http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Oktavianawati Ika,Santoso Mardi,Bakar Mohd Fadzelly Abu,Kim Yong-Ung,Fatmawati Sri 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
COVID-19 has been a major global health concern for the past three years, and currently we are still experiencing coronavirus patients in the following years. The virus, known as SARS-CoV-2, shares a similar genomic identity with previous viruses such as SARS-CoV and MERS-CoV. To combat the pandemic, modern drugs discovery techniques such as in silico experiments for docking and virtual screening have been employed to design new drugs against COVID-19. However, the release of new drugs for human use requires two safety assessment steps consisting of preclinical and clinical trials. To bypass these steps, scientists are exploring the potential of repurposing existing drugs for COVID-19 treatment. This approach involves evaluating antiviral activity of drugs previously used for treating respiratory diseases against other enveloped viruses such as HPV, HSV, and HIV. The aim of this study is to review repurposing of existing drugs, traditional medicines, and active secondary metabolites from plant-based natural products that target specific protein enzymes related to SARS-CoV-2. The review also analyzes the chemical structure and activity relationship between selected active molecules, particularly flavonol groups, as ligands and proteins or active sites of SARS-CoV-2.
Siti Hawa Ali Hassan,Jeffrey R. Fry,Mohd Fadzelly Abu Bakar 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5
Litsea garciae, known locally in Sabah, Malaysia as Pengolaban, is an underutilized edible fruit endemic to Borneo. This study was conducted to determine the antioxidant activity and total phenolic, total flavonoid, and total anthocyanin contents of different parts (i.e., flesh,stem cap, and seed) of the fruits. All samples were freezedried and extracted using 80% methanol and distilled water. For 80% methanol extract, stem cap of pengolaban displayed the highest free radical scavenging activity and ferric reducing activities as compared to other parts of the fruit. Total phenolic and total flavonoid content were highest in stem cap with the values of 8.29±0.70 mg gallic acid equivalents/g and 6.90±0.61 mg rutin equivalents/g,respectively. Total anthocyanin content was highest in flesh of the fruit with the value of 4.12±0.10 mg cyanidin-3-glucoside equivalents/100 g. The same trend of antioxidant and phytochemical content were also observed in the distilled water extract. These findings suggested that pengolaban has an acceptable high amount of phytochemicals which has a potential as natural antioxidant that can contribute to human health.