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RISS 인기검색어
- 검색키워드
- 저자 : Marcy Balunas (검색결과 2 건)
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( Lena Gerwick ),( Paul Boudrean ),( Hyuk Jae Choi ),( Sarnantha Mascuch ),( Franclsco A Villa ),( Marcy J Balunas ),( Karla L Malloy ),( Margaret E Teasdale ),( David C Rowley ),( Willam H Gerwick ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Several groups of structurally-related compounds, comprised of either five or six-memberedring structures with attached lipophilic carbon chains and in some cases possessing halogen atoms, have been isolated from various marine algae and filamentous cyanobacteria. The related compounds considered in the present work include the coibacins, laurenciones, honaucins, malyngamides and the tumonoic acids. Members of all of these compound families were assayed and found to inhibit the production of nitric oxide in lipopolysaccharides-stimulated macro-phages, indicating their anti-inflammatory potential In addition, several of these same marine natural products were found to inhibit quorum sensing mediated phenotypes in Vibrio harveyi BB120 and /or Escherichia coli JB525. The mechanism and evolutionary significance for inhibition of these cellular processes in prokaryotic and eukaryotic systems are speculated on and discussed.
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Chai Siah Ku,김보경,Tho X. Pham,Yue Yang,Casey J. Wegner,박영기,Marcy Balunas,이지영 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.12
Hyperlipidemia and inflammation contribute to the development of atherosclerotic lesions. Our objective was to determine antiatherogenic effect of edible blue-green algae (BGA) species, that is, Nostoc commune var. sphaeroides Ku¨tzing (NO) and Spirulina platensis (SP), in apolipoprotein E knockout (ApoE-/-) mice, a well-established mouse model of atherosclerosis. Male ApoE-/- mice were fed a high-fat/high-cholesterol (HF/HC, 15% fat and 0.2% cholesterol by wt) control diet or a HF/HC diet supplemented with 5% (w/w) of NO or SP powder for 12 weeks. Plasma total cholesterol (TC) and triglycerides (TG) were measured, and livers were analyzed for histology and gene expression. Morphometric analysis for lesions and immunohistochemical analysis for CD68 were conducted in the aorta and the aortic root. NO supplementation significantly decreased plasma TC and TG, and liver TC, compared to control and SP groups. In the livers of NO-fed mice, less lipid droplets were present with a concomitant decrease in fatty acid synthase protein levels than the other groups. There was a significant increase in hepatic low-density lipoprotein receptor protein levels in SP-supplemented mice than in control and NO groups. Quantification of aortic lesions by en face analysis demonstrated that both NO and SP decreased aortic lesion development to a similar degree compared with control. While lesions in the aortic root were not significantly different between groups, the CD68-stained area in the aortic root was significantly lowered in BGA-fed mice than controls. In conclusion, both NO and SP supplementation decreased the development of atherosclerotic lesions, suggesting that they may be used as a natural product for atheroprotection.
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