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Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents
Mohd Amir,Mohd Zaheen Hassan,Israr Ali 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.1
Aseries of 3-[(4-substituted-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-ones (5a–k) were synthesizedby reacting 3-amino-2-phenyl-1H-quinazolin-4-one withp-hydroxybenzaldehyde, and then further with various alkyl/benzyl halides or substituted phenacyl bromides. The structuresof the compounds were confirmed on the basis of IR,NMR,MSand elemental analysis. Anticonvulsant activities were evaluatedusing the MES and scPTZ tests. Some of the selectedcompounds were evaluated for antidepressant activity byforced swim pool test. Compound 3-[(4-butoxy-benzylidene)-amino]-2-phenyl-3H-quinazolin-4-one was emerged as themost promising anticonvulsant agent without any motorimpairment effect. The whole brain GABA estimation of brainhomogenate indicated that the anticonvulsant activity of abovementioned quinazolinone derivatives might be due to anincreased GABA concentration.
Machine learning and RSM models for prediction of compressive strength of smart bio-concrete
Hassan Amer Algaifi,Suhaimi Abu Bakar,Rayed Alyousef,Abdul Rahman Mohd. Sam,Ali S. Alqarni,M.H. Wan Ibrahim,Shahiron Shahidan,Mohammed Ibrahim,Babatunde Abiodun Salami 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.4
In recent years, bacteria-based self-healing concrete has been widely exploited to improve the compressive strength of concrete using different bacterial species. However, both the identification of the optimal involved reaction parameters and theoretical framework information are still limited. In the present study, both experimentally and numerical modelling using machine learning (ANN and ANFIS) and response surface methodology (RSM) were implemented to evaluate and optimse the evolution of bacterial concrete strength. Therefore, a total of 58 compressive strength tests of the concrete incorporating new bacterial species were designed using different concentrations of urea, cells concentration, calcium, nutrient and time. Based on the results, the compressive strength of the bacterial concrete improved by 16% due to the decrement of the pore percentage in the concrete skin; specifically, 5 mm from the concrete surface, compared to that of the control concrete. In the same context, both machine the learning and RSM models indicated that the optimal range of urea, calcium, nutrient and bacterial cells were (18-23 g/L), (150-350 mM), (1-3 g/L) and 2×107 cells/mL, respectively. Based on the statistical analysis, RMSE, <i>R</i><sup>2</sup>, MPE, RAE and RRSE were (0.793, 0.785), (0.985, 0.986), (1.508, 1.1), (0.11, 0.09) and (0.121, 0.12) from both the ANN and ANFIS models, respectively, while; the following values (0.839, 0.972, 1.678, 0.131 and 0.165) was obtained from RSM model, respectively. As such, it can be concluded that a high correlation and minimum error were obtained, however, machine learning models provided more accurate results compared to that of the RSM model.
Siti Hawa Ali Hassan,Jeffrey R. Fry,Mohd Fadzelly Abu Bakar 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5
Litsea garciae, known locally in Sabah, Malaysia as Pengolaban, is an underutilized edible fruit endemic to Borneo. This study was conducted to determine the antioxidant activity and total phenolic, total flavonoid, and total anthocyanin contents of different parts (i.e., flesh,stem cap, and seed) of the fruits. All samples were freezedried and extracted using 80% methanol and distilled water. For 80% methanol extract, stem cap of pengolaban displayed the highest free radical scavenging activity and ferric reducing activities as compared to other parts of the fruit. Total phenolic and total flavonoid content were highest in stem cap with the values of 8.29±0.70 mg gallic acid equivalents/g and 6.90±0.61 mg rutin equivalents/g,respectively. Total anthocyanin content was highest in flesh of the fruit with the value of 4.12±0.10 mg cyanidin-3-glucoside equivalents/100 g. The same trend of antioxidant and phytochemical content were also observed in the distilled water extract. These findings suggested that pengolaban has an acceptable high amount of phytochemicals which has a potential as natural antioxidant that can contribute to human health.
Use, Awareness, Knowledge and Beliefs of Medication During Pregnancy in Malaysia
Alani Ahmad Habeeb Hattab Dala Ali,Hassan Bassam Abdul Rasool,Suhaimi Azyyati Mohd,Mohammed Ali Haider 질병관리본부 2020 Osong Public Health and Research Persptectives Vol.11 No.6
Objectives This study aimed to assess medication use in pregnant women in Malaysia by measuring use, knowledge, awareness, and beliefs about medications. Methods This was an observational, cross-sectional study involving a total of 447 pregnant women who attended the Obstetrics and Gynecology Clinic, Hospital Kuala Lumpur (HKL), Malaysia. A validated, self-administered questionnaire was used to collect participant data. Results Most of pregnant women had taken medication during pregnancy and more than half of them (52.8%) showed a poor level of knowledge about the medication use during pregnancy. Eighty-three percent had a poor level of awareness and 56.5% had negative beliefs. Age and education level were significantly associated with the level of knowledge regarding medication use during pregnancy. Multiparous pregnant women, and pregnant women from rural areas were observed to have a higher level of awareness compared with those who lived in urban areas. Use of medication during pregnancy was determined to be significantly associated with education level, and race. Conclusion Although there was prevalent use of medication among pregnant women, many had negative beliefs, and insufficient knowledge and awareness about the risks of taking medication during pregnancy. Several sociodemographic characteristics were significantly associated with the use (race and education level), level of knowledge (age and education level), awareness (parity and place of residence), and beliefs (race, education level, and occupation status) towards medication use during pregnancy.
Abdul Rahman, Nor Aini,Shirai, Yoshihito,Shimizu, Kazuyuki,Hassan, Mohd Ali The Korean Society for Biotechnology and Bioengine 2002 Biotechnology and Bioprocess Engineering Vol.7 No.5
Recombinant Escherichia coli strain harboring the ${\lambda}$pR-pL promotor and heterologus poly-${\beta}$-hydroxybutyrate (PHB) biosynthesis genes was used to investigate the effect of culture conditions on the efficient PHB production. The expression of phb genes was induced by a temperature upshift from $33^{\circ}C\;to\;38^{\circ}C$. The protein expression levels were measured by using two-dimensional electrophoresis, and the enzyme activities were also measured to understand the effect of culture temperature, carbon sources, and the dissolved oxygen (DO) concentration on the metabolic regulations. AcetylCoA is an important branch point for PHB production. The decrease in DO concentration lowers the citrate synthase activity, thus limit the flux toward the TCA cycle, and increase the flux for PHB production. Since NADPH is required for PHB production, the PHB production does not continue leading the overproduction of acetate and lac-tate. Based on these observations, a new operation was considered where DO concentration was changed periodically, and it was verified its usefulness for the efficient PHB production by experiments.