Utility of Frozen Section Pathology with Endometrial Pre-Malignant Lesions

Oz, Murat,Ozgu, Emre,Korkmaz, Elmas,Bayramoglu, Hatice,Erkaya, Salim,Gungor, Tayfun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Aim: To determine utility of the frozen section (FS) in the operative management of endometrial pre-malignant lesions. Materials and Methods: We retrospectively analyzed patients who underwent abdominal hysterectomy with preoperative diagnosis of complex atypical endometrial hyperplasia (CAEH) and simple endometrial hyperplasia (SEH) between May 2007 and December 2013. Frozen and paraffin section (PS) results were compared. Sensitivity, specificity, the positive predictive value (PPV), the negative predictive value (NPV) and the accuracy in predicting EC on FS were evaluated with 95% confidence intervals (CIs) for each parameter. The correlation between FS and PS was calculated as an ${\kappa}$ coefficient. Results: Among 143 preoperatively diagnosed CAEH cases, 60 (42%) were malignant and 83 (58%) were benign in PS; and among 60 malignant cases diagnosed in PS, 43 (71%) were "malignant" in FS. Sensitivity, specificity, PPV and NPV for FS were 76%, 100%, 100% and 87.5%, respectively. Conclusions: We found that FS is reliable and applicable in the management of endometrial hyperplasias. It is important that the pathologist should be experienced because FS for endometrial pre-malignant lesions has significant inter-observer variability. The other conclusion is that patients with the diagnosis of EH, especially those who are postmenopausal, should undergo surgery where FS investigation is available.

Determining the Optimum Process Parameters of Selective Laser Melting via Particle Swarm Optimization Based on the Response Surface Method

Fahri Murat,İrfan Kaymaz,Abdullah Tahir Şensoy,İsmail H. Korkmaz 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.1

Manufacturing high-quality and desired products from additive manufacturing necessitate careful adjustment of the processparameters. Various methods can be utilised to determine optimum process parameters, such as the Taguchi method, Designof Experiments (DoE). Rather than evaluating limited information obtained from statistical analysis of the experiments, optimisationmethods can help find the best possible combination for the process parameters. Therefore, an optimisation approachbased on Particle Swarm Optimization (PSO) was utilised to find the optimum process parameters. The most importantprocess parameters of Selective Laser Melting (SLM) such as laser power, layer thickness, scan speed, and build orientationwere selected as input parameters, and their effects on the tensile properties of the manufactured part were investigated to findout the optimal operating conditions for the SLM process. Since there is not any explicit mathematical expression relatingthese process parameters to the tensile strength, the Response Surface Method (RSM) was used to obtain a meta-model sothat it can be used as an objective function in the optimisation formulation. This approach enabled us to predict the optimumprocess parameters to maximise the tensile strength without conducting an excessive number of experiments. Moreover, themathematical model can also predict tensile strength corresponding to the parameter values that are not tested according tothe DoE chosen for such studies. Furthermore, it was also shown that the PSO outperforms the Genetic Algorithm (GA),which is widely employed to find out the optimum process parameters, in terms of less number of iteration.

Diffuse Myocardial Uptake of 99mTc-HDP in Multiple Myeloma

Koray Demirel,Murat Sadic,Meliha Korkmaz,Aylin Comak,Hasan Ikbal Atilgan,Gökhan Koca 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.3

Soft tissue uptake is a rare finding in bone scintigraphy,with an incidence of 2%. Although the mechanism has not yet been fully clarified, several causes have been reported for this unusual uptake pattern. This paper presents a case of diffuse myocardial accumulation of technetium-99m hydroxymethylene diphosphonate (99mTc-HDP) without either solid/visceral organ or soft tissue with multiple myeloma (MM) in skeletal scintigraphy. A 93-year-old man with hypertension and chronic heart failure for 14 years underwent bone scanning due to a 2-month history of back pain within a 1-year period of MM. Three hours later,99mTc-HDP late static images showed diffuse myocardial radiotracer accumulation and there were no other sites of abnormal soft tissue or visceral uptake. Myocardial accumulation had disappeared on 24-h delayed static images. This accumulation was thought to be related with AL-type amyloidosis associated with MM.

Disorders Center, Fujieda Heisei Memorial Hospital, Fujieda, Shizuoka, Japan

Turgut Akgül,Kerim Sarıyılmaz,Murat Korkmaz,Okan Özkunt,Özcan Kaya,Fatih Dikici 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.1

Study Design: Retrospective analysis of adolescent idiopathic scoliosis. Purpose: This study aimed to investigate the influence of distinct distal fusion levels on spinopelvic parameters in patients with adolescent idiopathic scoliosis (AIS) who underwent posterior instrumentation and fusion surgery. Overview of Literature: The distal fusion level selection in treatment of AIS is the one of milestone to effect on surgical outcome. Most of the paper focused on the coronal deformity correction and balance. The literature have lack of knowledge about spinopelvic changing after surgical treatment and the relation with distal fusion level. We evaluate the spinopelvic and pelvic parameter alteration after fusion surgery in treatment of AIS. Methods: A total of 100 patients with AIS (88 females and 12 males) were retrospectively reviewed. Patients were assigned into the following three groups according to the distal fusion level: lumbar 2 (L2), lumbar 3 (L3), and lumbar 4 (L4). Using a lateral plane radiograph of the whole spine, spinopelvic angular parameters such as thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT) were radiologically assessed. Results: The mean age was 15±2.4 years, and the mean follow-up period was 24.27±11.69 months. Regarding the lowest instrumented vertebra, patients were categorized as follows: 30 patients in L2 (group 1), 40 patients in L3 (group 2), and 30 patients in L4 (group 3). TK decreased from 36.60±13.30 degrees preoperatively to 26.00±7.3 degrees postoperatively in each group (p =0.001). LL decreased from 52.8±9.4 degrees preoperatively to 44.30±7.50 degrees postoperatively (p =0.001). Although PI showed no difference preoperatively among the groups, it was statistically higher postoperatively in group 3 than in the other groups (p <0.05). In addition, in group 2, PI decreased from 50.60±8.74 degrees preoperatively to 48.00±6.84 degrees postoperatively (p =0.027). SS decreased from 35.20±6.40 degrees preoperatively to 33.40±5.80 degrees postoperatively (p =0.08, p >0.05). However, mean SS was significantly higher in group 3 (p =0.042, p <0.05). PT decreased from 15.50±7.90 degrees preoperatively to 15.2±7.10 degrees postoperatively. The positive relationship (28.5%) between LL and PI measurements was statistically significant (r =0.285; p =0.004, p <0.01). Furthermore, the positive relationship (36.5%) between LL and SS measurements was statistically significant (r =0.365; p =0.001, p <0.01). Conclusions: When the distal instrumentation level in AIS surgery is below L3, a significant change in PT and SS (pelvic parameters) is anticipated.

Comparison of Tool Wear, Surface Morphology, Specific Cutting Energy and Cutting Temperature in Machining of Titanium Alloys Under Hybrid and Green Cooling Strategies

Munish Kumar Gupta,P. Niesłony,Mehmet Erdi Korkmaz,Mustafa Kuntoğlu,G. M. Królczyk,Mustafa Günay,Murat Sarikaya 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.6

Cutting energy must be reduced in order to make machining processes more eco-friendly. More energy was expended for the same amount of material removed, hence a higher specific cutting energy (SCE) implies inefficient material removal. Usually, the type of coolants or lubricants affects the SCE, or the amount of energy needed to cut a given volume of material. Therefore, the present work deals with a study of SCE in the turning of Ti–3Al–2.5V alloy under green cooling strategies. In spite of this, the research effort is also focused on the mechanism of tool wear, surface roughness, and cutting temperature under hybrid cooling, i.e., minimum quantity lubrication (MQL) and cryogenic. The tool wear rate, were explored with tool mapping analysis, and the results were compared with dry, MQL, and liquid nitrogen (LN2) conditions. The tool wear rate analysis claims that the dry condition causes more built up edge (BUE) formation. In addition, the hybrid cooling conditions are helpful in reducing the SCE while machining titanium alloys.

Studies on Geometrical Features of Tool Wear and Other Important Machining Characteristics in Sustainable Turning of Aluminium Alloys

Munish Kumar Gupta,P. Niesłony,Murat Sarikaya,Mehmet Erdi Korkmaz,Mustafa Kuntoğlu,G. M. Królczyk 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.4

The aerospace and automotive industries make extensive use of aluminium and its alloys. Contrarily, machining of aluminium (Al) alloys presents a number of difficulties, including, but not limited to, poor surface finishing, excessive tool wear, decreased productivity etc. Therefore, it’s very important to measure the machining characteristics during machining of aluminium alloy with sustainable cooling strategies. In this work, a new approach of measurement was adopted to measure the critical geometrical aspects of tool wear, surface roughness, power consumption and microhardness while machining AA2024-T351 alloy under dry, minimum quantity lubrication (MQL), liquid nitrogen (LN2) and carbon dioxide (CO2) cooling conditions. Initially, the various aspects of tool wear were studied with the help of Sensofar Confocal Microscope integrated with Mountains map software and then, the other results such as surface roughness, power consumption and microhardness were measured as per the ISO standards. The outcome of these measurement studies confirms that LN2 and CO2 cooling is helpful in improving the machining characteristics of AA2024-T351 alloy. When compared to dry conditions, the surface roughness values of MQL, LN2, and CO2 all have values that are lowered by 11.90%, 30.95%, and 39.28% respectively, and also power consumption values were lowered by 3.11%, 6.46% and 11.5% for MQL, CO2 and LN2 conditions, respectively.