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Mechanical Analysis of Pion Capture Superconducting Solenoid System for COMET Experiment at J-PARC
Iio, Masami,Yoshida, Makoto,Ye Yang,Taekyung Ki,Okamura, Takahiro,Sasaki, Ken-ichi,Makida, Yasuhiro,Ogitsu, Toru,Mihara, Satoshi,Nakamoto, Tatsushi,Sugano, Michinaka,Terashima, Akio,Kawamata, Hiroshi IEEE 2017 IEEE transactions on applied superconductivity Vol.27 No.4
<P>KEK is currently constructing a long series of superconducting solenoid beamline for the COMET Phase-I experiment at the Hadron facility of J-PARC. The magnet system consists of a 5-T pion capture solenoid, a curved muon transport solenoid, and a large bore detector solenoid. The pion capture solenoid system consists of a large cold mass including four coils with an inner diameter of 1340 mm and a small cold mass including six small coils with an inner diameter of 500 mm. The peak magnetic field on the conductor reaches to 5.4 T at an operation current of 2700 A. This paper presents the design and structural details of a magnet, radiation-resistant coil, cold mass and vacuum vessel, apart from the results of the electromagnetic analysis in two-dimensional (2-D) and 3-D.</P>
Study for grain-filling of rice using 13C labeling flow-metabolome analysis
Okamura Masaki,Hirai Masami Yokota,Sawada Yuji,Okamoto Mami,Arai-Sanoh Yumiko,Yoshida Hiroe,Mukouyama Takehiro,Adachi Shunsuke,Fushimi Erina,Yabe Shiori,Nakagawa Hiroshi,Kobayashi Nobuya,Kondo Motohik 한국작물학회 2017 한국작물학회 학술발표대회 논문집 Vol.2017 No.-
Similarity of Intracellular Signaling Toward Apoptosis Following UVB and UVC Irradiation
Horikawa, Miwa,Matsuda, Naoki,Yoshida, Masahiro,Okumura, Yutaka,Watanabe, Masami,Mori, Toshio Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
UV irradiation activates various intracellular signaling pathways causing cell death in a DNA damage-dependent and an independent manner. As DNA photoproducts, major forms of DNA damage, are maximally formed by UV light at 260-nm, short wavelength UV (UVC) is more harmful than middle wavelength UV (UVB). However, the differences or similarities in responses of DNA damage-independent intracellular signaling molecules to UVB and UVC are not elucidated. We examined activation of signaling molecules towards apoptosis in normal human fibroblastic cells after irradiation with UVB or UVC at a dose generating the equal amount of DNA photoproducts. Both UVB and UVC induced transient phosphorylation of ERK and sustained phosphorylation of p38. Phosphorylation of p53 at Ser15 and at Ser392 residues were also observed, which were inhibited by a phosphoinositide 3-kinase inhibitor, wortmannin. In contrast, an antioxidant N-acetyl-cysteine and a p38 inhibitor SB203580 suppressed only Ser392 phosphorylation, suggesting that UV-induced oxidative stress and p38 activation were involved in the phosphorylation of this site. The apoptic signals such as mitochondrial cytochrome C release and annexin V binding were then observed. Overall, no difference was found in chronological responses of p53, MAPK, and apoptosis between UVB-irradiated and UVC-irradiated cells. These results suggested that DNA damage-independent intracellular signaling molecules similarly responded to UVB and UVC when the equal level of DNA photoproducts were generated.
Takasawa Ken,Asada Ken,Kaneko Syuzo,Shiraishi Kouya,Machino Hidenori,Takahashi Satoshi,Shinkai Norio,Kouno Nobuji,Kobayashi Kazuma,Komatsu Masaaki,Mizuno Takaaki,Okubo Yu,Mukai Masami,Yoshida Tatsuya 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
DNA methylation is an epigenetic modification that results in dynamic changes during ontogenesis and cell differentiation. DNA methylation patterns regulate gene expression and have been widely researched. While tools for DNA methylation analysis have been developed, most of them have focused on intergroup comparative analysis within a dataset; therefore, it is difficult to conduct cross-dataset studies, such as rare disease studies or cross-institutional studies. This study describes a novel method for DNA methylation analysis, namely, methPLIER, which enables interdataset comparative analyses. methPLIER combines Pathway Level Information Extractor (PLIER), which is a non-negative matrix factorization (NMF) method, with regularization by a knowledge matrix and transfer learning. methPLIER can be used to perform intersample and interdataset comparative analysis based on latent feature matrices, which are obtained via matrix factorization of large-scale data, and factor-loading matrices, which are obtained through matrix factorization of the data to be analyzed. We used methPLIER to analyze a lung cancer dataset and confirmed that the data decomposition reflected sample characteristics for recurrence-free survival. Moreover, methPLIER can analyze data obtained via different preprocessing methods, thereby reducing distributional bias among datasets due to preprocessing. Furthermore, methPLIER can be employed for comparative analyses of methylation data obtained from different platforms, thereby reducing bias in data distribution due to platform differences. methPLIER is expected to facilitate cross-sectional DNA methylation data analysis and enhance DNA methylation data resources.