae,Bongyoung Kim,Yaeji Lim,Jin-Won Chung 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.1
Background/Aims: To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19). Methods: Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient follow-up visit. Between January 11 and March 9, 2021 (study period), residual symptom investigations, chest computed tomography (CT) scans, pulmonary function tests (PFT), and neutralizing antibody tests (NAb) were performed at the outpatient visit (cross-sectional design). Additionally, data from patients who already had follow-up outpatient visits before the study period were collected retrospectively. Results: Investigation of residual symptoms, chest CT scans, PFT, and NAb were performed in 84, 35, 31, and 27 patients, respectively. After 6 months, chest discomfort and dyspnea persisted in 26.7% (4/15) and 33.3% (5/15) patients, respectively, and 40.0% (6/15) and 26.7% (4/15) patients experienced financial loss and emotional distress, respectively. When the ratio of later CT score to previous ones was calculated for each patient between three different time intervals (1–14, 15–60, and 61–365 days), the median values were 0.65 (the second interval to the first), 0.39 (the third to the second), and 0.20 (the third to the first), indicating that CT score decreases with time. In the high-severity group, the ratio was lower than in the low-severity group. Conclusions: In COVID-19 survivors, chest CT score recovers over time, but recovery is slower in severely ill patients. Subjects complained of various ongoing symptoms and socioeconomic problems for several months after recovery.