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Diagnostic Aspects of Fine Needle Aspiration for Lung Lesions: Series of 245 Cases
Kravtsov, Vladimir,Sukmanov, Inna,Yaffe, Dani,Shitrit, David,Gottfried, Maya,Cioca, Andreea,Kidron, Debora Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: Transthoracic fine needle aspiration (FNA) is one of several methods for establishing tissue diagnosis of lung lesions. Other tissue or cell sources for diagnosis include sputum, endobronchial biopsy, washing and brushing, endobronchial FNA, transthoracic core needle biopsy, biopsy from thoracoscopy or thoracotomy. The purpose of this study was to compare the sensitivity and specificity of FNA and other diagnostic tests in diagnosing lung lesions. Materials and Methods: The population included all patients undergoing FNA for lung lesions at Meir Medical Center from 2006 through 2010. Information regarding additional tissue tests was derived from the electronic archives of the Department of Pathology, patient records and files from the Department of Oncology. Sensitivity, specificity, diagnostic accuracy, and positive and negative predictive values were calculated for each test. Results: FNA was carried out in 245 patients. Malignant tumors were diagnosed in 190 cases (78%). They included adenocarcinoma (43%), squamous cell carcinoma (15%), non-small cell carcinoma, not otherwise specified (19%), neurondocrine tumors (7%), metastases (9%) and lymphoma (3%). The specificity of FNA for lung neoplasms was 100%; sensitivity and diagnostic accuracy were 87%. Conclusions: FNA is the most sensitive procedure for establishing tissue diagnoses of lung cancer. Combination with core needle biopsy increases the sensitivity. Factors related to the lesion (nature, degenerative changes, location) and to performance of all stages of test affect the ability to establish a diagnosis.
Debye screening in strongly coupled &calN; = 4 supersymmetric Yang-Mills plasma
Bak, Dongsu,Karch, Andreas,Yaffe, Laurence G. Institute of Physics Pub 2007 The journal of high energy physics Vol.2007 No.8
Using the AdS/CFT correspondence, we examine the behavior of correlators of Polyakov loops and other operators in &calN; = 4 supersymmetric Yang-Mills theory at non-zero temperature. The implications for Debye screening in this strongly coupled non-Abelian plasma, and comparisons with available results for thermal QCD, are discussed.
George Belev,Safa Kasap,J.A. Rowlands,David Hunter,Martin Yaffe 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4
Stabilized a-Se lms deposited at suciently low substrate temperatures aren-like in which electrons can drift but holes are deeplytrapped. Such layers can be conveniently incorporated in a multilayer a-Se detector structure to block the injection of holes from thepositive electrode. We have shown that a simple double-layer detector structure based on a cold depositedn-layer (which is thenannealed) on which an i-like layer is grown can have dark current densities lower than 10. 10 Acm. 2 at a eld of 10 V/l m. The darkcurrent depends on the thickness of then-like layer. An a-Se X-ray detector for slot scanning was fabricated by having thein a-Se photo-conductor structure coated onto a CCD chip. The latter detector was shown to have excellent resolution with a modulation transfer func-tion remaining above 0.5 up to a spatial frequency of 11-14 lp mm-¹
TAZ as a novel enhancer of MyoD‐mediated myogenic differentiation
Jeong, Hana,Bae, Sujung,An, Su Yeon,Byun, Mi Ran,Hwang, Jun‐,Ha,Yaffe, Michael B.,Hong, Jeong‐,Ho,Hwang, Eun Sook Federation of American Society for Experimental Bi 2010 The FASEB Journal Vol.24 No.9
<P>Myoblast differentiation is indispensable for skeletal muscle formation and is governed by the precisely coordinated regulation of a series of transcription factors, including MyoD and myogenin, and transcriptional coregulators. TAZ (transcriptional coactivator with PDZ-binding motif) has been characterized as a modulator of mesenchymal stem cell differentiation into osteoblasts and adipocytes through its regulation of lineage-specific master transcription factors. In this study, we investigated whether TAZ affects myoblast differentiation, which is one of the differentiated lineages of mesenchymal stem cells. Ectopic overexpression of TAZ in myoblasts increases myogenic gene expression in a MyoD-dependent manner and hastens myofiber formation, whereas TAZ knockdown delays myogenic differentiation. In addition, enforced coexpression of TAZ and MyoD in fibroblasts accelerates MyoD-induced myogenic differentiation. TAZ physically interacts with MyoD through the WW domain and activates MyoD-dependent gene transcription. TAZ additionally enhances the interaction of MyoD with the myogenin gene promoter. These results strongly suggest that TAZ functions as a novel transcriptional modulator of myogenic differentiation by promoting MyoD-mediated myogenic gene expression.</P>
TAZ as a novel enhancer of MyoD-mediated myogenic differentiation
Hwang, Eun Sook,Jeong, Hana,Bae, Su jung,An, Su Yeon,Byun, Mi Ran,Hwang, Jun Ha,Yaffe, Michael B,Hong, Jeong-Ho 梨花女子大學校 藥學硏究所 2011 藥學硏究論文集 Vol.- No.21
Myoblast differentiation is indispensable for skeletal muscle formation and is governed by the precisely coordinated regulation of a series of transcription factors, including MyoD and myogenin, and transcriptional coregulators. TAZ (transcriptional coactivator with PDZ-binding motif) has been characterized as a modulator of mesenchymal stem cell differentiation into osteoblasts and adipocytes through its regulation of lineage-specific master transcription factors. In this study, we investigated whether TAZ affects myoblast differentiation, which is one of the differentiated lineages of mesenchymal stem cells. Ectopic overexpression of TAZ in myoblasts increases myogenic gene expression in a MyoD-dependent manner and hastens myofiber formation, whereas TAZ knockdown delays myogenic differentiation. In addition, enforced coexpression of TAZ and MyoD in fibroblasts accelerates MyoD-induced myogenic differentiation. TAZ physically interacts with MyoD through the WW domain and activates MyoD-dependent gene transcription. TAZ additionally enhances the interaction of MyoD with the myogenin gene promoter. These results strongly suggest that TAZ functions as a novel transcriptional modulator of myogenic differentiation by promoting MyoD-mediated myogenic gene expression.
TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation
Hong, Jeong-Ho,Hwang, Eun-Sook,McManus, Michael T.,Amsterdam, Adam,Tian, Yu,Kalmukova, Ralitsa,Mueller, Elisabetta,Benjamin, Thomas,Spiegelman, Bruce M.,Sharp, Phillip A.,Hopkins, Nancy,Yaffe, Michael 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16
Mesenchymal stem celts (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome protiferator-activated receptor γ(PPARγ), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively. How these two transcription factors are regulated in order to specify these alternate cell fates remains a pivotal question. Here we report that a 14-3-3-binding protein, TAZ(transcrip-tional coactivator with PDZ-binding motif), coactivates RunxB-dependent gene transcription while repressing PPARγ-dependent gene transcription. By modulating TAZ expression in model cell lines, mouse embryonic fibroblasts, and primary MSCs in culture and in zebrafish in vivo, we observed alterations in osteogenic versus adipogenic potential. These results indicate that TAZ functions as a molecular rheostat that modulates MSC differentiation.