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The Structure of Kushenol M from Sophora flavescens
Ryu, Shi-Yong,Lee, Seung-Ho,No, Zaesung,Kim, Kye-Young,Lee, Sueg-Geun,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.1
The linkage pattem of two side chains i.e., a isopentenyl and a lavandulyl group in kushenol M(I), a flavonoid from Sophora flavescens was established by the aid of 2-D NMR techniques, especially DEPT, ${13}C-^1H$ COSY and COLOC experiments. Thus, I was unequivocally determined as (2R, 3R)-5, 7, 2', 4'-tetrahydroxy-6-isopentenyl-8-lavandulyflavanonol.
12-Hydroxyamoorastatone, a New Limonoid from Melia azedarach var. Japonica
Jong-Woong Ahn,Geon-Seek Yoo,Zaesung No,Seung-Ho Lee Korean Chemical Society 1993 Bulletin of the Korean Chemical Society Vol.14 No.5
A chemical investigation of the stem bark of Melia azedarach var. Japonica (Meliaceae) has led to a new limonoid, 12-hydroxyamoorastatone (1), whose structure has been elucidated by spectroscopic measurements including 2D-NMR. The 2D-NOESY experiment on its di-p-bromobenzoate derivative (1a) has established the relative configuration of 1.
The Structure of Kushenol M from Sophora flavescens
Ryu, Shi Yong,Lee, Seung Ho,No, Zaesung,Kim, Kye-Young,Lee, Sueng-Geun,Ahn, Jong Woong 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The linkage pattern of two side chains i.e., a isopentenyl and a lavandulyl group in kushenol M(I), a flavonoid form Sophora flavescns was established by the aid of 2-D NMR techniques, especially DEPT, ¹³C-¹H COSY and COLOC experiments. Thus, I was unequivocally determined and (2R, 3R)-5, 7, 2', 4'-tetrahydroxy-6-isopentenyl-8-lavandulylflavanonol.
Antitumor activity of Trichosanthes kirilowii
Ryu, Shi Yong,Lee, Seung Ho,Choi, Sang Un,ee, Chung Ock,No, Zaesung,Ahn, Jong Woong 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-
The acitivity-directed fractionation upon the MeOH extract of the not of trichosanthes kirilowill led to the isolation of eight cucurbitane triterpenes namely cucurbitacin B(Ⅰ), isocucubitacin B(Ⅱ), cucurbitacin D (Ⅲ), isocucurbitacin D (Ⅳ, 3-epi-isocucurbitacin B(Ⅴ), dihydrocucurbitacin B(Ⅵ), dihydroisocucurbitacin B(Ⅶ) and dihydrocucurbitacin E(Ⅷ), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, SK-OV-3, 5K-MIL-2, XF-498 and HCT 15, with an exceptionally high potency.
Lee, Seung-Ho,Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,No, Zaesung,Kim, Seong-Kie,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.2
The cytotoxicity-directed fractionation of MeOH extract of Terminalia chebula fruits led to the isolation of three hydrolyzed tannins and a related compound, gallic acid(1), $1,2,3,4,6-penta-O-galloy-{\beta}-_D/-glucopyranose(II)$,. chebulagic acid (III) and chebulinic acid(IV), as active principles. They were shoen to exhibit moderate cytotoxicity against cultured human tumor cell lines including A-549, SK-OV-3, Sk-MEL-2, XF-498 and HCT-15 in vitro.