Blood Pressure in Acute Ischemic Stroke

Michael McManus,David S Liebeskind 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.2

Hypertension is present in up to 84% of patients presenting with acute stroke, and a smaller proportion of patients have blood pressures that are below typical values in the context of cerebral ischemia. Outcomes are generally worse in those who present with either low or severely elevated blood pressure. Several studies have provided valuable information about malignant trends in blood pressure during the transition from the acute to the subacute phase of stroke. It is not uncommon for practitioners in clinical practice to identify what appear to be pressure-dependent neurologic deficits. Despite physiologic and clinical data suggesting the importance of blood pressure modulation to support cerebral blood flow to ischemic tissue, randomized controlled trials have not yielded robust evidence for this in acute ischemic stroke. We highlight previous studies involving acute-stroke patients that have defined trends in blood pressure and that have evaluated the safety and efficacy of blood-pressure modulation in acute ischemic stroke. This overview reports the current status of this topic from the perspective of a stroke neurologist and provides a framework for future research.

THE BRAND NEGATIVITY BIAS: UNFAVORABLE BRAND PLACEMENTS REDUCE EVALUATIONS FOR NEW MEDIA PRODUCTS BY INHIBITING THE CONSUMER-CHARACTER CONNECTION

Justin McManus,Sergio Carvalho,Valerie Trifts 글로벌지식마케팅경영학회 2020 Global Marketing Conference Vol.2020 No.11

Teaching Food Literacy in Australian Secondary Schools: Skills and Theory to Influence Adolescent Food Behaviours

Sarah McManus,Donna Pendergast,Harry Kanasa 한국가정과교육학회 2022 한국가정과교육학회지 Vol.34 No.5

Dietary behaviours are established during adolescence, making this stage important for adopting healthy lifelong food habits. Schools are highly influential on adolescent behaviours making school-based food literacy education a vital avenue for healthy food behaviour development. This mixed methods exploratory study examined how Queensland (Australia) home economics (HEc) teachers delivered food literacy education through the Australian Years 7-10 Design and Technologies Curriculum. It provides insights into the food literacy education strategies respondents used to enhance adolescents' lifelong healthy food behaviours. An online survey gathered data on food literacy concepts, lesson types, pedagogical approaches, and contextualisation strategies. Qualitative data were analysed using Leximancer and quantitative data through SPSS. Respondents (N = 117) reported teaching a wide variety of food literacy concepts, including food skills and behaviours, food and nutrition knowledge, food attitudes, ecological influences on food, and food decisions. Theoretical concepts dominated teaching time (42%). The most frequently (100%) employed teaching strategy was practical cooking skills. Only 9% reported limiting cooking ingredients to healthy foods. A critical focus was not prevalent. Teachers reported contextualising lessons to (in descending order) food types, health and nutrition, multicultural food, and food business. Results confirmed that Australian (Queensland) HEc teachers delivered a food literacy educational nexus by teaching many food literacy aspects to support optimal food education that links theory/knowledge and skill development.

THE NEGATIVE IMPACT OF USING DISLIKED BRANDS IN DIGITAL BRAND PLACEMENTS

Justin F. McManus,Sergio W. Carvalho,Valerie Trifts 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07

Consumers may not be fully aware of the level of personalization used in brand placements in digital advertising. Personalized brand placements use customer data to select and insert preferred brands into digital media content, such as having Coke appear in a YouTube video for someone who favors Coca-Cola. This personalization can enhance the consumer experience (Trifts & Aghakhani, 2018) but may also backfire if placements don't account for changes in brand preference or when personalized placements are co-consumed with a person whose preferences strongly diverge from one’s own (e.g., one’s romantic partner; Brick, Fitzsimons, Chartrand, & Fitzsimons, 2018). Brands have a significant impact on how people perceive each other. Brands convey social information and symbolic meaning (Keller, 1993; Levy, 1959) and can influence behavior (e.g., Fitzsimons, Chartrand, & Fitzsimons 2008) and provide a source of affiliation (Escalas & Bettman, 2003). However, less is known about how brands affect basic social connections like empathy. This notable gap is relevant to the evaluation of the impact of brand placements in digital advertising as brand logos are quite visible in brand placements and can be the first piece of information someone observes when forming an attitude towards another person. For example, imagine an Instagram post of a person wearing a Harley Davidson baseball cap. What kind of person did you imagine? Does your impression change if, instead, the brand was People for the Ethical Treatment of Animals, or the Trump Organization? Moreover, how likely would you be to engage with media showcasing a person supporting this brand. In the current research, we propose that personally disliked brands create a negative bias in person perception and consumer judgment, a phenomenon we coin “brand negativity bias.” Our results show that disliking a brand can reduce empathy for others and substantially bias attitudes toward a digital product associated with but not created by the brand. Specifically, we show process evidence that suggests disliked brand placements reduce (1) empathy toward others through reductions in perceived similarity and (2) attitudes toward a digital product through perceived similarity and empathy, as serial processes. In addition, although we do not empirically test an overall mechanism that explains the negativity bias in its entirety, we speculate several reasons that underlie the broad influence of personally disliked brands (e.g., symbolic, ideological, or moral). From a societal point of view, our findings inform the public to be mindful of how simple consumption cues can bias people’s decision making, which holds implications beyond consumer judgment in domains involving first impressions.

COLONIZATION OF ALKALI-TREATED FIBROUS ROUGHAGES BY ANAEROBIC RUMEN FUNGI

Wuliji, T.,McManus, W.R. Asian Australasian Association of Animal Productio 1988 Animal Bioscience Vol.1 No.2

This study reports light and electron microscope examination of rumen fungal colonization of alkali-treated roughage feeds incubated in decron bags in the rumen of cannulated sheep for varying time intervals. Six roughages, pre-treated with ammonium hydroxide or sodium hydroxide at 4% (w/w) level were examined together with untreated control samples. Alkali pre-treatment was associated with an earlier and more pronounced fungal colonization than all control roughages. Sodium hydroxide pre-treatment was significantly more effective than ammonium hydroxide in improving the susceptibility of roughages to rumen fungal colonization and studies by SEM showed that the pre-treatment permitted greater penetration of feeds by fungi. Sodium hydroxide pre-treatment also significantly increased dry matter disappearance from feed held in Dacron bags in the rumen with all feeds except Lucerne stem. It is not known to what extent fungal activity contributed to increased breakdown of the feeds.

Analyzing the adoption of radiofrequency ablation of thyroid nodules using the diffusion of innovations theory: understanding where we are in the United States?

Jennifer H.Kuo,Catherine McManus,James A.Lee 대한초음파의학회 2022 ULTRASONOGRAPHY Vol.41 No.1

Thyroid nodules are very common and found in up to 68% of the general U.S. population on ultrasound. Although thyroidectomy has long been the mainstay of treatment for malignant and symptomatic benign thyroid nodules, various interventional ablative techniques have emerged in the last couple of decades as alternative non-surgical treatment options. Globally, the most widely adopted technique has been ultrasound-guided radiofrequency ablation (RFA). RFA of thyroid nodules was first performed in 2002, and there has been an expanding body of evidence since 2006 showing that RFA and other interventional ablative techniques are effective treatments for benign solid thyroid nodules, toxic adenomas, and thyroid cysts. More recently, evidence has emerged that these techniques may be effective treatment for low-risk thyroid cancer and recurrent disease. Despite these findings, the United States has been slow to adopt these techniques, with only a single publication on RFA more than a decade after the first series was published. EM Rogers’ Diffusion of Innovation Theory provides us the appropriate lens to carefully analyze the process of adoption of RFA for thyroid nodules-to understand where we are currently, as well as, the important next steps that must be accomplished in order for RFA and other ablative techniques to be successfully adopted into the management algorithm of thyroid nodules in the United States.

Teaching out-of-field in Home Economics: A Systematic Quantitative Literature Review

Donna Pendergast,Sarah McManus,Jay R. Deagon,Anna Du Plessis 한국가정과교육학회 2022 한국가정과교육학회지 Vol.34 No.5

Out-of-field teaching (OOFT) is a global phenomenon impacting student learning outcomes and teacher attrition. Anecdotal evidence suggests that home economics teacher shortages drive OOFT, yet there is an absence of research regarding its impacts. A systematic quantitative literature review (SQLR) was conducted to address this research gap and establish a baseline. The inclusion criteria were secondary school home economics education and OOFT, peer reviewed, full-text, and published in English. The date of publication was not a limiting factor. Nine databases were searched in March 2022 and, following exclusion protocols, 25 papers were retained. The qualifying papers were published between 1979 and 2021 with authors from 13 countries. Five papers focussed exclusively on OOFT and home economics. The most used terminology to describe OOFT was 'qualified/unqualified' (n=19; 76%). A global shortage of in-field home economics teachers was the most reported cause for OOFT (n=17; 68%). Impacts on students included lower-quality teaching experiences. OOF teacher self-efficacy was negatively impacted. The impacts on students, teachers, and schools were found to be interlinked. This study provides a baseline to understand the causes and impacts of OOFT in home economics classrooms. Overall, t here was a p aucity o f data available regarding this t opic, e specially concerning i ts p revalence and reported experiences. This gap indicates the need for further research regarding OOFT in home economics, especially as OOFT is increasingly under scrutiny in all fields of education due to the negative effects on teachers, student learning outcomes, and school operations. The study also affirmed the need for advocacy to ensure policymakers are aware of the negative impacts of OOFT in home economics and act to seek remedies.

Codon usage and bias in mitochondrial genomes of parasitic platyhelminthes

Thanh Hoa LE,Donald Peter McMANUS,David BLAIR 대한기생충학열대의학회 2004 The Korean Journal of Parasitology Vol.42 No.4

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Hong, Jeong-Ho,Hwang, Eun-Sook,McManus, Michael T.,Amsterdam, Adam,Tian, Yu,Kalmukova, Ralitsa,Mueller, Elisabetta,Benjamin, Thomas,Spiegelman, Bruce M.,Sharp, Phillip A.,Hopkins, Nancy,Yaffe, Michael 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16

Mesenchymal stem celts (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome protiferator-activated receptor γ(PPARγ), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively. How these two transcription factors are regulated in order to specify these alternate cell fates remains a pivotal question. Here we report that a 14-3-3-binding protein, TAZ(transcrip-tional coactivator with PDZ-binding motif), coactivates RunxB-dependent gene transcription while repressing PPARγ-dependent gene transcription. By modulating TAZ expression in model cell lines, mouse embryonic fibroblasts, and primary MSCs in culture and in zebrafish in vivo, we observed alterations in osteogenic versus adipogenic potential. These results indicate that TAZ functions as a molecular rheostat that modulates MSC differentiation.

Molecular Approaches to Characterizing and Improving Bulb Composition in Onion

J. McCallum,M. J. Havey,Masayoshi Shigyo,M. T. McManus 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-